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The map label for this gene is lon [H]

Identifier: 87199382

GI number: 87199382

Start: 1408377

End: 1410788

Strand: Direct

Name: lon [H]

Synonym: Saro_1361

Alternate gene names: 87199382

Gene position: 1408377-1410788 (Clockwise)

Preceding gene: 87199380

Following gene: 87199383

Centisome position: 39.54

GC content: 63.93

Gene sequence:

>2412_bases
GTGCCCATGAATCTCTATCCTCTGCTTCCCCTTCGCGACATCGTCGTGTTCCCCGGCATGGTCGTGCCTCTGTTCGTGGG
GCGCGAGAAATCGGTGGCTGCGCTCGAGGCGGCGATGTCCGGCGACAAGGATATCTTCCTGCTCGCGCAGCTCGATCCAG
GTTGCGACGACCCGGACCGCGACGATCTTTACGATACCGGCGTGATTGCCAGCGTCCTGCAATTGCTAAAGCTGCCCGAC
GGCACCGTGCGCGTGCTCGTGGAAGGGCGCGAGCGTGCGATGCTGGAAGGTCTGCGCGAGGAAACCACCGCGCAGGGCGC
GATGCTGATTGCCCAGGTCGAGCCGATCGAGCCGGTGGTATCGCAAGGCACCGAAATTTCGGCGATGATGCGTTCGGTCG
TCGATCAATTCGCCGAGTACGCCAAGCTTTCCAAGAAGCTGCCGCAGGATGCGGGTGGTCAGCTCGGTGATATCGAGGAC
GCTGGCAAGCTGGCGGATTCGGTCGCGGCGAACCTTGCCGCGAAGGTCGCCGACAAGCAGGCGGTGCTTTCCGAAAACGA
CCCCATGAAGCGGCTCGAGATGGTGCTTTCCTTCATGGAAGGCGAGCTTGGTGTGCTGCAGGTGGAGCGCAAGATCCGTG
GCCGCGTGAAGCGTCAGATGGAGAAGACGCAGCGCGAGTACTACCTGAACGAGCAACTCAAGGCGATCCAGTCGGAGCTG
GGCGGCGGCGACGGTGAGGAAGCCAACGAGATCGCCGAACTGCAGGAGAAGATCGACAAGCTCAAGCTGTCGAAGGAAGC
GCGCGCCAAGGCGACGGCTGAGCTGAAGAAGCTCAAGACCATGCAGCCGATGAGCGCGGAGGCGACCGTCATCCGCAATT
ACCTCGACGTGCTGCTGGGCTTGCCGTGGGGCAAGCGCAGCAAGCTCAAGAAGGACATCCCGGCGGCGCAGGCCGTGCTC
GATGCCGATCACTATGCGCTCGACAAGGTCAAGGACCGGATCGTCGAGTACCTGGCGGTGCAGGCCCGCACGAACAAGCT
CAAGGGGCCGATCCTGTGCCTCGTCGGCCCTCCGGGCGTCGGCAAGACCAGCCTTGGCAAGTCCATCGCCAAGGCTACGG
GGCGCCAATTCGTGCGCCAGTCTCTGGGCGGCGTGCGTGACGAGGCCGAGATCCGCGGGCATCGCCGCACCTACATCGGC
TCGCTGCCGGGCAAGATCGTGACCAACCTCAAGAAGGCGGGTACGGCCAATCCCTTGTTCCTGCTGGATGAGATCGACAA
GTTGGGCCAGGACTTCCGCGGCGATCCGGCTTCGGCACTGCTCGAGGTGCTGGACCCGGAACAGAACGCCAAGTTCCAGG
ACCATTACCTGGAGCTGGACATCGACCTGTCCGACGTGATGTTCGTGTGCACCGCGAACAGCCTCAACCTGCCTCAGCCT
TTGCTTGACCGCATGGAGATCATCCGGCTCGAGGGCTATACCGAGGACGAGAAGGTCGAAATCGCCGAGCGTCATCTGGT
GCGCAAGCAGGTGGAGGCACATGGCCTCAAGAAGGGTGAGTTCACCTTGACCCAGGAAGGCCTGCGCGATCTGATCCGCT
ATTACACCCGCGAGGCGGGCGTGCGTACGCTGGAGCGCGAGATCGCGCGGCTGGCGCGCAAGTCGCTGCGTCAGATTCTC
GAGGGCAAGACCAAGAGCGTGACGATCACGTCGGACAACCTTTCCGACTTCGCCGGGGTCCGCAAGTTCCGGCATGGCGT
TTCGGACGAGGAGAACCAGGTCGGCGCGGTCACGGGTCTCGCCTGGACGGAAGTCGGCGGCGAACTGCTGACGATCGAGA
GCGTGACGGTGCCCGGCAAGGGCGCGGTCAAGACCACCGGCAAGCTGGGCGAGGTAATGAGCGAGAGCGTCCAGATGGCG
TTCAGCTTCGTCAAGGCGCGCAGCCCTGCCTACGGCATCAAGCCTTCGATCTTCAATCGCAAGGACCTGCATATCCACCT
GCCCGAAGGCGCGGTGCCCAAGGACGGACCAAGCGCCGGCATCGGCATGGTCACGGCAATGGTCTCGACGCTGACGGGCA
TTCCGGTGCGGGCGGACGTGGCCATGACCGGCGAAGTCACCTTGCGCGGTCGCGTGCTGGCGATCGGTGGCCTCAAGGAA
AAGCTGCTGGCCGCGCTGCGCGGCGGCATCAAGACGGTGTTGATCCCGGAAGAGAACCGCAAGGACCTTGCCGAGATTCC
GACCAACATCAAGGAAGGTCTCGAGATCGTGCCTGTGAGCCACGTGGACGAAGTGCTGGCGCGGGCGCTGGTCACGACGC
CCGAGGCGATCGAGTGGACTGAAGCGGACGATCTGGCGACCCAGCCCGCCCCTACGGTCGCTGGCCCTGCGACCTCGCCG
ACGGCCCACTGA

Upstream 100 bases:

>100_bases
GATCCACAAGCGAAGTCGCCAAGGCCATTGCGGCAAGGACAGGGGACCCCCATATCCGGGTCAAAGCGTCGGGCGGCGTG
CCCGACAGGACGGAAACGAA

Downstream 100 bases:

>100_bases
AAGGTTGATCGAGGGCCGCCTCGCGCAACGAAATTGCGCGGGGTGGCCCTCAGCTCGCCAAAGCCCCGAATTGTCGGGAA
TATTCCCGATTGTTCGTCGC

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MPMNLYPLLPLRDIVVFPGMVVPLFVGREKSVAALEAAMSGDKDIFLLAQLDPGCDDPDRDDLYDTGVIASVLQLLKLPD
GTVRVLVEGRERAMLEGLREETTAQGAMLIAQVEPIEPVVSQGTEISAMMRSVVDQFAEYAKLSKKLPQDAGGQLGDIED
AGKLADSVAANLAAKVADKQAVLSENDPMKRLEMVLSFMEGELGVLQVERKIRGRVKRQMEKTQREYYLNEQLKAIQSEL
GGGDGEEANEIAELQEKIDKLKLSKEARAKATAELKKLKTMQPMSAEATVIRNYLDVLLGLPWGKRSKLKKDIPAAQAVL
DADHYALDKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGKSIAKATGRQFVRQSLGGVRDEAEIRGHRRTYIG
SLPGKIVTNLKKAGTANPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNAKFQDHYLELDIDLSDVMFVCTANSLNLPQP
LLDRMEIIRLEGYTEDEKVEIAERHLVRKQVEAHGLKKGEFTLTQEGLRDLIRYYTREAGVRTLEREIARLARKSLRQIL
EGKTKSVTITSDNLSDFAGVRKFRHGVSDEENQVGAVTGLAWTEVGGELLTIESVTVPGKGAVKTTGKLGEVMSESVQMA
FSFVKARSPAYGIKPSIFNRKDLHIHLPEGAVPKDGPSAGIGMVTAMVSTLTGIPVRADVAMTGEVTLRGRVLAIGGLKE
KLLAALRGGIKTVLIPEENRKDLAEIPTNIKEGLEIVPVSHVDEVLARALVTTPEAIEWTEADDLATQPAPTVAGPATSP
TAH

Sequences:

>Translated_803_residues
MPMNLYPLLPLRDIVVFPGMVVPLFVGREKSVAALEAAMSGDKDIFLLAQLDPGCDDPDRDDLYDTGVIASVLQLLKLPD
GTVRVLVEGRERAMLEGLREETTAQGAMLIAQVEPIEPVVSQGTEISAMMRSVVDQFAEYAKLSKKLPQDAGGQLGDIED
AGKLADSVAANLAAKVADKQAVLSENDPMKRLEMVLSFMEGELGVLQVERKIRGRVKRQMEKTQREYYLNEQLKAIQSEL
GGGDGEEANEIAELQEKIDKLKLSKEARAKATAELKKLKTMQPMSAEATVIRNYLDVLLGLPWGKRSKLKKDIPAAQAVL
DADHYALDKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGKSIAKATGRQFVRQSLGGVRDEAEIRGHRRTYIG
SLPGKIVTNLKKAGTANPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNAKFQDHYLELDIDLSDVMFVCTANSLNLPQP
LLDRMEIIRLEGYTEDEKVEIAERHLVRKQVEAHGLKKGEFTLTQEGLRDLIRYYTREAGVRTLEREIARLARKSLRQIL
EGKTKSVTITSDNLSDFAGVRKFRHGVSDEENQVGAVTGLAWTEVGGELLTIESVTVPGKGAVKTTGKLGEVMSESVQMA
FSFVKARSPAYGIKPSIFNRKDLHIHLPEGAVPKDGPSAGIGMVTAMVSTLTGIPVRADVAMTGEVTLRGRVLAIGGLKE
KLLAALRGGIKTVLIPEENRKDLAEIPTNIKEGLEIVPVSHVDEVLARALVTTPEAIEWTEADDLATQPAPTVAGPATSP
TAH
>Mature_802_residues
PMNLYPLLPLRDIVVFPGMVVPLFVGREKSVAALEAAMSGDKDIFLLAQLDPGCDDPDRDDLYDTGVIASVLQLLKLPDG
TVRVLVEGRERAMLEGLREETTAQGAMLIAQVEPIEPVVSQGTEISAMMRSVVDQFAEYAKLSKKLPQDAGGQLGDIEDA
GKLADSVAANLAAKVADKQAVLSENDPMKRLEMVLSFMEGELGVLQVERKIRGRVKRQMEKTQREYYLNEQLKAIQSELG
GGDGEEANEIAELQEKIDKLKLSKEARAKATAELKKLKTMQPMSAEATVIRNYLDVLLGLPWGKRSKLKKDIPAAQAVLD
ADHYALDKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGKSIAKATGRQFVRQSLGGVRDEAEIRGHRRTYIGS
LPGKIVTNLKKAGTANPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNAKFQDHYLELDIDLSDVMFVCTANSLNLPQPL
LDRMEIIRLEGYTEDEKVEIAERHLVRKQVEAHGLKKGEFTLTQEGLRDLIRYYTREAGVRTLEREIARLARKSLRQILE
GKTKSVTITSDNLSDFAGVRKFRHGVSDEENQVGAVTGLAWTEVGGELLTIESVTVPGKGAVKTTGKLGEVMSESVQMAF
SFVKARSPAYGIKPSIFNRKDLHIHLPEGAVPKDGPSAGIGMVTAMVSTLTGIPVRADVAMTGEVTLRGRVLAIGGLKEK
LLAALRGGIKTVLIPEENRKDLAEIPTNIKEGLEIVPVSHVDEVLARALVTTPEAIEWTEADDLATQPAPTVAGPATSPT
AH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=614, Percent_Identity=44.1368078175896, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI31377667, Length=566, Percent_Identity=45.7597173144876, Blast_Score=507, Evalue=1e-143,
Organism=Escherichia coli, GI1786643, Length=777, Percent_Identity=60.6177606177606, Blast_Score=949, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=714, Percent_Identity=38.515406162465, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17556486, Length=542, Percent_Identity=39.1143911439114, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=721, Percent_Identity=40.9153952843273, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=701, Percent_Identity=39.5149786019972, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24666867, Length=701, Percent_Identity=39.5149786019972, Blast_Score=500, Evalue=1e-141,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87485; Mature: 87354

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMNLYPLLPLRDIVVFPGMVVPLFVGREKSVAALEAAMSGDKDIFLLAQLDPGCDDPDR
CCCCCCCCCCHHHHHHCCCHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
DDLYDTGVIASVLQLLKLPDGTVRVLVEGRERAMLEGLREETTAQGAMLIAQVEPIEPVV
CHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCCHHH
SQGTEISAMMRSVVDQFAEYAKLSKKLPQDAGGQLGDIEDAGKLADSVAANLAAKVADKQ
HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVLSENDPMKRLEMVLSFMEGELGVLQVERKIRGRVKRQMEKTQREYYLNEQLKAIQSEL
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGDGEEANEIAELQEKIDKLKLSKEARAKATAELKKLKTMQPMSAEATVIRNYLDVLLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
LPWGKRSKLKKDIPAAQAVLDADHYALDKVKDRIVEYLAVQARTNKLKGPILCLVGPPGV
CCCCCHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GKTSLGKSIAKATGRQFVRQSLGGVRDEAEIRGHRRTYIGSLPGKIVTNLKKAGTANPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHCCCCCCCH
LLDEIDKLGQDFRGDPASALLEVLDPEQNAKFQDHYLELDIDLSDVMFVCTANSLNLPQP
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCHH
LLDRMEIIRLEGYTEDEKVEIAERHLVRKQVEAHGLKKGEFTLTQEGLRDLIRYYTREAG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHH
VRTLEREIARLARKSLRQILEGKTKSVTITSDNLSDFAGVRKFRHGVSDEENQVGAVTGL
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHCCH
AWTEVGGELLTIESVTVPGKGAVKTTGKLGEVMSESVQMAFSFVKARSPAYGIKPSIFNR
HHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KDLHIHLPEGAVPKDGPSAGIGMVTAMVSTLTGIPVRADVAMTGEVTLRGRVLAIGGLKE
CCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECEEEECCEEEEEEEEEECCHHH
KLLAALRGGIKTVLIPEENRKDLAEIPTNIKEGLEIVPVSHVDEVLARALVTTPEAIEWT
HHHHHHHCCCEEEEECCCCCHHHHHCCCCHHCCCEEECHHHHHHHHHHHHHCCCCCCCCC
EADDLATQPAPTVAGPATSPTAH
CCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PMNLYPLLPLRDIVVFPGMVVPLFVGREKSVAALEAAMSGDKDIFLLAQLDPGCDDPDR
CCCCCCCCCHHHHHHCCCHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
DDLYDTGVIASVLQLLKLPDGTVRVLVEGRERAMLEGLREETTAQGAMLIAQVEPIEPVV
CHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCCHHH
SQGTEISAMMRSVVDQFAEYAKLSKKLPQDAGGQLGDIEDAGKLADSVAANLAAKVADKQ
HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVLSENDPMKRLEMVLSFMEGELGVLQVERKIRGRVKRQMEKTQREYYLNEQLKAIQSEL
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGDGEEANEIAELQEKIDKLKLSKEARAKATAELKKLKTMQPMSAEATVIRNYLDVLLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
LPWGKRSKLKKDIPAAQAVLDADHYALDKVKDRIVEYLAVQARTNKLKGPILCLVGPPGV
CCCCCHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GKTSLGKSIAKATGRQFVRQSLGGVRDEAEIRGHRRTYIGSLPGKIVTNLKKAGTANPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHCCCCCCCH
LLDEIDKLGQDFRGDPASALLEVLDPEQNAKFQDHYLELDIDLSDVMFVCTANSLNLPQP
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCHH
LLDRMEIIRLEGYTEDEKVEIAERHLVRKQVEAHGLKKGEFTLTQEGLRDLIRYYTREAG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHH
VRTLEREIARLARKSLRQILEGKTKSVTITSDNLSDFAGVRKFRHGVSDEENQVGAVTGL
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHCCH
AWTEVGGELLTIESVTVPGKGAVKTTGKLGEVMSESVQMAFSFVKARSPAYGIKPSIFNR
HHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KDLHIHLPEGAVPKDGPSAGIGMVTAMVSTLTGIPVRADVAMTGEVTLRGRVLAIGGLKE
CCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECEEEECCEEEEEEEEEECCHHH
KLLAALRGGIKTVLIPEENRKDLAEIPTNIKEGLEIVPVSHVDEVLARALVTTPEAIEWT
HHHHHHHCCCEEEEECCCCCHHHHHCCCCHHCCCEEECHHHHHHHHHHHHHCCCCCCCCC
EADDLATQPAPTVAGPATSPTAH
CCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655539 [H]