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The map label for this gene is hemF [H]

Identifier: 87200549

GI number: 87200549

Start: 2738577

End: 2739440

Strand: Reverse

Name: hemF [H]

Synonym: Saro_2536

Alternate gene names: 87200549

Gene position: 2739440-2738577 (Counterclockwise)

Preceding gene: 87200554

Following gene: 87200548

Centisome position: 76.92

GC content: 64.93

Gene sequence:

>864_bases
ATGAGCAACTGGACCGACCACACCGCCCGCGCCCGCACCTGGTTCGAAAGCCTGCGTGACCGCATCTGCGCGGAGTTCGA
AGCGATCGAGCGCGAGGCGGGCTCGGACGCGCGCTTCGCCTACACTCCGTGGAACCGCGAGCACGAAGGCGAGACCGTGG
AGAACGGGGGCGGCGGGGTCCAGGGCCTGATGAAGGGCCGGGTCTTCGAGAAGGTCGGCGTCAACGTATCGACCGTGCAG
GGGGAATTCTCGAAGGAGTTCGCTGGCACGATCAACGGGGCGAGCGCGGACGCGCCGGGCTTCACCGCAACCGGCATCAG
CCTTGTCGCCCACATGGCCAATCCGCACGTGCCCGCCGTCCACATGAACACCCGCTTCCTCACCACCAGCAAGGCATGGT
TCGGCGGCGGCGGCGATCTCAATCCGCCGATCCCCTATGAAGAGGATACGGTAGAGTTCCATGCCGAGTACAAGGCGGCC
TGCGACAGGCACGATCCGGAATACTATCCCCGGTTCAAGAAGTGGGCGGACGACTACTTCTGGATTCCCCACCGCAAGGT
CCATCGCGGCGTTGGCGGCATCTTCTACGACCACCTTGAATGTGCCGACGATGCGGCGTTCGAGGCGAACTTCGCCTTCA
CCCGCGACGTGGGCGAGGCTTTCATCAACGTGTTCCCGCGCCTCGTGCGGCGGCGGATGGGCATGGATTTCACGCCCGCC
GAAAAGCTGACCCAGCTCGAGTATCGCGGGCGCTATGCCGAGTTCAACCTTGTCTGGGACCGGGGCACGCTGTTCGGGCT
CAAGACCGGCGGCAACATCGACGCGATCCTGATGAGTCTGCCGCCGGAAGCCGTCTGGAGCTGA

Upstream 100 bases:

>100_bases
AGCGCTCTGGCCGCTCCGAGGCGAAACTCCTGCCCTGCGAACGAAAAGGGAACCATGGCTTCCCCTTGCCGTAAGCGGAT
TGTCTTGGCAAGGGCTGCCT

Downstream 100 bases:

>100_bases
GACCATGGACGTGCCGGGCGCGCCGCTGGCCGAGGGTTACCACAACGTGCGCGCGGGCGATCTTGCCTGCGTGGTCACCG
CGCTTGAAATGCGCTCCCCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSNWTDHTARARTWFESLRDRICAEFEAIEREAGSDARFAYTPWNREHEGETVENGGGGVQGLMKGRVFEKVGVNVSTVQ
GEFSKEFAGTINGASADAPGFTATGISLVAHMANPHVPAVHMNTRFLTTSKAWFGGGGDLNPPIPYEEDTVEFHAEYKAA
CDRHDPEYYPRFKKWADDYFWIPHRKVHRGVGGIFYDHLECADDAAFEANFAFTRDVGEAFINVFPRLVRRRMGMDFTPA
EKLTQLEYRGRYAEFNLVWDRGTLFGLKTGGNIDAILMSLPPEAVWS

Sequences:

>Translated_287_residues
MSNWTDHTARARTWFESLRDRICAEFEAIEREAGSDARFAYTPWNREHEGETVENGGGGVQGLMKGRVFEKVGVNVSTVQ
GEFSKEFAGTINGASADAPGFTATGISLVAHMANPHVPAVHMNTRFLTTSKAWFGGGGDLNPPIPYEEDTVEFHAEYKAA
CDRHDPEYYPRFKKWADDYFWIPHRKVHRGVGGIFYDHLECADDAAFEANFAFTRDVGEAFINVFPRLVRRRMGMDFTPA
EKLTQLEYRGRYAEFNLVWDRGTLFGLKTGGNIDAILMSLPPEAVWS
>Mature_286_residues
SNWTDHTARARTWFESLRDRICAEFEAIEREAGSDARFAYTPWNREHEGETVENGGGGVQGLMKGRVFEKVGVNVSTVQG
EFSKEFAGTINGASADAPGFTATGISLVAHMANPHVPAVHMNTRFLTTSKAWFGGGGDLNPPIPYEEDTVEFHAEYKAAC
DRHDPEYYPRFKKWADDYFWIPHRKVHRGVGGIFYDHLECADDAAFEANFAFTRDVGEAFINVFPRLVRRRMGMDFTPAE
KLTQLEYRGRYAEFNLVWDRGTLFGLKTGGNIDAILMSLPPEAVWS

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=264, Percent_Identity=43.9393939393939, Blast_Score=205, Evalue=3e-53,
Organism=Escherichia coli, GI1788777, Length=283, Percent_Identity=40.6360424028269, Blast_Score=207, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6320249, Length=298, Percent_Identity=39.261744966443, Blast_Score=194, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17864388, Length=288, Percent_Identity=42.7083333333333, Blast_Score=205, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 32317; Mature: 32186

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWTDHTARARTWFESLRDRICAEFEAIEREAGSDARFAYTPWNREHEGETVENGGGGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEECCCCCCH
QGLMKGRVFEKVGVNVSTVQGEFSKEFAGTINGASADAPGFTATGISLVAHMANPHVPAV
HHHHHHHHHHHHCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEE
HMNTRFLTTSKAWFGGGGDLNPPIPYEEDTVEFHAEYKAACDRHDPEYYPRFKKWADDYF
EECCEEEEECCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCHHHHHHCCCEE
WIPHRKVHRGVGGIFYDHLECADDAAFEANFAFTRDVGEAFINVFPRLVRRRMGMDFTPA
ECCCHHHHHCCCCHHHHHHHHCCCCCEECCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCH
EKLTQLEYRGRYAEFNLVWDRGTLFGLKTGGNIDAILMSLPPEAVWS
HHHHHHHHCCCEEEEEEEEECCEEEEEECCCCEEEEEEECCCHHHCC
>Mature Secondary Structure 
SNWTDHTARARTWFESLRDRICAEFEAIEREAGSDARFAYTPWNREHEGETVENGGGGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEECCCCCCH
QGLMKGRVFEKVGVNVSTVQGEFSKEFAGTINGASADAPGFTATGISLVAHMANPHVPAV
HHHHHHHHHHHHCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEE
HMNTRFLTTSKAWFGGGGDLNPPIPYEEDTVEFHAEYKAACDRHDPEYYPRFKKWADDYF
EECCEEEEECCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCHHHHHHCCCEE
WIPHRKVHRGVGGIFYDHLECADDAAFEANFAFTRDVGEAFINVFPRLVRRRMGMDFTPA
ECCCHHHHHCCCCHHHHHHHHCCCCCEECCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCH
EKLTQLEYRGRYAEFNLVWDRGTLFGLKTGGNIDAILMSLPPEAVWS
HHHHHHHHCCCEEEEEEEEECCEEEEEECCCCEEEEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA