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The map label for this gene is tktA [H]

Identifier: 87199985

GI number: 87199985

Start: 2085758

End: 2087725

Strand: Reverse

Name: tktA [H]

Synonym: Saro_1968

Alternate gene names: 87199985

Gene position: 2087725-2085758 (Counterclockwise)

Preceding gene: 87199986

Following gene: 87199984

Centisome position: 58.62

GC content: 63.97

Gene sequence:

>1968_bases
ATGACACGCGAAACCACCGCGCTGGCGCCCATGGCCAACGCGATCCGTGCGCTTGCCATGGACGCGGTCCAGGCAGCGAA
TTCGGGACACCCTGGCATGCCGATGGGCATGGCCGATGTCGCGACGGTGCTGTGGACGCAGTTTCTGAAGCACGATCCCG
CCGCGCCGAAGTGGTCGGATCGGGACCGCTTCATTCTGTCGGCCGGCCACGGCTCCATGCTGATCTACGCGCTGCTTCAC
CTGTCGGGCTACGAAAGCCCGACGATGGACGACATCCGCAAGTTCCGCCAGCTCGACAGCGTCTGCGCCGGTCACCCCGA
GAACTTCCTTATTCCCGGCGTTGAATGCACCACCGGTCCGCTCGGGCAGGGGCTTGCCATGGCAGTCGGCTTCGCAATGG
CCGAACGCCATCTTAATGCCCAGTTCGGCAGCGACCTGGTCGACCACAAGACGTGGGTCATTGCTGGCGACGGCTGCCTC
ATGGAAGGCATCAACCACGAAGCGGTCGGCCTTGCAGGCACACTCAAGCTTGGTCGCCTCAACGTGCTGTGGGACGACAA
CAAGATTACCATTGACGGTGACACATCGCTTTCGACAAGCGAGGACATTCTTGGCCGGTATGCCGCGTCGGGTTGGCACG
TCACCTCGTGCGACGGCCATGATTTTGCAGACATCGCACGCGCGCTGGCAGAAGCACAGGCCGATCCGCGCCCGTCGCTT
GTTGCCTGCCGCACCGTGATCGGAAAGGGTGCGCCCAACAAGCAGGGCGGGCACAACGTCCATGGCGCACCGCTCGGTGC
GGACGAGATCGCTGCCGCGCGTGAGTATCTTGGCTGGACCGCGGCTCCGTTCGAAGTCCCGGCCGACATCCTCGCCAACT
GGCGCTCCTCGGCAGAAGCCGGAAAGACCGCGCGAGCCGAATGGGAAAAGCGGGCTGCAGCCAATCCCAATGCCGCCGAA
CTGGCCCGCCGCATGGCCGGGGAACTCCCCGCCCAGACCGGTTTCGACGCCTATATCCAGTCGCTGATCGCCAGCCCGCC
CAAGGTCGCCACCCGCAAGTCGAGCGAGATGGCTCTCGAGGCCTTCACCGCGAACGTGCCCGAGATGGTGGGTGGTTCGG
CTGACCTCACCGGCTCGAACAACACGAAGACAAAGTCGACCGCGCCGTTCACGCCGGAAAGCTATGACGGACGCTACGTC
TACTACGGCATCCGCGAATTCGGCATGGCTGCCGCGATGAACGGCATGGCGCTGCATGGCGGGATCATCCCGTATGGCGG
CACGTTCCTCGTGTTCTCCGACTACTGTCGCAACGCCGTGCGCATGTCTGCGCTCCAGCACGTGCGAGCGATCTATGTGT
TCACTCACGATTCGATCGGCCTTGGCGAAGACGGCCCGACCCATCAGCCGGTCGAGCATGTCATGTCGCTGCGCATGATC
CCGAACCTGCTGGTATTCCGTCCTGCGGATGCCATCGAGACCGCTGAAGCGTGGGCTATCGCGCTTGCAAACAAGGACCG
TCCGTCGGTCCTCGCGCTGACCCGCCAAAATCTGCCGCCGGTCCGCTTCGACGCCGAGATGAAGAGCGCAAAGGGCGCCT
ATCGCCTTGTTGCCGCGCAGGCCGACCGCAAGGTTGTGCTGCTGGCTACCGGTTCGGAAGTGGAAGTCGCGATCAAGGTC
GCGGCCGAACTGGAAGCCAAGGGTCTGGGCGCCGACGTCGTTTCGGTTCCATGCTGGGAACTGTTCGACGAACAGGACGC
GGCCTACAAGGCTGACCTGCTGCCCGCCGACGCACTCAAGGTCTCGGTGGAGGCAGGCGTGACTCTGGGGTGGCAGAAGT
ACATCGGCGATGGCCTGGCCATCGGCATCGACACGTTCGGCGCGTCGGCCCCGGCCGAAGTGCTGTTCGACCACTTTGGC
CTCACGGCTGAAAAGATTGTCCCGCAGATTCTCGCGCGGGTTTCGTAA

Upstream 100 bases:

>100_bases
ACCATGAAGCCAGTGGTGACCAAAGAGGCCCCGCTCCGAATCATCGGAATTCGTGCACTTGCCGGTGTGGCCGCACGGAC
AAGGAAGGGCTTTTTCAAGC

Downstream 100 bases:

>100_bases
TTCAACAGGAGAAAGCTGACATGGCGATCAAGGTTGCGATCAACGGTTTCGGACGCATCGGGCGCAATGTGGCCCGCGCC
ATTCTCGAACGTCCCGATTG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 655; Mature: 654

Protein sequence:

>655_residues
MTRETTALAPMANAIRALAMDAVQAANSGHPGMPMGMADVATVLWTQFLKHDPAAPKWSDRDRFILSAGHGSMLIYALLH
LSGYESPTMDDIRKFRQLDSVCAGHPENFLIPGVECTTGPLGQGLAMAVGFAMAERHLNAQFGSDLVDHKTWVIAGDGCL
MEGINHEAVGLAGTLKLGRLNVLWDDNKITIDGDTSLSTSEDILGRYAASGWHVTSCDGHDFADIARALAEAQADPRPSL
VACRTVIGKGAPNKQGGHNVHGAPLGADEIAAAREYLGWTAAPFEVPADILANWRSSAEAGKTARAEWEKRAAANPNAAE
LARRMAGELPAQTGFDAYIQSLIASPPKVATRKSSEMALEAFTANVPEMVGGSADLTGSNNTKTKSTAPFTPESYDGRYV
YYGIREFGMAAAMNGMALHGGIIPYGGTFLVFSDYCRNAVRMSALQHVRAIYVFTHDSIGLGEDGPTHQPVEHVMSLRMI
PNLLVFRPADAIETAEAWAIALANKDRPSVLALTRQNLPPVRFDAEMKSAKGAYRLVAAQADRKVVLLATGSEVEVAIKV
AAELEAKGLGADVVSVPCWELFDEQDAAYKADLLPADALKVSVEAGVTLGWQKYIGDGLAIGIDTFGASAPAEVLFDHFG
LTAEKIVPQILARVS

Sequences:

>Translated_655_residues
MTRETTALAPMANAIRALAMDAVQAANSGHPGMPMGMADVATVLWTQFLKHDPAAPKWSDRDRFILSAGHGSMLIYALLH
LSGYESPTMDDIRKFRQLDSVCAGHPENFLIPGVECTTGPLGQGLAMAVGFAMAERHLNAQFGSDLVDHKTWVIAGDGCL
MEGINHEAVGLAGTLKLGRLNVLWDDNKITIDGDTSLSTSEDILGRYAASGWHVTSCDGHDFADIARALAEAQADPRPSL
VACRTVIGKGAPNKQGGHNVHGAPLGADEIAAAREYLGWTAAPFEVPADILANWRSSAEAGKTARAEWEKRAAANPNAAE
LARRMAGELPAQTGFDAYIQSLIASPPKVATRKSSEMALEAFTANVPEMVGGSADLTGSNNTKTKSTAPFTPESYDGRYV
YYGIREFGMAAAMNGMALHGGIIPYGGTFLVFSDYCRNAVRMSALQHVRAIYVFTHDSIGLGEDGPTHQPVEHVMSLRMI
PNLLVFRPADAIETAEAWAIALANKDRPSVLALTRQNLPPVRFDAEMKSAKGAYRLVAAQADRKVVLLATGSEVEVAIKV
AAELEAKGLGADVVSVPCWELFDEQDAAYKADLLPADALKVSVEAGVTLGWQKYIGDGLAIGIDTFGASAPAEVLFDHFG
LTAEKIVPQILARVS
>Mature_654_residues
TRETTALAPMANAIRALAMDAVQAANSGHPGMPMGMADVATVLWTQFLKHDPAAPKWSDRDRFILSAGHGSMLIYALLHL
SGYESPTMDDIRKFRQLDSVCAGHPENFLIPGVECTTGPLGQGLAMAVGFAMAERHLNAQFGSDLVDHKTWVIAGDGCLM
EGINHEAVGLAGTLKLGRLNVLWDDNKITIDGDTSLSTSEDILGRYAASGWHVTSCDGHDFADIARALAEAQADPRPSLV
ACRTVIGKGAPNKQGGHNVHGAPLGADEIAAAREYLGWTAAPFEVPADILANWRSSAEAGKTARAEWEKRAAANPNAAEL
ARRMAGELPAQTGFDAYIQSLIASPPKVATRKSSEMALEAFTANVPEMVGGSADLTGSNNTKTKSTAPFTPESYDGRYVY
YGIREFGMAAAMNGMALHGGIIPYGGTFLVFSDYCRNAVRMSALQHVRAIYVFTHDSIGLGEDGPTHQPVEHVMSLRMIP
NLLVFRPADAIETAEAWAIALANKDRPSVLALTRQNLPPVRFDAEMKSAKGAYRLVAAQADRKVVLLATGSEVEVAIKVA
AELEAKGLGADVVSVPCWELFDEQDAAYKADLLPADALKVSVEAGVTLGWQKYIGDGLAIGIDTFGASAPAEVLFDHFGL
TAEKIVPQILARVS

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=578, Percent_Identity=24.5674740484429, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI4507521, Length=578, Percent_Identity=24.5674740484429, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI133778974, Length=581, Percent_Identity=26.3339070567986, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI225637459, Length=664, Percent_Identity=20.7831325301205, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI225637463, Length=556, Percent_Identity=21.7625899280576, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225637461, Length=558, Percent_Identity=21.6845878136201, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=52.5114155251142, Blast_Score=663, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=653, Percent_Identity=50.8422664624809, Blast_Score=632, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=666, Percent_Identity=25.8258258258258, Blast_Score=177, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6325331, Length=665, Percent_Identity=45.1127819548872, Blast_Score=524, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6319593, Length=654, Percent_Identity=40.6727828746177, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45551847, Length=572, Percent_Identity=26.7482517482518, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI45550715, Length=572, Percent_Identity=26.7482517482518, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24666278, Length=580, Percent_Identity=25.6896551724138, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24645119, Length=538, Percent_Identity=26.3940520446097, Blast_Score=157, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 69776; Mature: 69645

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRETTALAPMANAIRALAMDAVQAANSGHPGMPMGMADVATVLWTQFLKHDPAAPKWSD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
RDRFILSAGHGSMLIYALLHLSGYESPTMDDIRKFRQLDSVCAGHPENFLIPGVECTTGP
CCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
LGQGLAMAVGFAMAERHLNAQFGSDLVDHKTWVIAGDGCLMEGINHEAVGLAGTLKLGRL
CCCHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCHHCCCCCCCCCCEEEEEEECEE
NVLWDDNKITIDGDTSLSTSEDILGRYAASGWHVTSCDGHDFADIARALAEAQADPRPSL
EEEECCCEEEECCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCHH
VACRTVIGKGAPNKQGGHNVHGAPLGADEIAAAREYLGWTAAPFEVPADILANWRSSAEA
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
GKTARAEWEKRAAANPNAAELARRMAGELPAQTGFDAYIQSLIASPPKVATRKSSEMALE
CCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHH
AFTANVPEMVGGSADLTGSNNTKTKSTAPFTPESYDGRYVYYGIREFGMAAAMNGMALHG
HHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCEEEEC
GIIPYGGTFLVFSDYCRNAVRMSALQHVRAIYVFTHDSIGLGEDGPTHQPVEHVMSLRMI
CCCCCCCEEEEHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
PNLLVFRPADAIETAEAWAIALANKDRPSVLALTRQNLPPVRFDAEMKSAKGAYRLVAAQ
CCEEEECCCHHHHHHHHEEEEECCCCCCCEEEEECCCCCCCEECCHHHHCCCCEEEEEEC
ADRKVVLLATGSEVEVAIKVAAELEAKGLGADVVSVPCWELFDEQDAAYKADLLPADALK
CCCEEEEEECCCCEEEEEEEEHHHHHCCCCCCHHCCCHHHHHCCCCCCHHHCCCCCHHEE
VSVEAGVTLGWQKYIGDGLAIGIDTFGASAPAEVLFDHFGLTAEKIVPQILARVS
EEECCCCEECHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TRETTALAPMANAIRALAMDAVQAANSGHPGMPMGMADVATVLWTQFLKHDPAAPKWSD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
RDRFILSAGHGSMLIYALLHLSGYESPTMDDIRKFRQLDSVCAGHPENFLIPGVECTTGP
CCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
LGQGLAMAVGFAMAERHLNAQFGSDLVDHKTWVIAGDGCLMEGINHEAVGLAGTLKLGRL
CCCHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCHHCCCCCCCCCCEEEEEEECEE
NVLWDDNKITIDGDTSLSTSEDILGRYAASGWHVTSCDGHDFADIARALAEAQADPRPSL
EEEECCCEEEECCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCHH
VACRTVIGKGAPNKQGGHNVHGAPLGADEIAAAREYLGWTAAPFEVPADILANWRSSAEA
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
GKTARAEWEKRAAANPNAAELARRMAGELPAQTGFDAYIQSLIASPPKVATRKSSEMALE
CCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHH
AFTANVPEMVGGSADLTGSNNTKTKSTAPFTPESYDGRYVYYGIREFGMAAAMNGMALHG
HHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCEEEEC
GIIPYGGTFLVFSDYCRNAVRMSALQHVRAIYVFTHDSIGLGEDGPTHQPVEHVMSLRMI
CCCCCCCEEEEHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
PNLLVFRPADAIETAEAWAIALANKDRPSVLALTRQNLPPVRFDAEMKSAKGAYRLVAAQ
CCEEEECCCHHHHHHHHEEEEECCCCCCCEEEEECCCCCCCEECCHHHHCCCCEEEEEEC
ADRKVVLLATGSEVEVAIKVAAELEAKGLGADVVSVPCWELFDEQDAAYKADLLPADALK
CCCEEEEEECCCCEEEEEEEEHHHHHCCCCCCHHCCCHHHHHCCCCCCHHHCCCCCHHEE
VSVEAGVTLGWQKYIGDGLAIGIDTFGASAPAEVLFDHFGLTAEKIVPQILARVS
EEECCCCEECHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8635754; 9256491 [H]