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The map label for this gene is bioF [H]

Identifier: 87201123

GI number: 87201123

Start: 3325484

End: 3326683

Strand: Direct

Name: bioF [H]

Synonym: Saro_3111

Alternate gene names: 87201123

Gene position: 3325484-3326683 (Clockwise)

Preceding gene: 87201122

Following gene: 87201124

Centisome position: 93.37

GC content: 64.17

Gene sequence:

>1200_bases
ATGACGGATCTTTTCAGCAAGTTCGACCCGCTGATCGAACAGCGCCGCGCGTTGCTGGCGGGCGGGGTCGAAGACCCGTT
CAACCTGGTGATGGAGCGGGTGATCAGCCCGACCGTGGCGGTGTGCAACGGTCGCGAGACGATCCTGCTCGGCACCTACA
ACTACATGGGCATGACTTTCGACCCCGACGTGATCGCGGCGGGCAAGCAGGCGCTGGACGACTTCGGTTCGGGCACCACC
GGCAGCCGCGTGCTGAACGGCACCTATGCCGGCCACAAGGCCTGCGAAGAGGCGCTCAAGGAGTTCTATGGCATGGATCA
TGCCATGGTGTTCTCCACCGGATACCAGGCGAACCTGGGCATCATCAGCACGATCGCCGGCAAGGGCGACTACATCATCC
TCGACATCGACAGCCACGCGTCGATCTGGGACGGCTGCAAGATGGGCGACGCCGAAGTGGTGCCGTTCAAGCACAACGAT
ATCGAGGCGATGGAAAAGCGCCTGAAGCGCGTGCCGGAAGGCGCGGGCAAGCTGGTGGTGCTTGAAGGCGTCTATTCGAT
GCTGGGGGACATCGCCCCGCTCAAGGAAATGATCCGCATCGCCAAGGAACACGGCGCGATGGTGCTGGTCGACGAGGCGC
ATTCGATGGGCTTCATCGGCCCCAACGGGCGCGGCGTGGCCGAAGAACAGGGCGTTCTCGACCAGGTCGACTTCGTGATC
GGCACGTTCTCGAAATCGGTCGGCACGGTCGGCGGCTTCTGTGTCTCGAACCACCCGAAGTTCGAGATCCTGCGCCTCGT
CTGCCGCCCCTATGTCTTCACCGCCTCGCTTCCGCCGAGCGTGGTCCACACCGCCGCGACTTCGATCCGCAAGCTCATGC
ACGCAGGGAACAAGCGCGCGCACCTGTGGGAGAACTCGAAGACGCTGCACAAGGGCCTGCGCGACAAGGGCTTCCAGCTT
GGCACGACCGAGCCGCAGAGCGCGATCATCTCGGTCATCATGCCCGACCTGGAACGCGGCGCGGCGATGTGGGAAGCACT
GCTGCACGAGGGACTCTACGTGAACCTCGCGCGGCCGCCCGCGACGCCTGCGGGCATGACGCTACTGCGCTGCTCGCTGT
GTGCCGAGCACACAGCCGAACAGGTGCAGACGATCATCGGCATGTTCGAGCGCGCCGGAAAGGCCGTGGGCATCATCTGA

Upstream 100 bases:

>100_bases
GAGGACGAATTCGACATCATCATCAGCATGAACCAGCAGGCCGAGATCGAGAACTATGGCCAGCTCGTCGATGCGGTGAC
GAAGCTGCAGGGATAAGCCA

Downstream 100 bases:

>100_bases
TGCGCAAGGCAATGGCGGGAGCGCTGGCGCTTGCGACGCTGGCGGCGGCAGGCACACCGGCGATGGCGCAGAACCGGGCG
GCACCTGCCGCGCCGCCTGC

Product: serine palmitoyltransferase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTDLFSKFDPLIEQRRALLAGGVEDPFNLVMERVISPTVAVCNGRETILLGTYNYMGMTFDPDVIAAGKQALDDFGSGTT
GSRVLNGTYAGHKACEEALKEFYGMDHAMVFSTGYQANLGIISTIAGKGDYIILDIDSHASIWDGCKMGDAEVVPFKHND
IEAMEKRLKRVPEGAGKLVVLEGVYSMLGDIAPLKEMIRIAKEHGAMVLVDEAHSMGFIGPNGRGVAEEQGVLDQVDFVI
GTFSKSVGTVGGFCVSNHPKFEILRLVCRPYVFTASLPPSVVHTAATSIRKLMHAGNKRAHLWENSKTLHKGLRDKGFQL
GTTEPQSAIISVIMPDLERGAAMWEALLHEGLYVNLARPPATPAGMTLLRCSLCAEHTAEQVQTIIGMFERAGKAVGII

Sequences:

>Translated_399_residues
MTDLFSKFDPLIEQRRALLAGGVEDPFNLVMERVISPTVAVCNGRETILLGTYNYMGMTFDPDVIAAGKQALDDFGSGTT
GSRVLNGTYAGHKACEEALKEFYGMDHAMVFSTGYQANLGIISTIAGKGDYIILDIDSHASIWDGCKMGDAEVVPFKHND
IEAMEKRLKRVPEGAGKLVVLEGVYSMLGDIAPLKEMIRIAKEHGAMVLVDEAHSMGFIGPNGRGVAEEQGVLDQVDFVI
GTFSKSVGTVGGFCVSNHPKFEILRLVCRPYVFTASLPPSVVHTAATSIRKLMHAGNKRAHLWENSKTLHKGLRDKGFQL
GTTEPQSAIISVIMPDLERGAAMWEALLHEGLYVNLARPPATPAGMTLLRCSLCAEHTAEQVQTIIGMFERAGKAVGII
>Mature_398_residues
TDLFSKFDPLIEQRRALLAGGVEDPFNLVMERVISPTVAVCNGRETILLGTYNYMGMTFDPDVIAAGKQALDDFGSGTTG
SRVLNGTYAGHKACEEALKEFYGMDHAMVFSTGYQANLGIISTIAGKGDYIILDIDSHASIWDGCKMGDAEVVPFKHNDI
EAMEKRLKRVPEGAGKLVVLEGVYSMLGDIAPLKEMIRIAKEHGAMVLVDEAHSMGFIGPNGRGVAEEQGVLDQVDFVIG
TFSKSVGTVGGFCVSNHPKFEILRLVCRPYVFTASLPPSVVHTAATSIRKLMHAGNKRAHLWENSKTLHKGLRDKGFQLG
TTEPQSAIISVIMPDLERGAAMWEALLHEGLYVNLARPPATPAGMTLLRCSLCAEHTAEQVQTIIGMFERAGKAVGII

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=398, Percent_Identity=31.6582914572864, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=32.4712643678161, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI83977442, Length=351, Percent_Identity=31.9088319088319, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI83977440, Length=351, Percent_Identity=31.9088319088319, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI83977444, Length=351, Percent_Identity=31.9088319088319, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=30.4347826086957, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=31.129476584022, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI4502025, Length=350, Percent_Identity=31.1428571428571, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI40316939, Length=350, Percent_Identity=31.1428571428571, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI5454084, Length=285, Percent_Identity=29.1228070175439, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1790046, Length=376, Percent_Identity=35.1063829787234, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=30.4597701149425, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=384, Percent_Identity=31.7708333333333, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI32566772, Length=371, Percent_Identity=29.3800539083558, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71982617, Length=284, Percent_Identity=29.2253521126761, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71982625, Length=284, Percent_Identity=29.2253521126761, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17560914, Length=357, Percent_Identity=26.890756302521, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17560912, Length=357, Percent_Identity=26.890756302521, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320438, Length=366, Percent_Identity=27.8688524590164, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=27.2479564032698, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=298, Percent_Identity=24.8322147651007, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662918, Length=385, Percent_Identity=28.8311688311688, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137420, Length=372, Percent_Identity=29.8387096774194, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24653280, Length=297, Percent_Identity=31.6498316498317, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24653276, Length=297, Percent_Identity=31.6498316498317, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24653278, Length=297, Percent_Identity=31.6498316498317, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI17136286, Length=373, Percent_Identity=27.6139410187668, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 43196; Mature: 43065

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLFSKFDPLIEQRRALLAGGVEDPFNLVMERVISPTVAVCNGRETILLGTYNYMGMTF
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEE
DPDVIAAGKQALDDFGSGTTGSRVLNGTYAGHKACEEALKEFYGMDHAMVFSTGYQANLG
CCHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
IISTIAGKGDYIILDIDSHASIWDGCKMGDAEVVPFKHNDIEAMEKRLKRVPEGAGKLVV
EEEEECCCCCEEEEEECCCCCHHCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCEEE
LEGVYSMLGDIAPLKEMIRIAKEHGAMVLVDEAHSMGFIGPNGRGVAEEQGVLDQVDFVI
HHHHHHHHHCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHCCHHHHHHHHH
GTFSKSVGTVGGFCVSNHPKFEILRLVCRPYVFTASLPPSVVHTAATSIRKLMHAGNKRA
HHHHHHHCCCCCEEECCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCE
HLWENSKTLHKGLRDKGFQLGTTEPQSAIISVIMPDLERGAAMWEALLHEGLYVNLARPP
EEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
ATPAGMTLLRCSLCAEHTAEQVQTIIGMFERAGKAVGII
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
TDLFSKFDPLIEQRRALLAGGVEDPFNLVMERVISPTVAVCNGRETILLGTYNYMGMTF
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEE
DPDVIAAGKQALDDFGSGTTGSRVLNGTYAGHKACEEALKEFYGMDHAMVFSTGYQANLG
CCHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
IISTIAGKGDYIILDIDSHASIWDGCKMGDAEVVPFKHNDIEAMEKRLKRVPEGAGKLVV
EEEEECCCCCEEEEEECCCCCHHCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCEEE
LEGVYSMLGDIAPLKEMIRIAKEHGAMVLVDEAHSMGFIGPNGRGVAEEQGVLDQVDFVI
HHHHHHHHHCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHCCHHHHHHHHH
GTFSKSVGTVGGFCVSNHPKFEILRLVCRPYVFTASLPPSVVHTAATSIRKLMHAGNKRA
HHHHHHHCCCCCEEECCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCE
HLWENSKTLHKGLRDKGFQLGTTEPQSAIISVIMPDLERGAAMWEALLHEGLYVNLARPP
EEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
ATPAGMTLLRCSLCAEHTAEQVQTIIGMFERAGKAVGII
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]