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The map label for this gene is guaB [H]

Identifier: 86750304

GI number: 86750304

Start: 3651197

End: 3652693

Strand: Reverse

Name: guaB [H]

Synonym: RPB_3193

Alternate gene names: 86750304

Gene position: 3652693-3651197 (Counterclockwise)

Preceding gene: 86750305

Following gene: 86750303

Centisome position: 68.51

GC content: 67.74

Gene sequence:

>1497_bases
ATGGCGTCATTGAGCGGATCACGGCAGTTTCAGGAAGCATACACGTTCGACGACGTGTTGCTGAAGCCCGGCCCGTCGGA
CGTGCTGCCGTCCGACGTCGATATTCGCTCCCGGATCACCCGCGCGATTTCGCTCAACATCCCGATCATCGCCTCGGCGA
TGGACACCGTGACCGAGGCGCGGATGGCGATCGCGATGGCGCAGGCCGGCGGCATCGGCGTGATCCACCGCAATTTCGAT
CCCGAGGGCCAGGCCGCGCAAGTCCGCCAGGTCAAAAAGTTCGAATCCGGCATGGTGGTCAATCCGCTGACCATCGCGCC
CGAGGCCAAGCTCGCCGACGCGCTGGCGCTGATGACTCAGTACGGCTTCTCCGGCATCCCGGTGGTGACCGGCGCGCAGG
GCGATGGTCCCGGCAAGCTGGTCGGCATCCTCACCAATCGCGACGTCCGCTTCGCCACCGATCCGGCGCAGAAGGTCTCG
GAGCTGATGACGCACGAGAACCTCGTCACCGTGCGTGAAGGGGTGAGCCAGGACGAGGCCAAGCGGCTGCTGCATCAGCA
CCGCATCGAGAAGCTGCTGGTGGTCGACGATCAATATCGCTGCGTCGGCCTGATCACCGTCAAGGACATGGAAAAGGCGG
TCGCGCATCCGCTGGCGTCGAAGGACGCGCAGGGCCGGCTGCGGGTCGCCGCCGCGACCACGGTCGGCGAGGGCGGCTAT
GAGCGCACCGAGCGACTGATCGAGGCCGGCGTCGACCTCGTCGTGGTCGACACCGCGCACGGCCATTCGGCGCGCGTGCT
GGAAGCGGTGACGCGGATCAAGCGGATCTCCAATGCGGTCCAGGTGATCGCCGGCAATATCGCCACCCGCGACGGCGCGC
AGGCGCTGATCGATTCCGGCGCCGACGCCATCAAGGTCGGCATCGGCCCGGGCTCGATCTGCACCACCCGGATCGTCGCC
GGCGTCGGCGTGCCGCAGCTCACCGCGATCATGGACGCGGTCGAGGCGGCCAAGAAGGCCGACATTCCGGTGATCGCCGA
TGGCGGCATCAAGTACTCGGGCGACCTCGCCAAGGCGCTCGCCGCCGGCGCCGACATCGCGATGGTCGGCTCGCTGCTCG
CCGGCACCGACGAGACGCCCGGCGAAGTGTTCCTGTGGCAGGGCCGCTCCTACAAGGCCTATCGCGGCATGGGCTCGGTC
GGCGCGATGGCGCGCGGCTCGGCCGATCGCTACTTCCAGCAGGACATCAAGGACACGCTGAAACTGGTGCCCGAAGGCAT
CGAGGGCCAGGTGCCGTACAAGGGCCCGGTCGGCAACGTGATGCATCAACTCGCTGGCGGCCTGCGCGCCGCGATGGGCT
ATGTCGGCGCGCGGACCCTGACCGAATTCCACGACAAGGCCGAGTTTGTCCGCATCACCGGCGCCGGCCTGCGCGAAAGC
CACGTCCACGACGTCACCATCACCCGCGAGAGCCCGAACTATCCGGGCGGGGTGTGA

Upstream 100 bases:

>100_bases
CGACGGGCTCGATTCGACGGCGCTGCTGCTGTGGCGCCGAACGCGGCTCCCGTCCCCCGAGCTAGAACGCGGCGTAACCT
GCCGCTGAACGGAGTTGGCA

Downstream 100 bases:

>100_bases
TAGTTCGCGTGTACTAACGCTTCCTCGGGGACGGAGCGTTACCGCACTCTCTTTCGTCATTTCGGGGCGCGAGCGCAGCT
CGCGAACCCGGAATCCATAA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MASLSGSRQFQEAYTFDDVLLKPGPSDVLPSDVDIRSRITRAISLNIPIIASAMDTVTEARMAIAMAQAGGIGVIHRNFD
PEGQAAQVRQVKKFESGMVVNPLTIAPEAKLADALALMTQYGFSGIPVVTGAQGDGPGKLVGILTNRDVRFATDPAQKVS
ELMTHENLVTVREGVSQDEAKRLLHQHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLASKDAQGRLRVAAATTVGEGGY
ERTERLIEAGVDLVVVDTAHGHSARVLEAVTRIKRISNAVQVIAGNIATRDGAQALIDSGADAIKVGIGPGSICTTRIVA
GVGVPQLTAIMDAVEAAKKADIPVIADGGIKYSGDLAKALAAGADIAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSV
GAMARGSADRYFQQDIKDTLKLVPEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGARTLTEFHDKAEFVRITGAGLRES
HVHDVTITRESPNYPGGV

Sequences:

>Translated_498_residues
MASLSGSRQFQEAYTFDDVLLKPGPSDVLPSDVDIRSRITRAISLNIPIIASAMDTVTEARMAIAMAQAGGIGVIHRNFD
PEGQAAQVRQVKKFESGMVVNPLTIAPEAKLADALALMTQYGFSGIPVVTGAQGDGPGKLVGILTNRDVRFATDPAQKVS
ELMTHENLVTVREGVSQDEAKRLLHQHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLASKDAQGRLRVAAATTVGEGGY
ERTERLIEAGVDLVVVDTAHGHSARVLEAVTRIKRISNAVQVIAGNIATRDGAQALIDSGADAIKVGIGPGSICTTRIVA
GVGVPQLTAIMDAVEAAKKADIPVIADGGIKYSGDLAKALAAGADIAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSV
GAMARGSADRYFQQDIKDTLKLVPEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGARTLTEFHDKAEFVRITGAGLRES
HVHDVTITRESPNYPGGV
>Mature_497_residues
ASLSGSRQFQEAYTFDDVLLKPGPSDVLPSDVDIRSRITRAISLNIPIIASAMDTVTEARMAIAMAQAGGIGVIHRNFDP
EGQAAQVRQVKKFESGMVVNPLTIAPEAKLADALALMTQYGFSGIPVVTGAQGDGPGKLVGILTNRDVRFATDPAQKVSE
LMTHENLVTVREGVSQDEAKRLLHQHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLASKDAQGRLRVAAATTVGEGGYE
RTERLIEAGVDLVVVDTAHGHSARVLEAVTRIKRISNAVQVIAGNIATRDGAQALIDSGADAIKVGIGPGSICTTRIVAG
VGVPQLTAIMDAVEAAKKADIPVIADGGIKYSGDLAKALAAGADIAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSVG
AMARGSADRYFQQDIKDTLKLVPEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGARTLTEFHDKAEFVRITGAGLRESH
VHDVTITRESPNYPGGV

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=42.5438596491228, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=42.5438596491228, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=42.8256070640177, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=42.5438596491228, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.2489626556017, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=42.8888888888889, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=41.6666666666667, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=39.2543859649123, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI50541956, Length=250, Percent_Identity=38.8, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541954, Length=250, Percent_Identity=38.8, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI50541952, Length=250, Percent_Identity=38.8, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI50541948, Length=250, Percent_Identity=38.8, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI156104880, Length=260, Percent_Identity=37.6923076923077, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=57.5819672131148, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1786293, Length=249, Percent_Identity=35.3413654618474, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=38.0753138075314, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=40.0473933649289, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=247, Percent_Identity=36.8421052631579, Blast_Score=165, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=39.3374741200828, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=38.9233954451346, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=39.7515527950311, Blast_Score=329, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=39.1691394658754, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641071, Length=493, Percent_Identity=38.7423935091278, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24641073, Length=493, Percent_Identity=38.7423935091278, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.2290249433107, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52601; Mature: 52470

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLSGSRQFQEAYTFDDVLLKPGPSDVLPSDVDIRSRITRAISLNIPIIASAMDTVTEA
CCCCCCCHHHHHHHCHHHEEECCCCCCCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHH
RMAIAMAQAGGIGVIHRNFDPEGQAAQVRQVKKFESGMVVNPLTIAPEAKLADALALMTQ
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEECCEEECCCHHHHHHHHHHHH
YGFSGIPVVTGAQGDGPGKLVGILTNRDVRFATDPAQKVSELMTHENLVTVREGVSQDEA
CCCCCCCEEECCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHHCCHHHHHHCCCHHHH
KRLLHQHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLASKDAQGRLRVAAATTVGEGGY
HHHHHHHHHHEEEEECCCCEEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCH
ERTERLIEAGVDLVVVDTAHGHSARVLEAVTRIKRISNAVQVIAGNIATRDGAQALIDSG
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
ADAIKVGIGPGSICTTRIVAGVGVPQLTAIMDAVEAAKKADIPVIADGGIKYSGDLAKAL
CCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHH
AAGADIAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSVGAMARGSADRYFQQDIKDTL
HCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCHHHHHHHHHHHHH
KLVPEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGARTLTEFHDKAEFVRITGAGLRES
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
HVHDVTITRESPNYPGGV
CCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
ASLSGSRQFQEAYTFDDVLLKPGPSDVLPSDVDIRSRITRAISLNIPIIASAMDTVTEA
CCCCCCHHHHHHHCHHHEEECCCCCCCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHH
RMAIAMAQAGGIGVIHRNFDPEGQAAQVRQVKKFESGMVVNPLTIAPEAKLADALALMTQ
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEECCEEECCCHHHHHHHHHHHH
YGFSGIPVVTGAQGDGPGKLVGILTNRDVRFATDPAQKVSELMTHENLVTVREGVSQDEA
CCCCCCCEEECCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHHCCHHHHHHCCCHHHH
KRLLHQHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLASKDAQGRLRVAAATTVGEGGY
HHHHHHHHHHEEEEECCCCEEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCH
ERTERLIEAGVDLVVVDTAHGHSARVLEAVTRIKRISNAVQVIAGNIATRDGAQALIDSG
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
ADAIKVGIGPGSICTTRIVAGVGVPQLTAIMDAVEAAKKADIPVIADGGIKYSGDLAKAL
CCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHH
AAGADIAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSVGAMARGSADRYFQQDIKDTL
HCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCHHHHHHHHHHHHH
KLVPEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGARTLTEFHDKAEFVRITGAGLRES
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
HVHDVTITRESPNYPGGV
CCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA