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The map label for this gene is lpd [H]

Identifier: 86749883

GI number: 86749883

Start: 3154268

End: 3155689

Strand: Reverse

Name: lpd [H]

Synonym: RPB_2766

Alternate gene names: 86749883

Gene position: 3155689-3154268 (Counterclockwise)

Preceding gene: 86749884

Following gene: 86749882

Centisome position: 59.19

GC content: 65.12

Gene sequence:

>1422_bases
ATGACCGACACCTCCTTCGACGTCATCATCATCGGCTCCGGCCCCGGCGGTTATGTCGCGGCGATCCGGGCGGCGCAGCT
CGGCTTCAAGACCGCGATCGTCGAGAAATCCTATCTCGGTGGCATCTGTCTCAACTGGGGCTGCATCCCGACCAAGGCGC
TGCTGCGTTCGGCCGAGGTCTACCACCTGATGCAACACGCCAAGGATTACGGGCTGTCGGCTGACAACATCAGCTACGAT
CCGAAGGCGGTGGTGGCGCGTTCGCGCGGGGTGTCGAAGCGGCTCAACGACGGCGTCGGCTTCCTCATGAAGAAGAACAA
GATCTCGATCATCTGGGGCGCGGCGACGGTCGACGCGCCGGGCAAGCTCACCGTCGCGGCGTCGAAGACCGAGGCGCCGA
AGGGCGCGCTGGGGCAGGGCAGCTATCAGGCCAAGCACATCATCGTTGCCACCGGCGCGCGGCCGCGCGTGCTGCCGGGG
CTGGAGCCGGACAGGAAGCTGGTCTGGACCTATTTCGAGGCGATGGTGCCGGAGACCATGCCGAAGTCTCTGCTGGTGGT
GGGCTCCGGCGCGATCGGCATCGAATTCGCGTCGTTCTTCCACACCATGGGCGCCGAGGTCACCGTGGTCGAGGTGCTGC
CGCAGATTCTGCCCGTCGAGGACGCGGAGATCGCCGGCCTCGCCCGCAAGCGGTTCGAAAAGCAGGGCATCAAGATCCTA
ACCGGGGCCAAGGTGACCAAGCTCGACAAGAAGGCGGACAGCGTCGTCGCCACCATCGATCCCGGCACCGGCAAGGCCGA
GACGCAGGAATTCGACCGGGTGATCTCGGCGGTCGGCGTGGTCGGCAATGTCGAGAATCTCGGACTGGAGAAGCTCGGCG
TGAAACTCGACCGTGGCACCATCGTCACAGACGGCCTGGGCCAAACCAGCGTCCCCGGCATCTATGCGATCGGCGACGTC
GCCGGTCCGCCGATGCTGGCGCACAAGGCCGAGCACGAGGGCGTGGTCTGCGTCGAGGCGATCAAGGGCCTGCATCCGCA
TCCGCTCGACAAGAGCCTGATTCCCGGTTGCACCTACTGCCATCCGCAGATTGCGTCCGTCGGCGTCACCGAGGCCAAGG
CGAAGGAGCAGGGGCGGGAGGTCCGCATCGGCCGCTTCCCGTTCACCGCCAACGGCAAGGCGATCGCGCTGGGCGAGGAC
CAGGGCCTGGTCAAGGTGATCTTCGACAAGAAGACCGGCCAGTTGCTTGGCGCGCATATGATCGGCGCGGAGGTCACCGA
GCTGATCCAGGGCTATGTGGTGGCGATGAACCTCGAGACCACCGAGGAAGAACTGATGCACACCATCTTCCCGCATCCGA
CACTGTCGGAAATGATGAAGGAAGCCGTGCTCGACGCCTACGGTCGCGTCCTCAACGCCTGA

Upstream 100 bases:

>100_bases
GAAGTCGCCAAAGAGAACTGGTCGTTCGGCAACGGCATTGCGCAATACGTCTGAGCCCTCGCGCGCCGCGTTCGACCCTA
TGAACTGATCCGGGGATCCC

Downstream 100 bases:

>100_bases
CATTCCCCTCCGGTCGCACAGACGGTGGCCGTGCGGCAACGCTTGTTGCCTCGACGCCACAGTTCCGGATCATTTAACCG
TCTTTGACGGTCGTTCTTGC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTDTSFDVIIIGSGPGGYVAAIRAAQLGFKTAIVEKSYLGGICLNWGCIPTKALLRSAEVYHLMQHAKDYGLSADNISYD
PKAVVARSRGVSKRLNDGVGFLMKKNKISIIWGAATVDAPGKLTVAASKTEAPKGALGQGSYQAKHIIVATGARPRVLPG
LEPDRKLVWTYFEAMVPETMPKSLLVVGSGAIGIEFASFFHTMGAEVTVVEVLPQILPVEDAEIAGLARKRFEKQGIKIL
TGAKVTKLDKKADSVVATIDPGTGKAETQEFDRVISAVGVVGNVENLGLEKLGVKLDRGTIVTDGLGQTSVPGIYAIGDV
AGPPMLAHKAEHEGVVCVEAIKGLHPHPLDKSLIPGCTYCHPQIASVGVTEAKAKEQGREVRIGRFPFTANGKAIALGED
QGLVKVIFDKKTGQLLGAHMIGAEVTELIQGYVVAMNLETTEEELMHTIFPHPTLSEMMKEAVLDAYGRVLNA

Sequences:

>Translated_473_residues
MTDTSFDVIIIGSGPGGYVAAIRAAQLGFKTAIVEKSYLGGICLNWGCIPTKALLRSAEVYHLMQHAKDYGLSADNISYD
PKAVVARSRGVSKRLNDGVGFLMKKNKISIIWGAATVDAPGKLTVAASKTEAPKGALGQGSYQAKHIIVATGARPRVLPG
LEPDRKLVWTYFEAMVPETMPKSLLVVGSGAIGIEFASFFHTMGAEVTVVEVLPQILPVEDAEIAGLARKRFEKQGIKIL
TGAKVTKLDKKADSVVATIDPGTGKAETQEFDRVISAVGVVGNVENLGLEKLGVKLDRGTIVTDGLGQTSVPGIYAIGDV
AGPPMLAHKAEHEGVVCVEAIKGLHPHPLDKSLIPGCTYCHPQIASVGVTEAKAKEQGREVRIGRFPFTANGKAIALGED
QGLVKVIFDKKTGQLLGAHMIGAEVTELIQGYVVAMNLETTEEELMHTIFPHPTLSEMMKEAVLDAYGRVLNA
>Mature_472_residues
TDTSFDVIIIGSGPGGYVAAIRAAQLGFKTAIVEKSYLGGICLNWGCIPTKALLRSAEVYHLMQHAKDYGLSADNISYDP
KAVVARSRGVSKRLNDGVGFLMKKNKISIIWGAATVDAPGKLTVAASKTEAPKGALGQGSYQAKHIIVATGARPRVLPGL
EPDRKLVWTYFEAMVPETMPKSLLVVGSGAIGIEFASFFHTMGAEVTVVEVLPQILPVEDAEIAGLARKRFEKQGIKILT
GAKVTKLDKKADSVVATIDPGTGKAETQEFDRVISAVGVVGNVENLGLEKLGVKLDRGTIVTDGLGQTSVPGIYAIGDVA
GPPMLAHKAEHEGVVCVEAIKGLHPHPLDKSLIPGCTYCHPQIASVGVTEAKAKEQGREVRIGRFPFTANGKAIALGEDQ
GLVKVIFDKKTGQLLGAHMIGAEVTELIQGYVVAMNLETTEEELMHTIFPHPTLSEMMKEAVLDAYGRVLNA

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=475, Percent_Identity=39.1578947368421, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=29.3736501079914, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI22035672, Length=464, Percent_Identity=28.8793103448276, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI291045266, Length=438, Percent_Identity=26.4840182648402, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI33519430, Length=466, Percent_Identity=24.8927038626609, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI33519428, Length=466, Percent_Identity=24.8927038626609, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI33519426, Length=466, Percent_Identity=24.8927038626609, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI148277065, Length=466, Percent_Identity=24.8927038626609, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI148277071, Length=466, Percent_Identity=24.8927038626609, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI291045268, Length=459, Percent_Identity=26.1437908496732, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=36.0262008733624, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082354, Length=479, Percent_Identity=27.1398747390397, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789915, Length=443, Percent_Identity=29.5711060948081, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI87081717, Length=472, Percent_Identity=27.3305084745763, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789065, Length=192, Percent_Identity=30.2083333333333, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=474, Percent_Identity=39.2405063291139, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17557007, Length=485, Percent_Identity=26.8041237113402, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71983429, Length=462, Percent_Identity=27.0562770562771, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=462, Percent_Identity=27.0562770562771, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=496, Percent_Identity=24.3951612903226, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=38.7966804979253, Blast_Score=292, Evalue=8e-80,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=28.2105263157895, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=28.3298097251586, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21358499, Length=474, Percent_Identity=39.662447257384, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=27.4261603375527, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24640549, Length=475, Percent_Identity=26.7368421052632, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24640553, Length=475, Percent_Identity=26.7368421052632, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=26.7932489451477, Blast_Score=122, Evalue=8e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50252; Mature: 50121

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTSFDVIIIGSGPGGYVAAIRAAQLGFKTAIVEKSYLGGICLNWGCIPTKALLRSAEV
CCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
YHLMQHAKDYGLSADNISYDPKAVVARSRGVSKRLNDGVGFLMKKNKISIIWGAATVDAP
HHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHCCCCEEEEECCEEEEEEEEEEECCC
GKLTVAASKTEAPKGALGQGSYQAKHIIVATGARPRVLPGLEPDRKLVWTYFEAMVPETM
CEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
PKSLLVVGSGAIGIEFASFFHTMGAEVTVVEVLPQILPVEDAEIAGLARKRFEKQGIKIL
CCEEEEEECCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEE
TGAKVTKLDKKADSVVATIDPGTGKAETQEFDRVISAVGVVGNVENLGLEKLGVKLDRGT
ECCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHCCHHHHCEEECCCE
IVTDGLGQTSVPGIYAIGDVAGPPMLAHKAEHEGVVCVEAIKGLHPHPLDKSLIPGCTYC
EEECCCCCCCCCCEEEECCCCCCCHHHCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCC
HPQIASVGVTEAKAKEQGREVRIGRFPFTANGKAIALGEDQGLVKVIFDKKTGQLLGAHM
CCCHHHCCCCHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCCHHHHHHH
IGAEVTELIQGYVVAMNLETTEEELMHTIFPHPTLSEMMKEAVLDAYGRVLNA
HHHHHHHHHCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDTSFDVIIIGSGPGGYVAAIRAAQLGFKTAIVEKSYLGGICLNWGCIPTKALLRSAEV
CCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
YHLMQHAKDYGLSADNISYDPKAVVARSRGVSKRLNDGVGFLMKKNKISIIWGAATVDAP
HHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHCCCCEEEEECCEEEEEEEEEEECCC
GKLTVAASKTEAPKGALGQGSYQAKHIIVATGARPRVLPGLEPDRKLVWTYFEAMVPETM
CEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
PKSLLVVGSGAIGIEFASFFHTMGAEVTVVEVLPQILPVEDAEIAGLARKRFEKQGIKIL
CCEEEEEECCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEE
TGAKVTKLDKKADSVVATIDPGTGKAETQEFDRVISAVGVVGNVENLGLEKLGVKLDRGT
ECCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHCCHHHHCEEECCCE
IVTDGLGQTSVPGIYAIGDVAGPPMLAHKAEHEGVVCVEAIKGLHPHPLDKSLIPGCTYC
EEECCCCCCCCCCEEEECCCCCCCHHHCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCC
HPQIASVGVTEAKAKEQGREVRIGRFPFTANGKAIALGEDQGLVKVIFDKKTGQLLGAHM
CCCHHHCCCCHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCCHHHHHHH
IGAEVTELIQGYVVAMNLETTEEELMHTIFPHPTLSEMMKEAVLDAYGRVLNA
HHHHHHHHHCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]