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The map label for this gene is degU [H]

Identifier: 86751143

GI number: 86751143

Start: 4605621

End: 4606307

Strand: Direct

Name: degU [H]

Synonym: RPB_4035

Alternate gene names: 86751143

Gene position: 4605621-4606307 (Clockwise)

Preceding gene: 86751142

Following gene: 86751155

Centisome position: 86.38

GC content: 68.27

Gene sequence:

>687_bases
ATGGAAGCACATCCGATGGACCAGCAGGCCCCCTCCCGATTGCGCGTCTTCCTCGCCGACGATCATCCGGTCGTGCTCAG
CGGCATGAAGGCGCTCGTCGCCGGCGATCCCGCCCTCGAGGTCGTGGGCGAGGCGAGCGACGGACCGAACGCGCTGCGTC
GCGCGACCGAATTGCGGCCCGACGTCGCGGTGCTCGATCTGTCGATGCCCGGCCTGAACGGCATCGAGGTAGCCCGGAAA
TTTCTCGCCGCTTGTCCCGAATGCCGGGTGCTGGTGCTGACCGTGCACGAGGACGGCGCTTATCTGCGCCAGTTGCTCGA
TCTCGGCGTGTCCGGCTACGTGCTGAAGCGCTCCGCCACCGAGGAGTTGATCCGCGGCATTCACGCGGTCGGCACCGGCG
GCATCTATCTCGATCCGGCGATCGCCGGCCGCGCGATCGGCCGCAGCGCGCCGCATGTGCACAACAGCGAGGAGCACAGC
GCGGTGTCCGAACTGTCGACCCGCGAGATCGAGGTGCTGCGGCTCGCCGCCGTCGGCCACAGCAACAAGACGATCGCCGC
CAAGCTGCAGATCGGCGCCAAGAGCGTCGAGACCTACAAGGCCCGCGGCATGGCCAAGCTCGGCTTCCACAACCGCGTCG
AAGTGGTGCGCTTCGCGCTCAGCATGGGCTGGCTGGCGGACCCGTAG

Upstream 100 bases:

>100_bases
CGGCATTCGCGAGCGGCTGACGCTGGTCCGCGGCTCGCTCGAAATCGAATCCGCGCCCGGCAAGGGCACCGCTCTATACG
CACGAATTCCGTTGTAAAGC

Downstream 100 bases:

>100_bases
CTAGACTTCGCTATTTGATCGAACGTCATTCCGGGGCGCTCGCGCAGCGAGCGAACCCGGAATCCCGAGATGTTCTGCGC
CCTCCTCCACCAGCTCGGGA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MEAHPMDQQAPSRLRVFLADDHPVVLSGMKALVAGDPALEVVGEASDGPNALRRATELRPDVAVLDLSMPGLNGIEVARK
FLAACPECRVLVLTVHEDGAYLRQLLDLGVSGYVLKRSATEELIRGIHAVGTGGIYLDPAIAGRAIGRSAPHVHNSEEHS
AVSELSTREIEVLRLAAVGHSNKTIAAKLQIGAKSVETYKARGMAKLGFHNRVEVVRFALSMGWLADP

Sequences:

>Translated_228_residues
MEAHPMDQQAPSRLRVFLADDHPVVLSGMKALVAGDPALEVVGEASDGPNALRRATELRPDVAVLDLSMPGLNGIEVARK
FLAACPECRVLVLTVHEDGAYLRQLLDLGVSGYVLKRSATEELIRGIHAVGTGGIYLDPAIAGRAIGRSAPHVHNSEEHS
AVSELSTREIEVLRLAAVGHSNKTIAAKLQIGAKSVETYKARGMAKLGFHNRVEVVRFALSMGWLADP
>Mature_228_residues
MEAHPMDQQAPSRLRVFLADDHPVVLSGMKALVAGDPALEVVGEASDGPNALRRATELRPDVAVLDLSMPGLNGIEVARK
FLAACPECRVLVLTVHEDGAYLRQLLDLGVSGYVLKRSATEELIRGIHAVGTGGIYLDPAIAGRAIGRSAPHVHNSEEHS
AVSELSTREIEVLRLAAVGHSNKTIAAKLQIGAKSVETYKARGMAKLGFHNRVEVVRFALSMGWLADP

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=29.0476190476191, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790102, Length=213, Percent_Identity=36.150234741784, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=28.1553398058252, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788521, Length=204, Percent_Identity=32.3529411764706, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788546, Length=210, Percent_Identity=30.4761904761905, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1787473, Length=209, Percent_Identity=32.0574162679426, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786747, Length=208, Percent_Identity=26.4423076923077, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24391; Mature: 24391

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAHPMDQQAPSRLRVFLADDHPVVLSGMKALVAGDPALEVVGEASDGPNALRRATELRP
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHCCC
DVAVLDLSMPGLNGIEVARKFLAACPECRVLVLTVHEDGAYLRQLLDLGVSGYVLKRSAT
CEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCEEEEHHHH
EELIRGIHAVGTGGIYLDPAIAGRAIGRSAPHVHNSEEHSAVSELSTREIEVLRLAAVGH
HHHHHHHHHHCCCCEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCC
SNKTIAAKLQIGAKSVETYKARGMAKLGFHNRVEVVRFALSMGWLADP
CCCEEEEEEEECCHHHHHHHHCCCHHCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEAHPMDQQAPSRLRVFLADDHPVVLSGMKALVAGDPALEVVGEASDGPNALRRATELRP
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHCCC
DVAVLDLSMPGLNGIEVARKFLAACPECRVLVLTVHEDGAYLRQLLDLGVSGYVLKRSAT
CEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCEEEEHHHH
EELIRGIHAVGTGGIYLDPAIAGRAIGRSAPHVHNSEEHSAVSELSTREIEVLRLAAVGH
HHHHHHHHHHCCCCEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCC
SNKTIAAKLQIGAKSVETYKARGMAKLGFHNRVEVVRFALSMGWLADP
CCCEEEEEEEECCHHHHHHHHCCCHHCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]