BacMap

Definition	Rhodopseudomonas palustris HaA2, complete genome.
Accession	NC_007778
Length	5,331,656

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The map label for this gene is fabG2 [H]

Identifier: 86751005

GI number: 86751005

Start: 4452690

End: 4453454

Strand: Direct

Name: fabG2 [H]

Synonym: RPB_3897

Alternate gene names: 86751005

Gene position: 4452690-4453454 (Clockwise)

Preceding gene: 86751004

Following gene: 86751006

Centisome position: 83.51

GC content: 69.28

Gene sequence:

>765_bases
ATGAGCGCGCCCTCCGCCAACAGCGAAGGACGCGTCGCGCTGGTCACCGGCGGCGGCAACGGGCTCGGCGAGATCATCGC
CGGCGCGCTGCACGGCGCGGGCTATCGGGTCGCCGTCGCCGACATCGACGAAGCTGCGGCGCAGACCGTCGCAACGCGGC
TGGACCCGGGCGGACAAACGGCGATCGCGCTGCATCTCGACGTCCGCCTCAAAGGCGATTTCGAGGCCGCGCTGGCGGCG
CTGCTGGCGCGCTGGGGTGGCGCCCACGTCCTCGTCAACAACGCCGCCGTCACCGTGGCGCGGCCGGTGATGGAGATCTC
GCCGGAGGAATTCGACGCGGTGATCGCGGTCAATCTGCGCGGCACGTTTCTCGGCTGCCAGGTGTTCGGCGCTTACTTCC
GCGATGCCGGGCACGGCCGCATCGTCAACATGGCCTCGCTCGCCGGCCAGAACGGCGGCACCGCCACCGGCGCGCACTAT
GCGGCATCGAAGGGCGGCATCGTCACGCTGACCAAAGTGTTCGCGCGCGATCTCGGCAAGGCCGGCGTCACCGTCAATGC
GATCGCGCCGGGGCCGCTCGATCTGCCGATCGTGCACAAGACGGTGCCGGCCGAGCGCTTCGCCGAGTTCAAGGCGAACA
TTCCGGTCGGCGATATCGGCGATCCGAAATTTGTCGCGCAGCTGGTGCTGCAACTGGCGTCGCCCGAATCCGGCTTCGTC
TCCGGCGCGACCTGGGACGTCAATGGCGGGCTGTTCATGCGATGA

Upstream 100 bases:

>100_bases
CCTATCGTCTGGTGCGAGGCCCGACCGGTCTGCAGATCGCCCGCAAGGTGGTCTGGCTGATCAACTCCACCGAGGCGCTC
GGCGGCATCGGCTACATCCT

Downstream 100 bases:

>100_bases
GGCCGACGATGAAGCAGGCCATGACGCCCACGGTCGAGCGCGACGAATTTCGCGAGGCGATGAGCCGGCTCGGCGCCGCG
GTCAACATCATCACCACCGA

Product: Short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSAPSANSEGRVALVTGGGNGLGEIIAGALHGAGYRVAVADIDEAAAQTVATRLDPGGQTAIALHLDVRLKGDFEAALAA
LLARWGGAHVLVNNAAVTVARPVMEISPEEFDAVIAVNLRGTFLGCQVFGAYFRDAGHGRIVNMASLAGQNGGTATGAHY
AASKGGIVTLTKVFARDLGKAGVTVNAIAPGPLDLPIVHKTVPAERFAEFKANIPVGDIGDPKFVAQLVLQLASPESGFV
SGATWDVNGGLFMR

Sequences:

>Translated_254_residues
MSAPSANSEGRVALVTGGGNGLGEIIAGALHGAGYRVAVADIDEAAAQTVATRLDPGGQTAIALHLDVRLKGDFEAALAA
LLARWGGAHVLVNNAAVTVARPVMEISPEEFDAVIAVNLRGTFLGCQVFGAYFRDAGHGRIVNMASLAGQNGGTATGAHY
AASKGGIVTLTKVFARDLGKAGVTVNAIAPGPLDLPIVHKTVPAERFAEFKANIPVGDIGDPKFVAQLVLQLASPESGFV
SGATWDVNGGLFMR
>Mature_253_residues
SAPSANSEGRVALVTGGGNGLGEIIAGALHGAGYRVAVADIDEAAAQTVATRLDPGGQTAIALHLDVRLKGDFEAALAAL
LARWGGAHVLVNNAAVTVARPVMEISPEEFDAVIAVNLRGTFLGCQVFGAYFRDAGHGRIVNMASLAGQNGGTATGAHYA
ASKGGIVTLTKVFARDLGKAGVTVNAIAPGPLDLPIVHKTVPAERFAEFKANIPVGDIGDPKFVAQLVLQLASPESGFVS
GATWDVNGGLFMR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=37.0517928286853, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=28.90625, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=33.8775510204082, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI4758504, Length=268, Percent_Identity=33.2089552238806, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=30.1652892561983, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI10190704, Length=252, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI59889578, Length=229, Percent_Identity=30.5676855895196, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI66933014, Length=247, Percent_Identity=27.5303643724696, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI83715985, Length=268, Percent_Identity=31.3432835820896, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4504505, Length=253, Percent_Identity=29.2490118577075, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI31542939, Length=246, Percent_Identity=30.0813008130081, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=26.5060240963855, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI166795268, Length=202, Percent_Identity=29.7029702970297, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=34.8, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=30.6122448979592, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=32.6612903225806, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI87082160, Length=248, Percent_Identity=29.0322580645161, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=31.9672131147541, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI87082100, Length=248, Percent_Identity=29.8387096774194, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=29.3436293436293, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=28.9256198347107, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=27.3469387755102, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=28.099173553719, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=25.6, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=29.2817679558011, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=28.6852589641434, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=35.3658536585366, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=33.0612244897959, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17538182, Length=261, Percent_Identity=33.7164750957854, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=30.5555555555556, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=28.6852589641434, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17536651, Length=248, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=251, Percent_Identity=26.2948207171315, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=199, Percent_Identity=24.1206030150754, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=26.1538461538462, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=25.5813953488372, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=183, Percent_Identity=27.3224043715847, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=27.2, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=27.8008298755187, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=257, Percent_Identity=30.3501945525292, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=25.187969924812, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=25.2873563218391, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=195, Percent_Identity=27.1794871794872, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=189, Percent_Identity=31.7460317460317, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=26.8, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=34.2857142857143, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=31.3725490196078, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=31.7073170731707, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=28.1746031746032, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=30.1204819277108, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=29.0836653386454, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=28.4, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24643142, Length=255, Percent_Identity=30.5882352941176, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859837, Length=234, Percent_Identity=27.3504273504274, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357673, Length=189, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24644337, Length=247, Percent_Identity=29.1497975708502, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25891; Mature: 25760

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPSANSEGRVALVTGGGNGLGEIIAGALHGAGYRVAVADIDEAAAQTVATRLDPGGQT
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCE
AIALHLDVRLKGDFEAALAALLARWGGAHVLVNNAAVTVARPVMEISPEEFDAVIAVNLR
EEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCEEEEEHHHHHCCCCCCCEEEEEEEC
GTFLGCQVFGAYFRDAGHGRIVNMASLAGQNGGTATGAHYAASKGGIVTLTKVFARDLGK
CEEEHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCCCEEECCCCCEEEHHHHHHHHCCC
AGVTVNAIAPGPLDLPIVHKTVPAERFAEFKANIPVGDIGDPKFVAQLVLQLASPESGFV
CCEEEEEECCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
SGATWDVNGGLFMR
CCCEEECCCCEEEC
>Mature Secondary Structure 
SAPSANSEGRVALVTGGGNGLGEIIAGALHGAGYRVAVADIDEAAAQTVATRLDPGGQT
CCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCE
AIALHLDVRLKGDFEAALAALLARWGGAHVLVNNAAVTVARPVMEISPEEFDAVIAVNLR
EEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCEEEEEHHHHHCCCCCCCEEEEEEEC
GTFLGCQVFGAYFRDAGHGRIVNMASLAGQNGGTATGAHYAASKGGIVTLTKVFARDLGK
CEEEHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCCCCEEECCCCCEEEHHHHHHHHCCC
AGVTVNAIAPGPLDLPIVHKTVPAERFAEFKANIPVGDIGDPKFVAQLVLQLASPESGFV
CCEEEEEECCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
SGATWDVNGGLFMR
CCCEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]