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The map label for this gene is cpg2 [H]

Identifier: 87198263

GI number: 87198263

Start: 246695

End: 248005

Strand: Direct

Name: cpg2 [H]

Synonym: Saro_0238

Alternate gene names: 87198263

Gene position: 246695-248005 (Clockwise)

Preceding gene: 87198248

Following gene: 87198264

Centisome position: 6.93

GC content: 66.9

Gene sequence:

>1311_bases
ATGCGTTTGCCGATGGGTCTGGTTGCCGTTCTCGCGCTCGTCGGAACCGCCGCACATGCAGCGCCCAAGGGTGCCGAGGC
ACGCATGATTGCCACCGTCGATGCCGAGCAGGCGCGCACGTTGAGGTTCCTCGAAGTGATGGTCAACCAGAACTCGGGCA
GCCGCAACCTCGAAGGCGTGCGAAGGTTGCGCGACATTGTCGTGCCCGAATTCACCGCGCTGGGCTTCACGTCCCGCTGG
ATCCCGATGGAACGGACCGGCCGGGCCGGGCACCTCGTCCTCACCCACAAGGGCCGCCAAGGCGCGAAGAAGCTTCTGCT
GATCGGCCACCTCGATACCGTGTTCGAACCTGACTCCCCCTTCCAGACCTATGTCCTGAACGGCGAAAAGGCGACCGGCC
CTGGCGTCGGCGATGACAAGGGTGGCATCGCCGTGATCCTCGCTGCGGTCCGCGCCATGAACGCTGCAGGAACGCTGAAG
GGCGCCAGCATCGAAGTCTTCCTTACCGGCGACGAAGAGGAGGCAGGCTCTCCCACCGAAGTCGCCCGCGCCGATCTCGT
TGCCGCCGCCAGGGCCGCCGACGTCGCGCTGGATTTCGAAGGCCTCTCCAGAGAGAACGGCCGCGACATGGGCTCGATCG
CCCGCCGATCCTCGCAAAGCTGGTCTTTGACGGTCGAGGCGAAGTCCGGCCACTCCAGCGGCGTCTGGGGCGCAAACGCG
GGCGATGGCGCGATCTATGCCGCCGCGAAGATCGTGAATGCCTTCCGCACCGAACTGCCCGAACCCTGGCTTACCCTCAA
CGTCGGCCTGATCGCGGGCGGGGCGGAGGCAGAGGTCGCCGAGGACAACGCCCACGTCTCGGCACAGGGCAAGACCAATA
TCATACCGGGCGAGGTCATCGCCCGCGGAGACCTGCGCACCCTCAGTCCCGAACAGAACCGCGCCGCCATGCGCAAGATG
GAGGAGATCGTCGGCAGGCCCTACCCCGGCGTCACCTCAGCCCGCATCGCATTTAGCGAAGGCTACCCGCCCATGGCCCC
GACCGAAGGCAACAAGGCGTTGCTGGCCCGCCTGAATCAGGTCAACGCCACGCTTGGCTTGCCCGAAATGCAGCCGCTCG
ATCCGATGAAGCGCGGGGCCGGGGACATCAGCTTCGTCGCGGAATACATCGACGGCCTCGTCGGCCTCGGCCCGCACTCC
ACCGGCGATCACGCGCCGGGCGAAACGGTCGACGTCCCCAGCATCTGGACCCAGGCCAAGCGCGCCGCCCTGCTGATGAC
CCGGCTCTCGGCGGAGAAGTCCGCGCGGTGA

Upstream 100 bases:

>100_bases
CACATAGGAGCGCCTCCGCAACAAGGCAAGGAAATTCGGGCAAAAGGCGGTTGCATCACCGCATGCGCGCCGCCAACGTG
CCCGCAAAAGGAGTGGGTCG

Downstream 100 bases:

>100_bases
GCGAAACGCACCCGCCCAGTCCCTGCACCGGCGTCTGCGAGATCGACCGGGTCACCGCCACCTGTCGCGGCTGTCACCGC
ACGCTCGACGAAATCACCGC

Product: peptidase M20

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MRLPMGLVAVLALVGTAAHAAPKGAEARMIATVDAEQARTLRFLEVMVNQNSGSRNLEGVRRLRDIVVPEFTALGFTSRW
IPMERTGRAGHLVLTHKGRQGAKKLLLIGHLDTVFEPDSPFQTYVLNGEKATGPGVGDDKGGIAVILAAVRAMNAAGTLK
GASIEVFLTGDEEEAGSPTEVARADLVAAARAADVALDFEGLSRENGRDMGSIARRSSQSWSLTVEAKSGHSSGVWGANA
GDGAIYAAAKIVNAFRTELPEPWLTLNVGLIAGGAEAEVAEDNAHVSAQGKTNIIPGEVIARGDLRTLSPEQNRAAMRKM
EEIVGRPYPGVTSARIAFSEGYPPMAPTEGNKALLARLNQVNATLGLPEMQPLDPMKRGAGDISFVAEYIDGLVGLGPHS
TGDHAPGETVDVPSIWTQAKRAALLMTRLSAEKSAR

Sequences:

>Translated_436_residues
MRLPMGLVAVLALVGTAAHAAPKGAEARMIATVDAEQARTLRFLEVMVNQNSGSRNLEGVRRLRDIVVPEFTALGFTSRW
IPMERTGRAGHLVLTHKGRQGAKKLLLIGHLDTVFEPDSPFQTYVLNGEKATGPGVGDDKGGIAVILAAVRAMNAAGTLK
GASIEVFLTGDEEEAGSPTEVARADLVAAARAADVALDFEGLSRENGRDMGSIARRSSQSWSLTVEAKSGHSSGVWGANA
GDGAIYAAAKIVNAFRTELPEPWLTLNVGLIAGGAEAEVAEDNAHVSAQGKTNIIPGEVIARGDLRTLSPEQNRAAMRKM
EEIVGRPYPGVTSARIAFSEGYPPMAPTEGNKALLARLNQVNATLGLPEMQPLDPMKRGAGDISFVAEYIDGLVGLGPHS
TGDHAPGETVDVPSIWTQAKRAALLMTRLSAEKSAR
>Mature_436_residues
MRLPMGLVAVLALVGTAAHAAPKGAEARMIATVDAEQARTLRFLEVMVNQNSGSRNLEGVRRLRDIVVPEFTALGFTSRW
IPMERTGRAGHLVLTHKGRQGAKKLLLIGHLDTVFEPDSPFQTYVLNGEKATGPGVGDDKGGIAVILAAVRAMNAAGTLK
GASIEVFLTGDEEEAGSPTEVARADLVAAARAADVALDFEGLSRENGRDMGSIARRSSQSWSLTVEAKSGHSSGVWGANA
GDGAIYAAAKIVNAFRTELPEPWLTLNVGLIAGGAEAEVAEDNAHVSAQGKTNIIPGEVIARGDLRTLSPEQNRAAMRKM
EEIVGRPYPGVTSARIAFSEGYPPMAPTEGNKALLARLNQVNATLGLPEMQPLDPMKRGAGDISFVAEYIDGLVGLGPHS
TGDHAPGETVDVPSIWTQAKRAALLMTRLSAEKSAR

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 45945; Mature: 45945

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPMGLVAVLALVGTAAHAAPKGAEARMIATVDAEQARTLRFLEVMVNQNSGSRNLEGV
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHH
RRLRDIVVPEFTALGFTSRWIPMERTGRAGHLVLTHKGRQGAKKLLLIGHLDTVFEPDSP
HHHHHHHCCCHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCHHHCCCCCC
FQTYVLNGEKATGPGVGDDKGGIAVILAAVRAMNAAGTLKGASIEVFLTGDEEEAGSPTE
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHH
VARADLVAAARAADVALDFEGLSRENGRDMGSIARRSSQSWSLTVEAKSGHSSGVWGANA
HHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCC
GDGAIYAAAKIVNAFRTELPEPWLTLNVGLIAGGAEAEVAEDNAHVSAQGKTNIIPGEVI
CCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEECCCCCEEEECCCCCCCCCCEE
ARGDLRTLSPEQNRAAMRKMEEIVGRPYPGVTSARIAFSEGYPPMAPTEGNKALLARLNQ
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
VNATLGLPEMQPLDPMKRGAGDISFVAEYIDGLVGLGPHSTGDHAPGETVDVPSIWTQAK
HHHEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
RAALLMTRLSAEKSAR
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLPMGLVAVLALVGTAAHAAPKGAEARMIATVDAEQARTLRFLEVMVNQNSGSRNLEGV
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHH
RRLRDIVVPEFTALGFTSRWIPMERTGRAGHLVLTHKGRQGAKKLLLIGHLDTVFEPDSP
HHHHHHHCCCHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCHHHCCCCCC
FQTYVLNGEKATGPGVGDDKGGIAVILAAVRAMNAAGTLKGASIEVFLTGDEEEAGSPTE
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHH
VARADLVAAARAADVALDFEGLSRENGRDMGSIARRSSQSWSLTVEAKSGHSSGVWGANA
HHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCC
GDGAIYAAAKIVNAFRTELPEPWLTLNVGLIAGGAEAEVAEDNAHVSAQGKTNIIPGEVI
CCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEECCCCCEEEECCCCCCCCCCEE
ARGDLRTLSPEQNRAAMRKMEEIVGRPYPGVTSARIAFSEGYPPMAPTEGNKALLARLNQ
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
VNATLGLPEMQPLDPMKRGAGDISFVAEYIDGLVGLGPHSTGDHAPGETVDVPSIWTQAK
HHHEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
RAALLMTRLSAEKSAR
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]