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The map label for this gene is bioF [H]

Identifier: 86751446

GI number: 86751446

Start: 4928765

End: 4929895

Strand: Reverse

Name: bioF [H]

Synonym: RPB_4344

Alternate gene names: 86751446

Gene position: 4929895-4928765 (Counterclockwise)

Preceding gene: 86751447

Following gene: 86751445

Centisome position: 92.46

GC content: 71.35

Gene sequence:

>1131_bases
ATGCATGAAGCATTCGAGTCGGACCTGCGCGAACTCGCGGGCCGGGGGCGGCTGCGCACGTTACGCGAGCGTTCGGGAAT
CGACTTCACCTCGAACGATTATCTCGGACTCGCCGAATCCGACGAGTTGCAGCGCGCGGCGGCCGCCGCGGTGGCGCGGG
GGGTGCCGGTGGGGTCGGGCGGCTCGCGGCTGCTGCGCGGCAATCATCCCGAGCACGAGGCGCTCGAGACCGAGGCCGCG
GCGTTCTTCGGCGCCGAGACGGCGCTGTATTTCGGCGGCGGCTATGTGGCCAATCTGGCGCTGTTCGCGACGCTGCCGCA
GCGTGGCGATCTGGTCGTCCACGACGAACTGATCCATGCCAGCGCCCATGAGGGGATGCGCAGGACGCGCGCCGAATGCG
TCAGCGTGGCGCACAACGATACGGACGCGTTCGACGCCGCGATCAAGCGCTGGCGCGCGGCCGGCGGCAAGGGCCGGCCA
TGGCTCGCGGTCGAGAGCCTCTACAGCATGGACGGCGACAGCCCCGATCTCGCCGCGCTGATGGCGGTCGCCGACCGCCA
CGACGCGATGATGGTGATCGACGAGGCGCATGCCACCGGCGTGCTCGGGCCGCAGGGCCGTGGGCTTGCCGCCACCTTCG
AGGGTCGCGACAACGTCGTCACGCTGCACACCTGCGGCAAGGCGCTCGGCACCGTCGGCGGCTTCATCCTGGCGCGGCGC
TCGATCCGGGATTTCCTCGTCAACCGCGCCCGGCCTTTCATTTTCGCGACCGCGCCGTCGCCGCTGGTCGCGGCGATCAC
GCGCGCGGCGATCGAATTGTCGCGCACCAATCCCGAGCGGCGTGAGCGGCTCGCGCGGCTGGTGCAGTTCGCCGGCGGCG
AGCTTCGCCGCCGCTGCGGCATCGCGCCGTCCGGGTCGCAGATCCTGCCGGTGATCATCGGCGCCGACACCGCCGCGGTC
GCGGTCGCGGCCTCGTTGCAGAGCCGCGGGTTCGATGTCCGCGCGATCCGCCCGCCGACCGTGCCCGAAGGCACCGCGCG
GCTGCGCATCGCGCTCACCGCCAATGTCGGCGAGGCGACGATCGCGGATCTGTTTGCGGCGATCGCCGAAGACATGCGGA
AGGCGGCATGA

Upstream 100 bases:

>100_bases
CACGACCGATCATCAGCGCCGGCGCTGCGGACCACGACAGCAGCAAAGCCGAACGTGTCGCTCACGGGTCGAAGCCGCGT
CCGACAGAGAGACGATCACC

Downstream 100 bases:

>100_bases
CCAAGCCCATCGTCGTCACCGGCACCGACACCGGCATCGGCAAGACCGTGTTCGCCGCTGCGCTCGCCGGCGCGCTCGAT
GCTTTCTACTGGAAGCCGGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MHEAFESDLRELAGRGRLRTLRERSGIDFTSNDYLGLAESDELQRAAAAAVARGVPVGSGGSRLLRGNHPEHEALETEAA
AFFGAETALYFGGGYVANLALFATLPQRGDLVVHDELIHASAHEGMRRTRAECVSVAHNDTDAFDAAIKRWRAAGGKGRP
WLAVESLYSMDGDSPDLAALMAVADRHDAMMVIDEAHATGVLGPQGRGLAATFEGRDNVVTLHTCGKALGTVGGFILARR
SIRDFLVNRARPFIFATAPSPLVAAITRAAIELSRTNPERRERLARLVQFAGGELRRRCGIAPSGSQILPVIIGADTAAV
AVAASLQSRGFDVRAIRPPTVPEGTARLRIALTANVGEATIADLFAAIAEDMRKAA

Sequences:

>Translated_376_residues
MHEAFESDLRELAGRGRLRTLRERSGIDFTSNDYLGLAESDELQRAAAAAVARGVPVGSGGSRLLRGNHPEHEALETEAA
AFFGAETALYFGGGYVANLALFATLPQRGDLVVHDELIHASAHEGMRRTRAECVSVAHNDTDAFDAAIKRWRAAGGKGRP
WLAVESLYSMDGDSPDLAALMAVADRHDAMMVIDEAHATGVLGPQGRGLAATFEGRDNVVTLHTCGKALGTVGGFILARR
SIRDFLVNRARPFIFATAPSPLVAAITRAAIELSRTNPERRERLARLVQFAGGELRRRCGIAPSGSQILPVIIGADTAAV
AVAASLQSRGFDVRAIRPPTVPEGTARLRIALTANVGEATIADLFAAIAEDMRKAA
>Mature_376_residues
MHEAFESDLRELAGRGRLRTLRERSGIDFTSNDYLGLAESDELQRAAAAAVARGVPVGSGGSRLLRGNHPEHEALETEAA
AFFGAETALYFGGGYVANLALFATLPQRGDLVVHDELIHASAHEGMRRTRAECVSVAHNDTDAFDAAIKRWRAAGGKGRP
WLAVESLYSMDGDSPDLAALMAVADRHDAMMVIDEAHATGVLGPQGRGLAATFEGRDNVVTLHTCGKALGTVGGFILARR
SIRDFLVNRARPFIFATAPSPLVAAITRAAIELSRTNPERRERLARLVQFAGGELRRRCGIAPSGSQILPVIIGADTAAV
AVAASLQSRGFDVRAIRPPTVPEGTARLRIALTANVGEATIADLFAAIAEDMRKAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=361, Percent_Identity=32.1329639889197, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI7657118, Length=349, Percent_Identity=31.5186246418338, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI83977444, Length=349, Percent_Identity=29.7994269340974, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI83977440, Length=349, Percent_Identity=29.7994269340974, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI83977442, Length=349, Percent_Identity=29.7994269340974, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4758668, Length=348, Percent_Identity=28.448275862069, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI119220554, Length=348, Percent_Identity=26.7241379310345, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI4502025, Length=339, Percent_Identity=30.6784660766962, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI40316939, Length=339, Percent_Identity=30.6784660766962, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI5454084, Length=264, Percent_Identity=25.7575757575758, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1786993, Length=344, Percent_Identity=36.6279069767442, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1790046, Length=335, Percent_Identity=34.3283582089552, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=365, Percent_Identity=29.3150684931507, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI32566772, Length=352, Percent_Identity=28.125, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560914, Length=347, Percent_Identity=25.0720461095101, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17560912, Length=347, Percent_Identity=24.7838616714697, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71982617, Length=244, Percent_Identity=25, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982625, Length=244, Percent_Identity=25, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320438, Length=355, Percent_Identity=32.9577464788732, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320267, Length=361, Percent_Identity=28.2548476454294, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=230, Percent_Identity=23.4782608695652, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24662918, Length=346, Percent_Identity=29.1907514450867, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17137420, Length=359, Percent_Identity=30.9192200557103, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17136286, Length=358, Percent_Identity=25.6983240223464, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653280, Length=294, Percent_Identity=24.8299319727891, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24653276, Length=294, Percent_Identity=24.8299319727891, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24653278, Length=294, Percent_Identity=24.8299319727891, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 39976; Mature: 39976

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEAFESDLRELAGRGRLRTLRERSGIDFTSNDYLGLAESDELQRAAAAAVARGVPVGSG
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GSRLLRGNHPEHEALETEAAAFFGAETALYFGGGYVANLALFATLPQRGDLVVHDELIHA
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHH
SAHEGMRRTRAECVSVAHNDTDAFDAAIKRWRAAGGKGRPWLAVESLYSMDGDSPDLAAL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHH
MAVADRHDAMMVIDEAHATGVLGPQGRGLAATFEGRDNVVTLHTCGKALGTVGGFILARR
HHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHH
SIRDFLVNRARPFIFATAPSPLVAAITRAAIELSRTNPERRERLARLVQFAGGELRRRCG
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHCC
IAPSGSQILPVIIGADTAAVAVAASLQSRGFDVRAIRPPTVPEGTARLRIALTANVGEAT
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEECCCHHH
IADLFAAIAEDMRKAA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHEAFESDLRELAGRGRLRTLRERSGIDFTSNDYLGLAESDELQRAAAAAVARGVPVGSG
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GSRLLRGNHPEHEALETEAAAFFGAETALYFGGGYVANLALFATLPQRGDLVVHDELIHA
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHH
SAHEGMRRTRAECVSVAHNDTDAFDAAIKRWRAAGGKGRPWLAVESLYSMDGDSPDLAAL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHH
MAVADRHDAMMVIDEAHATGVLGPQGRGLAATFEGRDNVVTLHTCGKALGTVGGFILARR
HHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHH
SIRDFLVNRARPFIFATAPSPLVAAITRAAIELSRTNPERRERLARLVQFAGGELRRRCG
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHCC
IAPSGSQILPVIIGADTAAVAVAASLQSRGFDVRAIRPPTVPEGTARLRIALTANVGEAT
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEECCCHHH
IADLFAAIAEDMRKAA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA