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The map label for this gene is pyrH

Identifier: 86749943

GI number: 86749943

Start: 3220405

End: 3221121

Strand: Reverse

Name: pyrH

Synonym: RPB_2826

Alternate gene names: 86749943

Gene position: 3221121-3220405 (Counterclockwise)

Preceding gene: 86749944

Following gene: 86749942

Centisome position: 60.42

GC content: 67.64

Gene sequence:

>717_bases
ATGGGTGAGCCGATCTATCGTCGTGTGGTGGTCAAGCTATCGGGCGAGTATTTCGCCGGCCCTCAGCATTACGGCATCGA
TCAACCCACCATCGATCGCGTCGCCGGCGACCTGATCGCAGCCCGCGGTCTCGGCGTCGAGATCGCCGTCGTGGTCGGTG
GCGGCAACATCTTCCGTGGCGTCGAGGTCTCGGCGCGCGGCGTGTCGCGCCCGACCGGCGACACCATGGGCATGCTGGCG
ACGGTGATGAACTGCCTCGCGCTCGGTGAAGCGCTGCGGCGCCACGGCCAGCCCGCCCGAACCTTCTCCGCACTGCTGAT
GCCCGAAGTCTGCGATCTGTACACCCGCGCGGCCGCACAGCAGACGCTGGCGGAGGGCGGTATCGCGCTGCTCGCGGGCG
GTACCGGCAACCCGTTCTTCACCACCGACACCACGGCAGTGTTGCGCGCAGCCGAGATCGACGCCGGGGCCGTGCTGAAA
GCCACCAATGTCGACGGCGTCTATACCGCCGACCCGAAGCGCGATCCGAATGCGAAGCGGTTCGAGCGGCTGACGCATTC
GGAAGCGCTCGCAGGCGGCTACAAGGTCATGGATGCGACGGCTTTCGCGCTTGCCCGCGAAACCTCGCTGCCTATCATCG
TGTTTTCCATCGCCGAGCCGGGATCGATCGGCGCCGTGCTGGGCGGCGCGGGCCGAGCGACTGTCGTCGCGGGTTGA

Upstream 100 bases:

>100_bases
CTCGGGCCAGAAGTAATTGGGTCAGAAGTAATCGCTTTTCACGTGATCAACTCCCGGCCGTTCCGGCCGGGAGCGAACCC
ACCGAGGACGCGACCGCATC

Downstream 100 bases:

>100_bases
GTTTCGCGTGCCGCGAGGCGTCGCGATGAGGATTCAGAATTCGAGAGGGAGTGACTGGCATGCAGTCCGAAAAGTTCGAC
ATCAATGATTTGAAGCGCCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MGEPIYRRVVVKLSGEYFAGPQHYGIDQPTIDRVAGDLIAARGLGVEIAVVVGGGNIFRGVEVSARGVSRPTGDTMGMLA
TVMNCLALGEALRRHGQPARTFSALLMPEVCDLYTRAAAQQTLAEGGIALLAGGTGNPFFTTDTTAVLRAAEIDAGAVLK
ATNVDGVYTADPKRDPNAKRFERLTHSEALAGGYKVMDATAFALARETSLPIIVFSIAEPGSIGAVLGGAGRATVVAG

Sequences:

>Translated_238_residues
MGEPIYRRVVVKLSGEYFAGPQHYGIDQPTIDRVAGDLIAARGLGVEIAVVVGGGNIFRGVEVSARGVSRPTGDTMGMLA
TVMNCLALGEALRRHGQPARTFSALLMPEVCDLYTRAAAQQTLAEGGIALLAGGTGNPFFTTDTTAVLRAAEIDAGAVLK
ATNVDGVYTADPKRDPNAKRFERLTHSEALAGGYKVMDATAFALARETSLPIIVFSIAEPGSIGAVLGGAGRATVVAG
>Mature_237_residues
GEPIYRRVVVKLSGEYFAGPQHYGIDQPTIDRVAGDLIAARGLGVEIAVVVGGGNIFRGVEVSARGVSRPTGDTMGMLAT
VMNCLALGEALRRHGQPARTFSALLMPEVCDLYTRAAAQQTLAEGGIALLAGGTGNPFFTTDTTAVLRAAEIDAGAVLKA
TNVDGVYTADPKRDPNAKRFERLTHSEALAGGYKVMDATAFALARETSLPIIVFSIAEPGSIGAVLGGAGRATVVAG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=234, Percent_Identity=48.2905982905983, Blast_Score=226, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_RHOP2 (Q2IW82)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486439.1
- ProteinModelPortal:   Q2IW82
- SMR:   Q2IW82
- STRING:   Q2IW82
- GeneID:   3910619
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2826
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   RPAL316058:RPB_2826-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24617; Mature: 24485

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 163-163 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEPIYRRVVVKLSGEYFAGPQHYGIDQPTIDRVAGDLIAARGLGVEIAVVVGGGNIFRG
CCCHHHEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCEEEC
VEVSARGVSRPTGDTMGMLATVMNCLALGEALRRHGQPARTFSALLMPEVCDLYTRAAAQ
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
QTLAEGGIALLAGGTGNPFFTTDTTAVLRAAEIDAGAVLKATNVDGVYTADPKRDPNAKR
HHHHHCCEEEEECCCCCCCEECCHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCCCHHH
FERLTHSEALAGGYKVMDATAFALARETSLPIIVFSIAEPGSIGAVLGGAGRATVVAG
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECCCCCEEEECC
>Mature Secondary Structure 
GEPIYRRVVVKLSGEYFAGPQHYGIDQPTIDRVAGDLIAARGLGVEIAVVVGGGNIFRG
CCHHHEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCEEEC
VEVSARGVSRPTGDTMGMLATVMNCLALGEALRRHGQPARTFSALLMPEVCDLYTRAAAQ
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
QTLAEGGIALLAGGTGNPFFTTDTTAVLRAAEIDAGAVLKATNVDGVYTADPKRDPNAKR
HHHHHCCEEEEECCCCCCCEECCHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCCCHHH
FERLTHSEALAGGYKVMDATAFALARETSLPIIVFSIAEPGSIGAVLGGAGRATVVAG
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA