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The map label for this gene is uvrD [H]

Identifier: 87199314

GI number: 87199314

Start: 1336587

End: 1338884

Strand: Reverse

Name: uvrD [H]

Synonym: Saro_1293

Alternate gene names: 87199314

Gene position: 1338884-1336587 (Counterclockwise)

Preceding gene: 87199317

Following gene: 87199311

Centisome position: 37.59

GC content: 65.88

Gene sequence:

>2298_bases
ATGTCCTCCCCTGTCCCCGCGAATCCGCACGCCAGCAATGCCTGGCTCGATGGCCTGAACCCGCCCCAGCGCGAGGCCGT
GACGACGACCGAGGGGCCGGTGCTGATGCTGGCCGGCGCGGGCACCGGAAAGACCGCCGCCCTGACCGCACGCCTTGCCA
ACCTGCTGCGCCAGCGGCTGGCCTGGCCGAGCGAGATCCTGTGCGTGACCTTTACCAACAAGGCCGCGCGCGAAATGCGC
GAGCGCGTGGGGAACCTGATCGGACCGGCGGTGGAAGGCATGCCTTGGCTGGGCACATTCCATGCCATCGCGGCGAAGAT
GCTGCGCCGCCATGCCGAACTGGTCGGACTGCAATCGAACTTCACGATCATCGACACCGACGACCAGCTTCGGCTGCTCA
AGCAGCTTGTCGTGGCGGAAGGCATTGACGAAAAGCGCTGGCCCGCGCGCCAGCTCGCCGGGCTGATCGACAAGTGGAAG
AACCGGGGGCTCAACCCTGCCGACCTCGATGCGCTGGAAAACGAGGCCTATGCCAACGGCAAGGGCCAGCGGTTCTATGC
ACTCTACCAGAATCGCCTGCGCGAACTGAATGCCTGCGATTTCGGCGACCTGCTGATGCACATGCTCAACATCTTCCGGC
GCGAACGCGAGGTGCTGGAAATGTGGCAGCAGCGCTTCAAGTACGTGATGGTGGACGAATACCAGGACACCAACGCGGTG
CAGTACCTGTGGCTGCGGCTGCTGGCGCAGAACCGCAAGAACATCTGCGTGGTGGGTGACGACGACCAGTCCATCTATTC
CTGGCGCGGCGCGGAAGTGGCCAACATACTGCGCTTCGAAAAGGATTTTCCCGGCGCGAAGGTGATCCGGCTGGAGCAGA
ACTACCGGTCTACCCCGCATATCCTGGGTGCTGCATCGGGGCTGATCGCGGAGAATTCCGAGCGGCTCGGCAAGACATTG
TGGACCGAGGTCGACGGCGGCGACAAGGTGCGCGTGATCGGCGTGTGGGACGCGCCGGAGGAAGCGCGGCGGATCGGCGA
CGAGATCGAACGGCTGGAGCGCGAGGGCGCGCCGCTCGACCGTGTGGCGATACTGGTGCGCGCGCAGTTCCAGACGCGGA
CGATCGAAGACAGGTTCATCCAGATCGGGCTGGGCTATCGCATCGTCGGCGGTTTCCGGTTCTACGAGCGCGCGGAGATC
CGCGATGCGCTCGCCTACCTGCGGATCATCGCAAGCCCGCAGGACGACCTCGCCTTCGAGCGGATCTACAATACGCCCAA
GCGCGGGCTTGGCGACAAGACGCTGGAGAAGCTGCACCGCCACGCACGGGCGCGGAGCATTCCGCTGTCGCTGGCATCGG
TCGAGATCCTCGACACCGACGAGCTTCCGGCGCGGGCGCGGGGCACGCTGGCAGCACTGATGCGCGACTTCGGCCGGTGG
CGCGATGCGTCGAAGTCGCTCGTCCCGGCGGAACTGGCGCGCACGATCCTCGACGAAAGCGGCTATACCGCCGCCCTTCA
GGCGGAGAAGACCGCGGAGGCCGCCGGACGCCTTGAAAACCTTACCGAACTTGCCCGCGCGATGGAGGAATACGAGACGC
TGGGGGACTTCCTCGAGCATGTCAGCCTGGTGATGGACAACGAGGCCGTGGCCGACGAGGAAAAGGTCACGATCATGACC
ATCCACGCGGCCAAGGGGCTGGAATTCGACAACGTGTTCCTGCCCGGATGGGAGGAAGGCGTGTTTCCTTCGCAACGCTC
GCTCGACGAAGGCGGCCTGGCCTCGCTGGAAGAAGAGCGCCGCCTTGCCTATGTGGCGATCACCCGCGCTCGGCGGCATT
GCACCATCCTTCACGCCGCCAATCGCCAGATCTATGGCCAGTGGACCAGTTCGATCCCCTCGCGCTTCATCGGCGAACTG
CCTGCGGAGCACATCGAGGAAGAGACCACGCTATCGGGCGGCGCATCGATGTGGCGGGCGAACTGGAGCGAACGCGAAGA
TCCCTTCGCCCATGTCGCGCAGGCAACGCCGTCGCGCGGAGCCTCGCGCGGGCCGGGCTGGCAGCGCGCCGCCGCGCAGC
CCTACAACCCGCAGCCGCGCCGGATCGCCGAAACCACCCGCAGCGCGGCGAGCTTTGCCGCCAAGCCGCGCAGCGACATC
AGCGTGGGCGCGCGCGTCTTCCACGAGAAGTTCGGCTACGGCACCGTGGCCGAGCAGGAAGGCAACAAGCTGGAGATCGA
TTTCGAAAGCGCGGGGCGGAAGCGCGTGATCGACAGCTTCGTGAAGCTCGCTGGCTAG

Upstream 100 bases:

>100_bases
TTGCGACGGGCCGCACTGCGATCCGGGACGAACCGCACCATGCCCGGATTGCTGGCAAAGGCGATTGCCGCAGCGGCGTT
TGGTCCCTATCTGTTCACGC

Downstream 100 bases:

>100_bases
GATTTAGGGGCGGGCTGGCGCACAGGCGCCCCGGATCATCTCAACGGCACGACCTCGCAATGACGGGTGCATTGTGCTGC
CTCGTCATTGTCAGCTTGGC

Product: ATP-dependent DNA helicase Rep

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MSSPVPANPHASNAWLDGLNPPQREAVTTTEGPVLMLAGAGTGKTAALTARLANLLRQRLAWPSEILCVTFTNKAAREMR
ERVGNLIGPAVEGMPWLGTFHAIAAKMLRRHAELVGLQSNFTIIDTDDQLRLLKQLVVAEGIDEKRWPARQLAGLIDKWK
NRGLNPADLDALENEAYANGKGQRFYALYQNRLRELNACDFGDLLMHMLNIFRREREVLEMWQQRFKYVMVDEYQDTNAV
QYLWLRLLAQNRKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKVIRLEQNYRSTPHILGAASGLIAENSERLGKTL
WTEVDGGDKVRVIGVWDAPEEARRIGDEIERLEREGAPLDRVAILVRAQFQTRTIEDRFIQIGLGYRIVGGFRFYERAEI
RDALAYLRIIASPQDDLAFERIYNTPKRGLGDKTLEKLHRHARARSIPLSLASVEILDTDELPARARGTLAALMRDFGRW
RDASKSLVPAELARTILDESGYTAALQAEKTAEAAGRLENLTELARAMEEYETLGDFLEHVSLVMDNEAVADEEKVTIMT
IHAAKGLEFDNVFLPGWEEGVFPSQRSLDEGGLASLEEERRLAYVAITRARRHCTILHAANRQIYGQWTSSIPSRFIGEL
PAEHIEEETTLSGGASMWRANWSEREDPFAHVAQATPSRGASRGPGWQRAAAQPYNPQPRRIAETTRSAASFAAKPRSDI
SVGARVFHEKFGYGTVAEQEGNKLEIDFESAGRKRVIDSFVKLAG

Sequences:

>Translated_765_residues
MSSPVPANPHASNAWLDGLNPPQREAVTTTEGPVLMLAGAGTGKTAALTARLANLLRQRLAWPSEILCVTFTNKAAREMR
ERVGNLIGPAVEGMPWLGTFHAIAAKMLRRHAELVGLQSNFTIIDTDDQLRLLKQLVVAEGIDEKRWPARQLAGLIDKWK
NRGLNPADLDALENEAYANGKGQRFYALYQNRLRELNACDFGDLLMHMLNIFRREREVLEMWQQRFKYVMVDEYQDTNAV
QYLWLRLLAQNRKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKVIRLEQNYRSTPHILGAASGLIAENSERLGKTL
WTEVDGGDKVRVIGVWDAPEEARRIGDEIERLEREGAPLDRVAILVRAQFQTRTIEDRFIQIGLGYRIVGGFRFYERAEI
RDALAYLRIIASPQDDLAFERIYNTPKRGLGDKTLEKLHRHARARSIPLSLASVEILDTDELPARARGTLAALMRDFGRW
RDASKSLVPAELARTILDESGYTAALQAEKTAEAAGRLENLTELARAMEEYETLGDFLEHVSLVMDNEAVADEEKVTIMT
IHAAKGLEFDNVFLPGWEEGVFPSQRSLDEGGLASLEEERRLAYVAITRARRHCTILHAANRQIYGQWTSSIPSRFIGEL
PAEHIEEETTLSGGASMWRANWSEREDPFAHVAQATPSRGASRGPGWQRAAAQPYNPQPRRIAETTRSAASFAAKPRSDI
SVGARVFHEKFGYGTVAEQEGNKLEIDFESAGRKRVIDSFVKLAG
>Mature_764_residues
SSPVPANPHASNAWLDGLNPPQREAVTTTEGPVLMLAGAGTGKTAALTARLANLLRQRLAWPSEILCVTFTNKAAREMRE
RVGNLIGPAVEGMPWLGTFHAIAAKMLRRHAELVGLQSNFTIIDTDDQLRLLKQLVVAEGIDEKRWPARQLAGLIDKWKN
RGLNPADLDALENEAYANGKGQRFYALYQNRLRELNACDFGDLLMHMLNIFRREREVLEMWQQRFKYVMVDEYQDTNAVQ
YLWLRLLAQNRKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKVIRLEQNYRSTPHILGAASGLIAENSERLGKTLW
TEVDGGDKVRVIGVWDAPEEARRIGDEIERLEREGAPLDRVAILVRAQFQTRTIEDRFIQIGLGYRIVGGFRFYERAEIR
DALAYLRIIASPQDDLAFERIYNTPKRGLGDKTLEKLHRHARARSIPLSLASVEILDTDELPARARGTLAALMRDFGRWR
DASKSLVPAELARTILDESGYTAALQAEKTAEAAGRLENLTELARAMEEYETLGDFLEHVSLVMDNEAVADEEKVTIMTI
HAAKGLEFDNVFLPGWEEGVFPSQRSLDEGGLASLEEERRLAYVAITRARRHCTILHAANRQIYGQWTSSIPSRFIGELP
AEHIEEETTLSGGASMWRANWSEREDPFAHVAQATPSRGASRGPGWQRAAAQPYNPQPRRIAETTRSAASFAAKPRSDIS
VGARVFHEKFGYGTVAEQEGNKLEIDFESAGRKRVIDSFVKLAG

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=763, Percent_Identity=40.2359108781127, Blast_Score=523, Evalue=1e-149,
Organism=Escherichia coli, GI48994965, Length=694, Percent_Identity=37.3198847262248, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1787196, Length=391, Percent_Identity=27.3657289002558, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=463, Percent_Identity=32.1814254859611, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 85853; Mature: 85722

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPVPANPHASNAWLDGLNPPQREAVTTTEGPVLMLAGAGTGKTAALTARLANLLRQRL
CCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHC
AWPSEILCVTFTNKAAREMRERVGNLIGPAVEGMPWLGTFHAIAAKMLRRHAELVGLQSN
CCCCCEEEEEECCHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCC
FTIIDTDDQLRLLKQLVVAEGIDEKRWPARQLAGLIDKWKNRGLNPADLDALENEAYANG
CEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
KGQRFYALYQNRLRELNACDFGDLLMHMLNIFRREREVLEMWQQRFKYVMVDEYQDTNAV
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHH
QYLWLRLLAQNRKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKVIRLEQNYRSTPH
HHHHHHHHHCCCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
ILGAASGLIAENSERLGKTLWTEVDGGDKVRVIGVWDAPEEARRIGDEIERLEREGAPLD
HHHHHCCHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCHH
RVAILVRAQFQTRTIEDRFIQIGLGYRIVGGFRFYERAEIRDALAYLRIIASPQDDLAFE
HHHHHHHHHHHHHHHHHHHEEEECCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RIYNTPKRGLGDKTLEKLHRHARARSIPLSLASVEILDTDELPARARGTLAALMRDFGRW
HHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
RDASKSLVPAELARTILDESGYTAALQAEKTAEAAGRLENLTELARAMEEYETLGDFLEH
HCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLVMDNEAVADEEKVTIMTIHAAKGLEFDNVFLPGWEEGVFPSQRSLDEGGLASLEEER
HHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHH
RLAYVAITRARRHCTILHAANRQIYGQWTSSIPSRFIGELPAEHIEEETTLSGGASMWRA
HEEHHHHHHHHHHEEEEEECCCCEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHC
NWSEREDPFAHVAQATPSRGASRGPGWQRAAAQPYNPQPRRIAETTRSAASFAAKPRSDI
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
SVGARVFHEKFGYGTVAEQEGNKLEIDFESAGRKRVIDSFVKLAG
HHHHHHHHHHCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SSPVPANPHASNAWLDGLNPPQREAVTTTEGPVLMLAGAGTGKTAALTARLANLLRQRL
CCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHC
AWPSEILCVTFTNKAAREMRERVGNLIGPAVEGMPWLGTFHAIAAKMLRRHAELVGLQSN
CCCCCEEEEEECCHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCC
FTIIDTDDQLRLLKQLVVAEGIDEKRWPARQLAGLIDKWKNRGLNPADLDALENEAYANG
CEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
KGQRFYALYQNRLRELNACDFGDLLMHMLNIFRREREVLEMWQQRFKYVMVDEYQDTNAV
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHH
QYLWLRLLAQNRKNICVVGDDDQSIYSWRGAEVANILRFEKDFPGAKVIRLEQNYRSTPH
HHHHHHHHHCCCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
ILGAASGLIAENSERLGKTLWTEVDGGDKVRVIGVWDAPEEARRIGDEIERLEREGAPLD
HHHHHCCHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCHH
RVAILVRAQFQTRTIEDRFIQIGLGYRIVGGFRFYERAEIRDALAYLRIIASPQDDLAFE
HHHHHHHHHHHHHHHHHHHEEEECCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RIYNTPKRGLGDKTLEKLHRHARARSIPLSLASVEILDTDELPARARGTLAALMRDFGRW
HHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
RDASKSLVPAELARTILDESGYTAALQAEKTAEAAGRLENLTELARAMEEYETLGDFLEH
HCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLVMDNEAVADEEKVTIMTIHAAKGLEFDNVFLPGWEEGVFPSQRSLDEGGLASLEEER
HHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHH
RLAYVAITRARRHCTILHAANRQIYGQWTSSIPSRFIGELPAEHIEEETTLSGGASMWRA
HEEHHHHHHHHHHEEEEEECCCCEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHC
NWSEREDPFAHVAQATPSRGASRGPGWQRAAAQPYNPQPRRIAETTRSAASFAAKPRSDI
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
SVGARVFHEKFGYGTVAEQEGNKLEIDFESAGRKRVIDSFVKLAG
HHHHHHHHHHCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA