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The map label for this gene is gabT [H]

Identifier: 86750248

GI number: 86750248

Start: 3585649

End: 3586923

Strand: Reverse

Name: gabT [H]

Synonym: RPB_3137

Alternate gene names: 86750248

Gene position: 3586923-3585649 (Counterclockwise)

Preceding gene: 86750249

Following gene: 86750247

Centisome position: 67.28

GC content: 66.43

Gene sequence:

>1275_bases
ATGACGAATAGTGAGTTGCTGGCACGCAGACACGAGGCCGTGGTGCGAGGCGTCAGCCAGGCCACGCCGATCTTTGCAGA
GCGTGCGCTGAACAGCGAAATTTGGGACGTCGAAGGCAAGCGTTACATCGACTTCGCCGGCGGCATCGCCGTGTTAAACA
CCGGCCACTGCCATCCGCGTGTGGTCGAAGCGGTCCGAGGCCAATTGGATCGGTTCACGCACACCTGCTTCCAGGTTCTT
CCCTACGAGTCGTATATTCGGCTCGCCGAGCGGCTGAACGCCCTGGCGCCGATCAACGGTCCGCTGAAATCGATCCTGCT
CAGCACCGGGGCGGAGGCCACCGAGAACGCCGTCAAGATCGCGCGTGCCGCGACCGGCCGCAGCGGCGTGATCGCGTTCA
CCGGCGGCTTCCACGGCCGCACCGCATTTGCATCCGCAATGACCGGCAAGGTCATCCCCTACAAGAAGGCCCTCGGCCCG
CCGCTGCCCGGCGTGTGGCATGCGCCGTTTCCCGCCGCCGGCGGTGACGTCACGGTGGAAGACGCGCTGCGCTGCGTGTC
CTTCATCTTCAAGGCCGATATCGACGCCTCGCAAGTGGCGGCGATCATCATCGAGCCCGTGCAGGGCGAGGGCGGATTCC
ATCAGGCGCCACCCGAACTGATGCGCGGCCTGCGCAGGATCTGCGACGAGAGCGGAATCGTGCTGATTGCCGACGAGGTG
CAGACCGGTTTCGGTCGCACCGGCAAGATGTTCGCGATGGAGCACTACGACGTGCAGGCCGACATCGTCTGCGTGGCGAA
GAGCCTGGCGGGCGGCATGCCGCTGTCGGGCGTGATCGGGCGCGCGGCGATCATGGATGCCGCCGAGCCGGGCGGCCTCG
GCGGCACCTATGCGGGTAATCCGCTGGCGTGCGCCGCCGCGCTCGCTGTGCTCGACGTGTTCGAAGACGAGAATCTGATT
GCGCGGGCGAACCAGATCGGCGAGCGGCTGCGCAATGCGATCGATCGATTCGCACTGTCGAACACGCTGGTGCCGACCTC
GGCCGCGCGCGGGCCCGGCGCGATGGTCGCGTTCGACATTCTGAAACAGCGTGGCAGCAGCGAGCCGGACGCCGAGACGA
CCAAGCGAGTGACGCGTCTCGCATACGAGAACGGTCTGATCCTGCTGTCGTGCGGCACCGCCGCCAACACCATTCGCATT
CTGGTGCCGCTGACCGCCTCCGACGCGATCGTCGACGAGGGGCTGGCGATCCTGGAGCGTTGCCTCGCTGCGTAG

Upstream 100 bases:

>100_bases
TCCGATCGATTGGTGCATGCAAGTCACCAGAGCGAACGTACAAGCTGATTGATTGCCGTCACGGGCGCTCTAGCTTCGCT
ATCAGTTCGGGAGAGAGCTG

Downstream 100 bases:

>100_bases
CACATGGCGCATCCGCGCCGAGACGGGACTAATCGAGATGCTGATGCCGAGTGATCCTGGCCTGTTGGCCGAGCGCTGCC
TGATTGGCGGCAAATGGTGT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTNSELLARRHEAVVRGVSQATPIFAERALNSEIWDVEGKRYIDFAGGIAVLNTGHCHPRVVEAVRGQLDRFTHTCFQVL
PYESYIRLAERLNALAPINGPLKSILLSTGAEATENAVKIARAATGRSGVIAFTGGFHGRTAFASAMTGKVIPYKKALGP
PLPGVWHAPFPAAGGDVTVEDALRCVSFIFKADIDASQVAAIIIEPVQGEGGFHQAPPELMRGLRRICDESGIVLIADEV
QTGFGRTGKMFAMEHYDVQADIVCVAKSLAGGMPLSGVIGRAAIMDAAEPGGLGGTYAGNPLACAAALAVLDVFEDENLI
ARANQIGERLRNAIDRFALSNTLVPTSAARGPGAMVAFDILKQRGSSEPDAETTKRVTRLAYENGLILLSCGTAANTIRI
LVPLTASDAIVDEGLAILERCLAA

Sequences:

>Translated_424_residues
MTNSELLARRHEAVVRGVSQATPIFAERALNSEIWDVEGKRYIDFAGGIAVLNTGHCHPRVVEAVRGQLDRFTHTCFQVL
PYESYIRLAERLNALAPINGPLKSILLSTGAEATENAVKIARAATGRSGVIAFTGGFHGRTAFASAMTGKVIPYKKALGP
PLPGVWHAPFPAAGGDVTVEDALRCVSFIFKADIDASQVAAIIIEPVQGEGGFHQAPPELMRGLRRICDESGIVLIADEV
QTGFGRTGKMFAMEHYDVQADIVCVAKSLAGGMPLSGVIGRAAIMDAAEPGGLGGTYAGNPLACAAALAVLDVFEDENLI
ARANQIGERLRNAIDRFALSNTLVPTSAARGPGAMVAFDILKQRGSSEPDAETTKRVTRLAYENGLILLSCGTAANTIRI
LVPLTASDAIVDEGLAILERCLAA
>Mature_423_residues
TNSELLARRHEAVVRGVSQATPIFAERALNSEIWDVEGKRYIDFAGGIAVLNTGHCHPRVVEAVRGQLDRFTHTCFQVLP
YESYIRLAERLNALAPINGPLKSILLSTGAEATENAVKIARAATGRSGVIAFTGGFHGRTAFASAMTGKVIPYKKALGPP
LPGVWHAPFPAAGGDVTVEDALRCVSFIFKADIDASQVAAIIIEPVQGEGGFHQAPPELMRGLRRICDESGIVLIADEVQ
TGFGRTGKMFAMEHYDVQADIVCVAKSLAGGMPLSGVIGRAAIMDAAEPGGLGGTYAGNPLACAAALAVLDVFEDENLIA
RANQIGERLRNAIDRFALSNTLVPTSAARGPGAMVAFDILKQRGSSEPDAETTKRVTRLAYENGLILLSCGTAANTIRIL
VPLTASDAIVDEGLAILERCLAA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=417, Percent_Identity=33.5731414868106, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI13994255, Length=447, Percent_Identity=30.2013422818792, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI37574042, Length=430, Percent_Identity=28.3720930232558, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI284507298, Length=328, Percent_Identity=33.2317073170732, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=28.5353535353535, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI24119277, Length=399, Percent_Identity=27.3182957393484, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI226442705, Length=430, Percent_Identity=27.4418604651163, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI188536080, Length=443, Percent_Identity=25.9593679458239, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI38679950, Length=443, Percent_Identity=25.9593679458239, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI38679946, Length=443, Percent_Identity=25.9593679458239, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=53.0805687203791, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1787560, Length=424, Percent_Identity=54.9528301886792, Blast_Score=450, Evalue=1e-128,
Organism=Escherichia coli, GI1789759, Length=415, Percent_Identity=33.2530120481928, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI145693181, Length=387, Percent_Identity=36.9509043927649, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788044, Length=405, Percent_Identity=33.5802469135802, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1786349, Length=313, Percent_Identity=35.1437699680511, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1786991, Length=310, Percent_Identity=35.1612903225806, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=400, Percent_Identity=32.25, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=452, Percent_Identity=28.7610619469027, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32564660, Length=422, Percent_Identity=28.6729857819905, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=31.6151202749141, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=474, Percent_Identity=24.2616033755274, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=151, Percent_Identity=31.1258278145695, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=31.0843373493976, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324432, Length=412, Percent_Identity=30.0970873786408, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=371, Percent_Identity=25.0673854447439, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321456, Length=433, Percent_Identity=24.7113163972286, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357415, Length=435, Percent_Identity=29.6551724137931, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI28574759, Length=409, Percent_Identity=29.5843520782396, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI161085790, Length=417, Percent_Identity=29.0167865707434, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21356575, Length=446, Percent_Identity=30.0448430493274, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI281366494, Length=347, Percent_Identity=26.8011527377522, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667139, Length=347, Percent_Identity=26.8011527377522, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667143, Length=347, Percent_Identity=26.8011527377522, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 44769; Mature: 44638

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSELLARRHEAVVRGVSQATPIFAERALNSEIWDVEGKRYIDFAGGIAVLNTGHCHPR
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEECCCEEEEECCCCCHH
VVEAVRGQLDRFTHTCFQVLPYESYIRLAERLNALAPINGPLKSILLSTGAEATENAVKI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHH
ARAATGRSGVIAFTGGFHGRTAFASAMTGKVIPYKKALGPPLPGVWHAPFPAAGGDVTVE
HHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEHH
DALRCVSFIFKADIDASQVAAIIIEPVQGEGGFHQAPPELMRGLRRICDESGIVLIADEV
HHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECC
QTGFGRTGKMFAMEHYDVQADIVCVAKSLAGGMPLSGVIGRAAIMDAAEPGGLGGTYAGN
CCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
PLACAAALAVLDVFEDENLIARANQIGERLRNAIDRFALSNTLVPTSAARGPGAMVAFDI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LKQRGSSEPDAETTKRVTRLAYENGLILLSCGTAANTIRILVPLTASDAIVDEGLAILER
HHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHH
CLAA
HHCC
>Mature Secondary Structure 
TNSELLARRHEAVVRGVSQATPIFAERALNSEIWDVEGKRYIDFAGGIAVLNTGHCHPR
CCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEECCCEEEEECCCCCHH
VVEAVRGQLDRFTHTCFQVLPYESYIRLAERLNALAPINGPLKSILLSTGAEATENAVKI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHH
ARAATGRSGVIAFTGGFHGRTAFASAMTGKVIPYKKALGPPLPGVWHAPFPAAGGDVTVE
HHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEHH
DALRCVSFIFKADIDASQVAAIIIEPVQGEGGFHQAPPELMRGLRRICDESGIVLIADEV
HHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECC
QTGFGRTGKMFAMEHYDVQADIVCVAKSLAGGMPLSGVIGRAAIMDAAEPGGLGGTYAGN
CCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
PLACAAALAVLDVFEDENLIARANQIGERLRNAIDRFALSNTLVPTSAARGPGAMVAFDI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LKQRGSSEPDAETTKRVTRLAYENGLILLSCGTAANTIRILVPLTASDAIVDEGLAILER
HHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHH
CLAA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]