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The map label for this gene is ilvC

Identifier: 87200277

GI number: 87200277

Start: 2402566

End: 2403585

Strand: Direct

Name: ilvC

Synonym: Saro_2263

Alternate gene names: 87200277

Gene position: 2402566-2403585 (Clockwise)

Preceding gene: 87200276

Following gene: 87200278

Centisome position: 67.46

GC content: 63.92

Gene sequence:

>1020_bases
ATGAAAGTCTATTACGACGCAGACTGCGATCTGAACCTCATCACGGACAAGAAGATCGCCATTCTCGGCTACGGCTCGCA
GGGCCACGCCCACGCGCAGAACCTGCGCGATTCGGGCGTCAAGGACGTGGCCATCGCGCTGCGCCCCGGTTCGGCCAGCG
CCAAGAAGGCCGAAGCCGCCGGCTTCAAGGTCCTCGCCAACGCCGATGCCGCCGCCTGGGCCGACATCCTCATGATCCTT
GCGCCGGACGAGCACCAGGCCGCAATCTATGCCGATGACCTGCACGCCAACATGAAGCCGGGCGCCGCGCTTGCCTTCGC
GCACGGCCTCAACATCCACTTCGGCCTGATCGAGGCGCGCGCCGACATCGACGTGATCATGATCGCGCCGAAGGGCCCGG
GCCACACCGTCCGCTCGGAATATCAGCGTGGCGGCGGCGTGCCCTGCCTGATCGCCGTCCATCAGAACGTGACCGGCAAC
GCCCACGACGTCGCTCTTGCCTATGCCTCGGGCGTCGGCGGTGGCCGTTCGGGCATCATCGAAACCAACTTCCGCGAGGA
ATGCGAAACCGACCTGTTCGGCGAGCAGGTCGTGCTGTGCGGTGGCACCACCGCCCTGATCCAGGCCGGTTTCGAAACGC
TGGTCGAAGCCGGCTACGCGCCGGAAATGGCCTACTTCGAATGCCTCCACGAACTGAAGCTGATCGTCGACCTGCTTTAT
GAAGGCGGCATCGCCAACATGCGCTACTCGATCTCGAACACTGCCGAATACGGCGACATCAAGACGGGTCCGCGCATCAT
CACCGAAGAGACCAAGAAGGAAATGAAGCGCGTCCTCGCCGACATCCAGGAAGGTCGCTTCGTCAAGGACTTCGTGCTCG
ACAACCGCGCCGGCCAGCCCGAACTCAAGGCTGCCCGCGGTCTCGCCAAGCGCCACCAGATCGAGGAAACCGGCGCCAAG
CTGCGCGCCATGATGCCCTGGATCGGCGCTAACAAGCTCGTGGACCAGACCAAGAACTGA

Upstream 100 bases:

>100_bases
TGTCGGTAAGCACTGCCTTTTTCTGGCGAGAACTGCGTACGCGACAAGATGGATGCTGAAACAGGTTCAGCATGACGATC
AGGACAAGAGGGAAAACACC

Downstream 100 bases:

>100_bases
TCGCAAGCATTTGAATTTGGCGACTCTTTACGGGTCGTCAAATTCCACCAACGGCCGCGCACAATCGACGAAAGCAGTGG
ACGCCACCGTATTGGACGCT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKVYYDADCDLNLITDKKIAILGYGSQGHAHAQNLRDSGVKDVAIALRPGSASAKKAEAAGFKVLANADAAAWADILMIL
APDEHQAAIYADDLHANMKPGAALAFAHGLNIHFGLIEARADIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQNVTGN
AHDVALAYASGVGGGRSGIIETNFREECETDLFGEQVVLCGGTTALIQAGFETLVEAGYAPEMAYFECLHELKLIVDLLY
EGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQEGRFVKDFVLDNRAGQPELKAARGLAKRHQIEETGAK
LRAMMPWIGANKLVDQTKN

Sequences:

>Translated_339_residues
MKVYYDADCDLNLITDKKIAILGYGSQGHAHAQNLRDSGVKDVAIALRPGSASAKKAEAAGFKVLANADAAAWADILMIL
APDEHQAAIYADDLHANMKPGAALAFAHGLNIHFGLIEARADIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQNVTGN
AHDVALAYASGVGGGRSGIIETNFREECETDLFGEQVVLCGGTTALIQAGFETLVEAGYAPEMAYFECLHELKLIVDLLY
EGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQEGRFVKDFVLDNRAGQPELKAARGLAKRHQIEETGAK
LRAMMPWIGANKLVDQTKN
>Mature_339_residues
MKVYYDADCDLNLITDKKIAILGYGSQGHAHAQNLRDSGVKDVAIALRPGSASAKKAEAAGFKVLANADAAAWADILMIL
APDEHQAAIYADDLHANMKPGAALAFAHGLNIHFGLIEARADIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQNVTGN
AHDVALAYASGVGGGRSGIIETNFREECETDLFGEQVVLCGGTTALIQAGFETLVEAGYAPEMAYFECLHELKLIVDLLY
EGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQEGRFVKDFVLDNRAGQPELKAARGLAKRHQIEETGAK
LRAMMPWIGANKLVDQTKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=295, Percent_Identity=38.3050847457627, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=344, Percent_Identity=30.5232558139535, Blast_Score=112, Evalue=7e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_NOVAD (Q2G623)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497534.1
- ProteinModelPortal:   Q2G623
- SMR:   Q2G623
- STRING:   Q2G623
- GeneID:   3916579
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2263
- NMPDR:   fig|48935.1.peg.1744
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q2G623
- ProtClustDB:   PRK05479
- BioCyc:   NARO279238:SARO_2263-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36488; Mature: 36488

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYDADCDLNLITDKKIAILGYGSQGHAHAQNLRDSGVKDVAIALRPGSASAKKAEAA
CEEEECCCCCEEEEECCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHC
GFKVLANADAAAWADILMILAPDEHQAAIYADDLHANMKPGAALAFAHGLNIHFGLIEAR
CEEEEECCCHHHHEEEEEEECCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEEEEEEEC
ADIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQNVTGNAHDVALAYASGVGGGRSGII
CCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCEE
ETNFREECETDLFGEQVVLCGGTTALIQAGFETLVEAGYAPEMAYFECLHELKLIVDLLY
ECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQEGRFVKDFVLDNRAGQP
CCCCCEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCC
ELKAARGLAKRHQIEETGAKLRAMMPWIGANKLVDQTKN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC
>Mature Secondary Structure
MKVYYDADCDLNLITDKKIAILGYGSQGHAHAQNLRDSGVKDVAIALRPGSASAKKAEAA
CEEEECCCCCEEEEECCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHC
GFKVLANADAAAWADILMILAPDEHQAAIYADDLHANMKPGAALAFAHGLNIHFGLIEAR
CEEEEECCCHHHHEEEEEEECCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEEEEEEEC
ADIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQNVTGNAHDVALAYASGVGGGRSGII
CCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCEE
ETNFREECETDLFGEQVVLCGGTTALIQAGFETLVEAGYAPEMAYFECLHELKLIVDLLY
ECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQEGRFVKDFVLDNRAGQP
CCCCCEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCC
ELKAARGLAKRHQIEETGAKLRAMMPWIGANKLVDQTKN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA