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The map label for this gene is envZ [H]

Identifier: 86751279

GI number: 86751279

Start: 4743086

End: 4744474

Strand: Reverse

Name: envZ [H]

Synonym: RPB_4172

Alternate gene names: 86751279

Gene position: 4744474-4743086 (Counterclockwise)

Preceding gene: 86751280

Following gene: 86751276

Centisome position: 88.99

GC content: 67.96

Gene sequence:

>1389_bases
ATGAGCACGCTCGCCACCGGCCTGACGCTGATCCGCTCCGCCAGGCGGCGGGTGTCGGCCGCCAATGGCTGGATGGGGCA
GCGCTTCAACGACTTCATGCCGAAGGGGCTGTACGCCCGCGCGCTGTTGATCATGATCGTGCCGATGGTGCTGCTGCAAT
CGGTGATCGCCTTCGTGTTCATGGAGCGGCACTGGAACACGGTGACGCAGCGGCTGTCGGCGGCGGTGGTGCAGGACATC
GCGGCGCTGATCGACGTCTACAAGAGCTACCCGCAGGACAAGGACAACGCCGCGCTGCGCCGGATCGCGCAGAACCGGCT
CGGTCTGGTGGTGGATTTCCTCGGCCCGAACGAGATGCCGCCGCCGGGCAGCAAGCCGTTCTTCTCGCTGCTCGATCAGT
CGATCAGCAAGCAGATCAGCAAGCAGATCGCGCGGCCGTTCTGGATCGACACCGTCGGCCGCTCCAATCTGGTCGAAATC
CGCATCCAGCTCGACGATGCGGTGATGCGGGTGTTCGCGCTGCGCAGCGCCGCCTACGCGTCGAATTCGGAAATCTTCCT
GTTGTGGATGGTCGGCACCTCGGCGGTGCTGCTGGTCGTCGCGGTGCTGTTCCTGCGCAACCAGATCCGGCCGATTCTGC
GGCTCGCCGACGCCGCCGAGAGCTTCGGCAAGGGCCGCGACGCGCCGAACTTCAAGCCGCGTGGCGCCCGCGAGGTGCGG
CGGGCGGCCTACGCCTTCATCGAGATGAAGACCCGCGTCGAGCGCTCGATCGAGCAGCGCACCGCGATGCTGGCCGGCGT
GTCTCACGATCTGCGCACCATCCTGACCCGGTTCAAGCTCGAACTCGAACTGATCGGCGACGCGCCGGAGACCGACGGCA
TGCGCAAGGACGTCGACGAGATGTCGGCGATGCTCGAGGCCTATCTCGCCTTCGCCCGTGGCGACAGCGGCGAGCGGGCG
CAGCCGACCGACATGGCGGCGGCGCTCGAGGAACTACGCAGCGACGCCGAGCGTCACGGCCACCGCGCCACTGTGGCGTT
CTCCGGCCAGCCGGTGGTGACGGTCAAGCCGGCGTCGTTCAAGCGCTGCCTCGCCAATCTGGTGTCGAACGCGGCGCGCC
ACGCCGACGCCATCGCCATCACCGGCCAGCGCGATCACCGCTATCTCACGGTGATGATCGACGACGACGGTCCCGGCATT
CCGATGGCGATGCGCGAGGAAGTGTTCAAGCCGTTCTTGCGGCTCGACGACGCCCGCAACCAGGACGAAGGCGGCACCGG
CCTCGGCCTTGCGATCGCCCGCGACATCGCCCGCTCGCATGGCGGCGACATCACGCTGGGCGACAGCCCGATGGGCGGCT
TGCGCGCGACGGTGCGGGTGCCGGTGTAG

Upstream 100 bases:

>100_bases
CCGCCTGCGCCGCAAGATCGAACGCGACCCGGCCAATCCGCTGTTCCTCCAGGCCGTCCGCGGCATCGGCTATCGCCTGG
TCGCGGCGCCGTAGCCAGCG

Downstream 100 bases:

>100_bases
GACGAAGCGATTCTGCACACACTGTCGTCATCACCCGCGCATGCGGGTGATCCAGTATTCCAGAGCGCACACGTCTATAA
CGACCACTCTGGAATACTGG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSTLATGLTLIRSARRRVSAANGWMGQRFNDFMPKGLYARALLIMIVPMVLLQSVIAFVFMERHWNTVTQRLSAAVVQDI
AALIDVYKSYPQDKDNAALRRIAQNRLGLVVDFLGPNEMPPPGSKPFFSLLDQSISKQISKQIARPFWIDTVGRSNLVEI
RIQLDDAVMRVFALRSAAYASNSEIFLLWMVGTSAVLLVVAVLFLRNQIRPILRLADAAESFGKGRDAPNFKPRGAREVR
RAAYAFIEMKTRVERSIEQRTAMLAGVSHDLRTILTRFKLELELIGDAPETDGMRKDVDEMSAMLEAYLAFARGDSGERA
QPTDMAAALEELRSDAERHGHRATVAFSGQPVVTVKPASFKRCLANLVSNAARHADAIAITGQRDHRYLTVMIDDDGPGI
PMAMREEVFKPFLRLDDARNQDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRATVRVPV

Sequences:

>Translated_462_residues
MSTLATGLTLIRSARRRVSAANGWMGQRFNDFMPKGLYARALLIMIVPMVLLQSVIAFVFMERHWNTVTQRLSAAVVQDI
AALIDVYKSYPQDKDNAALRRIAQNRLGLVVDFLGPNEMPPPGSKPFFSLLDQSISKQISKQIARPFWIDTVGRSNLVEI
RIQLDDAVMRVFALRSAAYASNSEIFLLWMVGTSAVLLVVAVLFLRNQIRPILRLADAAESFGKGRDAPNFKPRGAREVR
RAAYAFIEMKTRVERSIEQRTAMLAGVSHDLRTILTRFKLELELIGDAPETDGMRKDVDEMSAMLEAYLAFARGDSGERA
QPTDMAAALEELRSDAERHGHRATVAFSGQPVVTVKPASFKRCLANLVSNAARHADAIAITGQRDHRYLTVMIDDDGPGI
PMAMREEVFKPFLRLDDARNQDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRATVRVPV
>Mature_461_residues
STLATGLTLIRSARRRVSAANGWMGQRFNDFMPKGLYARALLIMIVPMVLLQSVIAFVFMERHWNTVTQRLSAAVVQDIA
ALIDVYKSYPQDKDNAALRRIAQNRLGLVVDFLGPNEMPPPGSKPFFSLLDQSISKQISKQIARPFWIDTVGRSNLVEIR
IQLDDAVMRVFALRSAAYASNSEIFLLWMVGTSAVLLVVAVLFLRNQIRPILRLADAAESFGKGRDAPNFKPRGAREVRR
AAYAFIEMKTRVERSIEQRTAMLAGVSHDLRTILTRFKLELELIGDAPETDGMRKDVDEMSAMLEAYLAFARGDSGERAQ
PTDMAAALEELRSDAERHGHRATVAFSGQPVVTVKPASFKRCLANLVSNAARHADAIAITGQRDHRYLTVMIDDDGPGIP
MAMREEVFKPFLRLDDARNQDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRATVRVPV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=38.0782918149466, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=31.4606741573034, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787894, Length=274, Percent_Identity=28.4671532846715, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=27.3722627737226, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=27.4247491638796, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787374, Length=293, Percent_Identity=26.6211604095563, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081816, Length=345, Percent_Identity=23.768115942029, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=26.1802575107296, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=27.0175438596491, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=273, Percent_Identity=27.4725274725275, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=24.2009132420091, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=245, Percent_Identity=24.4897959183673, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=25.9911894273128, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51061; Mature: 50930

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLATGLTLIRSARRRVSAANGWMGQRFNDFMPKGLYARALLIMIVPMVLLQSVIAFVF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MERHWNTVTQRLSAAVVQDIAALIDVYKSYPQDKDNAALRRIAQNRLGLVVDFLGPNEMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCEEEEECCCCCCC
PPGSKPFFSLLDQSISKQISKQIARPFWIDTVGRSNLVEIRIQLDDAVMRVFALRSAAYA
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHC
SNSEIFLLWMVGTSAVLLVVAVLFLRNQIRPILRLADAAESFGKGRDAPNFKPRGAREVR
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
RAAYAFIEMKTRVERSIEQRTAMLAGVSHDLRTILTRFKLELELIGDAPETDGMRKDVDE
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEECCCCCCCCHHCCHHH
MSAMLEAYLAFARGDSGERAQPTDMAAALEELRSDAERHGHRATVAFSGQPVVTVKPASF
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCHHH
KRCLANLVSNAARHADAIAITGQRDHRYLTVMIDDDGPGIPMAMREEVFKPFLRLDDARN
HHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
QDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRATVRVPV
CCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECC
>Mature Secondary Structure 
STLATGLTLIRSARRRVSAANGWMGQRFNDFMPKGLYARALLIMIVPMVLLQSVIAFVF
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MERHWNTVTQRLSAAVVQDIAALIDVYKSYPQDKDNAALRRIAQNRLGLVVDFLGPNEMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCEEEEECCCCCCC
PPGSKPFFSLLDQSISKQISKQIARPFWIDTVGRSNLVEIRIQLDDAVMRVFALRSAAYA
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHC
SNSEIFLLWMVGTSAVLLVVAVLFLRNQIRPILRLADAAESFGKGRDAPNFKPRGAREVR
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
RAAYAFIEMKTRVERSIEQRTAMLAGVSHDLRTILTRFKLELELIGDAPETDGMRKDVDE
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEECCCCCCCCHHCCHHH
MSAMLEAYLAFARGDSGERAQPTDMAAALEELRSDAERHGHRATVAFSGQPVVTVKPASF
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCHHH
KRCLANLVSNAARHADAIAITGQRDHRYLTVMIDDDGPGIPMAMREEVFKPFLRLDDARN
HHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
QDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRATVRVPV
CCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]