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The map label for this gene is purC

Identifier: 87199063

GI number: 87199063

Start: 1080291

End: 1081076

Strand: Reverse

Name: purC

Synonym: Saro_1041

Alternate gene names: 87199063

Gene position: 1081076-1080291 (Counterclockwise)

Preceding gene: 87199070

Following gene: 87199062

Centisome position: 30.35

GC content: 62.85

Gene sequence:

>786_bases
ATGTCCCGTCGCCGCCAGATCTACGAAGGCAAGGCCAAGATCCTTTACGAGGGCCCGGAACCCGGCACCCTGATCCAGTA
CTTCAAGGACGATGCCACCGCGTTCAACGCGCAGAAGCGCGGCACGATCAACGGCAAGGGCGTGATCAACAACCGCATCA
GCGAGTACGTGTTCACGCGCCTCGCCCATATCGGCATTCCCACGCACTTCATCCGCCGCCTCAACATGCGCGAGCAGCTG
GTTCGCCAGGCGGAAATCATTCCGATCGAAGTGGTCGTGCGCAACATCGCCGCCGGCTCCATCTCCAAGCGCCTCGGCAT
CGAAGAGGGTGAGCCGCTGCCGCACACCCTGATCGAATACTACTACAAGGACGATGCGCTGGGCGATCCGATGATCGCGG
AAGAGCACATCGCCTGCTTCGGCTGGGCCAGCAACGAGGAAATGCAGGACATCTCCTCGATGGCGATCCGCGTGAACGAT
TTCCTCTGCGGCATGTTCGCGGCGATCAACATCAGCCTGGTCGATTTCAAGCTCGAATTCGGCCGCATCTGGGACGGCGA
CTACAGCCGCGTGATCCTGGCCGACGAGATCAGCCCCGACGGCTGCCGCCTGTGGGACATGACCACCGGCGAAAAGCTCG
ACAAGGACCGCTTCCGCCGCGACCTCGGCGGCGAGGAAGAAGCCTACCAGGAAGTCGCCCGCCGCCTCGGCCTGCTCGAG
AATGACGGCGGCCCGAGCGAAGTCTTCGACCTCGGCGCCCACCGCAAGCTGCGCGGCAAGAAATAA

Upstream 100 bases:

>100_bases
ATCGAACGCCCCGGCCGCAGCGATGGAGTCGTCTCCACGTGATGCCGGGGTTTCTTATTCCGGCCGGGACATACCCGGCG
CCGTGCAGGAAGACGAAACG

Downstream 100 bases:

>100_bases
GCTTCTCAGCTCCGGCTGAAACACAAGACCCCCTTCGGCAACGGAGGGGGTTTTCGTTTGCCCCGCTCGTATGGACCAGA
CTCTTCCATATCGGTGCAAG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSRRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVINNRISEYVFTRLAHIGIPTHFIRRLNMREQL
VRQAEIIPIEVVVRNIAAGSISKRLGIEEGEPLPHTLIEYYYKDDALGDPMIAEEHIACFGWASNEEMQDISSMAIRVND
FLCGMFAAINISLVDFKLEFGRIWDGDYSRVILADEISPDGCRLWDMTTGEKLDKDRFRRDLGGEEEAYQEVARRLGLLE
NDGGPSEVFDLGAHRKLRGKK

Sequences:

>Translated_261_residues
MSRRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVINNRISEYVFTRLAHIGIPTHFIRRLNMREQL
VRQAEIIPIEVVVRNIAAGSISKRLGIEEGEPLPHTLIEYYYKDDALGDPMIAEEHIACFGWASNEEMQDISSMAIRVND
FLCGMFAAINISLVDFKLEFGRIWDGDYSRVILADEISPDGCRLWDMTTGEKLDKDRFRRDLGGEEEAYQEVARRLGLLE
NDGGPSEVFDLGAHRKLRGKK
>Mature_260_residues
SRRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVINNRISEYVFTRLAHIGIPTHFIRRLNMREQLV
RQAEIIPIEVVVRNIAAGSISKRLGIEEGEPLPHTLIEYYYKDDALGDPMIAEEHIACFGWASNEEMQDISSMAIRVNDF
LCGMFAAINISLVDFKLEFGRIWDGDYSRVILADEISPDGCRLWDMTTGEKLDKDRFRRDLGGEEEAYQEVARRLGLLEN
DGGPSEVFDLGAHRKLRGKK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=251, Percent_Identity=34.6613545816733, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI5453539, Length=251, Percent_Identity=34.6613545816733, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI119220559, Length=258, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=44.5378151260504, Blast_Score=211, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=223, Percent_Identity=34.0807174887892, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18860083, Length=226, Percent_Identity=33.6283185840708, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=30.9178743961353, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_NOVAD (Q2G9I7)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496320.1
- HSSP:   P0A7D7
- ProteinModelPortal:   Q2G9I7
- SMR:   Q2G9I7
- STRING:   Q2G9I7
- GeneID:   3915823
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1041
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q2G9I7
- ProtClustDB:   PRK09362
- BioCyc:   NARO279238:SARO_1041-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 29701; Mature: 29570

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVINNRISEYVFTR
CCCCCCHHCCCEEEEEECCCCCHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LAHIGIPTHFIRRLNMREQLVRQAEIIPIEVVVRNIAAGSISKRLGIEEGEPLPHTLIEY
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YYKDDALGDPMIAEEHIACFGWASNEEMQDISSMAIRVNDFLCGMFAAINISLVDFKLEF
HHCCCCCCCCCHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEE
GRIWDGDYSRVILADEISPDGCRLWDMTTGEKLDKDRFRRDLGGEEEAYQEVARRLGLLE
CEEECCCCCEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCC
NDGGPSEVFDLGAHRKLRGKK
CCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SRRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVINNRISEYVFTR
CCCCCHHCCCEEEEEECCCCCHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LAHIGIPTHFIRRLNMREQLVRQAEIIPIEVVVRNIAAGSISKRLGIEEGEPLPHTLIEY
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YYKDDALGDPMIAEEHIACFGWASNEEMQDISSMAIRVNDFLCGMFAAINISLVDFKLEF
HHCCCCCCCCCHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEE
GRIWDGDYSRVILADEISPDGCRLWDMTTGEKLDKDRFRRDLGGEEEAYQEVARRLGLLE
CEEECCCCCEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCC
NDGGPSEVFDLGAHRKLRGKK
CCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA