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The map label for this gene is panC

Identifier: 87201331

GI number: 87201331

Start: 3542259

End: 3543119

Strand: Direct

Name: panC

Synonym: Saro_3319

Alternate gene names: 87201331

Gene position: 3542259-3543119 (Clockwise)

Preceding gene: 87201327

Following gene: 87201332

Centisome position: 99.46

GC content: 67.48

Gene sequence:

>861_bases
GTGCAAACCATCAATCGGCTCGACGACCTGCGCCAGGCGGTGGACTCGCTCAAAAACGGGGGAAAAACCCTCGCTTTCGT
ACCCACGATGGGCGCCCTTCATGAAGGGCACCTGACCTTGGTGCGCGAAGCGGCGCGGCGGGCGGACCATGTTGTCGCCT
CGATTTTCGTGAACCCGCGCCAGTTCGGCCCGAACGAGGACCTCGACGCCTATCCCCGGCGCATGGCGACCGACGCCGCG
CTGCTCGAGGCGGAAGGCGTGGCGCTCCTCTGGGCGCCGACCGTCGACCAGATGTACCCCGATGGCTATGCGACCAACAT
CTCCGTGTCGGGCGTCAGCGAGGTCGCCTGCGGCGCAGCGCGGCCCGGCCATTTCGATGGCGTGGCGACGGTCGTGTGCA
AGCTGTTCAACCAGGTTCGACCTGATTTCGCGCTGTTCGGCGAAAAGGACTGGCAGCAGCTTGCGGTGATCCGCCGCATG
GCACGCGACCTCGACCTGACCCAGCCGCACGTCGACAGGATCATCGGCGTCCCCACCGTGCGCGAGGACAGCGGTCTCGC
GCTGAGCAGCCGCAACCAGTACCTGAGCGACACCGAACGCGCGCAGGCGACAGGTCTTTCGGCCGCGATGCGCCGCGCCA
TCGCCGCGATAGAGGGCGGTGCGGAGGTCGCCTCATCGCTTGCCGAACTGACTCGCGAAATTCTCGCCGCCGGCTTCGTC
TCGGTCGACTATGCCGACCTGCGCGATGCCGCAACGCTCGAGGAAGTCGTCCGCTTCGAAGGCCGCCCGGCGCGCCTCCT
CGTCGCCGCCCGCATCGGCGGCGCACGCCTGATCGACAACATGGGAGTAGGCCCGCAATGA

Upstream 100 bases:

>100_bases
AGGCGCGATACTCTCTCTGGTGAAGTGCTTCCCGGGCTTGCCGAGCGCTGGCGCGCCCCCTATCGCCCTTCCCTTCGGAC
TTAGTGGAGAGGCCGCGAAC

Downstream 100 bases:

>100_bases
CCGAGACCATCCAGCCCGGCCCGTCCTTCAAGGACAATCTCGTCCTGCTGCCGTCCATCGACGGCCTCGCGCGGATCGAC
ATCGTGGCTGGCGACGGCCG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MQTINRLDDLRQAVDSLKNGGKTLAFVPTMGALHEGHLTLVREAARRADHVVASIFVNPRQFGPNEDLDAYPRRMATDAA
LLEAEGVALLWAPTVDQMYPDGYATNISVSGVSEVACGAARPGHFDGVATVVCKLFNQVRPDFALFGEKDWQQLAVIRRM
ARDLDLTQPHVDRIIGVPTVREDSGLALSSRNQYLSDTERAQATGLSAAMRRAIAAIEGGAEVASSLAELTREILAAGFV
SVDYADLRDAATLEEVVRFEGRPARLLVAARIGGARLIDNMGVGPQ

Sequences:

>Translated_286_residues
MQTINRLDDLRQAVDSLKNGGKTLAFVPTMGALHEGHLTLVREAARRADHVVASIFVNPRQFGPNEDLDAYPRRMATDAA
LLEAEGVALLWAPTVDQMYPDGYATNISVSGVSEVACGAARPGHFDGVATVVCKLFNQVRPDFALFGEKDWQQLAVIRRM
ARDLDLTQPHVDRIIGVPTVREDSGLALSSRNQYLSDTERAQATGLSAAMRRAIAAIEGGAEVASSLAELTREILAAGFV
SVDYADLRDAATLEEVVRFEGRPARLLVAARIGGARLIDNMGVGPQ
>Mature_286_residues
MQTINRLDDLRQAVDSLKNGGKTLAFVPTMGALHEGHLTLVREAARRADHVVASIFVNPRQFGPNEDLDAYPRRMATDAA
LLEAEGVALLWAPTVDQMYPDGYATNISVSGVSEVACGAARPGHFDGVATVVCKLFNQVRPDFALFGEKDWQQLAVIRRM
ARDLDLTQPHVDRIIGVPTVREDSGLALSSRNQYLSDTERAQATGLSAAMRRAIAAIEGGAEVASSLAELTREILAAGFV
SVDYADLRDAATLEEVVRFEGRPARLLVAARIGGARLIDNMGVGPQ

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=286, Percent_Identity=46.5034965034965, Blast_Score=221, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322046, Length=289, Percent_Identity=37.7162629757785, Blast_Score=176, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_NOVAD (Q2G319)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_498588.1
- ProteinModelPortal:   Q2G319
- SMR:   Q2G319
- STRING:   Q2G319
- GeneID:   3915966
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_3319
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- PhylomeDB:   Q2G319
- ProtClustDB:   PRK00380
- BioCyc:   NARO279238:SARO_3319-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30834; Mature: 30834

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTINRLDDLRQAVDSLKNGGKTLAFVPTMGALHEGHLTLVREAARRADHVVASIFVNPR
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHEECHH
QFGPNEDLDAYPRRMATDAALLEAEGVALLWAPTVDQMYPDGYATNISVSGVSEVACGAA
HCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCEEEECCHHHHHHCCC
RPGHFDGVATVVCKLFNQVRPDFALFGEKDWQQLAVIRRMARDLDLTQPHVDRIIGVPTV
CCCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCE
REDSGLALSSRNQYLSDTERAQATGLSAAMRRAIAAIEGGAEVASSLAELTREILAAGFV
ECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SVDYADLRDAATLEEVVRFEGRPARLLVAARIGGARLIDNMGVGPQ
HCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCC
>Mature Secondary Structure
MQTINRLDDLRQAVDSLKNGGKTLAFVPTMGALHEGHLTLVREAARRADHVVASIFVNPR
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHEECHH
QFGPNEDLDAYPRRMATDAALLEAEGVALLWAPTVDQMYPDGYATNISVSGVSEVACGAA
HCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCEEEECCHHHHHHCCC
RPGHFDGVATVVCKLFNQVRPDFALFGEKDWQQLAVIRRMARDLDLTQPHVDRIIGVPTV
CCCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCE
REDSGLALSSRNQYLSDTERAQATGLSAAMRRAIAAIEGGAEVASSLAELTREILAAGFV
ECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SVDYADLRDAATLEEVVRFEGRPARLLVAARIGGARLIDNMGVGPQ
HCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA