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The map label for this gene is kdsA

Identifier: 86749901

GI number: 86749901

Start: 3174268

End: 3175131

Strand: Reverse

Name: kdsA

Synonym: RPB_2784

Alternate gene names: 86749901

Gene position: 3175131-3174268 (Counterclockwise)

Preceding gene: 86749902

Following gene: 86749900

Centisome position: 59.55

GC content: 67.25

Gene sequence:

>864_bases
TTGAACAAAAGCATTGCACCCGCGCCTGTCGTCGCAGCGGGAGACGTCAAATTCGGCAACGCACTGCCGCTATCGGTGAT
CGCCGGCCCGTGCCAGCTCGAGAGCCGCGCGCATGCGCTCGAGGTCGCCGCGGCGCTGCAGGAGATCGGCAAGCGGTTGG
GCATCGGCATCGTCTACAAGACGTCGTTCGACAAGGCCAATCGCACCAGCGCGGCGAGCGCGCGCGGAATCGGCCTCGAC
GGCGCGCTGCCGATATTCGCCGAGATCCGCGACAGCATCGGGCTGCCAGTGCTCACCGACGTTCACGAAGCCGGGCAATG
CGCCCGCGCCGCGGAGGCGGTGGATATCCTGCAGATCCCGGCTTTTCTTTGCCGGCAGACCGATCTGTTGCTGGCGGCGG
CTGCGACCGGCAGGATCGTCAACGTCAAGAAGGGCCAGTTCCTGGCGCCGTGGGACATGGGCAATGTCGTCGCCAAAATC
ACCAGCGCCGGCAACCCGAAGGTGCTGGTGACCGAGCGCGGGGTGTCTTTCGGCTACAACACGCTGGTCTCCGACATGCG
CGCGCTGCCGATTATGGCCAAGACCACCGGCGCCCCGGTGATCTTCGATGCCACGCATTCGGTACAGCAGCCGGGCGGCA
AGGGCACCTCGTCGGGCGGCGAACGTGAATTCGTGCCGGTGCTGGCGCGCGCCGCGGTCGCGGTCGGCGTCGCCGGTGTG
TTCATCGAGACCCATCCCGATCCGGATCACGCGCCGTCCGACGGCCCCAATATGGTGCCGCTGCGCGACTTCGAGAGCCT
GCTGCGCACGCTGATGGAGTTCGACGCGCTCGCCAAGCGGCGGTCCGGAGCCGGAACGATCTGA

Upstream 100 bases:

>100_bases
TGTTGCAGCAGAACGGGATCGGCGCGACGCGCCACATCGACCGCCTGGTCGTGCCGGATGTGTGCGGCGCGACGCTGATC
TTCGAACAAGGAATGGTCCG

Downstream 100 bases:

>100_bases
TGTCGCAGGGCGACAGTGCGGTCGTTCGGCCGAGCCTGCCGCCCGCGTTGAAGATCATTGCGCTGTCGGGCTTTGCCGCT
AGCCTGTCCGCCCGCGCGCT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNKSIAPAPVVAAGDVKFGNALPLSVIAGPCQLESRAHALEVAAALQEIGKRLGIGIVYKTSFDKANRTSAASARGIGLD
GALPIFAEIRDSIGLPVLTDVHEAGQCARAAEAVDILQIPAFLCRQTDLLLAAAATGRIVNVKKGQFLAPWDMGNVVAKI
TSAGNPKVLVTERGVSFGYNTLVSDMRALPIMAKTTGAPVIFDATHSVQQPGGKGTSSGGEREFVPVLARAAVAVGVAGV
FIETHPDPDHAPSDGPNMVPLRDFESLLRTLMEFDALAKRRSGAGTI

Sequences:

>Translated_287_residues
MNKSIAPAPVVAAGDVKFGNALPLSVIAGPCQLESRAHALEVAAALQEIGKRLGIGIVYKTSFDKANRTSAASARGIGLD
GALPIFAEIRDSIGLPVLTDVHEAGQCARAAEAVDILQIPAFLCRQTDLLLAAAATGRIVNVKKGQFLAPWDMGNVVAKI
TSAGNPKVLVTERGVSFGYNTLVSDMRALPIMAKTTGAPVIFDATHSVQQPGGKGTSSGGEREFVPVLARAAVAVGVAGV
FIETHPDPDHAPSDGPNMVPLRDFESLLRTLMEFDALAKRRSGAGTI
>Mature_287_residues
MNKSIAPAPVVAAGDVKFGNALPLSVIAGPCQLESRAHALEVAAALQEIGKRLGIGIVYKTSFDKANRTSAASARGIGLD
GALPIFAEIRDSIGLPVLTDVHEAGQCARAAEAVDILQIPAFLCRQTDLLLAAAATGRIVNVKKGQFLAPWDMGNVVAKI
TSAGNPKVLVTERGVSFGYNTLVSDMRALPIMAKTTGAPVIFDATHSVQQPGGKGTSSGGEREFVPVLARAAVAVGVAGV
FIETHPDPDHAPSDGPNMVPLRDFESLLRTLMEFDALAKRRSGAGTI

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=271, Percent_Identity=47.6014760147601, Blast_Score=257, Evalue=5e-70,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_RHOP2 (Q2IWC4)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486397.1
- HSSP:   O66496
- ProteinModelPortal:   Q2IWC4
- SMR:   Q2IWC4
- STRING:   Q2IWC4
- GeneID:   3910577
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2784
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   RSLPIMA
- ProtClustDB:   PRK05198
- BioCyc:   RPAL316058:RPB_2784-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 29825; Mature: 29825

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSIAPAPVVAAGDVKFGNALPLSVIAGPCQLESRAHALEVAAALQEIGKRLGIGIVYK
CCCCCCCCCEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
TSFDKANRTSAASARGIGLDGALPIFAEIRDSIGLPVLTDVHEAGQCARAAEAVDILQIP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHH
AFLCRQTDLLLAAAATGRIVNVKKGQFLAPWDMGNVVAKITSAGNPKVLVTERGVSFGYN
HHHHCCHHHEEEEECCCCEEEECCCCEECCCCCCHHHHHHCCCCCCEEEEEECCCCCCHH
TLVSDMRALPIMAKTTGAPVIFDATHSVQQPGGKGTSSGGEREFVPVLARAAVAVGVAGV
HHHHHHHHCCEEEECCCCCEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEE
FIETHPDPDHAPSDGPNMVPLRDFESLLRTLMEFDALAKRRSGAGTI
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNKSIAPAPVVAAGDVKFGNALPLSVIAGPCQLESRAHALEVAAALQEIGKRLGIGIVYK
CCCCCCCCCEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
TSFDKANRTSAASARGIGLDGALPIFAEIRDSIGLPVLTDVHEAGQCARAAEAVDILQIP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHH
AFLCRQTDLLLAAAATGRIVNVKKGQFLAPWDMGNVVAKITSAGNPKVLVTERGVSFGYN
HHHHCCHHHEEEEECCCCEEEECCCCEECCCCCCHHHHHHCCCCCCEEEEEECCCCCCHH
TLVSDMRALPIMAKTTGAPVIFDATHSVQQPGGKGTSSGGEREFVPVLARAAVAVGVAGV
HHHHHHHHCCEEEECCCCCEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEE
FIETHPDPDHAPSDGPNMVPLRDFESLLRTLMEFDALAKRRSGAGTI
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA