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The map label for this gene is dxs [H]

Identifier: 86751558

GI number: 86751558

Start: 5048763

End: 5050679

Strand: Direct

Name: dxs [H]

Synonym: RPB_4460

Alternate gene names: 86751558

Gene position: 5048763-5050679 (Clockwise)

Preceding gene: 86751557

Following gene: 86751559

Centisome position: 94.69

GC content: 66.46

Gene sequence:

>1917_bases
TTGAGTAAAACGCCGCTTCTCGACACCATCCGCACACCGGACGATCTGCGCAAGCTCCGCATCGACCAGGTCCAGCAGGT
TGCCGACGAATTGCGGCAGGAAACCATCGACGCGGTCTCGGTCACGGGCGGCCATTTCGGCGCCGGCCTCGGCGTCGTCG
AACTGACCACGGCGATCCACTACGTCTTCGATACGCCGCGCGACCGCCTGATCTGGGACGTCGGCCATCAGGCCTATCCG
CACAAGATCCTGACCGGCCGCCGCGACCGCATCCGCACGCTGCGCACCGCCGGCGGGCTGTCCGGCTTCACCAAGCGCAC
CGAGAGCGACTACGATCCGTTCGGCGCCGCGCATTCCTCGACCTCGATCTCCGCCGGCCTCGGCATGGCGGTGGCGCGCG
ACCTCGCCGGCGGGACCAACAACGTCATCGCGGTGATCGGCGACGGTTCGATCTCGGCCGGCATGGCCTACGAGGCGATG
AACAACGCCGGCGCGATGAACTCCCGTCTTATCGTCATTCTCAATGACAACAACATGTCGATCGCGCCCCCGGTCGGCGC
CATGTCGGCCTATCTGTCGCGGCTGTATTCGGGCAAGACCTACCGCTCGCTGCGCGAGGCCGGCAAGCAGATCGGCAAGC
ACCTGCCGAAGCTGATCGCCGACCGTGCCGCCCGCGCCGAGGAATATTCCCGCGGCTTCATGATGGGCGGCGGCACGCTG
TTCGAGGAACTCGGCTTCTATTACGTCGGCCCGATCGACGGCCACAATCTCGATCATCTGCTGCCGATCCTGCAGAACGT
CCGCGATGCCGAGACCGGCCCGTTCCTGATCCATGTCGTCACGCAGAAGGGCAAGGGCTACGCCCCGGCCGAAGCCGCGT
CCGACAAGTATCACGCGGTGGTCAAGTTCGACATCGCCACCGGCACCCAGGCCAAGGCCAAGTCGAACGCGCCGTCCTAT
CAGAACGTGTTCGGCCAGAGCCTGGTCAAGGAAGCCGCCAAGGACGACAAGGTCGTCGGCATCACCGCGGCGATGCCGTC
GGGCACCGGCATCGACATCTTCGAGAAGGCCTTCCCGGACCGCACCTTCGACGTCGGCATCGCCGAGCAGCACGCGGTGA
CTTTCGCGGCCGGCCTCGCCACCGAGGGCTTCAAGCCGTTCTGCGCGATCTACTCGACCTTCCTGCAGCGCGGTTACGAC
CAGATCGTCCACGACGTCGCGATCCAGAGCCTGCCGGTTCGCTTCGCGATCGACCGCGCCGGCCTCGTCGGCGCCGACGG
CGCGACCCATGCGGGCTCGTTCGACAACGCTTATCTCGGCTGCCTGCCGAATTTCGTGATCATGGCCGCCTCCGACGAGG
CCGAGCTGGTGCACATGGTGGCGACGCAAGTCGCGATCAACGACCGGCCGAGCGCGGTGCGCTATCCGCGCGGCGAAGGC
CGCGGCGTCGAGATGCCGGATGTCGGCGTCCCGCTCGAGATCGGCAAGGGCCGCGTCATTCGCCAGGGCAACAAGGTCGC
GCTGCTGTCGTTCGGCACGAGGCTCGCCGAGTGCGAAAAGGCCGCCGAGGAACTGGCGACGCTCGGTCTCTCCACCACCG
TCGCCGATGCCCGCTTCATGAAGCCGCTCGACGTCGATCTGGTGATCAAGCTCGCCAACGAGCACGAGATCCTGATCACC
ATCGAGGAAGGCTCGATCGGCGGCTTCGGCAGCCACGTGATGCAGACGCTGTCCGACCACGGCAAGCTCGACGGCGAGGT
CAAGATGCGGGCGATGGTGCTGCCCGACGTGTTCCTCGACCACGACACGCCCGCGGCGATGTACGCCGCCGCCGGCCTCG
ACGCCAAGGCGATCGTCAAGAAGGTGTTCGAAGCGCTCGGCAAGGAACACGCCGCCGAGACCGTCAAGCTGGCGTAA

Upstream 100 bases:

>100_bases
GCGGAAGCCAGGTGGGCTCCCGTGAATTGGACAAGTTCGGACCATTCGTCGCGGGCCTCACCACCCCCATAGTCAAGACT
GGAAGATCGCCGTGACCGAA

Downstream 100 bases:

>100_bases
GCGCCACGACGCTTCCGACTCTCTTCACCCTCCCCTGGAGGGGGAGGGTCGGCGGGTAGCGCGCGAAGCGCGGTGCCCGC
CGGGGTGGGGTGAGCCGCGA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MSKTPLLDTIRTPDDLRKLRIDQVQQVADELRQETIDAVSVTGGHFGAGLGVVELTTAIHYVFDTPRDRLIWDVGHQAYP
HKILTGRRDRIRTLRTAGGLSGFTKRTESDYDPFGAAHSSTSISAGLGMAVARDLAGGTNNVIAVIGDGSISAGMAYEAM
NNAGAMNSRLIVILNDNNMSIAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGGGTL
FEELGFYYVGPIDGHNLDHLLPILQNVRDAETGPFLIHVVTQKGKGYAPAEAASDKYHAVVKFDIATGTQAKAKSNAPSY
QNVFGQSLVKEAAKDDKVVGITAAMPSGTGIDIFEKAFPDRTFDVGIAEQHAVTFAAGLATEGFKPFCAIYSTFLQRGYD
QIVHDVAIQSLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNFVIMAASDEAELVHMVATQVAINDRPSAVRYPRGEG
RGVEMPDVGVPLEIGKGRVIRQGNKVALLSFGTRLAECEKAAEELATLGLSTTVADARFMKPLDVDLVIKLANEHEILIT
IEEGSIGGFGSHVMQTLSDHGKLDGEVKMRAMVLPDVFLDHDTPAAMYAAAGLDAKAIVKKVFEALGKEHAAETVKLA

Sequences:

>Translated_638_residues
MSKTPLLDTIRTPDDLRKLRIDQVQQVADELRQETIDAVSVTGGHFGAGLGVVELTTAIHYVFDTPRDRLIWDVGHQAYP
HKILTGRRDRIRTLRTAGGLSGFTKRTESDYDPFGAAHSSTSISAGLGMAVARDLAGGTNNVIAVIGDGSISAGMAYEAM
NNAGAMNSRLIVILNDNNMSIAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGGGTL
FEELGFYYVGPIDGHNLDHLLPILQNVRDAETGPFLIHVVTQKGKGYAPAEAASDKYHAVVKFDIATGTQAKAKSNAPSY
QNVFGQSLVKEAAKDDKVVGITAAMPSGTGIDIFEKAFPDRTFDVGIAEQHAVTFAAGLATEGFKPFCAIYSTFLQRGYD
QIVHDVAIQSLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNFVIMAASDEAELVHMVATQVAINDRPSAVRYPRGEG
RGVEMPDVGVPLEIGKGRVIRQGNKVALLSFGTRLAECEKAAEELATLGLSTTVADARFMKPLDVDLVIKLANEHEILIT
IEEGSIGGFGSHVMQTLSDHGKLDGEVKMRAMVLPDVFLDHDTPAAMYAAAGLDAKAIVKKVFEALGKEHAAETVKLA
>Mature_637_residues
SKTPLLDTIRTPDDLRKLRIDQVQQVADELRQETIDAVSVTGGHFGAGLGVVELTTAIHYVFDTPRDRLIWDVGHQAYPH
KILTGRRDRIRTLRTAGGLSGFTKRTESDYDPFGAAHSSTSISAGLGMAVARDLAGGTNNVIAVIGDGSISAGMAYEAMN
NAGAMNSRLIVILNDNNMSIAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGGGTLF
EELGFYYVGPIDGHNLDHLLPILQNVRDAETGPFLIHVVTQKGKGYAPAEAASDKYHAVVKFDIATGTQAKAKSNAPSYQ
NVFGQSLVKEAAKDDKVVGITAAMPSGTGIDIFEKAFPDRTFDVGIAEQHAVTFAAGLATEGFKPFCAIYSTFLQRGYDQ
IVHDVAIQSLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNFVIMAASDEAELVHMVATQVAINDRPSAVRYPRGEGR
GVEMPDVGVPLEIGKGRVIRQGNKVALLSFGTRLAECEKAAEELATLGLSTTVADARFMKPLDVDLVIKLANEHEILITI
EEGSIGGFGSHVMQTLSDHGKLDGEVKMRAMVLPDVFLDHDTPAAMYAAAGLDAKAIVKKVFEALGKEHAAETVKLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=621, Percent_Identity=24.6376811594203, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4507521, Length=621, Percent_Identity=24.6376811594203, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI225637461, Length=499, Percent_Identity=23.0460921843687, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI225637463, Length=280, Percent_Identity=27.8571428571429, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI225637459, Length=499, Percent_Identity=23.0460921843687, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI133778974, Length=362, Percent_Identity=25.9668508287293, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786622, Length=626, Percent_Identity=52.3961661341853, Blast_Score=624, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17539652, Length=429, Percent_Identity=25.8741258741259, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24666278, Length=597, Percent_Identity=24.4556113902848, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45551847, Length=310, Percent_Identity=27.741935483871, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45550715, Length=310, Percent_Identity=27.741935483871, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24645119, Length=310, Percent_Identity=27.741935483871, Blast_Score=83, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68286; Mature: 68154

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTPLLDTIRTPDDLRKLRIDQVQQVADELRQETIDAVSVTGGHFGAGLGVVELTTAIH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHH
YVFDTPRDRLIWDVGHQAYPHKILTGRRDRIRTLRTAGGLSGFTKRTESDYDPFGAAHSS
HHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCC
TSISAGLGMAVARDLAGGTNNVIAVIGDGSISAGMAYEAMNNAGAMNSRLIVILNDNNMS
CCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCEEEEEECCCCEE
IAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGGGTL
ECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHH
FEELGFYYVGPIDGHNLDHLLPILQNVRDAETGPFLIHVVTQKGKGYAPAEAASDKYHAV
HHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEE
VKFDIATGTQAKAKSNAPSYQNVFGQSLVKEAAKDDKVVGITAAMPSGTGIDIFEKAFPD
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCC
RTFDVGIAEQHAVTFAAGLATEGFKPFCAIYSTFLQRGYDQIVHDVAIQSLPVRFAIDRA
CCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GLVGADGATHAGSFDNAYLGCLPNFVIMAASDEAELVHMVATQVAINDRPSAVRYPRGEG
CEECCCCCCCCCCCCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
RGVEMPDVGVPLEIGKGRVIRQGNKVALLSFGTRLAECEKAAEELATLGLSTTVADARFM
CCCCCCCCCCCEECCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHC
KPLDVDLVIKLANEHEILITIEEGSIGGFGSHVMQTLSDHGKLDGEVKMRAMVLPDVFLD
CCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCC
HDTPAAMYAAAGLDAKAIVKKVFEALGKEHAAETVKLA
CCCCHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHEECC
>Mature Secondary Structure 
SKTPLLDTIRTPDDLRKLRIDQVQQVADELRQETIDAVSVTGGHFGAGLGVVELTTAIH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHH
YVFDTPRDRLIWDVGHQAYPHKILTGRRDRIRTLRTAGGLSGFTKRTESDYDPFGAAHSS
HHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCC
TSISAGLGMAVARDLAGGTNNVIAVIGDGSISAGMAYEAMNNAGAMNSRLIVILNDNNMS
CCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCEEEEEECCCCEE
IAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGGGTL
ECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHH
FEELGFYYVGPIDGHNLDHLLPILQNVRDAETGPFLIHVVTQKGKGYAPAEAASDKYHAV
HHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEE
VKFDIATGTQAKAKSNAPSYQNVFGQSLVKEAAKDDKVVGITAAMPSGTGIDIFEKAFPD
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCC
RTFDVGIAEQHAVTFAAGLATEGFKPFCAIYSTFLQRGYDQIVHDVAIQSLPVRFAIDRA
CCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GLVGADGATHAGSFDNAYLGCLPNFVIMAASDEAELVHMVATQVAINDRPSAVRYPRGEG
CEECCCCCCCCCCCCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
RGVEMPDVGVPLEIGKGRVIRQGNKVALLSFGTRLAECEKAAEELATLGLSTTVADARFM
CCCCCCCCCCCEECCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHC
KPLDVDLVIKLANEHEILITIEEGSIGGFGSHVMQTLSDHGKLDGEVKMRAMVLPDVFLD
CCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCC
HDTPAAMYAAAGLDAKAIVKKVFEALGKEHAAETVKLA
CCCCHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA