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The map label for this gene is aceA [C]

Identifier: 86751306

GI number: 86751306

Start: 4770642

End: 4772279

Strand: Reverse

Name: aceA [C]

Synonym: RPB_4199

Alternate gene names: 86751306

Gene position: 4772279-4770642 (Counterclockwise)

Preceding gene: 86751317

Following gene: 86751305

Centisome position: 89.51

GC content: 62.76

Gene sequence:

>1638_bases
ATGAATTTCCAGCCGCGTGGGATCAGCGATCTGGCCGCCCAGAAGCCCGCCTCCTATCAGAGCCAAATCGAGGCGGCCGA
AGCGCTCCTCAAGGACCAGCCCACCTGGAACGGCGTCAAGGCCGAAGCTGTGGCCCGGATGCGCCTGCAGAACCGTTTCA
AGACCGGCCTCGACGTCGCGCGCTACACCGCCGCGCTGATGCGCGCCGACATGGCAGCCTATGACGCCGACAGCACCAAA
TATACCCAGTCGCTCGGCTGCTGGCACGGCTTCATCGCGCAGCAGAAGCTGATTTCGGTGAAGAAGCATTTCAACACCAC
CGATCGCACCTACCTGTATCTGTCCGGCTGGATGATCGCGGCGCTGCGCTCCGAATTCGGCCCGCTGCCCGACCAGTCGA
TGCACGAGAAGACCTCGGTGCCGGCGCTGATCGAAGAGCTCTACACCTTCCTGCGTCAGGCCGACGCCCGTGAGCTCAAC
ACGATTTTCCGCGACCTCGACGCCGCCCGCAAGGCCGGCGACAAGGCCAAGGAAACCGCGCTGATCGAAAAGATCGACAA
TTTCCAGACCCACGTCGTGCCGGTGATCGCCGACATCGACGCCGGCTTCGGCAATGCCGAGGCGACCTATCTGCTCGCCA
AGAAGATGATCGAGGCCGGCGCCTGCGCGCTGCAGATCGAGAACCAGGTGTCCGACGAAAAGCAGTGCGGCCATCAGGAC
GGCAAGGTGACGGTGCCGCACGAGGTCTTCCTGGCGAAGATCCGCGCCTGCCGCCACGCCTTCCTCGAACTCGGCGTCGA
AGATGGCATCATCGTCACCCGCACCGATTCGCTCGGCGCAGGCCTGACCCAGCAGATCGCCGTCAGCCATGCGCCCGGCG
ACATCGGCGACCAGTACAACAGCTTCCTGGATTGCGAAGAGGTCGACGTGACGTCGGTCGGTAATGGCGACGTCATCATC
AGCCGCGAGGGCAAGCTGCTGCGCCCGAAGCGTCTGCCCAGCAACCTGTACCAGTTCCGCGAAGGCACCGGTGCGGATCG
CTGCGTGCTCGACTGCATCACCTCGCTGCAGAACGGCGCCGACCTGCTGTGGATCGAGACCGAGAAGCCGAACATCGCGC
AGATCGCCTCGATGGTCGATCGGATCCGCGAAGTGATCCCGAACGCCAAGCTGGCCTACAACAACTCGCCGTCGTTCAAC
TGGACCCTCAACTTCCGTTGGCAGGTCTACGACGAGATGAAGGCGGCCGGTAAGGACGTCAGCCAGTACAATCGGGCCGA
GCTGATGAAGGCGGAATACGACGAGACGCCGCTGGCGAAGGAAGCCGACGAGAAGATCCGGACCTTCCAGGCCGATTCGG
CCAAGCGCGCCGGCATCTTCCATCATCTGATCACATTGCCGACCTATCACACGGCAGCGTTGTCGACCGACAATCTCGCC
AAGGAATATTTTGGCGAACAGGGCATGCTGGGGTATGTCAAGAACGTGCAGCGCCAGGAAATCCGTCAGGGGATCGCCTG
CGTCAAGCACCAGGACATGGCCGGCTCGAACATCGGCGACGACCACAAGGAATACTTCGCCGGCGAGGCCGCTTTGAAGG
CCGGCGGCGCCCACAACACGATGAACCAGTTCGGCTAA

Upstream 100 bases:

>100_bases
TTCCTCGACTAGCGTTTAGCTCTCAGCACGTTTCGCAACGCACTGTCACGAATGTCGATGGTGTCGTTGCGGCATAATTC
GTACCGAAGGGATCAACAGC

Downstream 100 bases:

>100_bases
CGACAACAACAGGAGCGACGACGATGTCGAACGGCAGCAATTTCTGGGTGATTGGCGGCGAGTTCGGTTCGATGAACTTC
CACAAGCTCGTTGAAGGTTC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MNFQPRGISDLAAQKPASYQSQIEAAEALLKDQPTWNGVKAEAVARMRLQNRFKTGLDVARYTAALMRADMAAYDADSTK
YTQSLGCWHGFIAQQKLISVKKHFNTTDRTYLYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADARELN
TIFRDLDAARKAGDKAKETALIEKIDNFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
GKVTVPHEVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAVSHAPGDIGDQYNSFLDCEEVDVTSVGNGDVII
SREGKLLRPKRLPSNLYQFREGTGADRCVLDCITSLQNGADLLWIETEKPNIAQIASMVDRIREVIPNAKLAYNNSPSFN
WTLNFRWQVYDEMKAAGKDVSQYNRAELMKAEYDETPLAKEADEKIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
KEYFGEQGMLGYVKNVQRQEIRQGIACVKHQDMAGSNIGDDHKEYFAGEAALKAGGAHNTMNQFG

Sequences:

>Translated_545_residues
MNFQPRGISDLAAQKPASYQSQIEAAEALLKDQPTWNGVKAEAVARMRLQNRFKTGLDVARYTAALMRADMAAYDADSTK
YTQSLGCWHGFIAQQKLISVKKHFNTTDRTYLYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADARELN
TIFRDLDAARKAGDKAKETALIEKIDNFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
GKVTVPHEVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAVSHAPGDIGDQYNSFLDCEEVDVTSVGNGDVII
SREGKLLRPKRLPSNLYQFREGTGADRCVLDCITSLQNGADLLWIETEKPNIAQIASMVDRIREVIPNAKLAYNNSPSFN
WTLNFRWQVYDEMKAAGKDVSQYNRAELMKAEYDETPLAKEADEKIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
KEYFGEQGMLGYVKNVQRQEIRQGIACVKHQDMAGSNIGDDHKEYFAGEAALKAGGAHNTMNQFG
>Mature_545_residues
MNFQPRGISDLAAQKPASYQSQIEAAEALLKDQPTWNGVKAEAVARMRLQNRFKTGLDVARYTAALMRADMAAYDADSTK
YTQSLGCWHGFIAQQKLISVKKHFNTTDRTYLYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADARELN
TIFRDLDAARKAGDKAKETALIEKIDNFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
GKVTVPHEVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAVSHAPGDIGDQYNSFLDCEEVDVTSVGNGDVII
SREGKLLRPKRLPSNLYQFREGTGADRCVLDCITSLQNGADLLWIETEKPNIAQIASMVDRIREVIPNAKLAYNNSPSFN
WTLNFRWQVYDEMKAAGKDVSQYNRAELMKAEYDETPLAKEADEKIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
KEYFGEQGMLGYVKNVQRQEIRQGIACVKHQDMAGSNIGDDHKEYFAGEAALKAGGAHNTMNQFG

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=496, Percent_Identity=27.4193548387097, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982926, Length=413, Percent_Identity=27.6029055690073, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17561814, Length=413, Percent_Identity=27.6029055690073, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320908, Length=496, Percent_Identity=25.4032258064516, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 60514; Mature: 60514

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQPRGISDLAAQKPASYQSQIEAAEALLKDQPTWNGVKAEAVARMRLQNRFKTGLDVA
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RYTAALMRADMAAYDADSTKYTQSLGCWHGFIAQQKLISVKKHFNTTDRTYLYLSGWMIA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHH
ALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADARELNTIFRDLDAARKAGDKAKETA
HHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHH
LIEKIDNFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
HHHHHHCCHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECHHCCHHHHCCCCC
GKVTVPHEVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAVSHAPGDIGDQYN
CCEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCHHHHH
SFLDCEEVDVTSVGNGDVIISREGKLLRPKRLPSNLYQFREGTGADRCVLDCITSLQNGA
HCCCCCCCCEEECCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCC
DLLWIETEKPNIAQIASMVDRIREVIPNAKLAYNNSPSFNWTLNFRWQVYDEMKAAGKDV
CEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEEEHHHHHHHCCCH
SQYNRAELMKAEYDETPLAKEADEKIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCHHHHH
KEYFGEQGMLGYVKNVQRQEIRQGIACVKHQDMAGSNIGDDHKEYFAGEAALKAGGAHNT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCH
MNQFG
HHHCC
>Mature Secondary Structure
MNFQPRGISDLAAQKPASYQSQIEAAEALLKDQPTWNGVKAEAVARMRLQNRFKTGLDVA
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RYTAALMRADMAAYDADSTKYTQSLGCWHGFIAQQKLISVKKHFNTTDRTYLYLSGWMIA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHH
ALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADARELNTIFRDLDAARKAGDKAKETA
HHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHH
LIEKIDNFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
HHHHHHCCHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECHHCCHHHHCCCCC
GKVTVPHEVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAVSHAPGDIGDQYN
CCEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCHHHHH
SFLDCEEVDVTSVGNGDVIISREGKLLRPKRLPSNLYQFREGTGADRCVLDCITSLQNGA
HCCCCCCCCEEECCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCC
DLLWIETEKPNIAQIASMVDRIREVIPNAKLAYNNSPSFNWTLNFRWQVYDEMKAAGKDV
CEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEEEHHHHHHHCCCH
SQYNRAELMKAEYDETPLAKEADEKIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCHHHHH
KEYFGEQGMLGYVKNVQRQEIRQGIACVKHQDMAGSNIGDDHKEYFAGEAALKAGGAHNT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCH
MNQFG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]