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The map label for this gene is pbpC [H]

Identifier: 86750035

GI number: 86750035

Start: 3326640

End: 3328835

Strand: Reverse

Name: pbpC [H]

Synonym: RPB_2918

Alternate gene names: 86750035

Gene position: 3328835-3326640 (Counterclockwise)

Preceding gene: 86750036

Following gene: 86750034

Centisome position: 62.44

GC content: 69.76

Gene sequence:

>2196_bases
ATGAGCGGGGACCGCCTCACACGCTTGCTCTCGTCATTGCGAGGAGCGGAGCGACGAAGCAATCCAGAGGTGGCAACCGT
GGCCCCTGGATTGCTTCGCTCCGCTCGCAATGACGGGTGGAAAGGGTGGTGGTGGATCAAGACGACAGCAATCGTTTCGG
CCGTCCTCGTCATCGCTGCGATCGGCGCCATCGCGGCCTACGTCGCCTCGCTCGGGCCGCTGCCGCTCGACGAGGCGCGC
CGGACCTCGGTCAGCGTGGTGGATCGCCAGGGCAAGCTGCTGCGCGCTTATGCGATGGCCGACGGCCGCTGGCGGCTGCC
GGTCGATGCGCAGACGCAGGTCGATCCGCGCTATCTCACGCAACTGATCGCCTATGAGGACAAGCGGTTCTGGTCGCATC
GCGGCGTCGATCCCTGGGCGATCGGCCGCGCCGCGCTGCAGCTCGCGACCCATGGCCAGATCGTGTCCGGCGGATCGACC
ATCACCATGCAGCTCGCCCGGCTGATGGAGCCACGGCGGGAACGCTCGCTCTCGGCCAAGCTGCGCCAGATGGTCCGCGC
CATCGAGCTCGAACGCACACTGAGCAAGCCGCAGATCCTCGATCTGTATCTGGCGCTGGCGCCGTATGGCGGCAATCTCG
AAGGCATCCGCGCCGCCTCGATCGCGTATTTCGGCAAGGAGCCCAAGCGGCTGACATTGGCCGAATCCGCGTTGCTGGTG
GCGATTCCGCAATCGCCCGAGCGGCGGCGGCTCGACCGCCATCCGGCGACGGCGCAGGCGGCGCGCGATCGCGTGCTGAC
GCGGCTGGTCGAGGATCAGGTGGTCAGCACCGAGGACGCCGCGCAGGCGAGGGCGGTGCCGGTCGCGCGCGCGCGCAAGC
CGATGCCGGTGCTGGCGCCGCATTCGGCCGATCAGGCGACCGCCGTGATCAAAGACAAGCCGGTGATCCGGTTGACGCTC
GACGCCGGCATTCAGCACGCGCTGGAAGCGCTGGCGCGCGACCGTGCTGTGGCGCTCGGCCCCGACATCTCGATCGGCAT
CGTCGCGGTGGATAACGAAACCGGCGACGTGCTGGCCCATGTCGGCTCGGCCGACTATTTCGACGACCGCCGTGCCGGCC
AGGTCGACATGACCCGCGCGGTGCGCTCGCCCGGCTCGACACTGAAGCCATTCATCTACGGGCTCGCCTTCGAGGACGGT
TTCGTCCATCCGGAGAGCTTGATCGACGACCGGCCGGTCCGCTACGGCGCCTATGCGCCGGAGAATTTCGACATGACGTT
CCAGGGCACGGTGCCGGTGCGCAAGGCGCTGCAATTGTCGCTCAACGTCCCGGCGATCGAGCTGCTCGACCGGGTCGGTC
CGCACCGGCTGGCGTCGCGGCTGAAGCAGGCCGGCGTCGGCCTGGTGCTGCCGAAGGACGAAGCGCCCGGGCTGGCGATG
GGGCTCGGCGGCGTCGGCGTTCGGCTGACCGATCTGGTGCAGCTCTTCAGCGGCGTCGCGCGCCTCGGCAGCGTCGTGCC
GTTGCGGGAAATCGCCAGCGATGCCAAGGACGAACGCGAGACTCTGCGACTCCTGGATAAAGTCGCGGCCTGGCAGGTCG
GCAACGTCCTGCTCGGCACCCCGCCGCCGGACAACGCCGCCCGCAACCAGATCGCGTTCAAGACCGGCACCTCTTACGGC
TATCGCGACGCCTGGTCGGTGGGTTTCGACGGCCGGATGACGATCGGCGTCTGGGTCGGCCGGCCCGACGGCGCGCCGGT
GCCGGGCCTGATCGGCCGCGTCGCCGCCGCGCCGGTGCTGTTCGACGCCTTCGCCCGCACCGGCCAATTGCGCGCGCCGC
TGCCGAAACCGCCACGCGGAACGCTGATCGCCGGCAACGCCCAGTTGCCGCTGCCGCTGCGCCGGTTCCGGCCGGCGGGC
GAGCTGGTTCGTGCCGGCGGCGAGCAGGCTTTGAAGATCCAGTTTCCGCTGAACGGCTCGCGGATCGACGCGCTGAGCCA
GGCGTCCACCGGCGCACTGCCCGTCAAGGTCTCCGGCGGCGTGCTGCCGATGACGGTGATGGTCAACGGCCTGTCGGCCG
GCGAAATCGACGGCCGGCGTCAGCGGCTGATCGCGCCGCCCGGCCCGGGCTTCGTCCGGCTCACCGTGATGGACGCCGTC
GGCGCGGCGGCAACAGTCGTGGTGAGAATCCAGTAG

Upstream 100 bases:

>100_bases
CCGGCAAATACGTGCTCCCGCAGGCCATCGTCGAGGACATGTACAACCCCTCGCGTTACGGCCGCACCGGCACCGGCAGC
GTCGAGGTGACTAAGGCGAA

Downstream 100 bases:

>100_bases
CAGCCCGGCCAAGTGGTTGTCCGACTATCGGTTTCAGCGTATGCGAAACCGATGATCGAGACCTCTGCAACACGCCGCTT
TGGCGCCCCCCGCGAGCCGA

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 731; Mature: 730

Protein sequence:

>731_residues
MSGDRLTRLLSSLRGAERRSNPEVATVAPGLLRSARNDGWKGWWWIKTTAIVSAVLVIAAIGAIAAYVASLGPLPLDEAR
RTSVSVVDRQGKLLRAYAMADGRWRLPVDAQTQVDPRYLTQLIAYEDKRFWSHRGVDPWAIGRAALQLATHGQIVSGGST
ITMQLARLMEPRRERSLSAKLRQMVRAIELERTLSKPQILDLYLALAPYGGNLEGIRAASIAYFGKEPKRLTLAESALLV
AIPQSPERRRLDRHPATAQAARDRVLTRLVEDQVVSTEDAAQARAVPVARARKPMPVLAPHSADQATAVIKDKPVIRLTL
DAGIQHALEALARDRAVALGPDISIGIVAVDNETGDVLAHVGSADYFDDRRAGQVDMTRAVRSPGSTLKPFIYGLAFEDG
FVHPESLIDDRPVRYGAYAPENFDMTFQGTVPVRKALQLSLNVPAIELLDRVGPHRLASRLKQAGVGLVLPKDEAPGLAM
GLGGVGVRLTDLVQLFSGVARLGSVVPLREIASDAKDERETLRLLDKVAAWQVGNVLLGTPPPDNAARNQIAFKTGTSYG
YRDAWSVGFDGRMTIGVWVGRPDGAPVPGLIGRVAAAPVLFDAFARTGQLRAPLPKPPRGTLIAGNAQLPLPLRRFRPAG
ELVRAGGEQALKIQFPLNGSRIDALSQASTGALPVKVSGGVLPMTVMVNGLSAGEIDGRRQRLIAPPGPGFVRLTVMDAV
GAAATVVVRIQ

Sequences:

>Translated_731_residues
MSGDRLTRLLSSLRGAERRSNPEVATVAPGLLRSARNDGWKGWWWIKTTAIVSAVLVIAAIGAIAAYVASLGPLPLDEAR
RTSVSVVDRQGKLLRAYAMADGRWRLPVDAQTQVDPRYLTQLIAYEDKRFWSHRGVDPWAIGRAALQLATHGQIVSGGST
ITMQLARLMEPRRERSLSAKLRQMVRAIELERTLSKPQILDLYLALAPYGGNLEGIRAASIAYFGKEPKRLTLAESALLV
AIPQSPERRRLDRHPATAQAARDRVLTRLVEDQVVSTEDAAQARAVPVARARKPMPVLAPHSADQATAVIKDKPVIRLTL
DAGIQHALEALARDRAVALGPDISIGIVAVDNETGDVLAHVGSADYFDDRRAGQVDMTRAVRSPGSTLKPFIYGLAFEDG
FVHPESLIDDRPVRYGAYAPENFDMTFQGTVPVRKALQLSLNVPAIELLDRVGPHRLASRLKQAGVGLVLPKDEAPGLAM
GLGGVGVRLTDLVQLFSGVARLGSVVPLREIASDAKDERETLRLLDKVAAWQVGNVLLGTPPPDNAARNQIAFKTGTSYG
YRDAWSVGFDGRMTIGVWVGRPDGAPVPGLIGRVAAAPVLFDAFARTGQLRAPLPKPPRGTLIAGNAQLPLPLRRFRPAG
ELVRAGGEQALKIQFPLNGSRIDALSQASTGALPVKVSGGVLPMTVMVNGLSAGEIDGRRQRLIAPPGPGFVRLTVMDAV
GAAATVVVRIQ
>Mature_730_residues
SGDRLTRLLSSLRGAERRSNPEVATVAPGLLRSARNDGWKGWWWIKTTAIVSAVLVIAAIGAIAAYVASLGPLPLDEARR
TSVSVVDRQGKLLRAYAMADGRWRLPVDAQTQVDPRYLTQLIAYEDKRFWSHRGVDPWAIGRAALQLATHGQIVSGGSTI
TMQLARLMEPRRERSLSAKLRQMVRAIELERTLSKPQILDLYLALAPYGGNLEGIRAASIAYFGKEPKRLTLAESALLVA
IPQSPERRRLDRHPATAQAARDRVLTRLVEDQVVSTEDAAQARAVPVARARKPMPVLAPHSADQATAVIKDKPVIRLTLD
AGIQHALEALARDRAVALGPDISIGIVAVDNETGDVLAHVGSADYFDDRRAGQVDMTRAVRSPGSTLKPFIYGLAFEDGF
VHPESLIDDRPVRYGAYAPENFDMTFQGTVPVRKALQLSLNVPAIELLDRVGPHRLASRLKQAGVGLVLPKDEAPGLAMG
LGGVGVRLTDLVQLFSGVARLGSVVPLREIASDAKDERETLRLLDKVAAWQVGNVLLGTPPPDNAARNQIAFKTGTSYGY
RDAWSVGFDGRMTIGVWVGRPDGAPVPGLIGRVAAAPVLFDAFARTGQLRAPLPKPPRGTLIAGNAQLPLPLRRFRPAGE
LVRAGGEQALKIQFPLNGSRIDALSQASTGALPVKVSGGVLPMTVMVNGLSAGEIDGRRQRLIAPPGPGFVRLTVMDAVG
AAATVVVRIQ

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=580, Percent_Identity=44.6551724137931, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1786343, Length=517, Percent_Identity=29.0135396518375, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI87082258, Length=250, Percent_Identity=32.4, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1789601, Length=200, Percent_Identity=30, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 78559; Mature: 78428

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGDRLTRLLSSLRGAERRSNPEVATVAPGLLRSARNDGWKGWWWIKTTAIVSAVLVIAA
CCHHHHHHHHHHHHCHHHCCCCCEEEECHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHH
IGAIAAYVASLGPLPLDEARRTSVSVVDRQGKLLRAYAMADGRWRLPVDAQTQVDPRYLT
HHHHHHHHHHCCCCCCCHHHHCHHEEECCCCCEEEEEEECCCEEECCCCCCCCCCHHHHH
QLIAYEDKRFWSHRGVDPWAIGRAALQLATHGQIVSGGSTITMQLARLMEPRRERSLSAK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCHHHHHHHHHH
LRQMVRAIELERTLSKPQILDLYLALAPYGGNLEGIRAASIAYFGKEPKRLTLAESALLV
HHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCCEEEEEEECCCCCCEEEEECCEEEE
AIPQSPERRRLDRHPATAQAARDRVLTRLVEDQVVSTEDAAQARAVPVARARKPMPVLAP
EECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCCCCEECC
HSADQATAVIKDKPVIRLTLDAGIQHALEALARDRAVALGPDISIGIVAVDNETGDVLAH
CCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEECCCCCHHEE
VGSADYFDDRRAGQVDMTRAVRSPGSTLKPFIYGLAFEDGFVHPESLIDDRPVRYGAYAP
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHEEEEECCCCCCHHHHCCCCCCEECCCCC
ENFDMTFQGTVPVRKALQLSLNVPAIELLDRVGPHRLASRLKQAGVGLVLPKDEAPGLAM
CCCCEEEECCCHHHHHHHEECCCCHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCEEE
GLGGVGVRLTDLVQLFSGVARLGSVVPLREIASDAKDERETLRLLDKVAAWQVGNVLLGT
ECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEECC
PPPDNAARNQIAFKTGTSYGYRDAWSVGFDGRMTIGVWVGRPDGAPVPGLIGRVAAAPVL
CCCCCHHCCEEEEECCCCCCCCCCEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHH
FDAFARTGQLRAPLPKPPRGTLIAGNAQLPLPLRRFRPAGELVRAGGEQALKIQFPLNGS
HHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCHHHCCCHHHHHHCCCCCEEEEEECCCCC
RIDALSQASTGALPVKVSGGVLPMTVMVNGLSAGEIDGRRQRLIAPPGPGFVRLTVMDAV
HHHHHHHCCCCCEEEEECCCEEEEEEEEECCCCCCCCCCCCEEECCCCCCEEEEEEEHHC
GAAATVVVRIQ
CCEEEEEEEEC
>Mature Secondary Structure 
SGDRLTRLLSSLRGAERRSNPEVATVAPGLLRSARNDGWKGWWWIKTTAIVSAVLVIAA
CHHHHHHHHHHHHCHHHCCCCCEEEECHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHH
IGAIAAYVASLGPLPLDEARRTSVSVVDRQGKLLRAYAMADGRWRLPVDAQTQVDPRYLT
HHHHHHHHHHCCCCCCCHHHHCHHEEECCCCCEEEEEEECCCEEECCCCCCCCCCHHHHH
QLIAYEDKRFWSHRGVDPWAIGRAALQLATHGQIVSGGSTITMQLARLMEPRRERSLSAK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCHHHHHHHHHH
LRQMVRAIELERTLSKPQILDLYLALAPYGGNLEGIRAASIAYFGKEPKRLTLAESALLV
HHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCCEEEEEEECCCCCCEEEEECCEEEE
AIPQSPERRRLDRHPATAQAARDRVLTRLVEDQVVSTEDAAQARAVPVARARKPMPVLAP
EECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCCCCEECC
HSADQATAVIKDKPVIRLTLDAGIQHALEALARDRAVALGPDISIGIVAVDNETGDVLAH
CCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEECCCCCHHEE
VGSADYFDDRRAGQVDMTRAVRSPGSTLKPFIYGLAFEDGFVHPESLIDDRPVRYGAYAP
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHEEEEECCCCCCHHHHCCCCCCEECCCCC
ENFDMTFQGTVPVRKALQLSLNVPAIELLDRVGPHRLASRLKQAGVGLVLPKDEAPGLAM
CCCCEEEECCCHHHHHHHEECCCCHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCEEE
GLGGVGVRLTDLVQLFSGVARLGSVVPLREIASDAKDERETLRLLDKVAAWQVGNVLLGT
ECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEECC
PPPDNAARNQIAFKTGTSYGYRDAWSVGFDGRMTIGVWVGRPDGAPVPGLIGRVAAAPVL
CCCCCHHCCEEEEECCCCCCCCCCEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHH
FDAFARTGQLRAPLPKPPRGTLIAGNAQLPLPLRRFRPAGELVRAGGEQALKIQFPLNGS
HHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCHHHCCCHHHHHHCCCCCEEEEEECCCCC
RIDALSQASTGALPVKVSGGVLPMTVMVNGLSAGEIDGRRQRLIAPPGPGFVRLTVMDAV
HHHHHHHCCCCCEEEEECCCEEEEEEEEECCCCCCCCCCCCEEECCCCCCEEEEEEEHHC
GAAATVVVRIQ
CCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]