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The map label for this gene is coxS [H]

Identifier: 86750216

GI number: 86750216

Start: 3536645

End: 3537115

Strand: Reverse

Name: coxS [H]

Synonym: RPB_3103

Alternate gene names: 86750216

Gene position: 3537115-3536645 (Counterclockwise)

Preceding gene: 86750217

Following gene: 86750215

Centisome position: 66.34

GC content: 66.45

Gene sequence:

>471_bases
ATGCACGTCCAATTCAAACTCAACGGCCAGCCGGTCAGCGCCGAGGTCGAGCCGCGCACCACGCTCGCCGACTGCATTCG
GAACGATTTCGGCCAGACCGGCACGCATCTCGCCTGCGAGCATGGGGTTTGCGGGGCCTGCACCGTACTGGTGAACGGCG
AAGCCGTGCGCGCCTGCCTGATGCTCGCCGCCCAGGTCGAAGGCGACGCCGTCACCACAGTCGAGGGGCTGTCGGGCGAT
GAACTCACGCCGCTGCAGAAAGCCTTCCGCAAACACCATGCTCTGCAATGCGGATTCTGCACGCCGGGCTTCATCACCAC
CGCGCATGCGCTGCTGAGCAGCGAGCCGGACGCGAGCGAAGAGCGGATCCGCGAGGTGCTGTCCGGCAACCTCTGCCGCT
GCACTGGTTACGTCCCCATCGTCGACGCGGTAATGGAAGCGCGCGCCGCCTATGCCGAGGCGCAGCGATGA

Upstream 100 bases:

>100_bases
CCGCCGACCGACATCCACGCGCCGGGCGCCTATCGTGCCTCGCTCGCAGCGACGCTGCTGGCGCGGGCGCTCGCCAAGTC
CGCCGCCTAAGGAAACCCGC

Downstream 100 bases:

>100_bases
GCATGACGAAGGTCGCCAATTCGTACATTGGTCGCCCGATGGAGCGGGTCGAGGATCTGCGCATGGTGCGCGGGCGCGGC
ACTTATGTGGCCGACGTCAA

Product: (2Fe-2S)-binding protein

Products: NA

Alternate protein names: CO dehydrogenase subunit S; CO-DH S [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MHVQFKLNGQPVSAEVEPRTTLADCIRNDFGQTGTHLACEHGVCGACTVLVNGEAVRACLMLAAQVEGDAVTTVEGLSGD
ELTPLQKAFRKHHALQCGFCTPGFITTAHALLSSEPDASEERIREVLSGNLCRCTGYVPIVDAVMEARAAYAEAQR

Sequences:

>Translated_156_residues
MHVQFKLNGQPVSAEVEPRTTLADCIRNDFGQTGTHLACEHGVCGACTVLVNGEAVRACLMLAAQVEGDAVTTVEGLSGD
ELTPLQKAFRKHHALQCGFCTPGFITTAHALLSSEPDASEERIREVLSGNLCRCTGYVPIVDAVMEARAAYAEAQR
>Mature_156_residues
MHVQFKLNGQPVSAEVEPRTTLADCIRNDFGQTGTHLACEHGVCGACTVLVNGEAVRACLMLAAQVEGDAVTTVEGLSGD
ELTPLQKAFRKHHALQCGFCTPGFITTAHALLSSEPDASEERIREVLSGNLCRCTGYVPIVDAVMEARAAYAEAQR

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=150, Percent_Identity=40, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI71773480, Length=88, Percent_Identity=45.4545454545455, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1786480, Length=163, Percent_Identity=43.558282208589, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI1789232, Length=149, Percent_Identity=42.2818791946309, Blast_Score=112, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32566215, Length=152, Percent_Identity=44.7368421052632, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17539860, Length=152, Percent_Identity=44.078947368421, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540638, Length=151, Percent_Identity=44.3708609271523, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737937, Length=151, Percent_Identity=40.3973509933775, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24647199, Length=155, Percent_Identity=36.7741935483871, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24647201, Length=158, Percent_Identity=37.9746835443038, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24647197, Length=161, Percent_Identity=34.7826086956522, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24647195, Length=161, Percent_Identity=34.7826086956522, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24647193, Length=137, Percent_Identity=35.7664233576642, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 16644; Mature: 16644

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
5.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVQFKLNGQPVSAEVEPRTTLADCIRNDFGQTGTHLACEHGVCGACTVLVNGEAVRACL
CEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCHHHHHHH
MLAAQVEGDAVTTVEGLSGDELTPLQKAFRKHHALQCGFCTPGFITTAHALLSSEPDASE
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCEEECCCCCHHHHHHHHHHCCCCCCHH
ERIREVLSGNLCRCTGYVPIVDAVMEARAAYAEAQR
HHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHVQFKLNGQPVSAEVEPRTTLADCIRNDFGQTGTHLACEHGVCGACTVLVNGEAVRACL
CEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCHHHHHHH
MLAAQVEGDAVTTVEGLSGDELTPLQKAFRKHHALQCGFCTPGFITTAHALLSSEPDASE
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCEEECCCCCHHHHHHHHHHCCCCCCHH
ERIREVLSGNLCRCTGYVPIVDAVMEARAAYAEAQR
HHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 10430865; 12475995 [H]