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The map label for this gene is pyrE

Identifier: 87198934

GI number: 87198934

Start: 965522

End: 966106

Strand: Reverse

Name: pyrE

Synonym: Saro_0912

Alternate gene names: 87198934

Gene position: 966106-965522 (Counterclockwise)

Preceding gene: 87198950

Following gene: 87198933

Centisome position: 27.13

GC content: 68.21

Gene sequence:

>585_bases
ATGCTCGAAGACGAGATCCTTTCCGAATTCCGCGCCAGCCAGGCTCTTCTGGAAGGCCACTTCCTGCTCTCGTCCGGGCG
GCACAGCGCGCATTACCTGCAATGCGCGCGCGTGCTGATGGACCCGATGCGCGCCTCGCGCCTCGCCGCGGCCACCGCAG
CGAAGATCCCGCGTGACCTGCGCCATCAGATCCAGAAGGTCGTGTCGCCCGCGATGGGCGGCGTGATCATCGGCCACGAA
ATGGGCCGCGCGCTCGGCGTGGAGGCAATGTTCGTCGAACGCCCGACCGGTACCTTCGAACTTCGCCGGGGCTTTGCGCT
CAATCCGGGCGAGAAGGTCCTGATGGTCGAGGACGTGGTCACCACCGGCCTTTCCAGCCGCGAGGCGATCAAGGCCATCG
AGCAGGCCGGCGGCGAAGTCATCGCGGCTGCGGCCCTGGTCGACCGCTCGGCCGGCGCGGTCGATCTCGGCGTACCCTTC
TTTCCGCTGGTGGCCCTGAACTTCCCGACCTACGCGCCTGACGAGCTTCCGCCCGAACTCGCGGCGACCGAAGCCGTGAA
GCCCGGCAGCCGGGCCAAGCCGTGA

Upstream 100 bases:

>100_bases
TACCTATGCGCATGCCTGTCGGCACCCTCGGTCGAAATCCCTTGCCCCTCGTGCGCGCAAGCGTCATTTGGGCGCTCGTT
TTTCCGCCGTTAGGTGTCAG

Downstream 100 bases:

>100_bases
ACAGCGCCCTGACCTCGGGACGCCTCCGCCTCGGCGTCAACATCGACCACGTCGCCACCATCCGCAACGCGCGCGGCGGC
GACCATCCCGATCCCGTGCG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MLEDEILSEFRASQALLEGHFLLSSGRHSAHYLQCARVLMDPMRASRLAAATAAKIPRDLRHQIQKVVSPAMGGVIIGHE
MGRALGVEAMFVERPTGTFELRRGFALNPGEKVLMVEDVVTTGLSSREAIKAIEQAGGEVIAAAALVDRSAGAVDLGVPF
FPLVALNFPTYAPDELPPELAATEAVKPGSRAKP

Sequences:

>Translated_194_residues
MLEDEILSEFRASQALLEGHFLLSSGRHSAHYLQCARVLMDPMRASRLAAATAAKIPRDLRHQIQKVVSPAMGGVIIGHE
MGRALGVEAMFVERPTGTFELRRGFALNPGEKVLMVEDVVTTGLSSREAIKAIEQAGGEVIAAAALVDRSAGAVDLGVPF
FPLVALNFPTYAPDELPPELAATEAVKPGSRAKP
>Mature_194_residues
MLEDEILSEFRASQALLEGHFLLSSGRHSAHYLQCARVLMDPMRASRLAAATAAKIPRDLRHQIQKVVSPAMGGVIIGHE
MGRALGVEAMFVERPTGTFELRRGFALNPGEKVLMVEDVVTTGLSSREAIKAIEQAGGEVIAAAALVDRSAGAVDLGVPF
FPLVALNFPTYAPDELPPELAATEAVKPGSRAKP

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_NOVAD (Q2G9W6)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496191.1
- ProteinModelPortal:   Q2G9W6
- STRING:   Q2G9W6
- GeneID:   3917998
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0912
- eggNOG:   COG0461
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- BioCyc:   NARO279238:SARO_0912-MONOMER
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20695; Mature: 20695

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 121-121 BINDING 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEDEILSEFRASQALLEGHFLLSSGRHSAHYLQCARVLMDPMRASRLAAATAAKIPRDL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
RHQIQKVVSPAMGGVIIGHEMGRALGVEAMFVERPTGTFELRRGFALNPGEKVLMVEDVV
HHHHHHHHHHHHCCEEEHHHHHHHHCCEEEEEECCCCHHHHCCCCCCCCCCEEEEEHHHH
TTGLSSREAIKAIEQAGGEVIAAAALVDRSAGAVDLGVPFFPLVALNFPTYAPDELPPEL
HHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCCCHHHHHHHCCCCCCCCCCCHHH
AATEAVKPGSRAKP
HHHHCCCCCCCCCC
>Mature Secondary Structure
MLEDEILSEFRASQALLEGHFLLSSGRHSAHYLQCARVLMDPMRASRLAAATAAKIPRDL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
RHQIQKVVSPAMGGVIIGHEMGRALGVEAMFVERPTGTFELRRGFALNPGEKVLMVEDVV
HHHHHHHHHHHHCCEEEHHHHHHHHCCEEEEEECCCCHHHHCCCCCCCCCCEEEEEHHHH
TTGLSSREAIKAIEQAGGEVIAAAALVDRSAGAVDLGVPFFPLVALNFPTYAPDELPPEL
HHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCCCHHHHHHHCCCCCCCCCCCHHH
AATEAVKPGSRAKP
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA