BacMap

Definition	Novosphingobium aromaticivorans DSM 12444 chromosome, complete genome.
Accession	NC_007794
Length	3,561,584

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The map label for this gene is lvr [H]

Identifier: 87200486

GI number: 87200486

Start: 2672670

End: 2673440

Strand: Direct

Name: lvr [H]

Synonym: Saro_2473

Alternate gene names: 87200486

Gene position: 2672670-2673440 (Clockwise)

Preceding gene: 87200485

Following gene: 87200487

Centisome position: 75.04

GC content: 62.26

Gene sequence:

>771_bases
ATGCGCTTCAAGGACAAGGTCGTGATCGTGACGGGCGCAGGCTCCGGATTGGGTCTCGCGACGGTGCAACGACTGGCCGA
GGAGGGCGCAACGCTCGCCTTGGTGGATCTGCGCGAAGACTGGCTGGAAGCCGCTCGAGCCACGCTTCCCGATGCCACGC
GGACGAAGCTGATCAAGGCCGACGTTGCCGATGTCGCGCAAGTCGAGGCCTATGTAGATGCGACCGTCGCTCAATTTGGC
AGGATCGACGGCTTCTTCAACAATGCCGGGATCGAGGGGCGCCAGAACCTTACCGAAAACTTCGGCGCTGAAGAGTTCCA
CCGGGTCATCTCGATCAATCTCGATGGCGTATTCTACGGCATGGCGGCCGTGCTCAAGGTCATGCGTGAACAGGGCTTCG
GCGCCATCGTGAACACCGCATCGGTTGGCGGCATTCGCGGAGTCGGCAACCAGAGCGGCTATGCCGCCGCCAAACACGGC
GTCGTGGGTCTGACGCGCAACTCGGCGGTCGAGTACGGCCAGTACGGCGTCCAGATCAACGCCATCGCTCCGGGTGCGAT
CATGACTGCCATGGTCGAGGGTTCGCTGCGCCAGATCGGCGGCGAAAACTGGGAAGAGGCAGGGCGCCAGTTCGTCTCGG
TCAATCCGATGAAGCGCTTCGGCCGCCCCGAGGAAGTGGCTGCTTTGGTCGCTTTCCTGCTCTCGGGCGAGGCCATTTTC
ATCAATGGCGCAACCATTCCGATCGACGGCGGCCAGTCGTACAAGTATTGA

Upstream 100 bases:

>100_bases
TCAGACGGGTCGATCAATAGCAGGCCTGCTCAATGTGCCGGTTCACGAAAGTGGCCGGTCGTTGGTAGACCGCAATCAAA
TCAGGCAAAGGGACGTGGAT

Downstream 100 bases:

>100_bases
ACGCCATCTCGAACCCAATTGCAGGAGCACGTCGCGAATGGTCGAACGCCCCGGCATGCGCCTGATCGAAGGCGGCACTT
TCACCATGGGCTCGGAAGCC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MRFKDKVVIVTGAGSGLGLATVQRLAEEGATLALVDLREDWLEAARATLPDATRTKLIKADVADVAQVEAYVDATVAQFG
RIDGFFNNAGIEGRQNLTENFGAEEFHRVISINLDGVFYGMAAVLKVMREQGFGAIVNTASVGGIRGVGNQSGYAAAKHG
VVGLTRNSAVEYGQYGVQINAIAPGAIMTAMVEGSLRQIGGENWEEAGRQFVSVNPMKRFGRPEEVAALVAFLLSGEAIF
INGATIPIDGGQSYKY

Sequences:

>Translated_256_residues
MRFKDKVVIVTGAGSGLGLATVQRLAEEGATLALVDLREDWLEAARATLPDATRTKLIKADVADVAQVEAYVDATVAQFG
RIDGFFNNAGIEGRQNLTENFGAEEFHRVISINLDGVFYGMAAVLKVMREQGFGAIVNTASVGGIRGVGNQSGYAAAKHG
VVGLTRNSAVEYGQYGVQINAIAPGAIMTAMVEGSLRQIGGENWEEAGRQFVSVNPMKRFGRPEEVAALVAFLLSGEAIF
INGATIPIDGGQSYKY
>Mature_256_residues
MRFKDKVVIVTGAGSGLGLATVQRLAEEGATLALVDLREDWLEAARATLPDATRTKLIKADVADVAQVEAYVDATVAQFG
RIDGFFNNAGIEGRQNLTENFGAEEFHRVISINLDGVFYGMAAVLKVMREQGFGAIVNTASVGGIRGVGNQSGYAAAKHG
VVGLTRNSAVEYGQYGVQINAIAPGAIMTAMVEGSLRQIGGENWEEAGRQFVSVNPMKRFGRPEEVAALVAFLLSGEAIF
INGATIPIDGGQSYKY

Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=270, Percent_Identity=32.962962962963, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=32.319391634981, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI31542939, Length=201, Percent_Identity=35.3233830845771, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=32.6612903225806, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4758504, Length=258, Percent_Identity=33.7209302325581, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI66933014, Length=255, Percent_Identity=30.5882352941176, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=32.8125, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7705925, Length=247, Percent_Identity=30.3643724696356, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI59889578, Length=245, Percent_Identity=29.3877551020408, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI4504505, Length=201, Percent_Identity=34.3283582089552, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=26.2745098039216, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI224922801, Length=178, Percent_Identity=35.9550561797753, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI83715985, Length=258, Percent_Identity=32.5581395348837, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI7706318, Length=200, Percent_Identity=31.5, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=25.3012048192771, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503301, Length=253, Percent_Identity=30.8300395256917, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI223718074, Length=198, Percent_Identity=31.8181818181818, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI126723750, Length=258, Percent_Identity=26.3565891472868, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4503817, Length=185, Percent_Identity=30.8108108108108, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI20149619, Length=198, Percent_Identity=29.2929292929293, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI19743808, Length=214, Percent_Identity=28.9719626168224, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40807363, Length=198, Percent_Identity=28.2828282828283, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=35.0393700787402, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=35.4581673306773, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=31.5789473684211, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=29.9595141700405, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=28.1124497991968, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=28.1124497991968, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367175, Length=256, Percent_Identity=34.375, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=31.2741312741313, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=25.8823529411765, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=25.9842519685039, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1789057, Length=265, Percent_Identity=27.5471698113208, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=30.2788844621514, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787526, Length=257, Percent_Identity=23.7354085603113, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=26.5193370165746, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=30.9803921568627, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=31.7647058823529, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI115534694, Length=255, Percent_Identity=29.8039215686275, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=29.5275590551181, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=31.6, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=32.3308270676692, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=29.3233082706767, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=28.6245353159851, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=29.9242424242424, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=30.1115241635688, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=26.4822134387352, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=30.9803921568627, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=28.7878787878788, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=28.8389513108614, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17563726, Length=269, Percent_Identity=29.7397769516729, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=28.7313432835821, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=28.5185185185185, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=28.6245353159851, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=30.188679245283, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=28.6764705882353, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=30.3370786516854, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538182, Length=261, Percent_Identity=29.5019157088123, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=29.3436293436293, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=245, Percent_Identity=29.3877551020408, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=26.1992619926199, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=193, Percent_Identity=32.1243523316062, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=26.7657992565056, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=200, Percent_Identity=28.5, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=195, Percent_Identity=29.2307692307692, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=28.4974093264249, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=197, Percent_Identity=28.4263959390863, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=270, Percent_Identity=24.8148148148148, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=215, Percent_Identity=34.4186046511628, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324126, Length=259, Percent_Identity=30.8880308880309, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323882, Length=241, Percent_Identity=26.1410788381743, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=41.3385826771654, Blast_Score=147, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=34.4961240310078, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=36.8627450980392, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=35.546875, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=35.2941176470588, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24643142, Length=253, Percent_Identity=29.2490118577075, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17737361, Length=260, Percent_Identity=34.2307692307692, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24644337, Length=257, Percent_Identity=33.0739299610895, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=26.2745098039216, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859837, Length=262, Percent_Identity=30.5343511450382, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI116007236, Length=204, Percent_Identity=31.3725490196078, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24665243, Length=197, Percent_Identity=31.9796954314721, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221331218, Length=197, Percent_Identity=31.9796954314721, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI116007238, Length=201, Percent_Identity=29.8507462686567, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24665247, Length=198, Percent_Identity=32.3232323232323, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221331216, Length=198, Percent_Identity=32.3232323232323, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641232, Length=209, Percent_Identity=27.7511961722488, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648693, Length=215, Percent_Identity=29.3023255813954, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355889, Length=215, Percent_Identity=29.3023255813954, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281364892, Length=175, Percent_Identity=29.7142857142857, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24580925, Length=199, Percent_Identity=30.6532663316583, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641388, Length=206, Percent_Identity=29.6116504854369, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=25, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24649181, Length=189, Percent_Identity=26.984126984127, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24663911, Length=212, Percent_Identity=26.4150943396226, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27147; Mature: 27147

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFKDKVVIVTGAGSGLGLATVQRLAEEGATLALVDLREDWLEAARATLPDATRTKLIKA
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHH
DVADVAQVEAYVDATVAQFGRIDGFFNNAGIEGRQNLTENFGAEEFHRVISINLDGVFYG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHEEEEEECCHHHHH
MAAVLKVMREQGFGAIVNTASVGGIRGVGNQSGYAAAKHGVVGLTRNSAVEYGQYGVQIN
HHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHCCEEEEECCCCHHHCCCCEEEE
AIAPGAIMTAMVEGSLRQIGGENWEEAGRQFVSVNPMKRFGRPEEVAALVAFLLSGEAIF
EECCHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHCCCEEE
INGATIPIDGGQSYKY
EECEEEEECCCCCCCC
>Mature Secondary Structure
MRFKDKVVIVTGAGSGLGLATVQRLAEEGATLALVDLREDWLEAARATLPDATRTKLIKA
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHH
DVADVAQVEAYVDATVAQFGRIDGFFNNAGIEGRQNLTENFGAEEFHRVISINLDGVFYG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHEEEEEECCHHHHH
MAAVLKVMREQGFGAIVNTASVGGIRGVGNQSGYAAAKHGVVGLTRNSAVEYGQYGVQIN
HHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHCCEEEEECCCCHHHCCCCEEEE
AIAPGAIMTAMVEGSLRQIGGENWEEAGRQFVSVNPMKRFGRPEEVAALVAFLLSGEAIF
EECCHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHCCCEEE
INGATIPIDGGQSYKY
EECEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11388460; 10508066 [H]