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The map label for this gene is yuxG [H]

Identifier: 87199741

GI number: 87199741

Start: 1812584

End: 1814701

Strand: Direct

Name: yuxG [H]

Synonym: Saro_1724

Alternate gene names: 87199741

Gene position: 1812584-1814701 (Clockwise)

Preceding gene: 87199740

Following gene: 87199742

Centisome position: 50.89

GC content: 64.64

Gene sequence:

>2118_bases
ATGAACGCTCAGACCGAGACCTTGATTGCCGCTGCCGCCATTCCGTTCGCGGTTCCGACCAGCCGTTGGGACGATGCCGT
CGCGGCAAAGCTCGGCCCGGCAGAACTTCTGCTCTATCGCTCGAACCTGCTCGGTTCCGATCTTACCGTCACCAACTTCG
GTGGCGGCAATACGTCGGCCAAGCTTGAAGAGATGGATCCGCTGACTGGTGAGCCGGTCGAAGTGCTGTGGGTCAAGGGT
TCGGGCGGTGACATCGGCTCTATGAAGATCGACGGCTTTGCCACTCTTTACCAGGCAAAGCTGCTTGGCCTCGAGGCGCA
CTATGCCGGGCCGCAGGACGACGACAAGATGGTCGGCTTCCTGCCGCACTGCACGTTCAACCTCAACTGTCGCGCGGCCA
GCATTGATACGCCGCTGCACTCGCTGCTGCCCTTCGCGCATGTCGATCACGTCCATCCCGATGCGATCATCGCGCTGGCC
GCTTCCTCGGGGGGCGAGGCCGCCACGAAGGAAATCTGGGGCGGCCGGATCGGCTGGCTGCCGTGGAAGCGTCCCGGCTA
CACCCTTGGCGTGATGCTCCGCGATTTCGTCAAGGCTAACCCGGGCGTCGAAGGTGTCATGCTTGCCGGCCATGGCATCA
TCTGCTGGGCCGACAGCGCCAAGGCCTGCTATGAACATACCGTTCGGCTGATCGCGGACGCGGCCGGCTATCTCAATGCC
CGGCTCGCCGAAAAGCCAGCGTTCGGAGGTCGGAAAGTGGCGCCGAACCCGGATCGGGCAAAGATCGCCGCCGACCTCAT
GCCTCGCCTGCGTGGCTTCATGACCGGTGCGCGCAACAAGCTTGGGCACTTCTCGGACGATGCCGAGGCGCTGGAGTTCG
TTGGCTCGGTGGACTTCGAGCGTCTCGCCGCGCTTGGCACCTCGTGCCCCGACCATTTCCTGCGCACCAAGATCGCGCCG
CTGACGCTCGATCCCTCGCGGCTGCAAGACGACGACTACCTCGCGCGGAAGATTGCCGGCTATCGCGATCTCTATGCGGC
CTATTATGAACGCTGCAAGCGCCCGAACTCGCCGGCAATGCGCGATTCCAACCCTGTCGTCGTGCTCGTCCCGGGCGTCG
GACGCATCACGTTCGCCACCGACAAGACCACCGCGCGGCTCGCTGGCGAATTCTACGGCAACGCCATCAACGTGATGCGC
GGGGCCGAAGCCATCGGCGATTACATTGCGCTCGATGAGCAGGAAGCCTTCGACATCGAATACTGGCTGCTCGAAGAGGC
CAAGCTCCAGCGCATGCCTGCGCCCCGGCCTCTGGTCGGCAAGATCGCGCTGGTCACCGGCGGGGCAGGGGGCATCGGCG
CGGCATCGGCCGCCCGCCTGCTGCGCGAAGGCGCCTGCGTCGTGCTGGCCGATCGTGCCGCCGACGCGGTCGAGGACGTC
CGCGCCGGTTTCGCAAGGCAGTTCGGCAACGACGTCGTGCGCGCGGCCGTCTGCGACGTGACCGACGAGGCGCAGGTCCA
GGCTGCTTTCGACGTGGCCGCACGTGAATTTGGCGGGCTCGACATTCTGGTCGCCAACGCCGGCATCGCATCTTCTGCAC
CGCTCGAGGAAACGACCGTCGATCTGTGGAACCGCAACTACGACGTCCTCGCGCAGGGGTATTTCCTGACCTCCCGCTCC
GCCTGGCCGCTCATGAAGCGCATGAAGGAGCAGGGCGGCGCGTCTGTCGTGTTCATCGGTTCCAAGAACGGCGTTGCCGC
CGCTACGAACGCCAGTGCCTATGCTTCCGCGAAGGCTGCCGCGAACCATCTCGCGCGGTGCCTCGCGCTTGAAGGCGCGC
CGTTCGGCATCCGCGTCAATACCGTCAACCCCGATGCCGTCATCAAGGGCAGCAAGATCTGGGACGGCGACTGGCGCAAG
GAACGCGCCGGGGCCCACGGCATCGACAGCGGCAAGGAACTGGAAGAGCACTACCGCCAGCGCTCGATGCTCAAGCGCGA
TGTTCTGCCCGAAGATATCGCGGAAGCAGTCTATTTCCTCGCTTCGGACATGTCGGCAAAATCCACCGGCAACATGATCA
ACGTTGATGCGGGGAACGCCCAGGCCTTCACTCGCTGA

Upstream 100 bases:

>100_bases
CTCAAATAATCAATAACGATCATTCTTGATCGTTTATGTGCATCCTGCTATCGAGTCTCTCGACCGGCGCAAAGCCGACC
GATTTGCCCCCAGGGATGCC

Downstream 100 bases:

>100_bases
CCGTTCCCGGGAGAGGATAACGATGAAGAAAGCGGCATATCTTTTCGCGTTGGCGGCGAGCGTTCAGGTGGTTCCGGCCA
TCGCGCAGGACGGTCCGCCG

Product: short chain dehydrogenase

Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MNAQTETLIAAAAIPFAVPTSRWDDAVAAKLGPAELLLYRSNLLGSDLTVTNFGGGNTSAKLEEMDPLTGEPVEVLWVKG
SGGDIGSMKIDGFATLYQAKLLGLEAHYAGPQDDDKMVGFLPHCTFNLNCRAASIDTPLHSLLPFAHVDHVHPDAIIALA
ASSGGEAATKEIWGGRIGWLPWKRPGYTLGVMLRDFVKANPGVEGVMLAGHGIICWADSAKACYEHTVRLIADAAGYLNA
RLAEKPAFGGRKVAPNPDRAKIAADLMPRLRGFMTGARNKLGHFSDDAEALEFVGSVDFERLAALGTSCPDHFLRTKIAP
LTLDPSRLQDDDYLARKIAGYRDLYAAYYERCKRPNSPAMRDSNPVVVLVPGVGRITFATDKTTARLAGEFYGNAINVMR
GAEAIGDYIALDEQEAFDIEYWLLEEAKLQRMPAPRPLVGKIALVTGGAGGIGAASAARLLREGACVVLADRAADAVEDV
RAGFARQFGNDVVRAAVCDVTDEAQVQAAFDVAAREFGGLDILVANAGIASSAPLEETTVDLWNRNYDVLAQGYFLTSRS
AWPLMKRMKEQGGASVVFIGSKNGVAAATNASAYASAKAAANHLARCLALEGAPFGIRVNTVNPDAVIKGSKIWDGDWRK
ERAGAHGIDSGKELEEHYRQRSMLKRDVLPEDIAEAVYFLASDMSAKSTGNMINVDAGNAQAFTR

Sequences:

>Translated_705_residues
MNAQTETLIAAAAIPFAVPTSRWDDAVAAKLGPAELLLYRSNLLGSDLTVTNFGGGNTSAKLEEMDPLTGEPVEVLWVKG
SGGDIGSMKIDGFATLYQAKLLGLEAHYAGPQDDDKMVGFLPHCTFNLNCRAASIDTPLHSLLPFAHVDHVHPDAIIALA
ASSGGEAATKEIWGGRIGWLPWKRPGYTLGVMLRDFVKANPGVEGVMLAGHGIICWADSAKACYEHTVRLIADAAGYLNA
RLAEKPAFGGRKVAPNPDRAKIAADLMPRLRGFMTGARNKLGHFSDDAEALEFVGSVDFERLAALGTSCPDHFLRTKIAP
LTLDPSRLQDDDYLARKIAGYRDLYAAYYERCKRPNSPAMRDSNPVVVLVPGVGRITFATDKTTARLAGEFYGNAINVMR
GAEAIGDYIALDEQEAFDIEYWLLEEAKLQRMPAPRPLVGKIALVTGGAGGIGAASAARLLREGACVVLADRAADAVEDV
RAGFARQFGNDVVRAAVCDVTDEAQVQAAFDVAAREFGGLDILVANAGIASSAPLEETTVDLWNRNYDVLAQGYFLTSRS
AWPLMKRMKEQGGASVVFIGSKNGVAAATNASAYASAKAAANHLARCLALEGAPFGIRVNTVNPDAVIKGSKIWDGDWRK
ERAGAHGIDSGKELEEHYRQRSMLKRDVLPEDIAEAVYFLASDMSAKSTGNMINVDAGNAQAFTR
>Mature_705_residues
MNAQTETLIAAAAIPFAVPTSRWDDAVAAKLGPAELLLYRSNLLGSDLTVTNFGGGNTSAKLEEMDPLTGEPVEVLWVKG
SGGDIGSMKIDGFATLYQAKLLGLEAHYAGPQDDDKMVGFLPHCTFNLNCRAASIDTPLHSLLPFAHVDHVHPDAIIALA
ASSGGEAATKEIWGGRIGWLPWKRPGYTLGVMLRDFVKANPGVEGVMLAGHGIICWADSAKACYEHTVRLIADAAGYLNA
RLAEKPAFGGRKVAPNPDRAKIAADLMPRLRGFMTGARNKLGHFSDDAEALEFVGSVDFERLAALGTSCPDHFLRTKIAP
LTLDPSRLQDDDYLARKIAGYRDLYAAYYERCKRPNSPAMRDSNPVVVLVPGVGRITFATDKTTARLAGEFYGNAINVMR
GAEAIGDYIALDEQEAFDIEYWLLEEAKLQRMPAPRPLVGKIALVTGGAGGIGAASAARLLREGACVVLADRAADAVEDV
RAGFARQFGNDVVRAAVCDVTDEAQVQAAFDVAAREFGGLDILVANAGIASSAPLEETTVDLWNRNYDVLAQGYFLTSRS
AWPLMKRMKEQGGASVVFIGSKNGVAAATNASAYASAKAAANHLARCLALEGAPFGIRVNTVNPDAVIKGSKIWDGDWRK
ERAGAHGIDSGKELEEHYRQRSMLKRDVLPEDIAEAVYFLASDMSAKSTGNMINVDAGNAQAFTR

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG3347

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=267, Percent_Identity=31.4606741573034, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI19923817, Length=283, Percent_Identity=29.6819787985866, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI126723191, Length=213, Percent_Identity=32.3943661971831, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI126723750, Length=272, Percent_Identity=30.1470588235294, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI4503817, Length=195, Percent_Identity=29.7435897435897, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI7705925, Length=264, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4758504, Length=200, Percent_Identity=33.5, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI4504505, Length=210, Percent_Identity=30, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI10190704, Length=265, Percent_Identity=28.6792452830189, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI5031737, Length=264, Percent_Identity=29.9242424242424, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI40254992, Length=260, Percent_Identity=31.9230769230769, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI109715829, Length=256, Percent_Identity=27.34375, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI40807363, Length=214, Percent_Identity=27.5700934579439, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI31542939, Length=209, Percent_Identity=29.6650717703349, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503301, Length=295, Percent_Identity=26.4406779661017, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI59889578, Length=189, Percent_Identity=30.1587301587302, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI83715985, Length=193, Percent_Identity=32.1243523316062, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI224922801, Length=99, Percent_Identity=42.4242424242424, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI20149619, Length=187, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1787905, Length=264, Percent_Identity=32.1969696969697, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=29.3436293436293, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787335, Length=266, Percent_Identity=30.0751879699248, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=30.9433962264151, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI2367175, Length=263, Percent_Identity=31.9391634980989, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=27.9693486590038, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790717, Length=265, Percent_Identity=29.0566037735849, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI2367365, Length=260, Percent_Identity=29.6153846153846, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786812, Length=265, Percent_Identity=28.6792452830189, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1788459, Length=263, Percent_Identity=26.615969581749, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787820, Length=242, Percent_Identity=23.9669421487603, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=260, Percent_Identity=30, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=27.6923076923077, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17561402, Length=275, Percent_Identity=31.2727272727273, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17544670, Length=278, Percent_Identity=29.136690647482, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=31.7343173431734, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=196, Percent_Identity=34.6938775510204, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=276, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=267, Percent_Identity=27.7153558052434, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17536025, Length=266, Percent_Identity=28.1954887218045, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=275, Percent_Identity=29.4545454545455, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=275, Percent_Identity=28.3636363636364, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=195, Percent_Identity=29.7435897435897, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=270, Percent_Identity=28.5185185185185, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17568967, Length=208, Percent_Identity=27.8846153846154, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=268, Percent_Identity=28.3582089552239, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=250, Percent_Identity=27.6, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=29.8449612403101, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=201, Percent_Identity=30.3482587064677, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=275, Percent_Identity=28.3636363636364, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=264, Percent_Identity=27.6515151515151, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=272, Percent_Identity=27.9411764705882, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=270, Percent_Identity=29.2592592592593, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=209, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=202, Percent_Identity=35.1485148514851, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=197, Percent_Identity=30.4568527918782, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=195, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=195, Percent_Identity=31.7948717948718, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324126, Length=267, Percent_Identity=26.2172284644195, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=27.9620853080569, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=198, Percent_Identity=29.2929292929293, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=30.5019305019305, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=28.6821705426357, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=29.0697674418605, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=30.2681992337165, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=30.1158301158301, Blast_Score=88, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644337, Length=261, Percent_Identity=30.6513409961686, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643142, Length=201, Percent_Identity=32.3383084577114, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI18859837, Length=199, Percent_Identity=32.6633165829146, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639444, Length=265, Percent_Identity=29.811320754717, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24663911, Length=206, Percent_Identity=31.5533980582524, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI116007236, Length=195, Percent_Identity=28.7179487179487, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007238, Length=143, Percent_Identity=32.8671328671329, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737361, Length=192, Percent_Identity=31.7708333333333, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281364494, Length=141, Percent_Identity=34.0425531914894, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665243, Length=191, Percent_Identity=31.9371727748691, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221331218, Length=191, Percent_Identity=31.9371727748691, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28571387, Length=194, Percent_Identity=30.4123711340206, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303
- InterPro:   IPR013454
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short; PF00596 Aldolase_II [H]

EC number: 1.1.1.159 [C]

Molecular weight: Translated: 75457; Mature: 75457

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQTETLIAAAAIPFAVPTSRWDDAVAAKLGPAELLLYRSNLLGSDLTVTNFGGGNTSA
CCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHEEEHHCCCCCCEEEEECCCCCCCC
KLEEMDPLTGEPVEVLWVKGSGGDIGSMKIDGFATLYQAKLLGLEAHYAGPQDDDKMVGF
CHHHCCCCCCCCEEEEEEECCCCCCCCEEECHHHHHHHHHHHCEEEECCCCCCCCCEEEE
LPHCTFNLNCRAASIDTPLHSLLPFAHVDHVHPDAIIALAASSGGEAATKEIWGGRIGWL
ECCEEEECCEEEECCCCCHHHHCCHHHHCCCCCCEEEEEEECCCCCHHHHHHCCCCCCCC
PWKRPGYTLGVMLRDFVKANPGVEGVMLAGHGIICWADSAKACYEHTVRLIADAAGYLNA
CCCCCCCCHHHHHHHHHHCCCCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
RLAEKPAFGGRKVAPNPDRAKIAADLMPRLRGFMTGARNKLGHFSDDAEALEFVGSVDFE
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHH
RLAALGTSCPDHFLRTKIAPLTLDPSRLQDDDYLARKIAGYRDLYAAYYERCKRPNSPAM
HHHHHCCCCHHHHHHHCCCCEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RDSNPVVVLVPGVGRITFATDKTTARLAGEFYGNAINVMRGAEAIGDYIALDEQEAFDIE
CCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCEEE
YWLLEEAKLQRMPAPRPLVGKIALVTGGAGGIGAASAARLLREGACVVLADRAADAVEDV
EEEHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHH
RAGFARQFGNDVVRAAVCDVTDEAQVQAAFDVAAREFGGLDILVANAGIASSAPLEETTV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHH
DLWNRNYDVLAQGYFLTSRSAWPLMKRMKEQGGASVVFIGSKNGVAAATNASAYASAKAA
HHHCCCCEEEEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHH
ANHLARCLALEGAPFGIRVNTVNPDAVIKGSKIWDGDWRKERAGAHGIDSGKELEEHYRQ
HHHHHHHHHCCCCCCEEEEEEECCCCEEECCEEECCCCHHHHCCCCCCCCHHHHHHHHHH
RSMLKRDVLPEDIAEAVYFLASDMSAKSTGNMINVDAGNAQAFTR
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MNAQTETLIAAAAIPFAVPTSRWDDAVAAKLGPAELLLYRSNLLGSDLTVTNFGGGNTSA
CCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHEEEHHCCCCCCEEEEECCCCCCCC
KLEEMDPLTGEPVEVLWVKGSGGDIGSMKIDGFATLYQAKLLGLEAHYAGPQDDDKMVGF
CHHHCCCCCCCCEEEEEEECCCCCCCCEEECHHHHHHHHHHHCEEEECCCCCCCCCEEEE
LPHCTFNLNCRAASIDTPLHSLLPFAHVDHVHPDAIIALAASSGGEAATKEIWGGRIGWL
ECCEEEECCEEEECCCCCHHHHCCHHHHCCCCCCEEEEEEECCCCCHHHHHHCCCCCCCC
PWKRPGYTLGVMLRDFVKANPGVEGVMLAGHGIICWADSAKACYEHTVRLIADAAGYLNA
CCCCCCCCHHHHHHHHHHCCCCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
RLAEKPAFGGRKVAPNPDRAKIAADLMPRLRGFMTGARNKLGHFSDDAEALEFVGSVDFE
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHH
RLAALGTSCPDHFLRTKIAPLTLDPSRLQDDDYLARKIAGYRDLYAAYYERCKRPNSPAM
HHHHHCCCCHHHHHHHCCCCEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RDSNPVVVLVPGVGRITFATDKTTARLAGEFYGNAINVMRGAEAIGDYIALDEQEAFDIE
CCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCEEE
YWLLEEAKLQRMPAPRPLVGKIALVTGGAGGIGAASAARLLREGACVVLADRAADAVEDV
EEEHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHH
RAGFARQFGNDVVRAAVCDVTDEAQVQAAFDVAAREFGGLDILVANAGIASSAPLEETTV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHH
DLWNRNYDVLAQGYFLTSRSAWPLMKRMKEQGGASVVFIGSKNGVAAATNASAYASAKAA
HHHCCCCEEEEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHH
ANHLARCLALEGAPFGIRVNTVNPDAVIKGSKIWDGDWRKERAGAHGIDSGKELEEHYRQ
HHHHHHHHHCCCCCCEEEEEEECCCCEEECCEEECCCCHHHHCCCCCCCCHHHHHHHHHH
RSMLKRDVLPEDIAEAVYFLASDMSAKSTGNMINVDAGNAQAFTR
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]

Metal ions: CaCl2; KCl; MnCl2; NaCl [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.8 {cholic} 0.24 {taurochenodeoxycholic} 0.085 {glycochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]

Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]

Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]

General reaction: Redox reaction [C]

Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 8188684 [H]