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The map label for this gene is 86751529

Identifier: 86751529

GI number: 86751529

Start: 5016527

End: 5018599

Strand: Direct

Name: 86751529

Synonym: RPB_4428

Alternate gene names: NA

Gene position: 5016527-5018599 (Clockwise)

Preceding gene: 86751528

Following gene: 86751530

Centisome position: 94.09

GC content: 68.64

Gene sequence:

>2073_bases
ATGACGCCCGCCCGCCTGGCCGTCGATATCGGCGGCACGTTCACGGATTTCGCGCTCGAAGTGGGCGACAAGCGCTACAG
CCGCAAGGTGCTGACGACGCCGACCGCGCCCGAACAGGGCGTGCTCACCGGCGTCGGCCTGATCATGCAGGATGCCGGCC
TCGCGCCTTCCGATCTCGGCCTGATCATTCACGGCACCACGCTCGCCACCAACGCGATCATCGAACGCAAGGGCGCGAAG
ACGGCGCTGCTGGCGACGCGCGGTTTTCGCGATGCCATCGAGATGGCCTATGAGCATCGCTTCGAGCAATACGACATCTT
CATGGACAAGCCGCCGCCGCTGGTGCCGCGGAATCTGCGCCTCGAAGTGCCGGAGCGCATCGACGCCAACGGCGGCGTCG
TCGAACCGCTCGACGAGGCCGCCCTCGCCGGTCTCGTGCCGATCTTGCGCGCCGAAGGCGTGACCAGCGTCGCGCTCGGC
TATCTGCACTCTTACGCCAATCCGGCCCACGAGATCCGCAGCCGCGACATCCTCACCACGCTGGCGCCCGACCTCGCCAT
CACCATGTCGAGCGAGGTCTGCCCGGAGATGCGCGAATACGAGCGCTGGTCCACGGCCTGCGCCAACGCCTATGTGCAGC
CGGTGATGGACCGCTATCTGAAGCTGCTCGAGGAAGCGTTGCGCGCCCGCGGCTTCCGCTGTCCGATCTATCTCATTACG
TCCGCCGGCGGCCTGACCACCGTCGAGATCGCGCGGCGCTTCCCGATCCGCCTCGTCGAATCCGGCCCGGCCGGCGGCGC
CATTCTGGCCGCGCATATCGCCAACGAACGCCGGCACGATCATATCGTGTCGTTCGACATGGGCGGCACCACCGCGAAGA
TCTGCCTGATCGATCATGGCGAGCCGCATTTCGAACGCTCCTTCGAAGTCGCGCGGCAATATCGTTTTCTGAAGGGCAGC
GGGATTCCGATCCGCATCCCGGTGATCGAGATGGTCGAGATCGGCGCCGGCGGCGGCTCGATCGCGTCGGTCGATGCCAT
GCAACGCGTCCAGGTCGGCCCGGCGAGCGCCGGCTCCGAGCCGGGCCCGGCCTGTTACGGCCGCGGCGGCGCGAACGGCA
CGGTGACCGACGCCAATCTGCTGCTCGGGCGTCTGCAGGCCGATCGCTTCGCCGGCGGCAAAATGCAGCTCGATACCAAC
GCATCGGCCGCCGCCCTGCAGGCCTCGGTCGGTCGCGCGTTGTCGCTCGATGCCGCGACGGCGGCGCTCGGTGTCATCGA
GGTGGTCGAGGAGAACATGGCCAATGCCGCGCGCGTCCATGCGGTCGAGCGTGGCCGCGAACTCGCCAATCGCGTCATGA
TCGCGTTCGGCGGTGCCGCACCGATTCATGCCGCCCGCCTCGCCGAGAAGCTCGACATTGCGACGGTGATCGTCCCGGCC
GGCGCCGGCGTCGGCTCCGCCTTCGGCTTCCTACTGGCGCCGATCGCCTACGAGGTGGTGCGCACGCGCCATGTGCGGCT
CGATGACGGTTTCGATCCGGCGCCGCTCAACGCGCTGCGCAGCGAGATGCGCAAGGAGGCCGAAGACGTCGTCCGCCTCG
GCGCGCCGACCGCCGAGCTCGTGGAAGGCTGGAGCGCCAGCATGCGCTATCGCGGCCAGGGCCACGAACTCACCGTCACC
ATCCCGGCGAGCGATTTCACCGCGGGCTCGGTCGCCGAGCTGGAGCGGCTGTTCCTCGCCGATTACGAACAGCAATTCGG
CCGCCGGATTCCCGACCTCGACGTCGAGATTCTCGGCTGGTCGCTGCGGCTCGCCACCGTCAGTCCGCCGATCCTCCCCT
GCCCGCCAATGCCGTCCGGCACGGCCGCCGAGCCGGCGGCGCATGTCGATGTCGTGGCGCCGCAGACCGGCAAGACGGAA
TCCATCGCGCTCCACACTCGCCGCGACCTCGTGCCGGGCGCGATCGTCGCGGGCCCCGCGCTGATCGTCGAGGACGAAAC
CACGACGATGGTGACCCACCGCTACACCGCCCGCATCGACGCGCTCGGCAGCATCGTCATGACGAGGACCTGA

Upstream 100 bases:

>100_bases
TCGGCCGCAAGTTTCTCGAAGGCCCTGCCCGCGAAGTGCGCGACGATCCGCGCATCCGCGAGGCCTATCTGGGCGGCAAC
ATCAAGGAGACGATCGAGGA

Downstream 100 bases:

>100_bases
TCATGGACGTCCACGCCCCTCACGCCGATCCGATGAACGTGATCCATCAGCAGATCATGTGGGATCGCCTGATCTCCGTG
GTCGAAGAACAGGCCCAGAC

Product: 5-oxoprolinase (ATP-hydrolyzing)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MTPARLAVDIGGTFTDFALEVGDKRYSRKVLTTPTAPEQGVLTGVGLIMQDAGLAPSDLGLIIHGTTLATNAIIERKGAK
TALLATRGFRDAIEMAYEHRFEQYDIFMDKPPPLVPRNLRLEVPERIDANGGVVEPLDEAALAGLVPILRAEGVTSVALG
YLHSYANPAHEIRSRDILTTLAPDLAITMSSEVCPEMREYERWSTACANAYVQPVMDRYLKLLEEALRARGFRCPIYLIT
SAGGLTTVEIARRFPIRLVESGPAGGAILAAHIANERRHDHIVSFDMGGTTAKICLIDHGEPHFERSFEVARQYRFLKGS
GIPIRIPVIEMVEIGAGGGSIASVDAMQRVQVGPASAGSEPGPACYGRGGANGTVTDANLLLGRLQADRFAGGKMQLDTN
ASAAALQASVGRALSLDAATAALGVIEVVEENMANAARVHAVERGRELANRVMIAFGGAAPIHAARLAEKLDIATVIVPA
GAGVGSAFGFLLAPIAYEVVRTRHVRLDDGFDPAPLNALRSEMRKEAEDVVRLGAPTAELVEGWSASMRYRGQGHELTVT
IPASDFTAGSVAELERLFLADYEQQFGRRIPDLDVEILGWSLRLATVSPPILPCPPMPSGTAAEPAAHVDVVAPQTGKTE
SIALHTRRDLVPGAIVAGPALIVEDETTTMVTHRYTARIDALGSIVMTRT

Sequences:

>Translated_690_residues
MTPARLAVDIGGTFTDFALEVGDKRYSRKVLTTPTAPEQGVLTGVGLIMQDAGLAPSDLGLIIHGTTLATNAIIERKGAK
TALLATRGFRDAIEMAYEHRFEQYDIFMDKPPPLVPRNLRLEVPERIDANGGVVEPLDEAALAGLVPILRAEGVTSVALG
YLHSYANPAHEIRSRDILTTLAPDLAITMSSEVCPEMREYERWSTACANAYVQPVMDRYLKLLEEALRARGFRCPIYLIT
SAGGLTTVEIARRFPIRLVESGPAGGAILAAHIANERRHDHIVSFDMGGTTAKICLIDHGEPHFERSFEVARQYRFLKGS
GIPIRIPVIEMVEIGAGGGSIASVDAMQRVQVGPASAGSEPGPACYGRGGANGTVTDANLLLGRLQADRFAGGKMQLDTN
ASAAALQASVGRALSLDAATAALGVIEVVEENMANAARVHAVERGRELANRVMIAFGGAAPIHAARLAEKLDIATVIVPA
GAGVGSAFGFLLAPIAYEVVRTRHVRLDDGFDPAPLNALRSEMRKEAEDVVRLGAPTAELVEGWSASMRYRGQGHELTVT
IPASDFTAGSVAELERLFLADYEQQFGRRIPDLDVEILGWSLRLATVSPPILPCPPMPSGTAAEPAAHVDVVAPQTGKTE
SIALHTRRDLVPGAIVAGPALIVEDETTTMVTHRYTARIDALGSIVMTRT
>Mature_689_residues
TPARLAVDIGGTFTDFALEVGDKRYSRKVLTTPTAPEQGVLTGVGLIMQDAGLAPSDLGLIIHGTTLATNAIIERKGAKT
ALLATRGFRDAIEMAYEHRFEQYDIFMDKPPPLVPRNLRLEVPERIDANGGVVEPLDEAALAGLVPILRAEGVTSVALGY
LHSYANPAHEIRSRDILTTLAPDLAITMSSEVCPEMREYERWSTACANAYVQPVMDRYLKLLEEALRARGFRCPIYLITS
AGGLTTVEIARRFPIRLVESGPAGGAILAAHIANERRHDHIVSFDMGGTTAKICLIDHGEPHFERSFEVARQYRFLKGSG
IPIRIPVIEMVEIGAGGGSIASVDAMQRVQVGPASAGSEPGPACYGRGGANGTVTDANLLLGRLQADRFAGGKMQLDTNA
SAAALQASVGRALSLDAATAALGVIEVVEENMANAARVHAVERGRELANRVMIAFGGAAPIHAARLAEKLDIATVIVPAG
AGVGSAFGFLLAPIAYEVVRTRHVRLDDGFDPAPLNALRSEMRKEAEDVVRLGAPTAELVEGWSASMRYRGQGHELTVTI
PASDFTAGSVAELERLFLADYEQQFGRRIPDLDVEILGWSLRLATVSPPILPCPPMPSGTAAEPAAHVDVVAPQTGKTES
IALHTRRDLVPGAIVAGPALIVEDETTTMVTHRYTARIDALGSIVMTRT

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=738, Percent_Identity=29.4037940379404, Blast_Score=191, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI133901900, Length=398, Percent_Identity=31.4070351758794, Blast_Score=129, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322634, Length=549, Percent_Identity=29.143897996357, Blast_Score=193, Evalue=9e-50,
Organism=Drosophila melanogaster, GI45550492, Length=743, Percent_Identity=29.6096904441454, Blast_Score=218, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 73632; Mature: 73501

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPARLAVDIGGTFTDFALEVGDKRYSRKVLTTPTAPEQGVLTGVGLIMQDAGLAPSDLG
CCCCEEEEECCCCHHHHHHHHCCHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCE
LIIHGTTLATNAIIERKGAKTALLATRGFRDAIEMAYEHRFEQYDIFMDKPPPLVPRNLR
EEEECCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCE
LEVPERIDANGGVVEPLDEAALAGLVPILRAEGVTSVALGYLHSYANPAHEIRSRDILTT
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCHHHHH
LAPDLAITMSSEVCPEMREYERWSTACANAYVQPVMDRYLKLLEEALRARGFRCPIYLIT
HCCCEEEEECHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
SAGGLTTVEIARRFPIRLVESGPAGGAILAAHIANERRHDHIVSFDMGGTTAKICLIDHG
CCCCCEEHHHHHCCCEEEEECCCCCCEEEEEEHHCCCCCCCEEEEECCCCEEEEEEEECC
EPHFERSFEVARQYRFLKGSGIPIRIPVIEMVEIGAGGGSIASVDAMQRVQVGPASAGSE
CCHHHHHHHHHHHHHHHCCCCCEEEEEHEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCC
PGPACYGRGGANGTVTDANLLLGRLQADRFAGGKMQLDTNASAAALQASVGRALSLDAAT
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCEEECHHHH
AALGVIEVVEENMANAARVHAVERGRELANRVMIAFGGAAPIHAARLAEKLDIATVIVPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHCCEEEEEEEC
GAGVGSAFGFLLAPIAYEVVRTRHVRLDDGFDPAPLNALRSEMRKEAEDVVRLGAPTAEL
CCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
VEGWSASMRYRGQGHELTVTIPASDFTAGSVAELERLFLADYEQQFGRRIPDLDVEILGW
HCCCCCCEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
SLRLATVSPPILPCPPMPSGTAAEPAAHVDVVAPQTGKTESIALHTRRDLVPGAIVAGPA
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEHHHCCCCCCCCCCCE
LIVEDETTTMVTHRYTARIDALGSIVMTRT
EEEECCCEEEEEEEHHHHHHHHCCEEEECC
>Mature Secondary Structure 
TPARLAVDIGGTFTDFALEVGDKRYSRKVLTTPTAPEQGVLTGVGLIMQDAGLAPSDLG
CCCEEEEECCCCHHHHHHHHCCHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCE
LIIHGTTLATNAIIERKGAKTALLATRGFRDAIEMAYEHRFEQYDIFMDKPPPLVPRNLR
EEEECCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCE
LEVPERIDANGGVVEPLDEAALAGLVPILRAEGVTSVALGYLHSYANPAHEIRSRDILTT
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCHHHHH
LAPDLAITMSSEVCPEMREYERWSTACANAYVQPVMDRYLKLLEEALRARGFRCPIYLIT
HCCCEEEEECHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
SAGGLTTVEIARRFPIRLVESGPAGGAILAAHIANERRHDHIVSFDMGGTTAKICLIDHG
CCCCCEEHHHHHCCCEEEEECCCCCCEEEEEEHHCCCCCCCEEEEECCCCEEEEEEEECC
EPHFERSFEVARQYRFLKGSGIPIRIPVIEMVEIGAGGGSIASVDAMQRVQVGPASAGSE
CCHHHHHHHHHHHHHHHCCCCCEEEEEHEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCC
PGPACYGRGGANGTVTDANLLLGRLQADRFAGGKMQLDTNASAAALQASVGRALSLDAAT
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCEEECHHHH
AALGVIEVVEENMANAARVHAVERGRELANRVMIAFGGAAPIHAARLAEKLDIATVIVPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHCCEEEEEEEC
GAGVGSAFGFLLAPIAYEVVRTRHVRLDDGFDPAPLNALRSEMRKEAEDVVRLGAPTAEL
CCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
VEGWSASMRYRGQGHELTVTIPASDFTAGSVAELERLFLADYEQQFGRRIPDLDVEILGW
HCCCCCCEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
SLRLATVSPPILPCPPMPSGTAAEPAAHVDVVAPQTGKTESIALHTRRDLVPGAIVAGPA
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEHHHCCCCCCCCCCCE
LIVEDETTTMVTHRYTARIDALGSIVMTRT
EEEECCCEEEEEEEHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]