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The map label for this gene is rsh [H]

Identifier: 87200546

GI number: 87200546

Start: 2734524

End: 2736611

Strand: Reverse

Name: rsh [H]

Synonym: Saro_2533

Alternate gene names: 87200546

Gene position: 2736611-2734524 (Counterclockwise)

Preceding gene: 87200548

Following gene: 87200543

Centisome position: 76.84

GC content: 65.52

Gene sequence:

>2088_bases
ATGCTCCGCCAGTACGAACTTGTCGAACGTGTGCTCGCCTACGATCCGGATGCGGACGAGGCGATGCTCAACCGCGCCTA
TGTCTATACCGTCCAGAAGCACGGCACCCAGAAGCGCGCCAGCGGCGACCCCTATTTCTCGCACCCGGTCGAAGTCGCGG
GCCTGATGACCGAGCTGAAGCTCGACCAGGACACGATCATCACCGCGCTGCTCCACGATACGGTCGAGGACACGCTGACC
ACGGTGGAGGACATCGAGCGTCTGTTCGGCCCCGACGTTGCCCGGCTGGTCGACGGCGTGACCAAGCTCTCCAAGATCGA
GACGATGAGCGAGAGCGAGCGCGCGGCCGAAAACCTGCGCAAGTTCCTCCTGGCGATGAGCGAGGACCTGCGCGTCCTTC
TCGTCAAGCTCGCCGACCGCATGCACAACATGCGCACGCTCCACTACATCAAGAGCGAGGAAAAGCGCCGCCGCATCGCG
CGCGAGACCATGGATATCTATGCCCCGCTGGCAGAGCGGGTGGGCATGTACGAGTACATGCGCGAGATGCAGCTTCTGGC
TTTCGAGCAGCTTGAACCGGAAGCCTATGCCACGATCACCGGCCGCCTTGCCGCGATCCGCAGCGAGGAAGGCGCGCAGG
TCGATGCCATCGCGCTCGAGATCAAGAAGGCGCTGGCCGAGGCGGGCCTGCGGGTCGAGGTCTCGGGCCGCGAGAAGCAT
CCCTATTCGATCTGGCGCAAGATGGCCGAGCGGCACGTGTCGTTCGAGCAGATCACCGACATCATGGCGTTCCGCGTCCT
CACCGACGACGAGGACGACTGCTACAAGGCGCTGGGCATCCTCCACCGGGCGTGGCAGATGATCCCGGGGCGCTTCAAGG
ACTACATCTCCACGCCGAAGATGAACGGCTATCGTTCGCTCCACACGGCGCTGATCTATTCCAACGCCATGCGCGTCGAG
GTGCAGATCAAGACGCGCGACATGCACGAACGCAACGAGTTCGGCCTCGCGGCGCACTGGGCCTACAAGCAGGGTGGCAA
GCCCGACGGGCAGGTCGGCTGGCTGCGCGACCTGATCGAAATCCTCGAATCCAGCCACGATGCCGAGGAACTGCTCGAAA
ACACCAAGATGGCGATCTACCAGGATCGCATCTTCGCCTTCACCCCCAAGGGTTCGCTGTTCCAGCTGCCCAAGGGCGCG
ACGCCGATCGACTTCGCCTTTGCCGTCCATACCAACCTCGGCGCGCAGGCAGTCGGGGCCAAGATCAACGGCCGCCACGT
GCCACTGCGCACGCCGCTGGGCAATGGCGACGTGGTCGAGATCATCAAGAGCCGCACTTCCGAACCGCAGCTCTCGTGGC
TCGGTTTCGTCGTGACCGGCAAGGCCCGCGCCGCAATCCGCCGCTTCGTCCGGCAGAAGGAGCGCGCCGAAGTGGCCGCC
ATCGGCCGCAAGCTCTACGAGGAAATCGTCGAGCGGCTGCCCACGAAGATCGGCAAGAAGGCGCTGGCCGATGCGCTCAA
GCGGCTGAAGATGGCCTCGGAGGAGGACTTCATGTTCGCCATCGGCGCGGCCAAGCTGGATGACCGGCAGGTGATGGAAG
CGCTCGTGCCGGGAAGCGCGGCCAACATTCCCGAGGAGAACTGGCCCAGCCAGCGCCGCGCCATCGCGGTGCGCGGGTTG
ACGCCGGGCATGGCCTTCAAGCTCGCCGCCTGCTGCCACCCCGTGCCGGGCGACCGCATCGTCGGCCTGCGTCGCCCCGG
CAAGGGGGTCGAGGTCCACGCGATCGACTGCATGAAGCTGGCCGACGGCATCGACGCCGACTGGATCGACCTTTCGTGGG
ACGCGCGCACCGATGGCGCGATCGGCCGGGTGCGCGCCGAACTGTACAACCGCCCCGGCACGCTCGCCGAAATGGCGGGC
ATCTTCGCCAAGAACCACGCCAATGTCGTCAATCTCGAGATGACCCAGCGCGAGAACCCGTTCCACACCTACGAGGTGGA
CCTCGAGGTGCGCGACCTGGCGCACCTCACCCGGATCATCAGCGCCTTGCGCGCCAGCGACGCGGTGGCTCAGGCAGAGC
GGATCTGA

Upstream 100 bases:

>100_bases
CCCGCTTTGGACCGGACATGGCAAACAATCGGTAAAGATCGCGCCATCCGGGTTGTTTGCACTTGCGCAATGGTTCCGGT
TCCGCCCATTTTAAGGGCAG

Downstream 100 bases:

>100_bases
CGCCGGTCCCGCGTCGCGAAGAGCCACGCAAGCGCGCCCGTCAGCGCAATCGACAGCAGGTTCTGCGCAAGCGGGGCGCC
GTCGCGCGATACCTGGTGGG

Product: (p)ppGpp synthetase SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MLRQYELVERVLAYDPDADEAMLNRAYVYTVQKHGTQKRASGDPYFSHPVEVAGLMTELKLDQDTIITALLHDTVEDTLT
TVEDIERLFGPDVARLVDGVTKLSKIETMSESERAAENLRKFLLAMSEDLRVLLVKLADRMHNMRTLHYIKSEEKRRRIA
RETMDIYAPLAERVGMYEYMREMQLLAFEQLEPEAYATITGRLAAIRSEEGAQVDAIALEIKKALAEAGLRVEVSGREKH
PYSIWRKMAERHVSFEQITDIMAFRVLTDDEDDCYKALGILHRAWQMIPGRFKDYISTPKMNGYRSLHTALIYSNAMRVE
VQIKTRDMHERNEFGLAAHWAYKQGGKPDGQVGWLRDLIEILESSHDAEELLENTKMAIYQDRIFAFTPKGSLFQLPKGA
TPIDFAFAVHTNLGAQAVGAKINGRHVPLRTPLGNGDVVEIIKSRTSEPQLSWLGFVVTGKARAAIRRFVRQKERAEVAA
IGRKLYEEIVERLPTKIGKKALADALKRLKMASEEDFMFAIGAAKLDDRQVMEALVPGSAANIPEENWPSQRRAIAVRGL
TPGMAFKLAACCHPVPGDRIVGLRRPGKGVEVHAIDCMKLADGIDADWIDLSWDARTDGAIGRVRAELYNRPGTLAEMAG
IFAKNHANVVNLEMTQRENPFHTYEVDLEVRDLAHLTRIISALRASDAVAQAERI

Sequences:

>Translated_695_residues
MLRQYELVERVLAYDPDADEAMLNRAYVYTVQKHGTQKRASGDPYFSHPVEVAGLMTELKLDQDTIITALLHDTVEDTLT
TVEDIERLFGPDVARLVDGVTKLSKIETMSESERAAENLRKFLLAMSEDLRVLLVKLADRMHNMRTLHYIKSEEKRRRIA
RETMDIYAPLAERVGMYEYMREMQLLAFEQLEPEAYATITGRLAAIRSEEGAQVDAIALEIKKALAEAGLRVEVSGREKH
PYSIWRKMAERHVSFEQITDIMAFRVLTDDEDDCYKALGILHRAWQMIPGRFKDYISTPKMNGYRSLHTALIYSNAMRVE
VQIKTRDMHERNEFGLAAHWAYKQGGKPDGQVGWLRDLIEILESSHDAEELLENTKMAIYQDRIFAFTPKGSLFQLPKGA
TPIDFAFAVHTNLGAQAVGAKINGRHVPLRTPLGNGDVVEIIKSRTSEPQLSWLGFVVTGKARAAIRRFVRQKERAEVAA
IGRKLYEEIVERLPTKIGKKALADALKRLKMASEEDFMFAIGAAKLDDRQVMEALVPGSAANIPEENWPSQRRAIAVRGL
TPGMAFKLAACCHPVPGDRIVGLRRPGKGVEVHAIDCMKLADGIDADWIDLSWDARTDGAIGRVRAELYNRPGTLAEMAG
IFAKNHANVVNLEMTQRENPFHTYEVDLEVRDLAHLTRIISALRASDAVAQAERI
>Mature_695_residues
MLRQYELVERVLAYDPDADEAMLNRAYVYTVQKHGTQKRASGDPYFSHPVEVAGLMTELKLDQDTIITALLHDTVEDTLT
TVEDIERLFGPDVARLVDGVTKLSKIETMSESERAAENLRKFLLAMSEDLRVLLVKLADRMHNMRTLHYIKSEEKRRRIA
RETMDIYAPLAERVGMYEYMREMQLLAFEQLEPEAYATITGRLAAIRSEEGAQVDAIALEIKKALAEAGLRVEVSGREKH
PYSIWRKMAERHVSFEQITDIMAFRVLTDDEDDCYKALGILHRAWQMIPGRFKDYISTPKMNGYRSLHTALIYSNAMRVE
VQIKTRDMHERNEFGLAAHWAYKQGGKPDGQVGWLRDLIEILESSHDAEELLENTKMAIYQDRIFAFTPKGSLFQLPKGA
TPIDFAFAVHTNLGAQAVGAKINGRHVPLRTPLGNGDVVEIIKSRTSEPQLSWLGFVVTGKARAAIRRFVRQKERAEVAA
IGRKLYEEIVERLPTKIGKKALADALKRLKMASEEDFMFAIGAAKLDDRQVMEALVPGSAANIPEENWPSQRRAIAVRGL
TPGMAFKLAACCHPVPGDRIVGLRRPGKGVEVHAIDCMKLADGIDADWIDLSWDARTDGAIGRVRAELYNRPGTLAEMAG
IFAKNHANVVNLEMTQRENPFHTYEVDLEVRDLAHLTRIISALRASDAVAQAERI

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=142, Percent_Identity=36.6197183098592, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790082, Length=699, Percent_Identity=38.6266094420601, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1789147, Length=716, Percent_Identity=30.5865921787709, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24650996, Length=124, Percent_Identity=36.2903225806452, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 78344; Mature: 78344

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRQYELVERVLAYDPDADEAMLNRAYVYTVQKHGTQKRASGDPYFSHPVEVAGLMTELK
CCCHHHHHHHHHHCCCCCHHHHHCCCEEEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHC
LDQDTIITALLHDTVEDTLTTVEDIERLFGPDVARLVDGVTKLSKIETMSESERAAENLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLLAMSEDLRVLLVKLADRMHNMRTLHYIKSEEKRRRIARETMDIYAPLAERVGMYEYM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
REMQLLAFEQLEPEAYATITGRLAAIRSEEGAQVDAIALEIKKALAEAGLRVEVSGREKH
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCC
PYSIWRKMAERHVSFEQITDIMAFRVLTDDEDDCYKALGILHRAWQMIPGRFKDYISTPK
CHHHHHHHHHHCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
MNGYRSLHTALIYSNAMRVEVQIKTRDMHERNEFGLAAHWAYKQGGKPDGQVGWLRDLIE
CCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHCCCCCCCCHHHHHHHHH
ILESSHDAEELLENTKMAIYQDRIFAFTPKGSLFQLPKGATPIDFAFAVHTNLGAQAVGA
HHHCCCCHHHHHHHCCCEEEECEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCHHHCC
KINGRHVPLRTPLGNGDVVEIIKSRTSEPQLSWLGFVVTGKARAAIRRFVRQKERAEVAA
EECCCCCEEECCCCCCHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHH
IGRKLYEEIVERLPTKIGKKALADALKRLKMASEEDFMFAIGAAKLDDRQVMEALVPGSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCCC
ANIPEENWPSQRRAIAVRGLTPGMAFKLAACCHPVPGDRIVGLRRPGKGVEVHAIDCMKL
CCCCCCCCCCHHHEEEEECCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEEHHHHH
ADGIDADWIDLSWDARTDGAIGRVRAELYNRPGTLAEMAGIFAKNHANVVNLEMTQRENP
HCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCC
FHTYEVDLEVRDLAHLTRIISALRASDAVAQAERI
CEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRQYELVERVLAYDPDADEAMLNRAYVYTVQKHGTQKRASGDPYFSHPVEVAGLMTELK
CCCHHHHHHHHHHCCCCCHHHHHCCCEEEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHC
LDQDTIITALLHDTVEDTLTTVEDIERLFGPDVARLVDGVTKLSKIETMSESERAAENLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLLAMSEDLRVLLVKLADRMHNMRTLHYIKSEEKRRRIARETMDIYAPLAERVGMYEYM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
REMQLLAFEQLEPEAYATITGRLAAIRSEEGAQVDAIALEIKKALAEAGLRVEVSGREKH
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCC
PYSIWRKMAERHVSFEQITDIMAFRVLTDDEDDCYKALGILHRAWQMIPGRFKDYISTPK
CHHHHHHHHHHCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
MNGYRSLHTALIYSNAMRVEVQIKTRDMHERNEFGLAAHWAYKQGGKPDGQVGWLRDLIE
CCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHCCCCCCCCHHHHHHHHH
ILESSHDAEELLENTKMAIYQDRIFAFTPKGSLFQLPKGATPIDFAFAVHTNLGAQAVGA
HHHCCCCHHHHHHHCCCEEEECEEEEECCCCCEEECCCCCCCCEEEEEEECCCCCHHHCC
KINGRHVPLRTPLGNGDVVEIIKSRTSEPQLSWLGFVVTGKARAAIRRFVRQKERAEVAA
EECCCCCEEECCCCCCHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHH
IGRKLYEEIVERLPTKIGKKALADALKRLKMASEEDFMFAIGAAKLDDRQVMEALVPGSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCCC
ANIPEENWPSQRRAIAVRGLTPGMAFKLAACCHPVPGDRIVGLRRPGKGVEVHAIDCMKL
CCCCCCCCCCHHHEEEEECCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEEHHHHH
ADGIDADWIDLSWDARTDGAIGRVRAELYNRPGTLAEMAGIFAKNHANVVNLEMTQRENP
HCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCC
FHTYEVDLEVRDLAHLTRIISALRASDAVAQAERI
CEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA