Click here to switch to the map view.

The map label for this gene is ung [H]

Identifier: 87201268

GI number: 87201268

Start: 3476471

End: 3477151

Strand: Direct

Name: ung [H]

Synonym: Saro_3256

Alternate gene names: 87201268

Gene position: 3476471-3477151 (Clockwise)

Preceding gene: 87201266

Following gene: 87201279

Centisome position: 97.61

GC content: 72.25

Gene sequence:

>681_bases
ATGAACCTCTCCTTGCCCGCAGACTGGCGCGCCAGCCTCGAACCCCTGCTTGCCTCGCCCCCCTTGCGCGCACTGGGCGA
CTTCCTCGACGCGGAGGAGCGGGCCGGCAAGACGATCTACCCTCCCGCGACGCAGCGCCTCGCCGCTCTGGAGATGACCC
CGCTGGACAACGTGCGCATCGTGATCCTGGGGCAGGACCCCTACCACGGCCCCGGCCAGGCGCACGGCCTCGCCTTCTCG
GTCCAGGACGGGGTCAAGGTCCCGCCGAGCCTTGCCAACATCTACAAGGAACTGGAGGCCGACCTCGGCCTGCCCCGCCC
GCCCCACGGCAACCTCGCACGGTGGGCGCGGCAGGGAGTGCTGCTGCTCAACAGCGCACTGACGGTCGAGGCGGCAAGCG
CCGGCTCGCACCAGGGCAAGGGCTGGGAGGCCCTGACCGACGCCGCCATCGCCGCCGTCGCCGCGCGCGACGTACCGACG
GTGTTCATGCTCTGGGGCAGCCACGCGCAGAAGAAGGCGGCGCGCGTCGCCCGCCTGGCCAGCGGCCCCCACCTCGTGCT
CGAAGCCCCGCACCCCAGCCCGCTCTCGGCGCACAAGGGGTTCCTCGGATGCCGCCATTTCAGCAAGGCCAACGCCTTCC
TCGAGGCGCACGGGCGGCGCGCGGTGGACTGGCGGATCTGA

Upstream 100 bases:

>100_bases
GATATCGCGCCGGATACCGCGCCGTGGCTGTTAGCAAGCCACCTTCGACACAGGCAACCCCGCTTGCCCCGAACGCCTTG
CGGCGGCTACTTGCCGGGAC

Downstream 100 bases:

>100_bases
CGCAAAAGACCCCGCCGGAGCGGGGTCTCGTTGAAAATCCATACGCGCGAAGCGTCTGCCGGGAGATGCCTCAGCCGGGA
ATGGAGGCCGAGGCTGCCTG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNLSLPADWRASLEPLLASPPLRALGDFLDAEERAGKTIYPPATQRLAALEMTPLDNVRIVILGQDPYHGPGQAHGLAFS
VQDGVKVPPSLANIYKELEADLGLPRPPHGNLARWARQGVLLLNSALTVEAASAGSHQGKGWEALTDAAIAAVAARDVPT
VFMLWGSHAQKKAARVARLASGPHLVLEAPHPSPLSAHKGFLGCRHFSKANAFLEAHGRRAVDWRI

Sequences:

>Translated_226_residues
MNLSLPADWRASLEPLLASPPLRALGDFLDAEERAGKTIYPPATQRLAALEMTPLDNVRIVILGQDPYHGPGQAHGLAFS
VQDGVKVPPSLANIYKELEADLGLPRPPHGNLARWARQGVLLLNSALTVEAASAGSHQGKGWEALTDAAIAAVAARDVPT
VFMLWGSHAQKKAARVARLASGPHLVLEAPHPSPLSAHKGFLGCRHFSKANAFLEAHGRRAVDWRI
>Mature_226_residues
MNLSLPADWRASLEPLLASPPLRALGDFLDAEERAGKTIYPPATQRLAALEMTPLDNVRIVILGQDPYHGPGQAHGLAFS
VQDGVKVPPSLANIYKELEADLGLPRPPHGNLARWARQGVLLLNSALTVEAASAGSHQGKGWEALTDAAIAAVAARDVPT
VFMLWGSHAQKKAARVARLASGPHLVLEAPHPSPLSAHKGFLGCRHFSKANAFLEAHGRRAVDWRI

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=218, Percent_Identity=49.5412844036697, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI6224979, Length=218, Percent_Identity=49.5412844036697, Blast_Score=217, Evalue=7e-57,
Organism=Escherichia coli, GI1788934, Length=195, Percent_Identity=56.4102564102564, Blast_Score=224, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=46.7889908256881, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=38.3966244725738, Blast_Score=161, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24185; Mature: 24185

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSLPADWRASLEPLLASPPLRALGDFLDAEERAGKTIYPPATQRLAALEMTPLDNVRI
CCCCCCCCCHHCCCHHHCCCCHHHHHHHHHHHHHCCCEECCCHHHHHEEEECCCCCCEEE
VILGQDPYHGPGQAHGLAFSVQDGVKVPPSLANIYKELEADLGLPRPPHGNLARWARQGV
EEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCE
LLLNSALTVEAASAGSHQGKGWEALTDAAIAAVAARDVPTVFMLWGSHAQKKAARVARLA
EEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHC
SGPHLVLEAPHPSPLSAHKGFLGCRHFSKANAFLEAHGRRAVDWRI
CCCEEEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCEEEECCC
>Mature Secondary Structure
MNLSLPADWRASLEPLLASPPLRALGDFLDAEERAGKTIYPPATQRLAALEMTPLDNVRI
CCCCCCCCCHHCCCHHHCCCCHHHHHHHHHHHHHCCCEECCCHHHHHEEEECCCCCCEEE
VILGQDPYHGPGQAHGLAFSVQDGVKVPPSLANIYKELEADLGLPRPPHGNLARWARQGV
EEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCE
LLLNSALTVEAASAGSHQGKGWEALTDAAIAAVAARDVPTVFMLWGSHAQKKAARVARLA
EEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHC
SGPHLVLEAPHPSPLSAHKGFLGCRHFSKANAFLEAHGRRAVDWRI
CCCEEEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]