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The map label for this gene is guaA

Identifier: 87198574

GI number: 87198574

Start: 600682

End: 602304

Strand: Reverse

Name: guaA

Synonym: Saro_0550

Alternate gene names: 87198574

Gene position: 602304-600682 (Counterclockwise)

Preceding gene: 87198580

Following gene: 87198573

Centisome position: 16.91

GC content: 65.06

Gene sequence:

>1623_bases
ATGCAACTGTCACATTTGTCGCTCCATCTGGACAGAAACGGCCAGTGTGCTTATCGGCCAGCCATGAGCATCCAGCCTTC
AGAATCGATCCTGATCGTCGACTTCGGCAGCCAGGTTACCCAGCTAATCGCCCGCCGCGTGCGCGAGGCCGGGGTCTATT
CCGAGATCGCGCCCTTCAGCCAGGCCGAGGCGGCGTTCCACCGGATGAAGCCGAAGGGCATCATCCTGTCGGGATCGCCC
GCCAGCGTGCCCGCCGATGGCAGCCCGCGCGCACCTCAGGTGCTGTTCGACAGCGGCCTGCCGATCCTTGGCATCTGCTA
TGGCCAGCAGGTGATGAGCGAGCAGCTTGGCGGCAAGGTCGAGCCTGGCGATTCGGGCGAATTCGGCCGCGCCTTCCTGA
CCGTGACGGAACCCTGCGTACTGTTCGACGGCCTGTGGGCCGTGGGCGAACGCCACCAGGTATGGATGAGTCACGGCGAC
AAGGTGACGCAGTTCGCACCGGGCTTCCGCATCGTCGCCGTGTCCGACGGCGCGCCTTTTGCGGTGATCGCGAACGATGA
GAAGAAGTACTACGGAACCCAGTTCCACCCCGAAGTGGTGCACACGCCGGACGGTGGCAAGCTGATCGCCAATTTCGTGC
GCCATGTCTGCGGTTGCGCCGGCGACTGGTCGATGGCCGAGTTCCGCCGCACCAAGATCGCCGAGATCCGCGAGCAGGTG
GGCGACAGCCGGGTGATCTGCGGTCTTTCGGGCGGCGTCGATTCCGCCGTGGCGGCAGTGCTGATCCACGAGGCGATCGG
CGACCAGCTCACCTGCGTCTTCGTCGACCACGGCCTGATGCGCATGGGCGAGGCCGAGCAGGTCGTCAGCCTTTTCCGCA
ACCATTACAACATCCCGCTCGTCCACAAGGACGTGTCGGCCCTGTTCCTTGGCGGCCTCGCCGGGGTTACCGACCCCGAG
GCCAAGCGCAAGTTCATCGGCAAGACCTTCATCGACGTGTTCGAGGCCGAGGCCAGGCAGGTCGGCGGCGCGGACTTCCT
TGCGCAGGGCACGCTCTATCCGGACGTGATCGAATCGGTATCGTTCACCGGCGGGCCTTCGGTCACGATCAAGAGCCACC
ACAACGTCGGCGGCCTGCCCGAGCGCATGAACATGAAGCTGGTCGAGCCGCTTCGCGAGCTGTTCAAGGACGAAGTCCGC
GCGCTGGGCCGCGAGCTTGGCCTGCCCGAGATCTTCGTTGGTCGCCACCCCTTCCCCGGCCCGGGCCTTGCCATCCGCAT
CCCCGGCGAAGTGACGAAGGAGCGCTGCGACATCCTGCGCAAGGCCGACGCGATCTATCTCGAGGAGATCCGCAACGCGG
GCCTTTATGACGCGATCTGGCAGGCCTTTGCCGTGCTGCTTCCGGTCAAGACCGTGGGCGTTATGGGCGACGGGCGCACT
TATGACAGTGTCTGCGCACTGCGCGCGGTGACCAGCACCGACGGCATGACCGCCGACATCTATCCGTTCGACGCAGGCTT
CCTGAGCCGCGTGGCGACGCGCATCGTCAACGAGGTCAAGGGCATCAACCGCGTGGTCTACGACTACACCTCGAAGCCGC
CGGGCACGATCGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
TTCATCCGGCAGGGTGGGCTGGAAGCATCGGAACCGGGGGCGCAAATACGCTTATCGGCGTATGCTGCAAGTGCGAACAG
GACACTTGCGGTTGCGTGTA

Downstream 100 bases:

>100_bases
CGATCCGCGCTGCCGACCCGGCCGACCGTGAAGCCACGGTCGCGCTGTGGGAAGCTGCCGGACTGACGCGGCCGTGGAAC
GACCCACGCGCCGATTTCGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MQLSHLSLHLDRNGQCAYRPAMSIQPSESILIVDFGSQVTQLIARRVREAGVYSEIAPFSQAEAAFHRMKPKGIILSGSP
ASVPADGSPRAPQVLFDSGLPILGICYGQQVMSEQLGGKVEPGDSGEFGRAFLTVTEPCVLFDGLWAVGERHQVWMSHGD
KVTQFAPGFRIVAVSDGAPFAVIANDEKKYYGTQFHPEVVHTPDGGKLIANFVRHVCGCAGDWSMAEFRRTKIAEIREQV
GDSRVICGLSGGVDSAVAAVLIHEAIGDQLTCVFVDHGLMRMGEAEQVVSLFRNHYNIPLVHKDVSALFLGGLAGVTDPE
AKRKFIGKTFIDVFEAEARQVGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVR
ALGRELGLPEIFVGRHPFPGPGLAIRIPGEVTKERCDILRKADAIYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRT
YDSVCALRAVTSTDGMTADIYPFDAGFLSRVATRIVNEVKGINRVVYDYTSKPPGTIEWE

Sequences:

>Translated_540_residues
MQLSHLSLHLDRNGQCAYRPAMSIQPSESILIVDFGSQVTQLIARRVREAGVYSEIAPFSQAEAAFHRMKPKGIILSGSP
ASVPADGSPRAPQVLFDSGLPILGICYGQQVMSEQLGGKVEPGDSGEFGRAFLTVTEPCVLFDGLWAVGERHQVWMSHGD
KVTQFAPGFRIVAVSDGAPFAVIANDEKKYYGTQFHPEVVHTPDGGKLIANFVRHVCGCAGDWSMAEFRRTKIAEIREQV
GDSRVICGLSGGVDSAVAAVLIHEAIGDQLTCVFVDHGLMRMGEAEQVVSLFRNHYNIPLVHKDVSALFLGGLAGVTDPE
AKRKFIGKTFIDVFEAEARQVGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVR
ALGRELGLPEIFVGRHPFPGPGLAIRIPGEVTKERCDILRKADAIYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRT
YDSVCALRAVTSTDGMTADIYPFDAGFLSRVATRIVNEVKGINRVVYDYTSKPPGTIEWE
>Mature_540_residues
MQLSHLSLHLDRNGQCAYRPAMSIQPSESILIVDFGSQVTQLIARRVREAGVYSEIAPFSQAEAAFHRMKPKGIILSGSP
ASVPADGSPRAPQVLFDSGLPILGICYGQQVMSEQLGGKVEPGDSGEFGRAFLTVTEPCVLFDGLWAVGERHQVWMSHGD
KVTQFAPGFRIVAVSDGAPFAVIANDEKKYYGTQFHPEVVHTPDGGKLIANFVRHVCGCAGDWSMAEFRRTKIAEIREQV
GDSRVICGLSGGVDSAVAAVLIHEAIGDQLTCVFVDHGLMRMGEAEQVVSLFRNHYNIPLVHKDVSALFLGGLAGVTDPE
AKRKFIGKTFIDVFEAEARQVGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVR
ALGRELGLPEIFVGRHPFPGPGLAIRIPGEVTKERCDILRKADAIYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRT
YDSVCALRAVTSTDGMTADIYPFDAGFLSRVATRIVNEVKGINRVVYDYTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=36.7673179396092, Blast_Score=302, Evalue=5e-82,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=56.0077519379845, Blast_Score=586, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=37.3702422145329, Blast_Score=302, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=37.3702422145329, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=37.3702422145329, Blast_Score=301, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=53.4615384615385, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=34.4262295081967, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58741; Mature: 58741

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSHLSLHLDRNGQCAYRPAMSIQPSESILIVDFGSQVTQLIARRVREAGVYSEIAPFS
CCCCEEEEEECCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHCCCH
QAEAAFHRMKPKGIILSGSPASVPADGSPRAPQVLFDSGLPILGICYGQQVMSEQLGGKV
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEECCCCCEEEEHHHHHHHHHHHCCCC
EPGDSGEFGRAFLTVTEPCVLFDGLWAVGERHQVWMSHGDKVTQFAPGFRIVAVSDGAPF
CCCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHCCCEEHEECCCEEEEEECCCCCE
AVIANDEKKYYGTQFHPEVVHTPDGGKLIANFVRHVCGCAGDWSMAEFRRTKIAEIREQV
EEEECCCCHHCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
GDSRVICGLSGGVDSAVAAVLIHEAIGDQLTCVFVDHGLMRMGEAEQVVSLFRNHYNIPL
CCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCHHHHHHHHHCCCCCCE
VHKDVSALFLGGLAGVTDPEAKRKFIGKTFIDVFEAEARQVGGADFLAQGTLYPDVIESV
EECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHC
SFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRALGRELGLPEIFVGRHPFPG
CCCCCCEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
PGLAIRIPGEVTKERCDILRKADAIYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRT
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCC
YDSVCALRAVTSTDGMTADIYPFDAGFLSRVATRIVNEVKGINRVVYDYTSKPPGTIEWE
HHHHHHHHHEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MQLSHLSLHLDRNGQCAYRPAMSIQPSESILIVDFGSQVTQLIARRVREAGVYSEIAPFS
CCCCEEEEEECCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHCCCH
QAEAAFHRMKPKGIILSGSPASVPADGSPRAPQVLFDSGLPILGICYGQQVMSEQLGGKV
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEECCCCCEEEEHHHHHHHHHHHCCCC
EPGDSGEFGRAFLTVTEPCVLFDGLWAVGERHQVWMSHGDKVTQFAPGFRIVAVSDGAPF
CCCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHCCCEEHEECCCEEEEEECCCCCE
AVIANDEKKYYGTQFHPEVVHTPDGGKLIANFVRHVCGCAGDWSMAEFRRTKIAEIREQV
EEEECCCCHHCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
GDSRVICGLSGGVDSAVAAVLIHEAIGDQLTCVFVDHGLMRMGEAEQVVSLFRNHYNIPL
CCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCHHHHHHHHHCCCCCCE
VHKDVSALFLGGLAGVTDPEAKRKFIGKTFIDVFEAEARQVGGADFLAQGTLYPDVIESV
EECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHC
SFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRALGRELGLPEIFVGRHPFPG
CCCCCCEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
PGLAIRIPGEVTKERCDILRKADAIYLEEIRNAGLYDAIWQAFAVLLPVKTVGVMGDGRT
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCC
YDSVCALRAVTSTDGMTADIYPFDAGFLSRVATRIVNEVKGINRVVYDYTSKPPGTIEWE
HHHHHHHHHEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA