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The map label for this gene is lldP [C]

Identifier: 86749378

GI number: 86749378

Start: 2605479

End: 2606963

Strand: Direct

Name: lldP [C]

Synonym: RPB_2258

Alternate gene names: 86749378

Gene position: 2605479-2606963 (Clockwise)

Preceding gene: 86749377

Following gene: 86749380

Centisome position: 48.87

GC content: 67.41

Gene sequence:

>1485_bases
GTGACCGAGCTGCTCGCGCTGCTTCCGATCCTGATCCTGCTGCTGTGCATGGTCGGATTTGGCTGGACCGCGGCCCGTTC
CGGCATGATCAGCGCCGCCGCGGGTCTCGGTGTCGCATCATGGGCGTTTCAGCCGGCACCCGGCATCATGGCGGTCGTCG
GCCCTTTGGCAGAAGCGGTGTTCACCGCCGCGACGATTCTGTGGATCATCTTTCCGGCGCTCGCGCTGCACGAATTCCAG
ATGCGTTCCGGCGCGTCGGACCGGATCGGCGCCTGGCTCGTGTCGATTTCGGACAAGCGGGAAGTGCTTGCGCTGCTGCT
GGCCTGGTTCTTCGCCTTGCTGCTGGAAGGTGCGGCCGGGTTCGGCACGCCGGTGGCCCTGGTGGCTCCGATGCTGGTGA
CGCTCGGCTTCTCGCCGGAGCGTTCGCTGCTGCTGGCGCTGATCGGCCATGCGGCCGGGGTATCGTTCGGCGCGGTCGGC
ACTCCGATGCTGCCGCTGTTGGAGGTGCTCACGGTCGATCCAAAACTACTCTCAGGCAGCATCATGCTGATGCACGCCGC
GCTCGGCTGGATACTGACGCTGGTGGTGTTTCGGCTGGCTGCGTCGGCGAGCGGCGGAGCGATCTGGCTCGCCGTGCCGA
CGGCGGCGGGGCTCTTTCTGCTGCCGGCGCTGGCGCTCGCCTGGCTGAGTGGGCCTGAACTTCCCACCCTGGGCGGCGCC
TTGATCGGGCTGTTGATGTTCATCGGCCTGGCGAAGTGGCGATGGTCGACGGGCAGCCGGGCTCCGTCGGGCGCAAACGA
GGGCGTGCTCTCGGCTATCCTGCCCTACGGGCTGGTCCTCGTTGCGATCCTGGCCACACGAACGGTGCCGTCATTGGCCG
CATGGCTGCAGTCATTCACGCTGGAATGGACGCTCGGCGACCGCTTCTCCGGTTCGGTCAAGCCGCTCTATCATCCGGGC
ACGATGCTGATGCTGGCCCTTGCTGCTGCCGCCATGGCGAGCCAGCGCAACCGCGCTGTCATCCTGCCGGCGGTGTCCAG
CGCAGCCCGCCGTCTGCCGCTGGTGGCGCTTGCTCTGGTGTCGGTGCTGATGCTGGCGCGGATCATGGTTCACAGCGGGA
TGATCGACACTTTAGCCAACGCCGCAGCGGTCCTTCTTGGATCGGCTTGGCCGGTGGCCGTGCCGATGGTCGGCGCGCTC
GGCTCCTTCGTGACCGGATCGGCGACCGCGTCCAACGTCCTGTTCGCGGGCTTTCAGGTGGCCGCGGCCGAGGCCGTCGG
ATTTGCACCGATGGCGGCGCTGGCCGGCCAGAGCTTCGGCGCCGCGATCGGCAATGTGATCGCTCCGCACAACATCGTCG
CCGGGGCCGCGACGGTGGGCCTGATCGGTCGCGAAGGCGCGGTTCTCAAAAGGACGCTGCCGGTGTGTTTCGTCTATGCG
CTGCTCGGTGGCGGATTGCTGATCGCATTCGCGGGGCTTCGGTAA

Upstream 100 bases:

>100_bases
CTTTGATGGAGATCGCCGATACGACGATCCGGAATATCTCTCAATTCGAACTGACTGGACAGGCGGCGCATCCGATCTCG
TTGGAATTGCGTGTCTGAAC

Downstream 100 bases:

>100_bases
CGCCGACGATACCGACGCAGGCGGCAAGCCTCCCGTCGCTTGTGCGCGGATGCTGCACGCGTGGACGATCGACCGTGTGG
ACCTTGTCCATGCCGCTCAC

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTELLALLPILILLLCMVGFGWTAARSGMISAAAGLGVASWAFQPAPGIMAVVGPLAEAVFTAATILWIIFPALALHEFQ
MRSGASDRIGAWLVSISDKREVLALLLAWFFALLLEGAAGFGTPVALVAPMLVTLGFSPERSLLLALIGHAAGVSFGAVG
TPMLPLLEVLTVDPKLLSGSIMLMHAALGWILTLVVFRLAASASGGAIWLAVPTAAGLFLLPALALAWLSGPELPTLGGA
LIGLLMFIGLAKWRWSTGSRAPSGANEGVLSAILPYGLVLVAILATRTVPSLAAWLQSFTLEWTLGDRFSGSVKPLYHPG
TMLMLALAAAAMASQRNRAVILPAVSSAARRLPLVALALVSVLMLARIMVHSGMIDTLANAAAVLLGSAWPVAVPMVGAL
GSFVTGSATASNVLFAGFQVAAAEAVGFAPMAALAGQSFGAAIGNVIAPHNIVAGAATVGLIGREGAVLKRTLPVCFVYA
LLGGGLLIAFAGLR

Sequences:

>Translated_494_residues
MTELLALLPILILLLCMVGFGWTAARSGMISAAAGLGVASWAFQPAPGIMAVVGPLAEAVFTAATILWIIFPALALHEFQ
MRSGASDRIGAWLVSISDKREVLALLLAWFFALLLEGAAGFGTPVALVAPMLVTLGFSPERSLLLALIGHAAGVSFGAVG
TPMLPLLEVLTVDPKLLSGSIMLMHAALGWILTLVVFRLAASASGGAIWLAVPTAAGLFLLPALALAWLSGPELPTLGGA
LIGLLMFIGLAKWRWSTGSRAPSGANEGVLSAILPYGLVLVAILATRTVPSLAAWLQSFTLEWTLGDRFSGSVKPLYHPG
TMLMLALAAAAMASQRNRAVILPAVSSAARRLPLVALALVSVLMLARIMVHSGMIDTLANAAAVLLGSAWPVAVPMVGAL
GSFVTGSATASNVLFAGFQVAAAEAVGFAPMAALAGQSFGAAIGNVIAPHNIVAGAATVGLIGREGAVLKRTLPVCFVYA
LLGGGLLIAFAGLR
>Mature_493_residues
TELLALLPILILLLCMVGFGWTAARSGMISAAAGLGVASWAFQPAPGIMAVVGPLAEAVFTAATILWIIFPALALHEFQM
RSGASDRIGAWLVSISDKREVLALLLAWFFALLLEGAAGFGTPVALVAPMLVTLGFSPERSLLLALIGHAAGVSFGAVGT
PMLPLLEVLTVDPKLLSGSIMLMHAALGWILTLVVFRLAASASGGAIWLAVPTAAGLFLLPALALAWLSGPELPTLGGAL
IGLLMFIGLAKWRWSTGSRAPSGANEGVLSAILPYGLVLVAILATRTVPSLAAWLQSFTLEWTLGDRFSGSVKPLYHPGT
MLMLALAAAAMASQRNRAVILPAVSSAARRLPLVALALVSVLMLARIMVHSGMIDTLANAAAVLLGSAWPVAVPMVGALG
SFVTGSATASNVLFAGFQVAAAEAVGFAPMAALAGQSFGAAIGNVIAPHNIVAGAATVGLIGREGAVLKRTLPVCFVYAL
LGGGLLIAFAGLR

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=532, Percent_Identity=27.8195488721804, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1789347, Length=259, Percent_Identity=32.046332046332, Blast_Score=93, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 50467; Mature: 50336

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELLALLPILILLLCMVGFGWTAARSGMISAAAGLGVASWAFQPAPGIMAVVGPLAEAV
CHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHH
FTAATILWIIFPALALHEFQMRSGASDRIGAWLVSISDKREVLALLLAWFFALLLEGAAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
FGTPVALVAPMLVTLGFSPERSLLLALIGHAAGVSFGAVGTPMLPLLEVLTVDPKLLSGS
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHCCH
IMLMHAALGWILTLVVFRLAASASGGAIWLAVPTAAGLFLLPALALAWLSGPELPTLGGA
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHH
LIGLLMFIGLAKWRWSTGSRAPSGANEGVLSAILPYGLVLVAILATRTVPSLAAWLQSFT
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
LEWTLGDRFSGSVKPLYHPGTMLMLALAAAAMASQRNRAVILPAVSSAARRLPLVALALV
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
SVLMLARIMVHSGMIDTLANAAAVLLGSAWPVAVPMVGALGSFVTGSATASNVLFAGFQV
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AAAEAVGFAPMAALAGQSFGAAIGNVIAPHNIVAGAATVGLIGREGAVLKRTLPVCFVYA
HHHHHHCHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLGGGLLIAFAGLR
HHCCCHHHHCCCCC
>Mature Secondary Structure 
TELLALLPILILLLCMVGFGWTAARSGMISAAAGLGVASWAFQPAPGIMAVVGPLAEAV
HHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHH
FTAATILWIIFPALALHEFQMRSGASDRIGAWLVSISDKREVLALLLAWFFALLLEGAAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
FGTPVALVAPMLVTLGFSPERSLLLALIGHAAGVSFGAVGTPMLPLLEVLTVDPKLLSGS
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHCCH
IMLMHAALGWILTLVVFRLAASASGGAIWLAVPTAAGLFLLPALALAWLSGPELPTLGGA
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHH
LIGLLMFIGLAKWRWSTGSRAPSGANEGVLSAILPYGLVLVAILATRTVPSLAAWLQSFT
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
LEWTLGDRFSGSVKPLYHPGTMLMLALAAAAMASQRNRAVILPAVSSAARRLPLVALALV
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
SVLMLARIMVHSGMIDTLANAAAVLLGSAWPVAVPMVGALGSFVTGSATASNVLFAGFQV
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AAAEAVGFAPMAALAGQSFGAAIGNVIAPHNIVAGAATVGLIGREGAVLKRTLPVCFVYA
HHHHHHCHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLGGGLLIAFAGLR
HHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]