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The map label for this gene is ribBA [H]

Identifier: 87199493

GI number: 87199493

Start: 1513254

End: 1514396

Strand: Direct

Name: ribBA [H]

Synonym: Saro_1473

Alternate gene names: 87199493

Gene position: 1513254-1514396 (Clockwise)

Preceding gene: 87199492

Following gene: 87199494

Centisome position: 42.49

GC content: 59.84

Gene sequence:

>1143_bases
ATGACCGAAGTTTCACCGATCGAGACGATCATCGAGGACGCTCGCAATGGCCGGCCGTACATCCTTGTGGATGCGCCTGA
TCGCGAGAACGAGGGTGACGTGATCATCCCAGCGCAGTTCGCAACTCCCAATGCCATCAATTTCATGGCGATGCACGCGC
GAGGGCTCATTTGCCTTGCAATCTCGAGCGAGCGCGCCAGTCACCTCGATTTGCCAATGATGGAGGCGCGCAACCAATCT
TCCCTTAGCACTGCCTTCACCGTCTCGATCGAGGCGCGTGACGGAGTTACGACAGGAATATCTGCACATGACCGCGCCCA
CACCATTGCGGTTGCCGTCGATCCTTCCAAAGGGCCGGAAGACCTGGTCTCTCCCGGCCATGTGTTCCCGCTGGTTGCGC
GAGATGGTGGGGTGCTTGTCCGCGCTGGGCACACCGAAGCCGCCGTTGATATCTCGCGGCTGGCGGGGTTGGCGCCTGCT
GGCGTCATCTGCGAAATCATGAATCCTGACGGGTCTATGGCGCGTCTACCGGAATTGATTGAATTCGCGCGCAAGCACGA
GATGAACATCGGCACCATCGCCGACCTCATCGAATATCGCCGCCGTTCCGAGTCTCTTGTAGAGCGCGTGGTGGAGGCGC
CGTTCGACAGCTGGCACGGCGACTTCCGTATCATCGTTTATCGTAATGTGATCGACAGCGGCGAACACGTGGCGCTGGTT
CGCGGGGATCCCCACCAGGACATGCCAACGCTGGTGCGGGTCCATCAGCTTGACCTAACTGCGGATGTGCTGGGATGGCG
CGCGGCGCATCGCGACTATGTTCCGGCAGCGCTAGAGGTGCTTGCTGCGCACGATGGGCCTGCCGTGGCTGTTTTCGTCC
GCGACAACAGTCCCACGTCAATTTCGGAAAGAGTTAAGGGCAATCGTAAGGCCTATGCCGACACGCATGGCTACCGAGAT
TATGGCATAGGTGCTCAGATACTTCGCGACGTTGGTGTGCGCGAGATGGTCCTACTGTCTTCCAGCGCGGGCAAGCTCGC
AGCGCTGGAGGGTTTCGGGCTTTCGGTGGTAAACCGTGTGCCGCTGGTAGAGGACGAACGTGGAAAGCCGTCACGGTCGG
ATCAGCCGTTCGCATCAGCTTGA

Upstream 100 bases:

>100_bases
ACGGCTTCGGCTCGCTCGCTTTCGTGCGCGATTTCTCGACAGCGGTACGCACTGAGAAGCTGCCGCCAGCAATAAGAACA
CGTCTGAAGGATGCAGGAAG

Downstream 100 bases:

>100_bases
TGCTCACGCTTTTGCAGATAGTCAGCTGATCCAGCTTACGCAGGCGCCATTGCCCGTGCGCTTTGGCGCATGAGATACCG
TATCGCAGCGCTTTAAAAAT

Product: GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTEVSPIETIIEDARNGRPYILVDAPDRENEGDVIIPAQFATPNAINFMAMHARGLICLAISSERASHLDLPMMEARNQS
SLSTAFTVSIEARDGVTTGISAHDRAHTIAVAVDPSKGPEDLVSPGHVFPLVARDGGVLVRAGHTEAAVDISRLAGLAPA
GVICEIMNPDGSMARLPELIEFARKHEMNIGTIADLIEYRRRSESLVERVVEAPFDSWHGDFRIIVYRNVIDSGEHVALV
RGDPHQDMPTLVRVHQLDLTADVLGWRAAHRDYVPAALEVLAAHDGPAVAVFVRDNSPTSISERVKGNRKAYADTHGYRD
YGIGAQILRDVGVREMVLLSSSAGKLAALEGFGLSVVNRVPLVEDERGKPSRSDQPFASA

Sequences:

>Translated_380_residues
MTEVSPIETIIEDARNGRPYILVDAPDRENEGDVIIPAQFATPNAINFMAMHARGLICLAISSERASHLDLPMMEARNQS
SLSTAFTVSIEARDGVTTGISAHDRAHTIAVAVDPSKGPEDLVSPGHVFPLVARDGGVLVRAGHTEAAVDISRLAGLAPA
GVICEIMNPDGSMARLPELIEFARKHEMNIGTIADLIEYRRRSESLVERVVEAPFDSWHGDFRIIVYRNVIDSGEHVALV
RGDPHQDMPTLVRVHQLDLTADVLGWRAAHRDYVPAALEVLAAHDGPAVAVFVRDNSPTSISERVKGNRKAYADTHGYRD
YGIGAQILRDVGVREMVLLSSSAGKLAALEGFGLSVVNRVPLVEDERGKPSRSDQPFASA
>Mature_379_residues
TEVSPIETIIEDARNGRPYILVDAPDRENEGDVIIPAQFATPNAINFMAMHARGLICLAISSERASHLDLPMMEARNQSS
LSTAFTVSIEARDGVTTGISAHDRAHTIAVAVDPSKGPEDLVSPGHVFPLVARDGGVLVRAGHTEAAVDISRLAGLAPAG
VICEIMNPDGSMARLPELIEFARKHEMNIGTIADLIEYRRRSESLVERVVEAPFDSWHGDFRIIVYRNVIDSGEHVALVR
GDPHQDMPTLVRVHQLDLTADVLGWRAAHRDYVPAALEVLAAHDGPAVAVFVRDNSPTSISERVKGNRKAYADTHGYRDY
GIGAQILRDVGVREMVLLSSSAGKLAALEGFGLSVVNRVPLVEDERGKPSRSDQPFASA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=51.010101010101, Blast_Score=208, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=38.3495145631068, Blast_Score=157, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 41162; Mature: 41031

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVSPIETIIEDARNGRPYILVDAPDRENEGDVIIPAQFATPNAINFMAMHARGLICLA
CCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEEE
ISSERASHLDLPMMEARNQSSLSTAFTVSIEARDGVTTGISAHDRAHTIAVAVDPSKGPE
ECCCCCCCCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCHH
DLVSPGHVFPLVARDGGVLVRAGHTEAAVDISRLAGLAPAGVICEIMNPDGSMARLPELI
HHCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHH
EFARKHEMNIGTIADLIEYRRRSESLVERVVEAPFDSWHGDFRIIVYRNVIDSGEHVALV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEEE
RGDPHQDMPTLVRVHQLDLTADVLGWRAAHRDYVPAALEVLAAHDGPAVAVFVRDNSPTS
ECCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEECCCCCH
ISERVKGNRKAYADTHGYRDYGIGAQILRDVGVREMVLLSSSAGKLAALEGFGLSVVNRV
HHHHHCCCCCEECCCCCCCCCCCHHHHHHHCCHHEEEEEECCCCCEEEECCCCHHHHHCC
PLVEDERGKPSRSDQPFASA
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEVSPIETIIEDARNGRPYILVDAPDRENEGDVIIPAQFATPNAINFMAMHARGLICLA
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEEE
ISSERASHLDLPMMEARNQSSLSTAFTVSIEARDGVTTGISAHDRAHTIAVAVDPSKGPE
ECCCCCCCCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCHH
DLVSPGHVFPLVARDGGVLVRAGHTEAAVDISRLAGLAPAGVICEIMNPDGSMARLPELI
HHCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHH
EFARKHEMNIGTIADLIEYRRRSESLVERVVEAPFDSWHGDFRIIVYRNVIDSGEHVALV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEEE
RGDPHQDMPTLVRVHQLDLTADVLGWRAAHRDYVPAALEVLAAHDGPAVAVFVRDNSPTS
ECCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEECCCCCH
ISERVKGNRKAYADTHGYRDYGIGAQILRDVGVREMVLLSSSAGKLAALEGFGLSVVNRV
HHHHHCCCCCEECCCCCCCCCCCHHHHHHHCCHHEEEEEECCCCCEEEECCCCHHHHHCC
PLVEDERGKPSRSDQPFASA
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]