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The map label for this gene is crt [H]

Identifier: 87199483

GI number: 87199483

Start: 1504449

End: 1505219

Strand: Reverse

Name: crt [H]

Synonym: Saro_1463

Alternate gene names: 87199483

Gene position: 1505219-1504449 (Counterclockwise)

Preceding gene: 87199484

Following gene: 87199482

Centisome position: 42.26

GC content: 66.41

Gene sequence:

>771_bases
ATGGCCGATATTGACTTCAGGATCGAGGGCCACGTCGCTCACGTCCGCCTCAACCGCCCCCAGGGTCTGAACGCGATCAC
CCAGGAGATGGACGATCTGCTGCTCGATGCCTGGACCGAAGTAAACGCCAATTCCGACATCTGGGCGGTAGTGCTCTCGG
CCGAGGGCGAGAAGGCCTTCTGCATCGGCGCCGACGTCTCGGGCGGGGCCGAGCGCAAGACGCGCATGGCGCTCGGCGGT
GGCCTCACCGGGATCGGCGGCCCGCTGGTAACCTGCAAGAAGCCGATGGTGGCCGCGGTCCAGGGCTTCTGCGTCGGCGG
TGGCTTCGAACTCGCGATGTGCGCGGACATTATCGTCGCTGCAGACACTGCCCAGTTCGGCCTGCCCGAAACCAAGGTCG
GCATCATTGGCGAATGCGGCGTTGTCCATCGCGCCATGCGCCAGCTTCCCTATCACATCGCACTCCAGCTCATCCTCACC
GGCGAGCGCATCAAGGCCGATGAAGCGCGCCATTACGGCCTCGTCAACGAGGTCGTGCCCTTCGCCGAACTGGAGGAAGC
AGCGCTGCGCTGGGCATCCAAGCTCAATGCCGCTTCGCCGCTGGCTGTCCAGGCCGCCAAGGCCGCCGCGCTCGGCCGGC
TCGGCCATCCGCTCGAGGTAGCGCTGATGACCCGCTTCGAGCCGATCGAGGAGTATGCGGCGACCGAGGACAAGAAGGAA
GGCGAGCGCGCCGCCGGCGAACGACGCAAGCCGGTCTGGACCGGCAAGTGA

Upstream 100 bases:

>100_bases
CATCCGCGAGCGCATGACCACGCTCGGCCTCAAGGCCGTCCTCGACGAATACCGCGGTCCTTCCTCGACCGCCATCATGA
ACAGTTTCAAGGAGTAAGCC

Downstream 100 bases:

>100_bases
CGATCCGGATCGACCCGGTGATCGAGGGCGCCGCCTACCGGCGCGTCCTCGGCCATTACCCGACCGGGGTCTGCGTGGTA
ACGGCGACGCTGCCCGACGG

Product: short chain enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MADIDFRIEGHVAHVRLNRPQGLNAITQEMDDLLLDAWTEVNANSDIWAVVLSAEGEKAFCIGADVSGGAERKTRMALGG
GLTGIGGPLVTCKKPMVAAVQGFCVGGGFELAMCADIIVAADTAQFGLPETKVGIIGECGVVHRAMRQLPYHIALQLILT
GERIKADEARHYGLVNEVVPFAELEEAALRWASKLNAASPLAVQAAKAAALGRLGHPLEVALMTRFEPIEEYAATEDKKE
GERAAGERRKPVWTGK

Sequences:

>Translated_256_residues
MADIDFRIEGHVAHVRLNRPQGLNAITQEMDDLLLDAWTEVNANSDIWAVVLSAEGEKAFCIGADVSGGAERKTRMALGG
GLTGIGGPLVTCKKPMVAAVQGFCVGGGFELAMCADIIVAADTAQFGLPETKVGIIGECGVVHRAMRQLPYHIALQLILT
GERIKADEARHYGLVNEVVPFAELEEAALRWASKLNAASPLAVQAAKAAALGRLGHPLEVALMTRFEPIEEYAATEDKKE
GERAAGERRKPVWTGK
>Mature_255_residues
ADIDFRIEGHVAHVRLNRPQGLNAITQEMDDLLLDAWTEVNANSDIWAVVLSAEGEKAFCIGADVSGGAERKTRMALGGG
LTGIGGPLVTCKKPMVAAVQGFCVGGGFELAMCADIIVAADTAQFGLPETKVGIIGECGVVHRAMRQLPYHIALQLILTG
ERIKADEARHYGLVNEVVPFAELEEAALRWASKLNAASPLAVQAAKAAALGRLGHPLEVALMTRFEPIEEYAATEDKKEG
ERAAGERRKPVWTGK

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=243, Percent_Identity=34.9794238683128, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI31542718, Length=248, Percent_Identity=29.8387096774194, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI70995211, Length=234, Percent_Identity=32.4786324786325, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI20127408, Length=182, Percent_Identity=31.3186813186813, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI68989263, Length=191, Percent_Identity=32.9842931937173, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI37594471, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI37594469, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4502327, Length=251, Percent_Identity=29.8804780876494, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI221142681, Length=253, Percent_Identity=35.9683794466403, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1787659, Length=256, Percent_Identity=32.8125, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082183, Length=252, Percent_Identity=30.5555555555556, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788597, Length=258, Percent_Identity=30.6201550387597, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788682, Length=252, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787660, Length=255, Percent_Identity=28.6274509803922, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790281, Length=187, Percent_Identity=29.4117647058824, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=34.5528455284553, Blast_Score=141, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25145438, Length=245, Percent_Identity=33.469387755102, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17560910, Length=197, Percent_Identity=32.48730964467, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=203, Percent_Identity=32.0197044334975, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17536985, Length=215, Percent_Identity=28.3720930232558, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=200, Percent_Identity=29.5, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=229, Percent_Identity=26.2008733624454, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=213, Percent_Identity=27.6995305164319, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144157, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=202, Percent_Identity=28.7128712871287, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=193, Percent_Identity=25.9067357512953, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=33.739837398374, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=33.739837398374, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24653139, Length=259, Percent_Identity=32.8185328185328, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24650670, Length=174, Percent_Identity=33.9080459770115, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19920382, Length=221, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357171, Length=181, Percent_Identity=30.939226519337, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922422, Length=243, Percent_Identity=25.1028806584362, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 27352; Mature: 27221

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIDFRIEGHVAHVRLNRPQGLNAITQEMDDLLLDAWTEVNANSDIWAVVLSAEGEKAF
CCCCEEEEECEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEE
CIGADVSGGAERKTRMALGGGLTGIGGPLVTCKKPMVAAVQGFCVGGGFELAMCADIIVA
EEECCCCCCCHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHCEEECCCCHHHHHHHHHHE
ADTAQFGLPETKVGIIGECGVVHRAMRQLPYHIALQLILTGERIKADEARHYGLVNEVVP
ECCHHCCCCCCCEEEEECHHHHHHHHHHCCHHHEEEEEEECCHHCCCHHHHCCCHHHHCC
FAELEEAALRWASKLNAASPLAVQAAKAAALGRLGHPLEVALMTRFEPIEEYAATEDKKE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHCHHHHHHHCCCCHHH
GERAAGERRKPVWTGK
HHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ADIDFRIEGHVAHVRLNRPQGLNAITQEMDDLLLDAWTEVNANSDIWAVVLSAEGEKAF
CCCEEEEECEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEE
CIGADVSGGAERKTRMALGGGLTGIGGPLVTCKKPMVAAVQGFCVGGGFELAMCADIIVA
EEECCCCCCCHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHCEEECCCCHHHHHHHHHHE
ADTAQFGLPETKVGIIGECGVVHRAMRQLPYHIALQLILTGERIKADEARHYGLVNEVVP
ECCHHCCCCCCCEEEEECHHHHHHHHHHCCHHHEEEEEEECCHHCCCHHHHCCCHHHHCC
FAELEEAALRWASKLNAASPLAVQAAKAAALGRLGHPLEVALMTRFEPIEEYAATEDKKE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHCHHHHHHHCCCCHHH
GERAAGERRKPVWTGK
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]