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The map label for this gene is fabI1 [H]

Identifier: 87198077

GI number: 87198077

Start: 53851

End: 54654

Strand: Direct

Name: fabI1 [H]

Synonym: Saro_0051

Alternate gene names: 87198077

Gene position: 53851-54654 (Clockwise)

Preceding gene: 87198076

Following gene: 87198087

Centisome position: 1.51

GC content: 63.43

Gene sequence:

>804_bases
ATGACCGGACTGATGCAAGGGAAGCGTGGCCTGATCATGGGCCTTGCCAACGACAAGTCGTTGGCCTGGGGGATCGCGAA
GAAGCTGCACGAGCAGGGCGCGGAACTCGCCTTCTCCTATCAGGGCGAAGCGCTCGAGAAGCGCGTGCGCCCGCTGGCGG
AAAGCCTCGGCAGCGATTTCCTGATCGAATGCGACGTGTCCGACATGGCCGCGCTCGACCAGACGTTCGAGACGCTCAAG
GCGCGCTGGCCGACGATCGACTTCATCGTCCATGCCATCGGCTATTCGGACAAGAACCAGCTTCGCGGCAAGTTCTATGA
CACCACGCTCGACAACTTCCTGATGACGATGAACATTTCGGCGTACAGCCTCGTCGCGGTGACGAAGCGCGCGGCCGAGA
TGATGCCTGCGGGCGGCTCGATCCTGACGCTGACCTACTATGGCGCGGAAAAGGTCGTGCCGCACTACAACGTCATGGGC
GTTGCCAAGGCGGCGCTCGAAGCGAGCGTGAAGTACCTGGCGAACGACTGCGGCCCGGCGGGCATCCGCGTCAATGCGAT
CTCGGCCGGTCCGATCAAGACCCTGGCCGCCAGCGGCATCGGCGACTTCCGCTACATCCTCAAGTGGAACGAACTGAACA
GCCCGCTGCGTCGCAACGTGACCATCGAGGACGTGGGCGGCGCGGGGCTTTATTTCCTGTCCGACCTGTCTTCGGGCGTG
ACGGGCGAGACCCACCATGTCGATGCCGGCTATCACACCGTCGGCATGAAGCAGGAAGACGCGCCCGACATCGCCCTGGG
GTGA

Upstream 100 bases:

>100_bases
CGCTGACGGAAACACCGGAAGAACGCGACATGCTGGGCCAGGCAGACGATCGCGCCCGCGCGATCCGGAACAACGAAACA
AGAAGCGAGAACGAGAACGC

Downstream 100 bases:

>100_bases
CGGGCCGATCCCGGGCCTGTCGGGAACGATCCCGCGACAGGCCCGGTTCCATCAGCGGATACCGGCGATACCGGCAGGGG
CCCCTCAGGGGCGCAGGGGC

Product: enoyl-[acyl-carrier-protein] reductase [NADH]

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTGLMQGKRGLIMGLANDKSLAWGIAKKLHEQGAELAFSYQGEALEKRVRPLAESLGSDFLIECDVSDMAALDQTFETLK
ARWPTIDFIVHAIGYSDKNQLRGKFYDTTLDNFLMTMNISAYSLVAVTKRAAEMMPAGGSILTLTYYGAEKVVPHYNVMG
VAKAALEASVKYLANDCGPAGIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRNVTIEDVGGAGLYFLSDLSSGV
TGETHHVDAGYHTVGMKQEDAPDIALG

Sequences:

>Translated_267_residues
MTGLMQGKRGLIMGLANDKSLAWGIAKKLHEQGAELAFSYQGEALEKRVRPLAESLGSDFLIECDVSDMAALDQTFETLK
ARWPTIDFIVHAIGYSDKNQLRGKFYDTTLDNFLMTMNISAYSLVAVTKRAAEMMPAGGSILTLTYYGAEKVVPHYNVMG
VAKAALEASVKYLANDCGPAGIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRNVTIEDVGGAGLYFLSDLSSGV
TGETHHVDAGYHTVGMKQEDAPDIALG
>Mature_266_residues
TGLMQGKRGLIMGLANDKSLAWGIAKKLHEQGAELAFSYQGEALEKRVRPLAESLGSDFLIECDVSDMAALDQTFETLKA
RWPTIDFIVHAIGYSDKNQLRGKFYDTTLDNFLMTMNISAYSLVAVTKRAAEMMPAGGSILTLTYYGAEKVVPHYNVMGV
AKAALEASVKYLANDCGPAGIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRNVTIEDVGGAGLYFLSDLSSGVT
GETHHVDAGYHTVGMKQEDAPDIALG

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=257, Percent_Identity=49.4163424124514, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=25.2, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 28816; Mature: 28685

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLMQGKRGLIMGLANDKSLAWGIAKKLHEQGAELAFSYQGEALEKRVRPLAESLGSDF
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCE
LIECDVSDMAALDQTFETLKARWPTIDFIVHAIGYSDKNQLRGKFYDTTLDNFLMTMNIS
EEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCEEEHHHHHHEEEEECCC
AYSLVAVTKRAAEMMPAGGSILTLTYYGAEKVVPHYNVMGVAKAALEASVKYLANDCGPA
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRNVTIEDVGGAGLYFLSDLSSGV
CEEEEEECCCCHHHHHHCCCCCEEEEEEECCCCCHHHCCCEEEECCCCHHHHHHHHCCCC
TGETHHVDAGYHTVGMKQEDAPDIALG
CCCCEEECCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TGLMQGKRGLIMGLANDKSLAWGIAKKLHEQGAELAFSYQGEALEKRVRPLAESLGSDF
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCE
LIECDVSDMAALDQTFETLKARWPTIDFIVHAIGYSDKNQLRGKFYDTTLDNFLMTMNIS
EEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCEEEHHHHHHEEEEECCC
AYSLVAVTKRAAEMMPAGGSILTLTYYGAEKVVPHYNVMGVAKAALEASVKYLANDCGPA
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRNVTIEDVGGAGLYFLSDLSSGV
CEEEEEECCCCHHHHHHCCCCCEEEEEEECCCCCHHHCCCEEEECCCCHHHHHHHHCCCC
TGETHHVDAGYHTVGMKQEDAPDIALG
CCCCEEECCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]