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The map label for this gene is adk

Identifier: 87199291

GI number: 87199291

Start: 1309682

End: 1310332

Strand: Direct

Name: adk

Synonym: Saro_1270

Alternate gene names: 87199291

Gene position: 1309682-1310332 (Clockwise)

Preceding gene: 87199290

Following gene: 87199292

Centisome position: 36.77

GC content: 67.28

Gene sequence:

>651_bases
GTGAACATCATCCTGTTGGGCCCTCCGGGCGCGGGCAAGGGCACCCAGGCACAGCGTCTGGTCGAGCGGCATGGCATGAA
GCAGCTCTCGACGGGCGACATGCTGCGCGCCGCCGTCAAGGCGGAGACGCCGGTCGGCCTCAAGGCCAAGGCAGTGATGG
AGGCGGGGCAGCTCGTCTCGGACGAGATCGTCTCGGCGCTGATCGGCGACGAGCTCGACGCGATGCCGGCAGGCCAGGGC
GCGATCTTCGACGGTTATCCGCGCACTGCACCCCAGGCAGAGTCGCTTGATGCCATCCTCGAGAGCCGCGGGCGCAAGCT
TGACCACGTGATCGAGCTCGACGTCAACGAGGACGCGCTCGTCGAACGCATCACCGGCCGCTACACCTGCGCCACCTGCG
GGAAGGGCTATCACGACAAGTTCGAGAAGCCTGCGGTCGAGGGCACCTGCGACAAGTGCGGCGGTCATGAATTCAAGCGC
CGTCCCGACGACAACGAGGAAACCGTGCGCACGCGCATGGCGGAGTATCGCGCCAAGACCGCGCCGATCCTGCCGATCTA
CGAGAGCCGCGGCATCGTGTCGCGCGTCGACGGCATGGCCGACATGGACGACGTCACGGCGGCCATTGAGGCGATCCTCG
CGGCGCGCTAA

Upstream 100 bases:

>100_bases
CAGTCGCACCTGCTGGCGCACCAGTACGGCGACCTGATCAAGAAGGCGAAACTGAAGGGACGGCTGCGCTGAGAGCCAGC
GTCAAGAGGGGAACAATCGC

Downstream 100 bases:

>100_bases
CGCTGGCAGGTGACCCGCCCGTCCCGGCGCGGGCGAGGGGGCCTGCCATGCTCAAGCATCTGATCTTTCTGGCGGCGGGG
CTTGCGGGCTCCGCCGTTCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNIILLGPPGAGKGTQAQRLVERHGMKQLSTGDMLRAAVKAETPVGLKAKAVMEAGQLVSDEIVSALIGDELDAMPAGQG
AIFDGYPRTAPQAESLDAILESRGRKLDHVIELDVNEDALVERITGRYTCATCGKGYHDKFEKPAVEGTCDKCGGHEFKR
RPDDNEETVRTRMAEYRAKTAPILPIYESRGIVSRVDGMADMDDVTAAIEAILAAR

Sequences:

>Translated_216_residues
MNIILLGPPGAGKGTQAQRLVERHGMKQLSTGDMLRAAVKAETPVGLKAKAVMEAGQLVSDEIVSALIGDELDAMPAGQG
AIFDGYPRTAPQAESLDAILESRGRKLDHVIELDVNEDALVERITGRYTCATCGKGYHDKFEKPAVEGTCDKCGGHEFKR
RPDDNEETVRTRMAEYRAKTAPILPIYESRGIVSRVDGMADMDDVTAAIEAILAAR
>Mature_216_residues
MNIILLGPPGAGKGTQAQRLVERHGMKQLSTGDMLRAAVKAETPVGLKAKAVMEAGQLVSDEIVSALIGDELDAMPAGQG
AIFDGYPRTAPQAESLDAILESRGRKLDHVIELDVNEDALVERITGRYTCATCGKGYHDKFEKPAVEGTCDKCGGHEFKR
RPDDNEETVRTRMAEYRAKTAPILPIYESRGIVSRVDGMADMDDVTAAIEAILAAR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=45.0236966824645, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=45.0236966824645, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=36.9230769230769, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=36.9230769230769, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=36.9230769230769, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=36.9230769230769, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI19923437, Length=213, Percent_Identity=32.3943661971831, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=31.25, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI7706497, Length=216, Percent_Identity=27.3148148148148, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144899, Length=219, Percent_Identity=26.9406392694064, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI28144897, Length=219, Percent_Identity=26.9406392694064, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI22749187, Length=188, Percent_Identity=27.1276595744681, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=46.7889908256881, Blast_Score=180, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=44.0758293838863, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=32.8638497652582, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=214, Percent_Identity=26.6355140186916, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=198, Percent_Identity=45.959595959596, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.0253807106599, Blast_Score=128, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6322828, Length=212, Percent_Identity=29.7169811320755, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=42.7230046948357, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24663208, Length=216, Percent_Identity=31.4814814814815, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17647141, Length=216, Percent_Identity=31.4814814814815, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI221459597, Length=216, Percent_Identity=28.7037037037037, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356893, Length=216, Percent_Identity=28.7037037037037, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_NOVAD (Q2G8V9)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496548.1
- HSSP:   P16304
- ProteinModelPortal:   Q2G8V9
- SMR:   Q2G8V9
- STRING:   Q2G8V9
- GeneID:   3917901
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1270
- NMPDR:   fig|48935.1.peg.1808
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- PhylomeDB:   Q2G8V9
- ProtClustDB:   PRK00279
- BioCyc:   NARO279238:SARO_1270-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23296; Mature: 23296

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILLGPPGAGKGTQAQRLVERHGMKQLSTGDMLRAAVKAETPVGLKAKAVMEAGQLVS
CEEEEECCCCCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DEIVSALIGDELDAMPAGQGAIFDGYPRTAPQAESLDAILESRGRKLDHVIELDVNEDAL
HHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHH
VERITGRYTCATCGKGYHDKFEKPAVEGTCDKCGGHEFKRRPDDNEETVRTRMAEYRAKT
HHHHCCCEEEECCCCCHHHHHCCCCCCCCCHHCCCCHHHCCCCCCHHHHHHHHHHHHHHC
APILPIYESRGIVSRVDGMADMDDVTAAIEAILAAR
CCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIILLGPPGAGKGTQAQRLVERHGMKQLSTGDMLRAAVKAETPVGLKAKAVMEAGQLVS
CEEEEECCCCCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DEIVSALIGDELDAMPAGQGAIFDGYPRTAPQAESLDAILESRGRKLDHVIELDVNEDAL
HHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHH
VERITGRYTCATCGKGYHDKFEKPAVEGTCDKCGGHEFKRRPDDNEETVRTRMAEYRAKT
HHHHCCCEEEECCCCCHHHHHCCCCCCCCCHHCCCCHHHCCCCCCHHHHHHHHHHHHHHC
APILPIYESRGIVSRVDGMADMDDVTAAIEAILAAR
CCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA