Click here to switch to the map view.

The map label for this gene is iscS [H]

Identifier: 87200810

GI number: 87200810

Start: 3020625

End: 3021707

Strand: Reverse

Name: iscS [H]

Synonym: Saro_2797

Alternate gene names: 87200810

Gene position: 3021707-3020625 (Counterclockwise)

Preceding gene: 87200811

Following gene: 87200809

Centisome position: 84.84

GC content: 69.71

Gene sequence:

>1083_bases
GTGATCTACCTCGACTACCAGGCGACGACCCCTCTCGCCCCGGAAGCGCGCGCGGCGATGCTGCCGTGGCTGGCGGGGCC
CGAGGCACCGGGATTTGCCAATCCCCACAGTCCGCACCGCTATGGCCGCGCGGCGGCGGCGGCGGTCGAGGCGGCGCGCG
CGCAAGTGGCCGCGCTGCTGCCGCCCGGCGGGCGGGTGATCATCACCTCGGGCGCGACCGAGGCCATCAACCTCGCGATT
GTCGGGTCCGGGTGCACGCGACTGGCGGCATCGGCGATCGAACATGCGGCGGTGCTGGATACGGCACGCTTCGTCGATCC
CGGAGTCGCGGTGTTGCCGGTGGATGGCGAGGGGCTGGTCGATCCTGATGCGGCGATTCCCGAGGGCACCGGGCTGGTCG
CGGTGATGCAGGTCAACAACGAGATCGGTACGGTGCAGCCGATCGTGGAGCTGGCCCGGCGGGCGCGGGAAGCAGGAGCG
CTGTTCCTGTGCGACGCGGTGCAGGGCGCGGGCAAGCTTGAGGCGCCCGAGGGCGCGGACATGATCGCGATCTCCGCGCA
CAAGCTTTACGGGCCCAAGGGCATCGGCGCGCTGTGGGTGCGCGACGGCATCGAGCTTCAGCCCCTGATCCACGGCGGCG
GGCAGGAAGGGGGGCTGCGCTCGGGCACATTGAGCCCCGCGCTTTGCGCCGGGTTCGGAGCAGCGGCCGCCCTGTGTACA
AGTCTGCGGGAAAAGGATGCGCACCATGTGGAAAAGCTGTGGACCCGCGCGCGTTCGCTGTTCGACGGCTGGTTGCTGAA
CGGCAGCGCGACCCGGCGCTGGCACGGCAACCTCAACCTTCGCCTGCCGGGGCTGGATGTGAGCCGACTGTTGTCGGAAT
GCCGCACCGTGGCGTTTTCCGCAGGCTCGGCCTGCGCCAGCGGCTCGGGCAGGCCAAGCCACGTCTTGCGCGCGCTCGGA
CTTTCCGACAGGGATGGAAAAAACGCGATCCGACTGGGATTTGGACGCTACACGACGGAAGAGGAACTGGAACAGGCGGC
TGCGGCAATCCTTGCCGCCGCGCGGTCGCAGGGAGTCTGGTAG

Upstream 100 bases:

>100_bases
GCTATGCGCACCCGGGCGAAGTGATCCGCGTTTCCATCGGGCGCGAGACGACCGAGGCCGAAATCGCGCGGTTCGTGGAA
GTGTGGAAGGGCATTCGCGG

Downstream 100 bases:

>100_bases
AATGGTCCGTGTCACCTTCGTCAAACCCGATGGCGAGAAAGTGTCCGCCGAAGGCGAGGAAGGGCAGCGGCTGCTCGAAG
TCGGCCAGAACGTGGGCATG

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MIYLDYQATTPLAPEARAAMLPWLAGPEAPGFANPHSPHRYGRAAAAAVEAARAQVAALLPPGGRVIITSGATEAINLAI
VGSGCTRLAASAIEHAAVLDTARFVDPGVAVLPVDGEGLVDPDAAIPEGTGLVAVMQVNNEIGTVQPIVELARRAREAGA
LFLCDAVQGAGKLEAPEGADMIAISAHKLYGPKGIGALWVRDGIELQPLIHGGGQEGGLRSGTLSPALCAGFGAAAALCT
SLREKDAHHVEKLWTRARSLFDGWLLNGSATRRWHGNLNLRLPGLDVSRLLSECRTVAFSAGSACASGSGRPSHVLRALG
LSDRDGKNAIRLGFGRYTTEEELEQAAAAILAAARSQGVW

Sequences:

>Translated_360_residues
MIYLDYQATTPLAPEARAAMLPWLAGPEAPGFANPHSPHRYGRAAAAAVEAARAQVAALLPPGGRVIITSGATEAINLAI
VGSGCTRLAASAIEHAAVLDTARFVDPGVAVLPVDGEGLVDPDAAIPEGTGLVAVMQVNNEIGTVQPIVELARRAREAGA
LFLCDAVQGAGKLEAPEGADMIAISAHKLYGPKGIGALWVRDGIELQPLIHGGGQEGGLRSGTLSPALCAGFGAAAALCT
SLREKDAHHVEKLWTRARSLFDGWLLNGSATRRWHGNLNLRLPGLDVSRLLSECRTVAFSAGSACASGSGRPSHVLRALG
LSDRDGKNAIRLGFGRYTTEEELEQAAAAILAAARSQGVW
>Mature_360_residues
MIYLDYQATTPLAPEARAAMLPWLAGPEAPGFANPHSPHRYGRAAAAAVEAARAQVAALLPPGGRVIITSGATEAINLAI
VGSGCTRLAASAIEHAAVLDTARFVDPGVAVLPVDGEGLVDPDAAIPEGTGLVAVMQVNNEIGTVQPIVELARRAREAGA
LFLCDAVQGAGKLEAPEGADMIAISAHKLYGPKGIGALWVRDGIELQPLIHGGGQEGGLRSGTLSPALCAGFGAAAALCT
SLREKDAHHVEKLWTRARSLFDGWLLNGSATRRWHGNLNLRLPGLDVSRLLSECRTVAFSAGSACASGSGRPSHVLRALG
LSDRDGKNAIRLGFGRYTTEEELEQAAAAILAAARSQGVW

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=367, Percent_Identity=41.1444141689373, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI156713448, Length=406, Percent_Identity=32.7586206896552, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI48994898, Length=368, Percent_Identity=38.5869565217391, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1787970, Length=167, Percent_Identity=29.940119760479, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25143064, Length=372, Percent_Identity=41.1290322580645, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17533177, Length=326, Percent_Identity=27.6073619631902, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319831, Length=375, Percent_Identity=41.8666666666667, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI20129463, Length=371, Percent_Identity=41.2398921832884, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 37268; Mature: 37268

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLDYQATTPLAPEARAAMLPWLAGPEAPGFANPHSPHRYGRAAAAAVEAARAQVAALL
CEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEE
PPGGRVIITSGATEAINLAIVGSGCTRLAASAIEHAAVLDTARFVDPGVAVLPVDGEGLV
CCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
DPDAAIPEGTGLVAVMQVNNEIGTVQPIVELARRAREAGALFLCDAVQGAGKLEAPEGAD
CCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCC
MIAISAHKLYGPKGIGALWVRDGIELQPLIHGGGQEGGLRSGTLSPALCAGFGAAAALCT
EEEEEHHHHCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
SLREKDAHHVEKLWTRARSLFDGWLLNGSATRRWHGNLNLRLPGLDVSRLLSECRTVAFS
HHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHC
AGSACASGSGRPSHVLRALGLSDRDGKNAIRLGFGRYTTEEELEQAAAAILAAARSQGVW
CCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIYLDYQATTPLAPEARAAMLPWLAGPEAPGFANPHSPHRYGRAAAAAVEAARAQVAALL
CEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEE
PPGGRVIITSGATEAINLAIVGSGCTRLAASAIEHAAVLDTARFVDPGVAVLPVDGEGLV
CCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
DPDAAIPEGTGLVAVMQVNNEIGTVQPIVELARRAREAGALFLCDAVQGAGKLEAPEGAD
CCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCC
MIAISAHKLYGPKGIGALWVRDGIELQPLIHGGGQEGGLRSGTLSPALCAGFGAAAALCT
EEEEEHHHHCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
SLREKDAHHVEKLWTRARSLFDGWLLNGSATRRWHGNLNLRLPGLDVSRLLSECRTVAFS
HHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHC
AGSACASGSGRPSHVLRALGLSDRDGKNAIRLGFGRYTTEEELEQAAAAILAAARSQGVW
CCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA