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The map label for this gene is livH [H]

Identifier: 86751525

GI number: 86751525

Start: 5013159

End: 5014046

Strand: Direct

Name: livH [H]

Synonym: RPB_4424

Alternate gene names: 86751525

Gene position: 5013159-5014046 (Clockwise)

Preceding gene: 86751505

Following gene: 86751526

Centisome position: 94.03

GC content: 63.63

Gene sequence:

>888_bases
ATGGAAGTCAGCGCGACATATCTGCTGCAACTACTTATGAACGGCCTGATGCTCGGCCTGATCTACGCGTTGATCGCGGT
GGGCCTGGCACTGATCTTCGGTGTGCTCGAGGTGATCAACTTCGCCCATGGCGAGCTGTTGATGCTCGGCGGTTACGCCA
TGGCGCTGACTCTGCCGCTGGTCGGCCTGTCGTATTGGCCCTCGCTGCTGGTCGCCGTGATCGTGACTTCGCTGGTCGGC
GTCGTGCTCTACGAAGTCTTCTTGCGTCACATCGGCCAGAAGGAATTCGAGCGCAGCATCCTGACCACGCTCGGCATCTC
GATGATCCTGCTTTACGGCATGCAGTACCTGTTCACGGCGACGCCGATGATGGTGGACACCGCCTACGGGTTCGACGGTG
TCCAGATCGGCTCGATCCGCATCACGCTGACCCGCCTGATCGCCGGCGCGCTGTCGGTCGCCGCCTTCACGGGTCTTTAT
TGTCTGCTGAGATTCACCCAGTTCGGCCGCGCCATGCGGGCCATCGCCCAGAACCGCGAAGCCGCGCTGATGGTCGGCAT
CAAGCCGCGCCACGTCGCCCGCAATGCCGTCGCGCTCGCCGCCGCCTTGTGCGGCCTCGCCGGTGCTGCACTGGCGCCGA
TCCAGCTGCTGCACCCGGCGATGGGCCAGGCGATGATCTTCAAGGCTTTCGCTCTGGTCGTCATCGGCGGCCTCGGCAAC
ATGACCGGCGCCGTCGTGGTCGCCATCGCGCTCGGCATGATCGAGAGCTGGATCGGCGGCTTCTTCAGCATCGTCTGGCA
AGAAGGCGCGATCTTCGTGATCATGATCGTCGCGGTGTTGCTCCGTCCGGACGGACTTTTCAAGCGCGGGAGCATGCGCG
TCGGATGA

Upstream 100 bases:

>100_bases
GTTCATTGGCAAATTGACGCGCCGATCCCGCTCCCCTAGATTGACCGGAACGGTGTTCTCTTTATCGAAACACTTGTCGA
GACGTCAGACGCGGGATGCA

Downstream 100 bases:

>100_bases
CCGAGCCCCGCTGGACTCCCTACGCCGTTCTCGTCGCGATCGCCCTGCTGGCGGCGCTGCCTTTGATGACCGGTTCCAAC
TACATCGTCGGCATCGCGAT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MEVSATYLLQLLMNGLMLGLIYALIAVGLALIFGVLEVINFAHGELLMLGGYAMALTLPLVGLSYWPSLLVAVIVTSLVG
VVLYEVFLRHIGQKEFERSILTTLGISMILLYGMQYLFTATPMMVDTAYGFDGVQIGSIRITLTRLIAGALSVAAFTGLY
CLLRFTQFGRAMRAIAQNREAALMVGIKPRHVARNAVALAAALCGLAGAALAPIQLLHPAMGQAMIFKAFALVVIGGLGN
MTGAVVVAIALGMIESWIGGFFSIVWQEGAIFVIMIVAVLLRPDGLFKRGSMRVG

Sequences:

>Translated_295_residues
MEVSATYLLQLLMNGLMLGLIYALIAVGLALIFGVLEVINFAHGELLMLGGYAMALTLPLVGLSYWPSLLVAVIVTSLVG
VVLYEVFLRHIGQKEFERSILTTLGISMILLYGMQYLFTATPMMVDTAYGFDGVQIGSIRITLTRLIAGALSVAAFTGLY
CLLRFTQFGRAMRAIAQNREAALMVGIKPRHVARNAVALAAALCGLAGAALAPIQLLHPAMGQAMIFKAFALVVIGGLGN
MTGAVVVAIALGMIESWIGGFFSIVWQEGAIFVIMIVAVLLRPDGLFKRGSMRVG
>Mature_295_residues
MEVSATYLLQLLMNGLMLGLIYALIAVGLALIFGVLEVINFAHGELLMLGGYAMALTLPLVGLSYWPSLLVAVIVTSLVG
VVLYEVFLRHIGQKEFERSILTTLGISMILLYGMQYLFTATPMMVDTAYGFDGVQIGSIRITLTRLIAGALSVAAFTGLY
CLLRFTQFGRAMRAIAQNREAALMVGIKPRHVARNAVALAAALCGLAGAALAPIQLLHPAMGQAMIFKAFALVVIGGLGN
MTGAVVVAIALGMIESWIGGFFSIVWQEGAIFVIMIVAVLLRPDGLFKRGSMRVG

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=301, Percent_Identity=27.5747508305648, Blast_Score=91, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31472; Mature: 31472

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVSATYLLQLLMNGLMLGLIYALIAVGLALIFGVLEVINFAHGELLMLGGYAMALTLPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
VGLSYWPSLLVAVIVTSLVGVVLYEVFLRHIGQKEFERSILTTLGISMILLYGMQYLFTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPMMVDTAYGFDGVQIGSIRITLTRLIAGALSVAAFTGLYCLLRFTQFGRAMRAIAQNRE
CHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AALMVGIKPRHVARNAVALAAALCGLAGAALAPIQLLHPAMGQAMIFKAFALVVIGGLGN
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MTGAVVVAIALGMIESWIGGFFSIVWQEGAIFVIMIVAVLLRPDGLFKRGSMRVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MEVSATYLLQLLMNGLMLGLIYALIAVGLALIFGVLEVINFAHGELLMLGGYAMALTLPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
VGLSYWPSLLVAVIVTSLVGVVLYEVFLRHIGQKEFERSILTTLGISMILLYGMQYLFTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPMMVDTAYGFDGVQIGSIRITLTRLIAGALSVAAFTGLYCLLRFTQFGRAMRAIAQNRE
CHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AALMVGIKPRHVARNAVALAAALCGLAGAALAPIQLLHPAMGQAMIFKAFALVVIGGLGN
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MTGAVVVAIALGMIESWIGGFFSIVWQEGAIFVIMIVAVLLRPDGLFKRGSMRVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]