Click here to switch to the map view.

The map label for this gene is ywrD [H]

Identifier: 86751333

GI number: 86751333

Start: 4803264

End: 4804850

Strand: Reverse

Name: ywrD [H]

Synonym: RPB_4227

Alternate gene names: 86751333

Gene position: 4804850-4803264 (Counterclockwise)

Preceding gene: 86751335

Following gene: 86751332

Centisome position: 90.12

GC content: 67.11

Gene sequence:

>1587_bases
ATGAGGAATTTCCACTTCGCCGGCCGGTCCACGGTCCATGCCCGCAATGCCATGGTGGCGACCTCGCATCCGCAGGCGGC
GCTCGCCGCGATCGAGATTCTGCAGGCCGGCGGCACCGCGGCCGACGCCGCGATCGCGGCCTCCGCGCTGCTGGCGGTGA
TCGAACCGCAATCGACCGGCATCGGCGGCGACTGCTTCGCGCTGTACCAGCCCAAAGGCACCGGCAAAATCGTCGCCTAT
AACGGCTCCGGCCGGGCGCCGGCGGCCGCCAAGGCCGAGTGGTTTCTGGAACGCGGCATCGACGCCATTCCGCTGACCAG
CCCGCATTCGGTGACGATCCCCGGCGCCATCGATGCCTGGGCGACGATCCTGCGCGACCACGGCCGGTTCGGCTTCGACA
AATTGCTGCAGCCGGCGATCAAGGCGGCGGCCGAAGGCTACGTGGTGGCGCCGCGGGTCGCGTTCGACTGGAAGAACGGC
TTTGCGAAGCTGAAGAAGGGCCACAACACCGAGCGCTATCTGCTGCCGAACGGCGAGGCCGCTGTGACCGGCGACGTCAT
CAAGCAGCCGGAGCTGGCGCAGACGCTGCGCCTGATCGCCGACAACGGACCGGATGCGTTCTACAAGGGCTCGGTCGCCG
AGGATATGGTCGAGACGCTGCGCGGGCTCGGCGGCCTGCACACGCTGGAGGATTTCGCCGGCCACACCACCGAAACCACG
TCGCCGCTCGGCACCCTCTACAAGGGCTTCGACGTCTGGCAGTGCCCGCCGAACGGTCCGGGCATCACCATGCTGGTGAT
GCTGAACATCCTCAGCCGGTTCGATCTGACGAAGTTCGGCCCGCTCAGCGTCGAGCGCTTCCATCTCGAAGCGGAAGCGG
CGCGGATCGCCTATATGATGCGCGAGCTTCACATCGGCGACCCCGGCCATGTCGAAGTCGACGTCATCCGCATTCTGGCG
CGCGACTTCGCCGAGGAGCATTTCAGCAAGATCGCGCTCGACAAGATCCTGGACCTGCCGAAGGTGTCGCCGCCGATGAA
CCCGTCGACGGTGTACATCACCGTGGTCGACGAAGACCGCAACGTCTGTTCGTTCATCAACTCGATCGCGCATTCGTTCG
GGTCGGCGATCGTCACCGACAAGACCGGCATCCTGCTGCAGAATCGCGGCGCCGGCTTCCGCATTCAGCCCGGCCATCCG
AACTGCATCGCGCCGAACAAGCGGCCGTTGCACACCATCATCCCGGCGCTCGCCACCGAGAACGGCCGGGCGCGGATGTC
GTTCGGCGTGATGGGCGGCCAGTACCAGCCGGTCGGTCAGGTCCGCGTGCTGACCAACATGCTCGACTACGGGCTCGACG
TGCAGGAGGCGATCGATCTGCCGCGCGGCTTGCACTACGAGAACATCTATCAGCTCGAGGAGGGCGTGCCCGCCGCGACG
GTCGAGGGCCTGAAGGCGCTCGGCCATCAGGTCGCGCCGATCGGCCCGCCGCACGGTGGCGGCCAGGCGATCTGGATCGA
CTGGGAGAAGGGAACGCTCACCGGCGGCTCGGACCCGCGCAAGGACGGCTGCGCGCTGGGCTACTGA

Upstream 100 bases:

>100_bases
GGCGCAAGGCATGCAGTGGCGAGGATTGCCCCCGCCCGCCGGAATATGCCAATTAGGCCGGCGCCGAAGTGCGGCGCGGT
GAACCAATGAGCTTGTTCCC

Downstream 100 bases:

>100_bases
GGGTCGAGGCCAGCGCCGCTGGCCTCGCTCCTTCCACCACGAGAATAACCACCGCAACGGGAGCTTGCGCCGCGTGAAAG
TCGCCATTCTCGACGATTAC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MRNFHFAGRSTVHARNAMVATSHPQAALAAIEILQAGGTAADAAIAASALLAVIEPQSTGIGGDCFALYQPKGTGKIVAY
NGSGRAPAAAKAEWFLERGIDAIPLTSPHSVTIPGAIDAWATILRDHGRFGFDKLLQPAIKAAAEGYVVAPRVAFDWKNG
FAKLKKGHNTERYLLPNGEAAVTGDVIKQPELAQTLRLIADNGPDAFYKGSVAEDMVETLRGLGGLHTLEDFAGHTTETT
SPLGTLYKGFDVWQCPPNGPGITMLVMLNILSRFDLTKFGPLSVERFHLEAEAARIAYMMRELHIGDPGHVEVDVIRILA
RDFAEEHFSKIALDKILDLPKVSPPMNPSTVYITVVDEDRNVCSFINSIAHSFGSAIVTDKTGILLQNRGAGFRIQPGHP
NCIAPNKRPLHTIIPALATENGRARMSFGVMGGQYQPVGQVRVLTNMLDYGLDVQEAIDLPRGLHYENIYQLEEGVPAAT
VEGLKALGHQVAPIGPPHGGGQAIWIDWEKGTLTGGSDPRKDGCALGY

Sequences:

>Translated_528_residues
MRNFHFAGRSTVHARNAMVATSHPQAALAAIEILQAGGTAADAAIAASALLAVIEPQSTGIGGDCFALYQPKGTGKIVAY
NGSGRAPAAAKAEWFLERGIDAIPLTSPHSVTIPGAIDAWATILRDHGRFGFDKLLQPAIKAAAEGYVVAPRVAFDWKNG
FAKLKKGHNTERYLLPNGEAAVTGDVIKQPELAQTLRLIADNGPDAFYKGSVAEDMVETLRGLGGLHTLEDFAGHTTETT
SPLGTLYKGFDVWQCPPNGPGITMLVMLNILSRFDLTKFGPLSVERFHLEAEAARIAYMMRELHIGDPGHVEVDVIRILA
RDFAEEHFSKIALDKILDLPKVSPPMNPSTVYITVVDEDRNVCSFINSIAHSFGSAIVTDKTGILLQNRGAGFRIQPGHP
NCIAPNKRPLHTIIPALATENGRARMSFGVMGGQYQPVGQVRVLTNMLDYGLDVQEAIDLPRGLHYENIYQLEEGVPAAT
VEGLKALGHQVAPIGPPHGGGQAIWIDWEKGTLTGGSDPRKDGCALGY
>Mature_528_residues
MRNFHFAGRSTVHARNAMVATSHPQAALAAIEILQAGGTAADAAIAASALLAVIEPQSTGIGGDCFALYQPKGTGKIVAY
NGSGRAPAAAKAEWFLERGIDAIPLTSPHSVTIPGAIDAWATILRDHGRFGFDKLLQPAIKAAAEGYVVAPRVAFDWKNG
FAKLKKGHNTERYLLPNGEAAVTGDVIKQPELAQTLRLIADNGPDAFYKGSVAEDMVETLRGLGGLHTLEDFAGHTTETT
SPLGTLYKGFDVWQCPPNGPGITMLVMLNILSRFDLTKFGPLSVERFHLEAEAARIAYMMRELHIGDPGHVEVDVIRILA
RDFAEEHFSKIALDKILDLPKVSPPMNPSTVYITVVDEDRNVCSFINSIAHSFGSAIVTDKTGILLQNRGAGFRIQPGHP
NCIAPNKRPLHTIIPALATENGRARMSFGVMGGQYQPVGQVRVLTNMLDYGLDVQEAIDLPRGLHYENIYQLEEGVPAAT
VEGLKALGHQVAPIGPPHGGGQAIWIDWEKGTLTGGSDPRKDGCALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=542, Percent_Identity=28.2287822878229, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI73915090, Length=542, Percent_Identity=28.2287822878229, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI73915096, Length=542, Percent_Identity=28.2287822878229, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI73915094, Length=542, Percent_Identity=28.2287822878229, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI113429324, Length=544, Percent_Identity=27.0220588235294, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI113429326, Length=553, Percent_Identity=26.5822784810127, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI153266901, Length=539, Percent_Identity=26.1595547309833, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI153266885, Length=470, Percent_Identity=27.0212765957447, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI109148539, Length=504, Percent_Identity=25.9920634920635, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI153266907, Length=469, Percent_Identity=25.1599147121535, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1789856, Length=541, Percent_Identity=32.7171903881701, Blast_Score=265, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI212646519, Length=498, Percent_Identity=26.3052208835341, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI72000294, Length=498, Percent_Identity=25.9036144578313, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17506189, Length=492, Percent_Identity=26.0162601626016, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193208245, Length=560, Percent_Identity=25.3571428571429, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193208247, Length=560, Percent_Identity=25.3571428571429, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17542894, Length=491, Percent_Identity=27.4949083503055, Blast_Score=121, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323330, Length=511, Percent_Identity=21.7221135029354, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI18859893, Length=533, Percent_Identity=25.328330206379, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161077880, Length=527, Percent_Identity=25.426944971537, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI161077878, Length=527, Percent_Identity=25.426944971537, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45551474, Length=527, Percent_Identity=25.426944971537, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24642670, Length=527, Percent_Identity=25.426944971537, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24642666, Length=527, Percent_Identity=25.426944971537, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=24.5009074410163, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161077496, Length=488, Percent_Identity=25, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56635; Mature: 56635

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNFHFAGRSTVHARNAMVATSHPQAALAAIEILQAGGTAADAAIAASALLAVIEPQSTG
CCCCCCCCCCEEECCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCC
IGGDCFALYQPKGTGKIVAYNGSGRAPAAAKAEWFLERGIDAIPLTSPHSVTIPGAIDAW
CCCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHH
ATILRDHGRFGFDKLLQPAIKAAAEGYVVAPRVAFDWKNGFAKLKKGHNTERYLLPNGEA
HHHHHHCCCCCHHHHHHHHHHHHCCCEEEECEEEEECHHHHHHHHCCCCCCEEECCCCCC
AVTGDVIKQPELAQTLRLIADNGPDAFYKGSVAEDMVETLRGLGGLHTLEDFAGHTTETT
EEEHHHHCCCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
SPLGTLYKGFDVWQCPPNGPGITMLVMLNILSRFDLTKFGPLSVERFHLEAEAARIAYMM
CHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHH
RELHIGDPGHVEVDVIRILARDFAEEHFSKIALDKILDLPKVSPPMNPSTVYITVVDEDR
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCC
NVCSFINSIAHSFGSAIVTDKTGILLQNRGAGFRIQPGHPNCIAPNKRPLHTIIPALATE
HHHHHHHHHHHHHCCEEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCC
NGRARMSFGVMGGQYQPVGQVRVLTNMLDYGLDVQEAIDLPRGLHYENIYQLEEGVPAAT
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHCCCCHHH
VEGLKALGHQVAPIGPPHGGGQAIWIDWEKGTLTGGSDPRKDGCALGY
HHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRNFHFAGRSTVHARNAMVATSHPQAALAAIEILQAGGTAADAAIAASALLAVIEPQSTG
CCCCCCCCCCEEECCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCC
IGGDCFALYQPKGTGKIVAYNGSGRAPAAAKAEWFLERGIDAIPLTSPHSVTIPGAIDAW
CCCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHH
ATILRDHGRFGFDKLLQPAIKAAAEGYVVAPRVAFDWKNGFAKLKKGHNTERYLLPNGEA
HHHHHHCCCCCHHHHHHHHHHHHCCCEEEECEEEEECHHHHHHHHCCCCCCEEECCCCCC
AVTGDVIKQPELAQTLRLIADNGPDAFYKGSVAEDMVETLRGLGGLHTLEDFAGHTTETT
EEEHHHHCCCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
SPLGTLYKGFDVWQCPPNGPGITMLVMLNILSRFDLTKFGPLSVERFHLEAEAARIAYMM
CHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHH
RELHIGDPGHVEVDVIRILARDFAEEHFSKIALDKILDLPKVSPPMNPSTVYITVVDEDR
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCC
NVCSFINSIAHSFGSAIVTDKTGILLQNRGAGFRIQPGHPNCIAPNKRPLHTIIPALATE
HHHHHHHHHHHHHCCEEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCC
NGRARMSFGVMGGQYQPVGQVRVLTNMLDYGLDVQEAIDLPRGLHYENIYQLEEGVPAAT
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHCCCCHHH
VEGLKALGHQVAPIGPPHGGGQAIWIDWEKGTLTGGSDPRKDGCALGY
HHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]