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The map label for this gene is epr [H]

Identifier: 86750657

GI number: 86750657

Start: 4059770

End: 4061440

Strand: Reverse

Name: epr [H]

Synonym: RPB_3547

Alternate gene names: 86750657

Gene position: 4061440-4059770 (Counterclockwise)

Preceding gene: 86750658

Following gene: 86750656

Centisome position: 76.18

GC content: 69.66

Gene sequence:

>1671_bases
ATGAGCGATCGAGCATGGCAAAGGCCGGTATGGATTGCGGCGGTGGCGGCGGCGACGCTGGTGATGACGGCGGGGGTCGC
ATTTTCCCAATCGCTGGCGCCTCCACCTCTGACCAACCTTCCGCCAGTCACCACGGCGCCGACCATCACGCCGTCGGTCG
GCCCGACCATTCCCGCGCTACGCCCGCCAGGGCCGGACGTGCTGCCGTCGGTCGAGCGTGAGTATCGGCGGCTGCGCGAT
GCGCCGCTGCCGCCCTCGCGCTGCAACTATCTCGACAATGGCCGAACCTGCGCCAAGCTGTGGGTGATCGGCGATTGGCG
GTCCGTGACCAAGCACAAGCGCGGCAAGGCAAAGGCCGATCGCGTCCGCCGGGCTCCGCCGCAAATCGTCGCCGCGCGCG
GGCAGCGCCCGGCGGTCGCCGCTCGCGACCATGTTCCCGGCGAAGTGCTGATCGAATTCGACGGCGGTCTGTCCGAGCAG
CAACTCCGTGCGCTGGCGCGACGGCACCGGCTCACGCGCGTCAGCGTTGACACCGTCGCACTGGTCGGGACCCGCATCGG
ACTGTTTCGGATCAACGATCGCCGCTCGCCGCAAACGGTCGCACGCGCACTCGCCGCTGACGGTCGGATACGCGCCGCGC
AGGCCAATTTCGTCTACACGCTGCAGAGCGATGCCAAGCCCGCTGCCGCCGACAATTCGATGCTGTATCCGCACGGCCGG
CTGCGGCTGGCCGAGGCGCATGCGCTGGCGCGCGGACGCGGCATTGTCGTTGCGGTGATCGATTCCGGCGTCGACATCGC
CCATCCGGAACTCGTCGGTGCGCTCGCCGGTTCGTTCGACCCGCTCGGCAGCAAGGAGAAGCCGCATCAGCACGGCACCG
GCGTCGCCGGGGCGATCGTCGCGCGCGCCAAACTCACCGGTGGCGCACCGGAGGCGAAAATACTGGCGATCCGGGCGTTC
GGCGAGGGCAAGACCGGAAGCCAGAGCAGCACGTCTTATCTGATCCTCAAAAGCCTCGATATCGCCCTCGGTCATGGCGC
CCGAATCGTCAATATGAGCTTTGCCGGATCGCAGGACCCGCTGATTGCGCGCGGCGTCGCGGCTGCTGCAGCGCGGGGGA
TCGTGATGATTGCCGCCGCCGGCAATGCCGGGCCGAAGTCCCCGCCATTGTATCCTGCGGCGCTGCCGGGCGTGATCGCG
GTCAGCGCGACGAGTCCGGGCGACACGTTGTTTGCGGCATCGAACCGTGGCCCGCAAATCGCCGTGGCAGCTCCCGGCGT
CGACGTCCTGCTGCCGGCGCCCGACGGCAAATACGAGGTGATGACGGGGACGTCGTTCTCTGCAGCATTCGTCAGCGGTA
TCGCCGCGCTGATGATCGAGCGCAATCCCACGCTCGTGCCCGATCAGGTGCGGGCCGTTCTGAGCCAGACCGCCCGCGAT
CTTGGAGCGCCGGGCCGTGACGATCTGTTCGGGGCCGGCGAAGCCGATGCATTTGCTGCCCTGTCGCGGGTGGACAGCCT
GGCGGCCCCGCTGGTTGCGGCGCCCGCGACCGCGCCGCAGCCCTCTGTCGCGACAGCGCAACCTGCGACGCCCGGCGCTG
CGTTGGCAGCGCCCGCCGGGGCAGAGCAGGAGGTCGGCCCGGCGCCGGCCGCCGCGATCCCGGCCCGCTGA

Upstream 100 bases:

>100_bases
TCGAAGCAGGAGCAGGACAGGCTGATCTCGCGCCTGCAGAACGAAGCGATCGTCGCGATGGTGTTGCCCGCGCCATAGCA
GGTCCGAGCCGGAGGCTGCG

Downstream 100 bases:

>100_bases
TCGGCGCCGATCAGGTTCGAAAAAAATCTGCGACGGCTTTGAACGTTCGGCCTGGTCTCGATGACGAATAGGTGTGGGAG
CGGAAAGCCCCTCCCCAAAG

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MSDRAWQRPVWIAAVAAATLVMTAGVAFSQSLAPPPLTNLPPVTTAPTITPSVGPTIPALRPPGPDVLPSVEREYRRLRD
APLPPSRCNYLDNGRTCAKLWVIGDWRSVTKHKRGKAKADRVRRAPPQIVAARGQRPAVAARDHVPGEVLIEFDGGLSEQ
QLRALARRHRLTRVSVDTVALVGTRIGLFRINDRRSPQTVARALAADGRIRAAQANFVYTLQSDAKPAAADNSMLYPHGR
LRLAEAHALARGRGIVVAVIDSGVDIAHPELVGALAGSFDPLGSKEKPHQHGTGVAGAIVARAKLTGGAPEAKILAIRAF
GEGKTGSQSSTSYLILKSLDIALGHGARIVNMSFAGSQDPLIARGVAAAAARGIVMIAAAGNAGPKSPPLYPAALPGVIA
VSATSPGDTLFAASNRGPQIAVAAPGVDVLLPAPDGKYEVMTGTSFSAAFVSGIAALMIERNPTLVPDQVRAVLSQTARD
LGAPGRDDLFGAGEADAFAALSRVDSLAAPLVAAPATAPQPSVATAQPATPGAALAAPAGAEQEVGPAPAAAIPAR

Sequences:

>Translated_556_residues
MSDRAWQRPVWIAAVAAATLVMTAGVAFSQSLAPPPLTNLPPVTTAPTITPSVGPTIPALRPPGPDVLPSVEREYRRLRD
APLPPSRCNYLDNGRTCAKLWVIGDWRSVTKHKRGKAKADRVRRAPPQIVAARGQRPAVAARDHVPGEVLIEFDGGLSEQ
QLRALARRHRLTRVSVDTVALVGTRIGLFRINDRRSPQTVARALAADGRIRAAQANFVYTLQSDAKPAAADNSMLYPHGR
LRLAEAHALARGRGIVVAVIDSGVDIAHPELVGALAGSFDPLGSKEKPHQHGTGVAGAIVARAKLTGGAPEAKILAIRAF
GEGKTGSQSSTSYLILKSLDIALGHGARIVNMSFAGSQDPLIARGVAAAAARGIVMIAAAGNAGPKSPPLYPAALPGVIA
VSATSPGDTLFAASNRGPQIAVAAPGVDVLLPAPDGKYEVMTGTSFSAAFVSGIAALMIERNPTLVPDQVRAVLSQTARD
LGAPGRDDLFGAGEADAFAALSRVDSLAAPLVAAPATAPQPSVATAQPATPGAALAAPAGAEQEVGPAPAAAIPAR
>Mature_555_residues
SDRAWQRPVWIAAVAAATLVMTAGVAFSQSLAPPPLTNLPPVTTAPTITPSVGPTIPALRPPGPDVLPSVEREYRRLRDA
PLPPSRCNYLDNGRTCAKLWVIGDWRSVTKHKRGKAKADRVRRAPPQIVAARGQRPAVAARDHVPGEVLIEFDGGLSEQQ
LRALARRHRLTRVSVDTVALVGTRIGLFRINDRRSPQTVARALAADGRIRAAQANFVYTLQSDAKPAAADNSMLYPHGRL
RLAEAHALARGRGIVVAVIDSGVDIAHPELVGALAGSFDPLGSKEKPHQHGTGVAGAIVARAKLTGGAPEAKILAIRAFG
EGKTGSQSSTSYLILKSLDIALGHGARIVNMSFAGSQDPLIARGVAAAAARGIVMIAAAGNAGPKSPPLYPAALPGVIAV
SATSPGDTLFAASNRGPQIAVAAPGVDVLLPAPDGKYEVMTGTSFSAAFVSGIAALMIERNPTLVPDQVRAVLSQTARDL
GAPGRDDLFGAGEADAFAALSRVDSLAAPLVAAPATAPQPSVATAQPATPGAALAAPAGAEQEVGPAPAAAIPAR

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319893, Length=240, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320775, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550681, Length=311, Percent_Identity=26.0450160771704, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020
- InterPro:   IPR010259 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 57151; Mature: 57020

Theoretical pI: Translated: 10.82; Mature: 10.82

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRAWQRPVWIAAVAAATLVMTAGVAFSQSLAPPPLTNLPPVTTAPTITPSVGPTIPAL
CCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RPPGPDVLPSVEREYRRLRDAPLPPSRCNYLDNGRTCAKLWVIGDWRSVTKHKRGKAKAD
CCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEEEEECHHHHHHHHCCCCHHH
RVRRAPPQIVAARGQRPAVAARDHVPGEVLIEFDGGLSEQQLRALARRHRLTRVSVDTVA
HHHCCCHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEHHHEE
LVGTRIGLFRINDRRSPQTVARALAADGRIRAAQANFVYTLQSDAKPAAADNSMLYPHGR
EECCEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCEEEEECCCCCCCCCCCCEECCCCC
LRLAEAHALARGRGIVVAVIDSGVDIAHPELVGALAGSFDPLGSKEKPHQHGTGVAGAIV
EEEHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
ARAKLTGGAPEAKILAIRAFGEGKTGSQSSTSYLILKSLDIALGHGARIVNMSFAGSQDP
HHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEEEEEEECCCEEEEEEECCCCCCC
LIARGVAAAAARGIVMIAAAGNAGPKSPPLYPAALPGVIAVSATSPGDTLFAASNRGPQI
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCEE
AVAAPGVDVLLPAPDGKYEVMTGTSFSAAFVSGIAALMIERNPTLVPDQVRAVLSQTARD
EEECCCCEEEEECCCCCEEEEECCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHH
LGAPGRDDLFGAGEADAFAALSRVDSLAAPLVAAPATAPQPSVATAQPATPGAALAAPAG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCC
AEQEVGPAPAAAIPAR
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDRAWQRPVWIAAVAAATLVMTAGVAFSQSLAPPPLTNLPPVTTAPTITPSVGPTIPAL
CCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RPPGPDVLPSVEREYRRLRDAPLPPSRCNYLDNGRTCAKLWVIGDWRSVTKHKRGKAKAD
CCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEEEEECHHHHHHHHCCCCHHH
RVRRAPPQIVAARGQRPAVAARDHVPGEVLIEFDGGLSEQQLRALARRHRLTRVSVDTVA
HHHCCCHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEHHHEE
LVGTRIGLFRINDRRSPQTVARALAADGRIRAAQANFVYTLQSDAKPAAADNSMLYPHGR
EECCEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCEEEEECCCCCCCCCCCCEECCCCC
LRLAEAHALARGRGIVVAVIDSGVDIAHPELVGALAGSFDPLGSKEKPHQHGTGVAGAIV
EEEHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
ARAKLTGGAPEAKILAIRAFGEGKTGSQSSTSYLILKSLDIALGHGARIVNMSFAGSQDP
HHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEEEEEEECCCEEEEEEECCCCCCC
LIARGVAAAAARGIVMIAAAGNAGPKSPPLYPAALPGVIAVSATSPGDTLFAASNRGPQI
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCEE
AVAAPGVDVLLPAPDGKYEVMTGTSFSAAFVSGIAALMIERNPTLVPDQVRAVLSQTARD
EEECCCCEEEEECCCCCEEEEECCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHH
LGAPGRDDLFGAGEADAFAALSRVDSLAAPLVAAPATAPQPSVATAQPATPGAALAAPAG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCC
AEQEVGPAPAAAIPAR
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2116590; 3142851; 7934828; 9384377 [H]