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The map label for this gene is msrA [H]

Identifier: 86751807

GI number: 86751807

Start: 5329093

End: 5329749

Strand: Reverse

Name: msrA [H]

Synonym: RPB_4709

Alternate gene names: 86751807

Gene position: 5329749-5329093 (Counterclockwise)

Preceding gene: 86751808

Following gene: 86751806

Centisome position: 99.96

GC content: 67.43

Gene sequence:

>657_bases
ATGTTCTTCACGCGCAAATCCGCCGCGATGCCGAGCGCCAGCGAAGCGCTGCCGGGCCGCGCCACGCCGATCCCGACCGC
GCGCAGCCATTTCGTCAACGGCGCTCGCATTCAGCCGCCTTATCCCGAGGGGCTGCAGCAGGCGGTGTTCGGTCTCGGCT
GTTTCTGGGGCGCGGAGCGCAAGTTCTGGGAACTCGGCGACGGGGTCTACACCACCGCGGTCGGCTATGCCGGCGGCCAC
ACGCCGAACCCGACCTATGAGGAAACCTGCTCCGGCCGCACCGGCCACACCGAGGCGGTACTGGTGGTGTTCGATCCGAC
GAAGATCTCCTACGAGGCGCTGCTGAAGACGTTCTGGGAAAGTCACGACCCGACCCAGGGCATGCGCCAGGGCAACGATG
TCGGCTCGCAATATCGCTCGGCGATCTACACCTTCGGCGACGCGCAGGCACGCGCCGCCGAGGCGTCGCGCGAGGCCTAT
CAGCAGGCACTCGGCGCCAGGCGCTTCGGACCGATCACCACCGAGATCGCGCCGGCCGGCGCGTTCTATTTCGCCGAGGA
CTATCACCAGCAATATCTCGCCAAGAATCCCGGCGGCTATTGCGGGCTCGGCGGAACCGGGGTGTCGTGCCCGGTCGGTA
TCGGTGTCACGGCCTGA

Upstream 100 bases:

>100_bases
GTCGAGAGAAGGTGGCGGCAGCGTTCGGCTGCCCGCCAGCATCATCCAGCAAACGGGCGCCCGGGCGAGCTTGACCGCCG
CGGCGCGCCGGGAGGTGTCT

Downstream 100 bases:

>100_bases
TCCGCCTGCGATCCGGCACGGCGCAACCTCTCCCGCTTGCGGGGGAGGTCGGATCGCGTCAGCGATCCGGGTGGGGGAAG
AGCTCTCCGCGATGAGCAGG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MFFTRKSAAMPSASEALPGRATPIPTARSHFVNGARIQPPYPEGLQQAVFGLGCFWGAERKFWELGDGVYTTAVGYAGGH
TPNPTYEETCSGRTGHTEAVLVVFDPTKISYEALLKTFWESHDPTQGMRQGNDVGSQYRSAIYTFGDAQARAAEASREAY
QQALGARRFGPITTEIAPAGAFYFAEDYHQQYLAKNPGGYCGLGGTGVSCPVGIGVTA

Sequences:

>Translated_218_residues
MFFTRKSAAMPSASEALPGRATPIPTARSHFVNGARIQPPYPEGLQQAVFGLGCFWGAERKFWELGDGVYTTAVGYAGGH
TPNPTYEETCSGRTGHTEAVLVVFDPTKISYEALLKTFWESHDPTQGMRQGNDVGSQYRSAIYTFGDAQARAAEASREAY
QQALGARRFGPITTEIAPAGAFYFAEDYHQQYLAKNPGGYCGLGGTGVSCPVGIGVTA
>Mature_218_residues
MFFTRKSAAMPSASEALPGRATPIPTARSHFVNGARIQPPYPEGLQQAVFGLGCFWGAERKFWELGDGVYTTAVGYAGGH
TPNPTYEETCSGRTGHTEAVLVVFDPTKISYEALLKTFWESHDPTQGMRQGNDVGSQYRSAIYTFGDAQARAAEASREAY
QQALGARRFGPITTEIAPAGAFYFAEDYHQQYLAKNPGGYCGLGGTGVSCPVGIGVTA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=208, Percent_Identity=63.9423076923077, Blast_Score=281, Evalue=3e-76,
Organism=Homo sapiens, GI208609995, Length=186, Percent_Identity=66.6666666666667, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI208609993, Length=203, Percent_Identity=50.7389162561576, Blast_Score=198, Evalue=4e-51,
Organism=Escherichia coli, GI1790665, Length=211, Percent_Identity=59.2417061611374, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=40.5405405405405, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=35.5421686746988, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=41.4965986394558, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=40.8163265306122, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=40.5594405594406, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23379; Mature: 23379

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFTRKSAAMPSASEALPGRATPIPTARSHFVNGARIQPPYPEGLQQAVFGLGCFWGAER
CCCCCCCCCCCCHHHCCCCCCCCCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHHHCCCC
KFWELGDGVYTTAVGYAGGHTPNPTYEETCSGRTGHTEAVLVVFDPTKISYEALLKTFWE
HHHHHCCCCEEHEEECCCCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
SHDPTQGMRQGNDVGSQYRSAIYTFGDAQARAAEASREAYQQALGARRFGPITTEIAPAG
CCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHCCCCCHHHCCCC
AFYFAEDYHQQYLAKNPGGYCGLGGTGVSCPVGIGVTA
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFFTRKSAAMPSASEALPGRATPIPTARSHFVNGARIQPPYPEGLQQAVFGLGCFWGAER
CCCCCCCCCCCCHHHCCCCCCCCCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHHHCCCC
KFWELGDGVYTTAVGYAGGHTPNPTYEETCSGRTGHTEAVLVVFDPTKISYEALLKTFWE
HHHHHCCCCEEHEEECCCCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
SHDPTQGMRQGNDVGSQYRSAIYTFGDAQARAAEASREAYQQALGARRFGPITTEIAPAG
CCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHCCCCCHHHCCCC
AFYFAEDYHQQYLAKNPGGYCGLGGTGVSCPVGIGVTA
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA