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The map label for this gene is ubiB [C]

Identifier: 86751424

GI number: 86751424

Start: 4905011

End: 4906411

Strand: Reverse

Name: ubiB [C]

Synonym: RPB_4322

Alternate gene names: 86751424

Gene position: 4906411-4905011 (Counterclockwise)

Preceding gene: 86751425

Following gene: 86751423

Centisome position: 92.02

GC content: 69.09

Gene sequence:

>1401_bases
ATGGGGCTGGTTTCGGCTTCGTTCCGCGCCATCTGCACCCCGCCTGCCCCGAAGGGAGACCCCGTGCCGCATCGGACGAT
CGAGAGGCGAGCCTTCGAGCGGAGAGCGTTGGCCGTGCCCAGTTCGCGGCTGTCGCGGCTGGCGCAATTGGGCGGGCTGG
CCTCGTCCATTGCCGGCAACGTCGCTGCCGAGGTGGTGGGGCAACTCGCGCGCGGCCAGCGCCCGCGGATGGAAGACCTG
CTGCTCACGCCGTCCAATGCGCTGAAGGTGGCCGACAGGCTGGCGCAGATGCGCGGGGCGGCGATGAAGGTCGGCCAGCT
GATCTCGATGGATGCCGGCGACATGCTGCCGCCCGAGCTCGCCGACATCCTCGGCCGGCTGCGCTCGGAAGCGCATCACA
TGCCGCTCATGCAGCTCAGGCGGGTGCTGACCGAGGCCTGGGGGCGCGACTGGCAGCGCCGGTTCGAGGTGTTCGACGCC
CACCCGGTCGCCGCGGCCTCGATCGGTCAGGTCCACCGGGTGCGCACCACGGACGGCCGCGACCTCGCGATCAAGGTGCA
ATATCCCGGCGTGCGCCGCAGCATCGATTCCGACGTGAACAACGTCGCCTCGCTGATGCGCATGGCCGGCCTGGTGCCCA
AGGGCGTCGACGTCGCGCCGATGATCGCCGAGGCCAAGCGGCAGTTGCACGAGGAGGCCGACTACCAGCGGGAAGGCCGA
TGCCTGTCGACATTCGGCGCGCTGCTCGCCGATCGGCCCGAATTTCGCGTGCCCGAGCTGCACGCCGACCTGACGACGCC
GAACGTGCTGGCGATGAGTTACGTCGAGGGCGTGCCGGTGGACAACCTCGCCGACGCGCCGCAGGCCGAGCGCGATCGGG
TGATGACGCTGATGATCGGCCTGATTTTCCGCGAGCTGTTCGAATTCCGGCTGATGCAGACTGATCCGAACTTCGCCAAT
TATCGCTATTCGCCGGCGACCGGGCAGGTGATGCTGCTCGACTTCGGCGCCACCCGCGCCTTCCCGGAGGATTTCGCCGA
CCTCTACCGGCGGCTGTTGCGCGCCGGGCTGGCCGGCGACCGTCCGGGCGTCCGCGCCGCCGCGCTCGAGATCGGCTTCC
TCGCCGGCGACACGCCCGCCCGGCTGGAACAGGCGATGCTTGAGATCTTCGAAATGTCGCTCGAGCCGCTGCGGCAGGAC
GGGCCGTTCGACTTCGGCGCCAGCGACCTCGCGGTGCAGATGCGCGAAGCCGGCATGGCGATGGCCCAGGACCATACGTA
TTTCCGCATCCCCCCGATGGACACGCTGTTTCTGCAGCGCAAATTCGGCGGCATCTACATGCTGGCGACGCGGATGCGGG
CGCGTGTCGACCTGCGCGCCATCGTCGAGCCGCATCTGTGA

Upstream 100 bases:

>100_bases
CCACGCTATCGCACGCGCGCACTGACGCTCGCTGACCGCCGCCGGTGGTGACATCGTCACAGACGGCGAGGCCGCGTCAG
CAGAAACGGGGTATGCGGCT

Downstream 100 bases:

>100_bases
CCGCCCGGCTGGAAGGACCCGCGATGGCTGCGATCCATCAGGTGAAATTCTGGGACAAGGTCGCCGACCGCTACGCGGCG
CGGCCGATCAAGGACCCGGC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGLVSASFRAICTPPAPKGDPVPHRTIERRAFERRALAVPSSRLSRLAQLGGLASSIAGNVAAEVVGQLARGQRPRMEDL
LLTPSNALKVADRLAQMRGAAMKVGQLISMDAGDMLPPELADILGRLRSEAHHMPLMQLRRVLTEAWGRDWQRRFEVFDA
HPVAAASIGQVHRVRTTDGRDLAIKVQYPGVRRSIDSDVNNVASLMRMAGLVPKGVDVAPMIAEAKRQLHEEADYQREGR
CLSTFGALLADRPEFRVPELHADLTTPNVLAMSYVEGVPVDNLADAPQAERDRVMTLMIGLIFRELFEFRLMQTDPNFAN
YRYSPATGQVMLLDFGATRAFPEDFADLYRRLLRAGLAGDRPGVRAAALEIGFLAGDTPARLEQAMLEIFEMSLEPLRQD
GPFDFGASDLAVQMREAGMAMAQDHTYFRIPPMDTLFLQRKFGGIYMLATRMRARVDLRAIVEPHL

Sequences:

>Translated_466_residues
MGLVSASFRAICTPPAPKGDPVPHRTIERRAFERRALAVPSSRLSRLAQLGGLASSIAGNVAAEVVGQLARGQRPRMEDL
LLTPSNALKVADRLAQMRGAAMKVGQLISMDAGDMLPPELADILGRLRSEAHHMPLMQLRRVLTEAWGRDWQRRFEVFDA
HPVAAASIGQVHRVRTTDGRDLAIKVQYPGVRRSIDSDVNNVASLMRMAGLVPKGVDVAPMIAEAKRQLHEEADYQREGR
CLSTFGALLADRPEFRVPELHADLTTPNVLAMSYVEGVPVDNLADAPQAERDRVMTLMIGLIFRELFEFRLMQTDPNFAN
YRYSPATGQVMLLDFGATRAFPEDFADLYRRLLRAGLAGDRPGVRAAALEIGFLAGDTPARLEQAMLEIFEMSLEPLRQD
GPFDFGASDLAVQMREAGMAMAQDHTYFRIPPMDTLFLQRKFGGIYMLATRMRARVDLRAIVEPHL
>Mature_465_residues
GLVSASFRAICTPPAPKGDPVPHRTIERRAFERRALAVPSSRLSRLAQLGGLASSIAGNVAAEVVGQLARGQRPRMEDLL
LTPSNALKVADRLAQMRGAAMKVGQLISMDAGDMLPPELADILGRLRSEAHHMPLMQLRRVLTEAWGRDWQRRFEVFDAH
PVAAASIGQVHRVRTTDGRDLAIKVQYPGVRRSIDSDVNNVASLMRMAGLVPKGVDVAPMIAEAKRQLHEEADYQREGRC
LSTFGALLADRPEFRVPELHADLTTPNVLAMSYVEGVPVDNLADAPQAERDRVMTLMIGLIFRELFEFRLMQTDPNFANY
RYSPATGQVMLLDFGATRAFPEDFADLYRRLLRAGLAGDRPGVRAAALEIGFLAGDTPARLEQAMLEIFEMSLEPLRQDG
PFDFGASDLAVQMREAGMAMAQDHTYFRIPPMDTLFLQRKFGGIYMLATRMRARVDLRAIVEPHL

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=445, Percent_Identity=37.9775280898876, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI27363457, Length=454, Percent_Identity=36.784140969163, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI217416386, Length=368, Percent_Identity=36.6847826086957, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI40254938, Length=314, Percent_Identity=30.5732484076433, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI217035081, Length=232, Percent_Identity=30.1724137931034, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI41393593, Length=252, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI2367309, Length=284, Percent_Identity=24.2957746478873, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI32565180, Length=430, Percent_Identity=36.9767441860465, Blast_Score=304, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17559152, Length=281, Percent_Identity=27.4021352313167, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=449, Percent_Identity=37.4164810690423, Blast_Score=321, Evalue=2e-88,
Organism=Drosophila melanogaster, GI18859849, Length=423, Percent_Identity=37.3522458628842, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI22024280, Length=303, Percent_Identity=25.7425742574257, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24662575, Length=301, Percent_Identity=23.2558139534884, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 51680; Mature: 51548

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLVSASFRAICTPPAPKGDPVPHRTIERRAFERRALAVPSSRLSRLAQLGGLASSIAGN
CCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHH
VAAEVVGQLARGQRPRMEDLLLTPSNALKVADRLAQMRGAAMKVGQLISMDAGDMLPPEL
HHHHHHHHHHCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
ADILGRLRSEAHHMPLMQLRRVLTEAWGRDWQRRFEVFDAHPVAAASIGQVHRVRTTDGR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCC
DLAIKVQYPGVRRSIDSDVNNVASLMRMAGLVPKGVDVAPMIAEAKRQLHEEADYQREGR
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCC
CLSTFGALLADRPEFRVPELHADLTTPNVLAMSYVEGVPVDNLADAPQAERDRVMTLMIG
HHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LIFRELFEFRLMQTDPNFANYRYSPATGQVMLLDFGATRAFPEDFADLYRRLLRAGLAGD
HHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
RPGVRAAALEIGFLAGDTPARLEQAMLEIFEMSLEPLRQDGPFDFGASDLAVQMREAGMA
CCCCEEHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHH
MAQDHTYFRIPPMDTLFLQRKFGGIYMLATRMRARVDLRAIVEPHL
HHCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GLVSASFRAICTPPAPKGDPVPHRTIERRAFERRALAVPSSRLSRLAQLGGLASSIAGN
CCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHH
VAAEVVGQLARGQRPRMEDLLLTPSNALKVADRLAQMRGAAMKVGQLISMDAGDMLPPEL
HHHHHHHHHHCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
ADILGRLRSEAHHMPLMQLRRVLTEAWGRDWQRRFEVFDAHPVAAASIGQVHRVRTTDGR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCC
DLAIKVQYPGVRRSIDSDVNNVASLMRMAGLVPKGVDVAPMIAEAKRQLHEEADYQREGR
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCC
CLSTFGALLADRPEFRVPELHADLTTPNVLAMSYVEGVPVDNLADAPQAERDRVMTLMIG
HHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LIFRELFEFRLMQTDPNFANYRYSPATGQVMLLDFGATRAFPEDFADLYRRLLRAGLAGD
HHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
RPGVRAAALEIGFLAGDTPARLEQAMLEIFEMSLEPLRQDGPFDFGASDLAVQMREAGMA
CCCCEEHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHH
MAQDHTYFRIPPMDTLFLQRKFGGIYMLATRMRARVDLRAIVEPHL
HHCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]