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The map label for this gene is kefC [H]

Identifier: 86750679

GI number: 86750679

Start: 4091725

End: 4093503

Strand: Direct

Name: kefC [H]

Synonym: RPB_3569

Alternate gene names: 86750679

Gene position: 4091725-4093503 (Clockwise)

Preceding gene: 86750677

Following gene: 86750681

Centisome position: 76.74

GC content: 65.77

Gene sequence:

>1779_bases
ATGCATGACATTACCTTTAATGTCCGCCCGGCAGATTCAACGGCGGCTGAGGGCATGCACGAACTGATTCGCGACATCAC
GCTGTGCATCCTGTTCGCCTGGATGCTCGGTCTGTCGGCGCATTTTTTCCGTCAGCCGCTGATCCTCGCCTATCTTGTCG
CCGGCTTCGCGATCGGACCGTTCGGCCTCGGGCTGGTGCAGTCGCAAGAATCGATCTCGGTGATTTCCGAGCTCGGCCTG
ATCTTCATGCTGTTCATGATCGGGCTGGAGATCGACCTGAAGAAGGTCGTGCGCGCCGGCAGCGTGATTCTGGTGGCCGC
CGGCGGGCAGTTGATCGGCGGCTGCCTGCTCGGCTTCGCCTTCTTCCTCGCCATCGGCCTGTCGTTCGGCGGCGGCCGGT
TCGATGCCCTGTACCTCACCGTCGCCTGCGCGCTGTCCTCCACCGTCATCATCGTCAAGGTGCTGTACGAGAAGCGCGAA
CTCGACACCCTGCCCGGCCGCCTCACGCTCGGCGTGCTGGTGCTGCAGGACATCTTCGCGATCCTGTTCCTCGCGGTGCA
ACCCAGCCTCGCCGAGTTGCAGATCAGCGTGCTGCTGCTGTCGATCGGCCGCGTCGCGGCGCTGGTCGCGACCGCGATCG
TGCTCAGCCGCTACGTGCTGCCCTGGCTGTTCCACCGCATCGCGCGCACCCCCGAACTGGTGCTGCTCGGCGCGCTGGCG
TGGTGCTTCCTGATCGGCGAGATCGCCGAGCGGCTGCATCTGTCGCGCGAGATGGGCTCGCTGGTCGCCGGCGTGTCGCT
GTCGACCTTCCCCTATGCGCTCGACGTCACCGCCAAGGTGACGACGCTGCGGGACTTCTTCATCACGCTGTTCTTCGTCG
CCGTCGGCATGACGATCCCGGTCCCGAACGGGTCGGTGATCATGCTGGCGCTGGCGATCGCCGCCTTCACCGTGGTCAGC
CGCGTCGTCACCACCTTCGTGCCGCTGTATCTGATGCGACAGGGGCTGCGCGCCAGCCTGCTGCCGGCGCTGAATCTGGC
GCAGATCAGCGAATTCTCGCTGGTGGTGATCCAGACCGGAATCGTCGCCGGCCACATCCGCACCGAAACCGCGAGCGCGG
CGTCGTTCGCCTTCGTGCTGCTGGCGGTGCTGTCGACCTTCGTGATGGTGCGCAGCGATCAGATCACGCGTGCGGCGATC
CGGATGCTGAAGGCGATCGGCCTGCGCGATCTCGACCACAAGGCCGAGGACGCCGACGACGCCGCCGGCCACGGCGCGGT
GCGGCGGATCGTGATTCTCGGCTTCTTCCGCGCCGCCAGCGCGCTGATCAGCGAGATCGAGCGGCAGAATCCCGAGCTAT
TGAAGCAGATCAGCGTGATCGATTTCAACCCGATGGTGTATCGCACCCTCACCGATCGCGGCATGCACGTCGTCTATGGC
GACATCAGCAATGTCGACACGCTGTTGCACGCCGGCGTCGGCAAGGCCGAGATGATCATCCTCAGCGTGCCGGACTCGCT
GCTGAAAGGCGCCAACAACGAACGCCTGGTACGCCACGTCCGCGTGCTCAACCCGACCGCGAAGATCGTTGCCACCGCGG
ATCTGCTGGCCGACGTCGCGGCGCTGTACGCGGCCGGCGCCGACTACGTCACCGTGACCCGGCTCAGCGACGCCGAGGAG
CTGTTCAGCGTGATCGACGCGGTCGAATGCGGCCTGCTGTCGGACAAGCGCGCCGAACTCGACGCGCGGCTCGCCGAGCG
TCGCGAAGTGCTGCCTTAG

Upstream 100 bases:

>100_bases
ACGGATCGGCGGCCAGTGCCTCACCAACACGACGCCCCCCTCGACCGTTCGGTCCCCGAGGGGGCCGGCCGATCGGCAAC
GGGCGACTTATGTCTTTCGG

Downstream 100 bases:

>100_bases
CGGCGGCGGCCGGCGATCAGAATTCCCGCGCGATCTTGCCGAGCATCGCCAGCAACGCGGCGCGATTGTCGTCGCCGAGA
AGTTCGCTGAGCCGTTCCTC

Product: Sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MHDITFNVRPADSTAAEGMHELIRDITLCILFAWMLGLSAHFFRQPLILAYLVAGFAIGPFGLGLVQSQESISVISELGL
IFMLFMIGLEIDLKKVVRAGSVILVAAGGQLIGGCLLGFAFFLAIGLSFGGGRFDALYLTVACALSSTVIIVKVLYEKRE
LDTLPGRLTLGVLVLQDIFAILFLAVQPSLAELQISVLLLSIGRVAALVATAIVLSRYVLPWLFHRIARTPELVLLGALA
WCFLIGEIAERLHLSREMGSLVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVAVGMTIPVPNGSVIMLALAIAAFTVVS
RVVTTFVPLYLMRQGLRASLLPALNLAQISEFSLVVIQTGIVAGHIRTETASAASFAFVLLAVLSTFVMVRSDQITRAAI
RMLKAIGLRDLDHKAEDADDAAGHGAVRRIVILGFFRAASALISEIERQNPELLKQISVIDFNPMVYRTLTDRGMHVVYG
DISNVDTLLHAGVGKAEMIILSVPDSLLKGANNERLVRHVRVLNPTAKIVATADLLADVAALYAAGADYVTVTRLSDAEE
LFSVIDAVECGLLSDKRAELDARLAERREVLP

Sequences:

>Translated_592_residues
MHDITFNVRPADSTAAEGMHELIRDITLCILFAWMLGLSAHFFRQPLILAYLVAGFAIGPFGLGLVQSQESISVISELGL
IFMLFMIGLEIDLKKVVRAGSVILVAAGGQLIGGCLLGFAFFLAIGLSFGGGRFDALYLTVACALSSTVIIVKVLYEKRE
LDTLPGRLTLGVLVLQDIFAILFLAVQPSLAELQISVLLLSIGRVAALVATAIVLSRYVLPWLFHRIARTPELVLLGALA
WCFLIGEIAERLHLSREMGSLVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVAVGMTIPVPNGSVIMLALAIAAFTVVS
RVVTTFVPLYLMRQGLRASLLPALNLAQISEFSLVVIQTGIVAGHIRTETASAASFAFVLLAVLSTFVMVRSDQITRAAI
RMLKAIGLRDLDHKAEDADDAAGHGAVRRIVILGFFRAASALISEIERQNPELLKQISVIDFNPMVYRTLTDRGMHVVYG
DISNVDTLLHAGVGKAEMIILSVPDSLLKGANNERLVRHVRVLNPTAKIVATADLLADVAALYAAGADYVTVTRLSDAEE
LFSVIDAVECGLLSDKRAELDARLAERREVLP
>Mature_592_residues
MHDITFNVRPADSTAAEGMHELIRDITLCILFAWMLGLSAHFFRQPLILAYLVAGFAIGPFGLGLVQSQESISVISELGL
IFMLFMIGLEIDLKKVVRAGSVILVAAGGQLIGGCLLGFAFFLAIGLSFGGGRFDALYLTVACALSSTVIIVKVLYEKRE
LDTLPGRLTLGVLVLQDIFAILFLAVQPSLAELQISVLLLSIGRVAALVATAIVLSRYVLPWLFHRIARTPELVLLGALA
WCFLIGEIAERLHLSREMGSLVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVAVGMTIPVPNGSVIMLALAIAAFTVVS
RVVTTFVPLYLMRQGLRASLLPALNLAQISEFSLVVIQTGIVAGHIRTETASAASFAFVLLAVLSTFVMVRSDQITRAAI
RMLKAIGLRDLDHKAEDADDAAGHGAVRRIVILGFFRAASALISEIERQNPELLKQISVIDFNPMVYRTLTDRGMHVVYG
DISNVDTLLHAGVGKAEMIILSVPDSLLKGANNERLVRHVRVLNPTAKIVATADLLADVAALYAAGADYVTVTRLSDAEE
LFSVIDAVECGLLSDKRAELDARLAERREVLP

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=395, Percent_Identity=25.5696202531646, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1786232, Length=518, Percent_Identity=29.1505791505791, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786685, Length=570, Percent_Identity=25.0877192982456, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1789749, Length=533, Percent_Identity=24.953095684803, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 63938; Mature: 63938

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDITFNVRPADSTAAEGMHELIRDITLCILFAWMLGLSAHFFRQPLILAYLVAGFAIGP
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FGLGLVQSQESISVISELGLIFMLFMIGLEIDLKKVVRAGSVILVAAGGQLIGGCLLGFA
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHH
FFLAIGLSFGGGRFDALYLTVACALSSTVIIVKVLYEKRELDTLPGRLTLGVLVLQDIFA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ILFLAVQPSLAELQISVLLLSIGRVAALVATAIVLSRYVLPWLFHRIARTPELVLLGALA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
WCFLIGEIAERLHLSREMGSLVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVAVGMTIP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCEEE
VPNGSVIMLALAIAAFTVVSRVVTTFVPLYLMRQGLRASLLPALNLAQISEFSLVVIQTG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCEEEEEECC
IVAGHIRTETASAASFAFVLLAVLSTFVMVRSDQITRAAIRMLKAIGLRDLDHKAEDADD
HHCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
AAGHGAVRRIVILGFFRAASALISEIERQNPELLKQISVIDFNPMVYRTLTDRGMHVVYG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHEEEHHCCCCEEEEC
DISNVDTLLHAGVGKAEMIILSVPDSLLKGANNERLVRHVRVLNPTAKIVATADLLADVA
CCCHHHHHHHCCCCCEEEEEEECCHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALYAAGADYVTVTRLSDAEELFSVIDAVECGLLSDKRAELDARLAERREVLP
HHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHDITFNVRPADSTAAEGMHELIRDITLCILFAWMLGLSAHFFRQPLILAYLVAGFAIGP
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FGLGLVQSQESISVISELGLIFMLFMIGLEIDLKKVVRAGSVILVAAGGQLIGGCLLGFA
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHH
FFLAIGLSFGGGRFDALYLTVACALSSTVIIVKVLYEKRELDTLPGRLTLGVLVLQDIFA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ILFLAVQPSLAELQISVLLLSIGRVAALVATAIVLSRYVLPWLFHRIARTPELVLLGALA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
WCFLIGEIAERLHLSREMGSLVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVAVGMTIP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCEEE
VPNGSVIMLALAIAAFTVVSRVVTTFVPLYLMRQGLRASLLPALNLAQISEFSLVVIQTG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCEEEEEECC
IVAGHIRTETASAASFAFVLLAVLSTFVMVRSDQITRAAIRMLKAIGLRDLDHKAEDADD
HHCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
AAGHGAVRRIVILGFFRAASALISEIERQNPELLKQISVIDFNPMVYRTLTDRGMHVVYG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHEEEHHCCCCEEEEC
DISNVDTLLHAGVGKAEMIILSVPDSLLKGANNERLVRHVRVLNPTAKIVATADLLADVA
CCCHHHHHHHCCCCCEEEEEEECCHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALYAAGADYVTVTRLSDAEELFSVIDAVECGLLSDKRAELDARLAERREVLP
HHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA