Click here to switch to the map view.

The map label for this gene is zraS [C]

Identifier: 87198062

GI number: 87198062

Start: 37528

End: 39198

Strand: Direct

Name: zraS [C]

Synonym: Saro_0036

Alternate gene names: 87198062

Gene position: 37528-39198 (Clockwise)

Preceding gene: 87198061

Following gene: 87198069

Centisome position: 1.05

GC content: 67.21

Gene sequence:

>1671_bases
TTGGCGAAAGCGCGCCCATCCCCGCAGGCTGCCGCGCTGGACCGCGAGATCTACCGCATCCTGTTCGAGAACATGGACGA
TGGCTTCTGCGTCATCGAGTTTCTCGACGGGCCGCATGGTCCGCTCAGCGATTACGTCCACGTCCTCGCCAACTCCGCCT
ATGAACGCAACACCGGCATTCCCAACGTCGTCGGCCAGTACCTGCGCGAGATGGTGCCCGACGAGGCTGACGACTGGATC
GCGTTCTACGGCAAGGTCCTGCGCACCGGAGAACCGATCCGCTTCCGCAACGAACTGGTCGTCACCGGCCGCCATCTCGA
AGTCTCGGCCTTCCGCCTCGGAACCTTCGAGGACCGGTTGGTGGCAGTCCTTTTCAAGGACGTCACGGAACGGGTCGACG
CCGAAAGCGCTCTGCACCAGCTGAACGAAACCCTCGAGCAGCGCGTCGCCGATGCGCTGGCGCAGCGGGAGCTGGCCGAA
AGCGCGTTGAGGCAGGCGCAGAAGATGGAAGCGGTCGGCCAGTTGACCGGCGGCCTTGCGCACGATTTCAACAATCTCCT
CGCCGGGATCACCGGGGCGTTCGAGATGATCGCGCGACGACTGGAGCAGGGCCGCACCGCCGATGTAGAGCGTTATCTTG
CGGCGGGCCTCGGAGCGGCCCACCGCGCGGCCGCGCTCACGCACCGCCTGCTTGCCTTCTCACGCCGCCAGACGCTGTCC
CCCCGCACGACCGAGGCGAACCGCCTGCTGGTCGATTTCGCCGAACTGGTGCGGCGCACGGTCGGCCCGCAGATCGCGGT
CGAGGTGCGCACCAACCCCGCGCTATGGGCCGCGCTGGTCGATGCAAACCAGCTCGAGAACGCGCTGCTGAACCTGTGCA
TCAATGCTCGCGACGCCATGCCGGACGGCGGTCGACTTGCCATCGAAACCGATAACGTCACCCTCGACGAAGCCAGCGCT
ACCGAGCGGGGCCTTCCGCCAGGCGACTACGTGACGATAACCGTGAGCGACACCGGCGTCGGCATTCCGGAAGAGGATCT
CGACCGCGTGTTCGAGCCGTTCTTCACCACCAAGCCGACCGGGCGCGGAACGGGCTTGGGGTTGTCGATGGTCTACGGCT
TTGCCCGGCAGAGCGATGGTATCGTGCGCATCCGCTCCCGCCCCGGCGAAGGCACGCAGGTCCGCATCTACCTTCCGCGC
CACGAGGGCCCGGCCGAAGTCCCTCGCGAAACCGGCGTTCACGAACCGCAGCCCGAATTGCCTGGCGCGACGGTCCTCGT
CGTCGACGACGAGCCGACGGTGCGCATGATGATGGTCGATGCGCTCGACCTGATCGGTGTCGAATGCCTCGAGGCGCACG
ACGGGCCCGCCGCGCTCGCGATGCTCGAACGCCACCCGGGGATCGACCTGCTCGTCACCGACGTCGGGCTTCCCGGCGGC
CTCAACGGCCGCCAGGTGGCCGACGAGGCGCGGCGGCGGCGGTCGGACCTGGGAGTCCTCTTCGTCACCGGCTATGCCGA
CAGCGTAATCCTCCAGCGCGACACCATGGAACCGGGCATCGACATCCTGACCAAGCCGTTCACCATCGAGGACCTGCAAT
CGCGCGTCGCAGTGCTGCTTTGCGCGCGTGGGGGGCCAGGCAGGCCTGAAACCGGACCGAACGCCGCCTAG

