Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 87199361

GI number: 87199361

Start: 1381416

End: 1382678

Strand: Direct

Name: fabF [H]

Synonym: Saro_1340

Alternate gene names: 87199361

Gene position: 1381416-1382678 (Clockwise)

Preceding gene: 87199360

Following gene: 87199362

Centisome position: 38.79

GC content: 65.16

Gene sequence:

>1263_bases
ATGCGTCGTGTCGTCGTAACCGGACTTGGACTGGTCACCCCGCTGGGTGCGGACGTTGAAACAGTGTGGAAGAACCTGCT
TGCCGGCAAGAGCGGCGCGGGGCTCATCACCAAGTTCGACACCACGGACCAGAAGTGCAAGATCGCCTGTGAGGTGAAGC
CGGCCGACCACGAGTATGGTTTCGATGCCGGCAAGCGCGTGGACCACAAGATCCAGCGCCAGGTCGATCCCTTCATCGTC
TTCGGCATCGATGCCGCAGGGCAGGCGCTCGAAGACGCAGGGCTCGCCGACATGGACGACGATCTCAAGATGCGCACCGG
CTGCTCGATCGGTTCGGGCATCGGCGGCCTGCCGGGAATCGAGAGCGAATCGATCATCCTGCACGAAAAGGGCCCCGGCC
GTGTTTCGCCGCACTTCGTCCATGGTCGCCTGATCAACCTGATTTCCGGTCAGGTCTCGATCAAGTACGGCCTGATGGGG
CCGAACCATGCGGTCGTCACCGCCTGCTCGACCGGCGCACACTCGATCGGCGACGCCGCGCGCATGATCAAGGACGGAGA
TGCCGACGTCATGCTGGCCGGCGGCGCCGAGAGCACGATCAACCCGCTGGGCGTTGCCGGCTTCGCCCAGGCCCGCGCGC
TGAACTGCAGCTACAACGACCGCCCGACCGAGGCGAGCCGGCCCTACGACAAGGACCGCGACGGCTTCGTCATGGGCGAG
GGCGCGGGCGTTGTGGTGCTCGAGGAATACGAGCACGCCAAGGCGCGCGGCGCGAAGATCTATGCCGAAGTCGTCGGTTA
TGGCCTGTCGGGCGACGCTTACCACGTCACGGCGCCGCATCCTGAAGGCAAGGGCGCGGAACTGGCGATGCGCATGGCGC
TGCGCAAGGCAGGTCTTTCGGCCGGCGACATCGATTACGTCAATGCCCACGGCACCTCGACCATGGCCGACACGATCGAG
CTGGCGGCCGTGAAGCGCGTGCTGGGCGACGACCTTTCCGGCGCTTCGATGAGCAGTACCAAGTCTGCCATTGGCCACCT
TCTTGGCGGTGCCGGCGCGGTCGAGACGATCTTCTGCATCCTGGCGATCCGCGACCAGATCGTGCCGCCGACGCTCAACC
TGCACAATCCGGACGAAGGCACCGAAGGCGTGGACCTCGTCCCGCTCAAGGCCAAGCCCCGCAAGGTGCGCGCGGCGCTG
AACAATTCGTTCGGCTTTGGCGGCACCAATGCCAGTGTGATCGTCAAGGCGGTCGAAGACTGA

Upstream 100 bases:

>100_bases
TCGAAGGGCTGCTGTCCGTGATGGGCCGCAGGGGAGGACTTCGGCAGGCTCAGCCCTCATGCAGGGGCTGGGCCTGTTTG
CATATTTCCCGGAGAATTCA

Downstream 100 bases:

>100_bases
GGCAGGCAAGATGGCCCGCCGCCGCCGATCCAGATTGCCGCTGCTGGCGGCGGCCCTTGTCGTGCTGGTCGTGGCGGCGT
GGCTCGTCGGCGGCTGGTTC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRRVVVTGLGLVTPLGADVETVWKNLLAGKSGAGLITKFDTTDQKCKIACEVKPADHEYGFDAGKRVDHKIQRQVDPFIV
FGIDAAGQALEDAGLADMDDDLKMRTGCSIGSGIGGLPGIESESIILHEKGPGRVSPHFVHGRLINLISGQVSIKYGLMG
PNHAVVTACSTGAHSIGDAARMIKDGDADVMLAGGAESTINPLGVAGFAQARALNCSYNDRPTEASRPYDKDRDGFVMGE
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPHPEGKGAELAMRMALRKAGLSAGDIDYVNAHGTSTMADTIE
LAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVETIFCILAIRDQIVPPTLNLHNPDEGTEGVDLVPLKAKPRKVRAAL
NNSFGFGGTNASVIVKAVED

Sequences:

>Translated_420_residues
MRRVVVTGLGLVTPLGADVETVWKNLLAGKSGAGLITKFDTTDQKCKIACEVKPADHEYGFDAGKRVDHKIQRQVDPFIV
FGIDAAGQALEDAGLADMDDDLKMRTGCSIGSGIGGLPGIESESIILHEKGPGRVSPHFVHGRLINLISGQVSIKYGLMG
PNHAVVTACSTGAHSIGDAARMIKDGDADVMLAGGAESTINPLGVAGFAQARALNCSYNDRPTEASRPYDKDRDGFVMGE
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPHPEGKGAELAMRMALRKAGLSAGDIDYVNAHGTSTMADTIE
LAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVETIFCILAIRDQIVPPTLNLHNPDEGTEGVDLVPLKAKPRKVRAAL
NNSFGFGGTNASVIVKAVED
>Mature_420_residues
MRRVVVTGLGLVTPLGADVETVWKNLLAGKSGAGLITKFDTTDQKCKIACEVKPADHEYGFDAGKRVDHKIQRQVDPFIV
FGIDAAGQALEDAGLADMDDDLKMRTGCSIGSGIGGLPGIESESIILHEKGPGRVSPHFVHGRLINLISGQVSIKYGLMG
PNHAVVTACSTGAHSIGDAARMIKDGDADVMLAGGAESTINPLGVAGFAQARALNCSYNDRPTEASRPYDKDRDGFVMGE
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPHPEGKGAELAMRMALRKAGLSAGDIDYVNAHGTSTMADTIE
LAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVETIFCILAIRDQIVPPTLNLHNPDEGTEGVDLVPLKAKPRKVRAAL
NNSFGFGGTNASVIVKAVED

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=47.8468899521531, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI223972627, Length=187, Percent_Identity=39.0374331550802, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=23.4883720930233, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=54.653937947494, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=35.4609929078014, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=426, Percent_Identity=40.6103286384976, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=256, Percent_Identity=48.046875, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI212642053, Length=370, Percent_Identity=27.8378378378378, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=264, Percent_Identity=25.7575757575758, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=41.2026726057906, Blast_Score=301, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=44.8441247002398, Blast_Score=334, Evalue=7e-92,
Organism=Drosophila melanogaster, GI19920632, Length=378, Percent_Identity=25.6613756613757, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221330659, Length=378, Percent_Identity=25.6613756613757, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581345, Length=435, Percent_Identity=23.6781609195402, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43794; Mature: 43794

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGLVTPLGADVETVWKNLLAGKSGAGLITKFDTTDQKCKIACEVKPADHEYG
CCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCC
FDAGKRVDHKIQRQVDPFIVFGIDAAGQALEDAGLADMDDDLKMRTGCSIGSGIGGLPGI
CCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCC
ESESIILHEKGPGRVSPHFVHGRLINLISGQVSIKYGLMGPNHAVVTACSTGAHSIGDAA
CCCEEEEECCCCCCCCCEEHHHHHEEHHCCEEEEEEECCCCCCEEEEEECCCCCHHHHHH
RMIKDGDADVMLAGGAESTINPLGVAGFAQARALNCSYNDRPTEASRPYDKDRDGFVMGE
HHHCCCCCCEEEECCCCCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCCCEEEEC
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPHPEGKGAELAMRMALRKAGLS
CCCEEEEECCCHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
AGDIDYVNAHGTSTMADTIELAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVETIFCI
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
LAIRDQIVPPTLNLHNPDEGTEGVDLVPLKAKPRKVRAALNNSFGFGGTNASVIVKAVED
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MRRVVVTGLGLVTPLGADVETVWKNLLAGKSGAGLITKFDTTDQKCKIACEVKPADHEYG
CCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCC
FDAGKRVDHKIQRQVDPFIVFGIDAAGQALEDAGLADMDDDLKMRTGCSIGSGIGGLPGI
CCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCC
ESESIILHEKGPGRVSPHFVHGRLINLISGQVSIKYGLMGPNHAVVTACSTGAHSIGDAA
CCCEEEEECCCCCCCCCEEHHHHHEEHHCCEEEEEEECCCCCCEEEEEECCCCCHHHHHH
RMIKDGDADVMLAGGAESTINPLGVAGFAQARALNCSYNDRPTEASRPYDKDRDGFVMGE
HHHCCCCCCEEEECCCCCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCCCEEEEC
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPHPEGKGAELAMRMALRKAGLS
CCCEEEEECCCHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
AGDIDYVNAHGTSTMADTIELAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVETIFCI
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
LAIRDQIVPPTLNLHNPDEGTEGVDLVPLKAKPRKVRAALNNSFGFGGTNASVIVKAVED
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]