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The map label for this gene is resE [H]

Identifier: 86751212

GI number: 86751212

Start: 4673771

End: 4675444

Strand: Direct

Name: resE [H]

Synonym: RPB_4104

Alternate gene names: 86751212

Gene position: 4673771-4675444 (Clockwise)

Preceding gene: 86751210

Following gene: 86751213

Centisome position: 87.66

GC content: 61.95

Gene sequence:

>1674_bases
GTGCCCGAGCGGCTGATCGCCGACAAGCTGCGAACAGCGGAAGACGCACGGACCCAGCAAATCGGAACCGGCATCGAACT
GATCGCGCGCCGCAAGGACGGCAGCGAATTCCCGATCGAGATCATGTTGAGCCCGCTCGACAGTCCCGAAGGCGTCCTGG
TCACCGCTGCCATACGCGACATCTCGGAGCGTAAGGACGCGGAAAAGCACCTGGTGCAGATGGAGGGACGATACCAGGCG
CTGCTGGAGGCGGCGCCTGACGCGATGGTGGTGGTGAATCAAACCGGGGAGATCGTCCTGCTCAACCTGCAAGCGGAAAA
GCAGTTCGCCTATCGTCGCGACGAACTGCTCGGCCAGAAGGTGACGAACATCATCCCCGAAGGATTCGCCGAGCGGTTGA
TCGCCGACCGGTTACGATCCAGGGAAGATGCATTGGCCCAGCACATCGGCGCAGGAATCGAGCTCACCGGCCGGCGAAAG
GACGGCAGCGAATTTCCGATCGAGATCATGCTCAGCCCGCTGGAAAGCGAAGGCAGCATCCTGGTAACCGCCGCGATCCG
CGAGATCAGCGCCCGCAAGCACATGGAGCGCCTCAGGGACGAATTCGTCGCGACCGTCAGCCACGAATTGCGCACGCCGC
TGACGTCGATCTCGGGCTCACTCGGCCTTCTGGTGGGGCAATGGGTCGGCATTTTTCCGGAGCCCGCGGCGAGGCTCGTG
GCCATTGCCTACAAGAACAGCCAACGGCTGGTGCGCCTGATCAACGACATCCTCGATATCGAAAAACTCGGCGACGGTCG
CGTGGTCTTCAATCTGTGTCGCGTCGACGTGCACGCCATTGTGGAGCAGGCGATCGAGAGCAACCGCGGATTTGCCGAAG
GCTACGGCGTCAATGTCGGGCTCACCACCGCATCGAGGAGCAGCGACGTCAACGCCGACCCGGATCGCCTCGCGCAGGTG
ATTACCAACCTTCTTTCGAACGCGATCAAGGCCTCGCCTCCTGGTCGGGACGTCCTTGTCGCGGTCGAACCACACGACGC
GTTTGTCCGCATTTCCGTTCGCGATCAGGGCGACGGAATTCCAGCCACCTTCCGGCTGCACATCTTCGAAAAATTCGCCC
AGGCGGATGCGACCGACGCACGACAGAAAGGCGGTACCGGCCTCGGCCTCAGCATCGTCAAGCAGATCGTCGAACGGCTC
AATGGCCGGGTCAGCTTCGAAGACGCGGCCGGCGGCGGCACGGTGTTCTGCGTCGATCTTCCGGAATGGAAGATTCCGAT
CGATGAACGGCCGTCGGTTCCAAAGTATCGAGTTCTGCACCTCGATGATGATCCCAACATTCTGGCGGCTGTCGCCCATG
CCCTCAGCCCGGCAGCCCAGGTGATATCGGTCGGGTCCCTCCAGGACGCACGACGCATCTTGTCGGTCGATCCGGTCGAC
ATGGTCCTGCTGGACATCTCGCTCGGCGAGCACTCCGGGCTGGAATTATTGGCTGATCTGCACGACGCTGACGGTGAAGC
CATCCCGGTTATCGTCTTTTGCACCAGCCCGATCGAACTGACACCCGACGGACAAGTGCATGTGATCCTCGTCAAATCAC
GGACCCCGCTGGATTCCTTGCTGGCGTCGGTGCGGGACTGCCTGGCTCATCGCGAACATCGCGAGGTGGCATGA

Upstream 100 bases:

>100_bases
GCGGCGCACGCCGCTGCCATCAGCTTTTTCATGCTCTTGTCCTGTCGGTGTTGGAGAGAAAGCCGGATCAGGCCGGCTGG
AGATAGCGCTGCTTGAGCAC

Downstream 100 bases:

>100_bases
CGATTCGTGTCCTTCACGTCGATGACGAGCCGGACATTCGCGAGATTGCAGCGATCTCGCTCGGTCTGAATTCCGAGTTC
ATCACGCGCAGCTGTGGATC

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MPERLIADKLRTAEDARTQQIGTGIELIARRKDGSEFPIEIMLSPLDSPEGVLVTAAIRDISERKDAEKHLVQMEGRYQA
LLEAAPDAMVVVNQTGEIVLLNLQAEKQFAYRRDELLGQKVTNIIPEGFAERLIADRLRSREDALAQHIGAGIELTGRRK
DGSEFPIEIMLSPLESEGSILVTAAIREISARKHMERLRDEFVATVSHELRTPLTSISGSLGLLVGQWVGIFPEPAARLV
AIAYKNSQRLVRLINDILDIEKLGDGRVVFNLCRVDVHAIVEQAIESNRGFAEGYGVNVGLTTASRSSDVNADPDRLAQV
ITNLLSNAIKASPPGRDVLVAVEPHDAFVRISVRDQGDGIPATFRLHIFEKFAQADATDARQKGGTGLGLSIVKQIVERL
NGRVSFEDAAGGGTVFCVDLPEWKIPIDERPSVPKYRVLHLDDDPNILAAVAHALSPAAQVISVGSLQDARRILSVDPVD
MVLLDISLGEHSGLELLADLHDADGEAIPVIVFCTSPIELTPDGQVHVILVKSRTPLDSLLASVRDCLAHREHREVA

Sequences:

>Translated_557_residues
MPERLIADKLRTAEDARTQQIGTGIELIARRKDGSEFPIEIMLSPLDSPEGVLVTAAIRDISERKDAEKHLVQMEGRYQA
LLEAAPDAMVVVNQTGEIVLLNLQAEKQFAYRRDELLGQKVTNIIPEGFAERLIADRLRSREDALAQHIGAGIELTGRRK
DGSEFPIEIMLSPLESEGSILVTAAIREISARKHMERLRDEFVATVSHELRTPLTSISGSLGLLVGQWVGIFPEPAARLV
AIAYKNSQRLVRLINDILDIEKLGDGRVVFNLCRVDVHAIVEQAIESNRGFAEGYGVNVGLTTASRSSDVNADPDRLAQV
ITNLLSNAIKASPPGRDVLVAVEPHDAFVRISVRDQGDGIPATFRLHIFEKFAQADATDARQKGGTGLGLSIVKQIVERL
NGRVSFEDAAGGGTVFCVDLPEWKIPIDERPSVPKYRVLHLDDDPNILAAVAHALSPAAQVISVGSLQDARRILSVDPVD
MVLLDISLGEHSGLELLADLHDADGEAIPVIVFCTSPIELTPDGQVHVILVKSRTPLDSLLASVRDCLAHREHREVA
>Mature_556_residues
PERLIADKLRTAEDARTQQIGTGIELIARRKDGSEFPIEIMLSPLDSPEGVLVTAAIRDISERKDAEKHLVQMEGRYQAL
LEAAPDAMVVVNQTGEIVLLNLQAEKQFAYRRDELLGQKVTNIIPEGFAERLIADRLRSREDALAQHIGAGIELTGRRKD
GSEFPIEIMLSPLESEGSILVTAAIREISARKHMERLRDEFVATVSHELRTPLTSISGSLGLLVGQWVGIFPEPAARLVA
IAYKNSQRLVRLINDILDIEKLGDGRVVFNLCRVDVHAIVEQAIESNRGFAEGYGVNVGLTTASRSSDVNADPDRLAQVI
TNLLSNAIKASPPGRDVLVAVEPHDAFVRISVRDQGDGIPATFRLHIFEKFAQADATDARQKGGTGLGLSIVKQIVERLN
GRVSFEDAAGGGTVFCVDLPEWKIPIDERPSVPKYRVLHLDDDPNILAAVAHALSPAAQVISVGSLQDARRILSVDPVDM
VLLDISLGEHSGLELLADLHDADGEAIPVIVFCTSPIELTPDGQVHVILVKSRTPLDSLLASVRDCLAHREHREVA

Specific function: Member of the two-component regulatory system resD/resE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates resD [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=32.0175438596491, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=32.6446280991736, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786600, Length=370, Percent_Identity=28.6486486486486, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=36.3247863247863, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=29.646017699115, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI48994928, Length=466, Percent_Identity=24.2489270386266, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081816, Length=316, Percent_Identity=28.4810126582279, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=30.3030303030303, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=30.9417040358744, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=358, Percent_Identity=24.3016759776536, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=26.4462809917355, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=246, Percent_Identity=26.4227642276423, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=222, Percent_Identity=28.3783783783784, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789808, Length=241, Percent_Identity=27.3858921161826, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790300, Length=266, Percent_Identity=25.187969924812, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1789403, Length=311, Percent_Identity=26.6881028938907, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60755; Mature: 60624

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPERLIADKLRTAEDARTQQIGTGIELIARRKDGSEFPIEIMLSPLDSPEGVLVTAAIRD
CCCHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCEEEEEECCCCCCCEEEEHHHHH
ISERKDAEKHLVQMEGRYQALLEAAPDAMVVVNQTGEIVLLNLQAEKQFAYRRDELLGQK
HHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHH
VTNIIPEGFAERLIADRLRSREDALAQHIGAGIELTGRRKDGSEFPIEIMLSPLESEGSI
HHHHCCHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCE
LVTAAIREISARKHMERLRDEFVATVSHELRTPLTSISGSLGLLVGQWVGIFPEPAARLV
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCCHHHEE
AIAYKNSQRLVRLINDILDIEKLGDGRVVFNLCRVDVHAIVEQAIESNRGFAEGYGVNVG
EEEECCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
LTTASRSSDVNADPDRLAQVITNLLSNAIKASPPGRDVLVAVEPHDAFVRISVRDQGDGI
EEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCC
PATFRLHIFEKFAQADATDARQKGGTGLGLSIVKQIVERLNGRVSFEDAAGGGTVFCVDL
CEEEHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCEEEEEEC
PEWKIPIDERPSVPKYRVLHLDDDPNILAAVAHALSPAAQVISVGSLQDARRILSVDPVD
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCE
MVLLDISLGEHSGLELLADLHDADGEAIPVIVFCTSPIELTPDGQVHVILVKSRTPLDSL
EEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCEEECCCCCEEEEEEECCCCHHHH
LASVRDCLAHREHREVA
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PERLIADKLRTAEDARTQQIGTGIELIARRKDGSEFPIEIMLSPLDSPEGVLVTAAIRD
CCHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCEEEEEECCCCCCCEEEEHHHHH
ISERKDAEKHLVQMEGRYQALLEAAPDAMVVVNQTGEIVLLNLQAEKQFAYRRDELLGQK
HHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHH
VTNIIPEGFAERLIADRLRSREDALAQHIGAGIELTGRRKDGSEFPIEIMLSPLESEGSI
HHHHCCHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCE
LVTAAIREISARKHMERLRDEFVATVSHELRTPLTSISGSLGLLVGQWVGIFPEPAARLV
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCCHHHEE
AIAYKNSQRLVRLINDILDIEKLGDGRVVFNLCRVDVHAIVEQAIESNRGFAEGYGVNVG
EEEECCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
LTTASRSSDVNADPDRLAQVITNLLSNAIKASPPGRDVLVAVEPHDAFVRISVRDQGDGI
EEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCC
PATFRLHIFEKFAQADATDARQKGGTGLGLSIVKQIVERLNGRVSFEDAAGGGTVFCVDL
CEEEHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCEEEEEEC
PEWKIPIDERPSVPKYRVLHLDDDPNILAAVAHALSPAAQVISVGSLQDARRILSVDPVD
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCE
MVLLDISLGEHSGLELLADLHDADGEAIPVIVFCTSPIELTPDGQVHVILVKSRTPLDSL
EEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCEEECCCCCEEEEEEECCCCHHHH
LASVRDCLAHREHREVA
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715 [H]