Upstream 100 bases:

>100_bases
CCGGTTCCCGCCGGGAACCAACTGCGACAAGCCGCGTTGGCCGTGCGATGAAACGCGCCAGGATTTCTCTCGCCAGATTG
CCGCAGTCGTGAAGGACGGA

Downstream 100 bases:

>100_bases
GTGCGCTCCAGCAGGTCGACGATTACACCATCGGCCAGTTCGTGCTCGCCGTAGCGCACGAAGCCCAGTCGTTCGGCGAG
GGCGACCGAGGCCGCGTTGC

Product: histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MAKARPSPQAAALDREIYRILFENMDDGFCVIEFLDGPHGPLSDYVHVLANSAYERNTGIPNVVGQYLREMVPDEADDWI
AFYGKVLRTGEPIRFRNELVVTGRHLEVSAFRLGTFEDRLVAVLFKDVTERVDAESALHQLNETLEQRVADALAQRELAE
SALRQAQKMEAVGQLTGGLAHDFNNLLAGITGAFEMIARRLEQGRTADVERYLAAGLGAAHRAAALTHRLLAFSRRQTLS
PRTTEANRLLVDFAELVRRTVGPQIAVEVRTNPALWAALVDANQLENALLNLCINARDAMPDGGRLAIETDNVTLDEASA
TERGLPPGDYVTITVSDTGVGIPEEDLDRVFEPFFTTKPTGRGTGLGLSMVYGFARQSDGIVRIRSRPGEGTQVRIYLPR
HEGPAEVPRETGVHEPQPELPGATVLVVDDEPTVRMMMVDALDLIGVECLEAHDGPAALAMLERHPGIDLLVTDVGLPGG
LNGRQVADEARRRRSDLGVLFVTGYADSVILQRDTMEPGIDILTKPFTIEDLQSRVAVLLCARGGPGRPETGPNAA

Sequences:

>Translated_556_residues
MAKARPSPQAAALDREIYRILFENMDDGFCVIEFLDGPHGPLSDYVHVLANSAYERNTGIPNVVGQYLREMVPDEADDWI
AFYGKVLRTGEPIRFRNELVVTGRHLEVSAFRLGTFEDRLVAVLFKDVTERVDAESALHQLNETLEQRVADALAQRELAE
SALRQAQKMEAVGQLTGGLAHDFNNLLAGITGAFEMIARRLEQGRTADVERYLAAGLGAAHRAAALTHRLLAFSRRQTLS
PRTTEANRLLVDFAELVRRTVGPQIAVEVRTNPALWAALVDANQLENALLNLCINARDAMPDGGRLAIETDNVTLDEASA
TERGLPPGDYVTITVSDTGVGIPEEDLDRVFEPFFTTKPTGRGTGLGLSMVYGFARQSDGIVRIRSRPGEGTQVRIYLPR
HEGPAEVPRETGVHEPQPELPGATVLVVDDEPTVRMMMVDALDLIGVECLEAHDGPAALAMLERHPGIDLLVTDVGLPGG
LNGRQVADEARRRRSDLGVLFVTGYADSVILQRDTMEPGIDILTKPFTIEDLQSRVAVLLCARGGPGRPETGPNAA
>Mature_555_residues
AKARPSPQAAALDREIYRILFENMDDGFCVIEFLDGPHGPLSDYVHVLANSAYERNTGIPNVVGQYLREMVPDEADDWIA
FYGKVLRTGEPIRFRNELVVTGRHLEVSAFRLGTFEDRLVAVLFKDVTERVDAESALHQLNETLEQRVADALAQRELAES
ALRQAQKMEAVGQLTGGLAHDFNNLLAGITGAFEMIARRLEQGRTADVERYLAAGLGAAHRAAALTHRLLAFSRRQTLSP
RTTEANRLLVDFAELVRRTVGPQIAVEVRTNPALWAALVDANQLENALLNLCINARDAMPDGGRLAIETDNVTLDEASAT
ERGLPPGDYVTITVSDTGVGIPEEDLDRVFEPFFTTKPTGRGTGLGLSMVYGFARQSDGIVRIRSRPGEGTQVRIYLPRH
EGPAEVPRETGVHEPQPELPGATVLVVDDEPTVRMMMVDALDLIGVECLEAHDGPAALAMLERHPGIDLLVTDVGLPGGL
NGRQVADEARRRRSDLGVLFVTGYADSVILQRDTMEPGIDILTKPFTIEDLQSRVAVLLCARGGPGRPETGPNAA

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=29.4354838709677, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788549, Length=251, Percent_Identity=29.4820717131474, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI145693157, Length=341, Percent_Identity=25.5131964809384, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788713, Length=404, Percent_Identity=24.5049504950495, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790300, Length=291, Percent_Identity=30.5841924398625, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI48994928, Length=393, Percent_Identity=24.4274809160305, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=245, Percent_Identity=26.9387755102041, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=258, Percent_Identity=29.8449612403101, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60652; Mature: 60520

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKARPSPQAAALDREIYRILFENMDDGFCVIEFLDGPHGPLSDYVHVLANSAYERNTGI
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHCCCCC
PNVVGQYLREMVPDEADDWIAFYGKVLRTGEPIRFRNELVVTGRHLEVSAFRLGTFEDRL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCEEEEECCEEEEEEEECCCHHHHH
VAVLFKDVTERVDAESALHQLNETLEQRVADALAQRELAESALRQAQKMEAVGQLTGGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDFNNLLAGITGAFEMIARRLEQGRTADVERYLAAGLGAAHRAAALTHRLLAFSRRQTLS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
PRTTEANRLLVDFAELVRRTVGPQIAVEVRTNPALWAALVDANQLENALLNLCINARDAM
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PDGGRLAIETDNVTLDEASATERGLPPGDYVTITVSDTGVGIPEEDLDRVFEPFFTTKPT
CCCCEEEEEECCEEECCCCCHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
GRGTGLGLSMVYGFARQSDGIVRIRSRPGEGTQVRIYLPRHEGPAEVPRETGVHEPQPEL
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCHHCCCCCCCCCC
PGATVLVVDDEPTVRMMMVDALDLIGVECLEAHDGPAALAMLERHPGIDLLVTDVGLPGG
CCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCC
LNGRQVADEARRRRSDLGVLFVTGYADSVILQRDTMEPGIDILTKPFTIEDLQSRVAVLL
CCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCHHHHCCCCCHHHHHHHHEEEE
CARGGPGRPETGPNAA
ECCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKARPSPQAAALDREIYRILFENMDDGFCVIEFLDGPHGPLSDYVHVLANSAYERNTGI
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHCCCCC
PNVVGQYLREMVPDEADDWIAFYGKVLRTGEPIRFRNELVVTGRHLEVSAFRLGTFEDRL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCEEEEECCEEEEEEEECCCHHHHH
VAVLFKDVTERVDAESALHQLNETLEQRVADALAQRELAESALRQAQKMEAVGQLTGGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDFNNLLAGITGAFEMIARRLEQGRTADVERYLAAGLGAAHRAAALTHRLLAFSRRQTLS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
PRTTEANRLLVDFAELVRRTVGPQIAVEVRTNPALWAALVDANQLENALLNLCINARDAM
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PDGGRLAIETDNVTLDEASATERGLPPGDYVTITVSDTGVGIPEEDLDRVFEPFFTTKPT
CCCCEEEEEECCEEECCCCCHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
GRGTGLGLSMVYGFARQSDGIVRIRSRPGEGTQVRIYLPRHEGPAEVPRETGVHEPQPEL
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCHHCCCCCCCCCC
PGATVLVVDDEPTVRMMMVDALDLIGVECLEAHDGPAALAMLERHPGIDLLVTDVGLPGG
CCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCC
LNGRQVADEARRRRSDLGVLFVTGYADSVILQRDTMEPGIDILTKPFTIEDLQSRVAVLL
CCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCHHHHCCCCCHHHHHHHHEEEE
CARGGPGRPETGPNAA
ECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA