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The map label for this gene is cusR [H]

Identifier: 86750553

GI number: 86750553

Start: 3947699

End: 3948424

Strand: Reverse

Name: cusR [H]

Synonym: RPB_3442

Alternate gene names: 86750553

Gene position: 3948424-3947699 (Counterclockwise)

Preceding gene: 86750554

Following gene: 86750552

Centisome position: 74.06

GC content: 65.7

Gene sequence:

>726_bases
ATGGTGCCAGAAACCGTGAAACTCGCGAGCGAATCTGAATCCCATATGCGCCTGCTGATCATCGAGGATGACCGCGAATC
CGCCGATTATCTGGTGAAGGCGTTTCGTGAAGTCGGCCACGTCGCCGATCTCGCCAGCGACGGCGAGGAAGGGCTCGCGC
TCGCCGACAGCGGCGACTACGACGTGCTGGTGATCGACCGCATGCTGCCCAAGCGCGACGGCCTGTCGGTGATCGGCACG
CTGCGCGACAAGGGCAACCGCACCCCGGCACTCATCCTGTCGGCGCTGGGCCAGGTCGACGACCGCATCAAGGGTCTGCG
CGCCGGCGGCGACGACTATCTGCCGAAGCCCTACGCCTTCGCCGAACTCTTGGCGCGCGTCGAGGTGCTGTCACGCCGCC
ACGGCGGCCCGGCGGAGGAGACCAGCTACCGCGTCGGCGATCTCGAACTCGACCGGCTGTCGCACCGCGTCACCCGCGGC
AGCGAGGAGCTGACACTGCAGCCGCGCGAATTCCGGCTGCTCGAATATCTGATGAAGCACGCCGGCCAGGTCGTCACCCG
CACCATGCTGCTGGAGAACGTCTGGGACTATCACTTCGACCCGCAGACCAACGTCATCGACGTCCACATCTCCCGCCTGC
GCGGCAAGATCGACAAGGGCTTCGACCGTCCGCTGCTGCACACCATCCGCGGCGCGGGGTATATGATCCGTGACGGCATT
CGGTAA

Upstream 100 bases:

>100_bases
GGAAGGACCAGGCGGGCGGTGGAGTTCCCCCAGCTCCATCGCCCGCTTCCATGTCCGGCGGGCGTGTCGTGCCGCCTTGC
ATGGAGGCTGAAGTCCCGCC

Downstream 100 bases:

>100_bases
ACTGATCCGAACCACCGCGTTTCGGCTGACGCTGGTTTATCTGTTCCTGTTCGGGCTGTTCGCGGCGTCGCTGCTGGGGT
ATTTCGCCTGGAACACGCGG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MVPETVKLASESESHMRLLIIEDDRESADYLVKAFREVGHVADLASDGEEGLALADSGDYDVLVIDRMLPKRDGLSVIGT
LRDKGNRTPALILSALGQVDDRIKGLRAGGDDYLPKPYAFAELLARVEVLSRRHGGPAEETSYRVGDLELDRLSHRVTRG
SEELTLQPREFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRGKIDKGFDRPLLHTIRGAGYMIRDGI
R

Sequences:

>Translated_241_residues
MVPETVKLASESESHMRLLIIEDDRESADYLVKAFREVGHVADLASDGEEGLALADSGDYDVLVIDRMLPKRDGLSVIGT
LRDKGNRTPALILSALGQVDDRIKGLRAGGDDYLPKPYAFAELLARVEVLSRRHGGPAEETSYRVGDLELDRLSHRVTRG
SEELTLQPREFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRGKIDKGFDRPLLHTIRGAGYMIRDGI
R
>Mature_241_residues
MVPETVKLASESESHMRLLIIEDDRESADYLVKAFREVGHVADLASDGEEGLALADSGDYDVLVIDRMLPKRDGLSVIGT
LRDKGNRTPALILSALGQVDDRIKGLRAGGDDYLPKPYAFAELLARVEVLSRRHGGPAEETSYRVGDLELDRLSHRVTRG
SEELTLQPREFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRGKIDKGFDRPLLHTIRGAGYMIRDGI
R

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=47.0588235294118, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=41.5525114155251, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.0090497737557, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=38.4615384615385, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=34.0909090909091, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=34.2465753424658, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=29.8642533936652, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=30.7359307359307, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.9649122807018, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=31.5315315315315, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=30.6666666666667, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.9559471365639, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=27.6315789473684, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.2127659574468, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27130; Mature: 27130

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPETVKLASESESHMRLLIIEDDRESADYLVKAFREVGHVADLASDGEEGLALADSGDY
CCCCHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
DVLVIDRMLPKRDGLSVIGTLRDKGNRTPALILSALGQVDDRIKGLRAGGDDYLPKPYAF
EEEEEECCCCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
AELLARVEVLSRRHGGPAEETSYRVGDLELDRLSHRVTRGSEELTLQPREFRLLEYLMKH
HHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHH
AGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRGKIDKGFDRPLLHTIRGAGYMIRDGI
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
R
C
>Mature Secondary Structure
MVPETVKLASESESHMRLLIIEDDRESADYLVKAFREVGHVADLASDGEEGLALADSGDY
CCCCHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
DVLVIDRMLPKRDGLSVIGTLRDKGNRTPALILSALGQVDDRIKGLRAGGDDYLPKPYAF
EEEEEECCCCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
AELLARVEVLSRRHGGPAEETSYRVGDLELDRLSHRVTRGSEELTLQPREFRLLEYLMKH
HHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHH
AGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRGKIDKGFDRPLLHTIRGAGYMIRDGI
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]