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The map label for this gene is ahcY

Identifier: 87200019

GI number: 87200019

Start: 2137479

End: 2138885

Strand: Reverse

Name: ahcY

Synonym: Saro_2003

Alternate gene names: 87200019

Gene position: 2138885-2137479 (Counterclockwise)

Preceding gene: 87200021

Following gene: 87200018

Centisome position: 60.05

GC content: 62.69

Gene sequence:

>1407_bases
GTGGCCAGCGTGCTTGACGCCCAGAACGATTATGTTGTCGCCGACATCGGCCTTGCCGACTTCGGCCGCGCTGAAATCCG
CATTGCGGAAACGGAAATGCCGGGCCTGATGGCCCTGCGCGAGGAGTTCGGCGCTTCGCAGCCGCTCAAGGGCGCGCGCA
TCACCGGCTCGCTGCACATGACCATCCAGACCGCCGTGCTGATCGAGACCCTGGTCGCGCTGGGCGCCGAAGTGCGCTGG
GCCACGTGCAACATCTTCTCCACGCAGGACCACGCCGCTGCCGCGATCGCCGCCGCCGGCATTCCGGTCTTCGCGGTGAA
GGGCGAAAGCCTTGCCGAATACTGGGACTACGTCGGCTCGATCTTCGACTGGGGCGACCAGACCGCCAACATGATCCTCG
ACGATGGCGGCGACGCCACGATGTTCGCCCTGTGGGGCGCGCGCGTCGAAGCCGGCGAGCCGCTGTTCGAACCCTCGAAC
GCCGAGGAAATCGAATTCGTCCGCGCGCTCAAGGAATTCCTCAAGCGCAAGCCGGGCTACCTCACCATGTCCGTCGCCCA
CATCAAGGGCGTTTCGGAAGAGACCACCACCGGCGTTCACCGCCTCTACCAGATCGCCAAGGACGGCAAGCTGCCGTTCC
CAGCGATCAACGTGAACGACAGCGTTACCAAGTCGAAGTTCGACAACCTCTATGGCTGCAAGGAATCACTGGTCGACGCG
ATCCGCCGCGCCACTGACGTGATGCTGGCCGGCAAGGTCGCATGCGTTGCCGGCTTCGGTGACGTGGGCAAGGGTTCGGC
CGCATCGCTGCGCCAGGGCGGCGCGCGCGTGATGGTGACCGAGATCGATCCGATCTGCGCGCTCCAGGCCGCGATGGAAG
GCTATGAAGTCGTCACGATGGAAGAAGCCGTCCAGCGCTGCGACATCTTCGTCACCGCCACCGGCAACGAAGACGTCATC
ACCGCCGAGCACATGAAGGCGATGAAGCCGATGAGCATCGTCTGCAACATCGGCCACTTCGACAGCGAGATCCAGATCTC
GGCGCTGAACAACTACAAGTGGACCGAGATCAAGCCGGGCACTGACCTGGTCGAGTTCCCCGACGGCAAGCAGATCATCA
TCCTTGCCAAGGGACGTCTGGTGAACCTGGGCTGCGCCACCGGCCACCCGAGCTTCGTGATGTCCTCGTCGTTCACCAAC
CAGGTGCTGGCTCAGATCGAGCTGTTCACCAAGAACGCCGAATACAAGAACGAAGTCTACGTCCTGCCCAAGCACCTCGA
CGAAAAGGTCGCGGCGCTGCATCTCGAGAAGCTTGGCGTCAAGTTGACCAAGCTGAGCAAGAAGCAGGCGGACTATATCG
GCGTTTCGCAGGAAGGTCCGTTCAAGCCGGATCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
AAGAAGTCTTTATATTAAGTTTGCACGTCGCGGCGCCCCGCGCTATGGGCAGCCGCAGGCGCGCTTGCCGCGCAGACCGA
ACATTTCAGGAGACTGCCAC

Downstream 100 bases:

>100_bases
GCGACCGTGCGGCGGGGCCTCGCGGTGTCGGGCCCAGCCTTTCGGCGACACATGGAAAGAGAGAGCCTCCGCCCGCGCGG
GGGCTCTCTTTTCGTGTACA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MASVLDAQNDYVVADIGLADFGRAEIRIAETEMPGLMALREEFGASQPLKGARITGSLHMTIQTAVLIETLVALGAEVRW
ATCNIFSTQDHAAAAIAAAGIPVFAVKGESLAEYWDYVGSIFDWGDQTANMILDDGGDATMFALWGARVEAGEPLFEPSN
AEEIEFVRALKEFLKRKPGYLTMSVAHIKGVSEETTTGVHRLYQIAKDGKLPFPAINVNDSVTKSKFDNLYGCKESLVDA
IRRATDVMLAGKVACVAGFGDVGKGSAASLRQGGARVMVTEIDPICALQAAMEGYEVVTMEEAVQRCDIFVTATGNEDVI
TAEHMKAMKPMSIVCNIGHFDSEIQISALNNYKWTEIKPGTDLVEFPDGKQIIILAKGRLVNLGCATGHPSFVMSSSFTN
QVLAQIELFTKNAEYKNEVYVLPKHLDEKVAALHLEKLGVKLTKLSKKQADYIGVSQEGPFKPDHYRY

Sequences:

>Translated_468_residues
MASVLDAQNDYVVADIGLADFGRAEIRIAETEMPGLMALREEFGASQPLKGARITGSLHMTIQTAVLIETLVALGAEVRW
ATCNIFSTQDHAAAAIAAAGIPVFAVKGESLAEYWDYVGSIFDWGDQTANMILDDGGDATMFALWGARVEAGEPLFEPSN
AEEIEFVRALKEFLKRKPGYLTMSVAHIKGVSEETTTGVHRLYQIAKDGKLPFPAINVNDSVTKSKFDNLYGCKESLVDA
IRRATDVMLAGKVACVAGFGDVGKGSAASLRQGGARVMVTEIDPICALQAAMEGYEVVTMEEAVQRCDIFVTATGNEDVI
TAEHMKAMKPMSIVCNIGHFDSEIQISALNNYKWTEIKPGTDLVEFPDGKQIIILAKGRLVNLGCATGHPSFVMSSSFTN
QVLAQIELFTKNAEYKNEVYVLPKHLDEKVAALHLEKLGVKLTKLSKKQADYIGVSQEGPFKPDHYRY
>Mature_467_residues
ASVLDAQNDYVVADIGLADFGRAEIRIAETEMPGLMALREEFGASQPLKGARITGSLHMTIQTAVLIETLVALGAEVRWA
TCNIFSTQDHAAAAIAAAGIPVFAVKGESLAEYWDYVGSIFDWGDQTANMILDDGGDATMFALWGARVEAGEPLFEPSNA
EEIEFVRALKEFLKRKPGYLTMSVAHIKGVSEETTTGVHRLYQIAKDGKLPFPAINVNDSVTKSKFDNLYGCKESLVDAI
RRATDVMLAGKVACVAGFGDVGKGSAASLRQGGARVMVTEIDPICALQAAMEGYEVVTMEEAVQRCDIFVTATGNEDVIT
AEHMKAMKPMSIVCNIGHFDSEIQISALNNYKWTEIKPGTDLVEFPDGKQIIILAKGRLVNLGCATGHPSFVMSSSFTNQ
VLAQIELFTKNAEYKNEVYVLPKHLDEKVAALHLEKLGVKLTKLSKKQADYIGVSQEGPFKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=460, Percent_Identity=60.4347826086956, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI239937451, Length=438, Percent_Identity=60.2739726027397, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI24308043, Length=463, Percent_Identity=47.9481641468683, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI195539349, Length=463, Percent_Identity=47.9481641468683, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI298286489, Length=463, Percent_Identity=47.9481641468683, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI195539337, Length=463, Percent_Identity=47.9481641468683, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI21361647, Length=463, Percent_Identity=47.0842332613391, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=464, Percent_Identity=61.6379310344828, Blast_Score=538, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320882, Length=480, Percent_Identity=59.1666666666667, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24642172, Length=465, Percent_Identity=61.7204301075269, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24656245, Length=464, Percent_Identity=48.7068965517241, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=462, Percent_Identity=48.2683982683983, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45553385, Length=461, Percent_Identity=48.1561822125813, Blast_Score=420, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_NOVAD (Q2G6T1)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497276.1
- ProteinModelPortal:   Q2G6T1
- SMR:   Q2G6T1
- STRING:   Q2G6T1
- GeneID:   3917323
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2003
- NMPDR:   fig|48935.1.peg.2270
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   Q2G6T1
- ProtClustDB:   PRK05476
- BioCyc:   NARO279238:SARO_2003-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 50901; Mature: 50770

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 61-61 BINDING 135-135 BINDING 194-194 BINDING 224-224 BINDING 228-228 BINDING 229-229 BINDING 281-281 BINDING 316-316 BINDING 382-382

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVLDAQNDYVVADIGLADFGRAEIRIAETEMPGLMALREEFGASQPLKGARITGSLHM
CCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEEEE
TIQTAVLIETLVALGAEVRWATCNIFSTQDHAAAAIAAAGIPVFAVKGESLAEYWDYVGS
EHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
IFDWGDQTANMILDDGGDATMFALWGARVEAGEPLFEPSNAEEIEFVRALKEFLKRKPGY
HHHCCCCCCCEEEECCCCEEEEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
LTMSVAHIKGVSEETTTGVHRLYQIAKDGKLPFPAINVNDSVTKSKFDNLYGCKESLVDA
EEEEEHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHCHHHHHHHH
IRRATDVMLAGKVACVAGFGDVGKGSAASLRQGGARVMVTEIDPICALQAAMEGYEVVTM
HHHHHHHHHCCCEEEEECCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEEH
EEAVQRCDIFVTATGNEDVITAEHMKAMKPMSIVCNIGHFDSEIQISALNNYKWTEIKPG
HHHHHHCEEEEEECCCCCEEEHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEEEECCC
TDLVEFPDGKQIIILAKGRLVNLGCATGHPSFVMSSSFTNQVLAQIELFTKNAEYKNEVY
CCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECHHHHHHHHHHHHEECCCCCCCEEE
VLPKHLDEKVAALHLEKLGVKLTKLSKKQADYIGVSQEGPFKPDHYRY
EECCHHHHHHHHHHHHHHCCCHHHHHHHHCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASVLDAQNDYVVADIGLADFGRAEIRIAETEMPGLMALREEFGASQPLKGARITGSLHM
CCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEEEE
TIQTAVLIETLVALGAEVRWATCNIFSTQDHAAAAIAAAGIPVFAVKGESLAEYWDYVGS
EHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
IFDWGDQTANMILDDGGDATMFALWGARVEAGEPLFEPSNAEEIEFVRALKEFLKRKPGY
HHHCCCCCCCEEEECCCCEEEEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
LTMSVAHIKGVSEETTTGVHRLYQIAKDGKLPFPAINVNDSVTKSKFDNLYGCKESLVDA
EEEEEHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHCHHHHHHHH
IRRATDVMLAGKVACVAGFGDVGKGSAASLRQGGARVMVTEIDPICALQAAMEGYEVVTM
HHHHHHHHHCCCEEEEECCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEEH
EEAVQRCDIFVTATGNEDVITAEHMKAMKPMSIVCNIGHFDSEIQISALNNYKWTEIKPG
HHHHHHCEEEEEECCCCCEEEHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEEEECCC
TDLVEFPDGKQIIILAKGRLVNLGCATGHPSFVMSSSFTNQVLAQIELFTKNAEYKNEVY
CCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECHHHHHHHHHHHHEECCCCCCCEEE
VLPKHLDEKVAALHLEKLGVKLTKLSKKQADYIGVSQEGPFKPDHYRY
EECCHHHHHHHHHHHHHHCCCHHHHHHHHCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA