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The map label for this gene is degP [C]

Identifier: 86749369

GI number: 86749369

Start: 2594943

End: 2596109

Strand: Direct

Name: degP [C]

Synonym: RPB_2249

Alternate gene names: 86749369

Gene position: 2594943-2596109 (Clockwise)

Preceding gene: 86749366

Following gene: 86749370

Centisome position: 48.67

GC content: 69.41

Gene sequence:

>1167_bases
ATGCCCCCATCCGTCCCGCCGACCAGGCCTCCGCCCGATCCGCAGATCCGCCGGGCGCAGCGCACTGACCTGCTGCTCCG
AGCCGCCGTGATCTGGCTGTTGTTGCTGGCAACGGCCTGGGTCGCGCAGCCTTATCTCTCGTCGTTGTGGTTCTCGGTGT
CCGGGCCCCGGACCGTCACCGCCCGGGGTGATCTGGCCCCGGCGGAGACCGCGACCATCGAGCTGTTCAAACGGGTGTCG
CCGTCGGTGGTGCACGTCTTTGCCCAGTCGAGCCGGCGCTCGCCGTCGCTGTTCGAGCAGCAACAGGAGGGCGGGGTGCA
GTCCGGCTCCGGTGTGATCTGGGACGCCGCGGGCCACGTCATCACCAACAACCACGTCATCCAGGGCGCAACTGCACTGG
GCGCGCGGCTGTCGACCGGCGAGTTCGTCACCGCGCGCGTGGTCGGCACCGCGCCGAACTACGACCTCGCGGTGCTGCAG
CTCGAGCGACCGCGCGCCGAGCTGCGCCCGATTGCGATCGGCAGTTCGTCGGACCTGCAGGTCGGGCAGTCGGCGTTCGC
CATCGGCAGCCCCTATGGTCTGGAGCAGACGCTGACCACCGGCATCGTCAGCGCGCTGCAGCGGCGGCTACCGACCGCGG
CTGCCCATGAAGTCAGTGGCGTGATCCAGACCGATGCGGCGATCAATCCCGGCAATTCGGGCGGCCCCTTGCTCGACAGC
GCCGGCCGCTTGATCGGCTTGAACACCGCAATCATTTCCGGATCGGGCGCTTCGGCCGGAATCGGCTTCGCGATCCCGGT
CGATTCCGTCAATCGGATCGCCACCGCGCTGATCAAGACCGGCACCGTGCCGGTGCCCGGCATCGGCATCATCGCCGCCG
ACGAGAACGAGGCCGCCCGCCTCGGCATCGACGGCGTCGTCGTCGTGCGTACGCTGCCGGGCTCCCCGGCGGCACGCGCG
GGGCTCACCGGCGCCAGCGAGACCGGCATGGTCGAGGACGTCATCGTCGGTGCCAACGGCCAGGAGATCCACAGCATGTC
GGATCTCGCCGCGACGCTCGAACGCGTCGGCATCGGCAACGAGGTCAAGCTGCAGGTGATTCGCGACGGCCGCGCCCGGA
CCATCAACGTCGAGGTCACCGATATTGCCCGATTGCGGCGCAGCTAG

Upstream 100 bases:

>100_bases
TGTCCGTCACCGGGGTGGAACCCCCGGACATCGCCGGGCATTATGCAGCGGAACTCGTCGGAACCCGATCTGCGTTCCGA
TGAGATGCAAGGACCGAACG

Downstream 100 bases:

>100_bases
CCCCGGTCGCCGGCGCTCGGTCGCATCGAGGAAGCTGCTCGGCGCGAGCGAAGGGTGCAGAATGTGAGTAGTTCGAACGG
CTTCGGGGCCCTGAACTTTC

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPPSVPPTRPPPDPQIRRAQRTDLLLRAAVIWLLLLATAWVAQPYLSSLWFSVSGPRTVTARGDLAPAETATIELFKRVS
PSVVHVFAQSSRRSPSLFEQQQEGGVQSGSGVIWDAAGHVITNNHVIQGATALGARLSTGEFVTARVVGTAPNYDLAVLQ
LERPRAELRPIAIGSSSDLQVGQSAFAIGSPYGLEQTLTTGIVSALQRRLPTAAAHEVSGVIQTDAAINPGNSGGPLLDS
AGRLIGLNTAIISGSGASAGIGFAIPVDSVNRIATALIKTGTVPVPGIGIIAADENEAARLGIDGVVVVRTLPGSPAARA
GLTGASETGMVEDVIVGANGQEIHSMSDLAATLERVGIGNEVKLQVIRDGRARTINVEVTDIARLRRS

Sequences:

>Translated_388_residues
MPPSVPPTRPPPDPQIRRAQRTDLLLRAAVIWLLLLATAWVAQPYLSSLWFSVSGPRTVTARGDLAPAETATIELFKRVS
PSVVHVFAQSSRRSPSLFEQQQEGGVQSGSGVIWDAAGHVITNNHVIQGATALGARLSTGEFVTARVVGTAPNYDLAVLQ
LERPRAELRPIAIGSSSDLQVGQSAFAIGSPYGLEQTLTTGIVSALQRRLPTAAAHEVSGVIQTDAAINPGNSGGPLLDS
AGRLIGLNTAIISGSGASAGIGFAIPVDSVNRIATALIKTGTVPVPGIGIIAADENEAARLGIDGVVVVRTLPGSPAARA
GLTGASETGMVEDVIVGANGQEIHSMSDLAATLERVGIGNEVKLQVIRDGRARTINVEVTDIARLRRS
>Mature_387_residues
PPSVPPTRPPPDPQIRRAQRTDLLLRAAVIWLLLLATAWVAQPYLSSLWFSVSGPRTVTARGDLAPAETATIELFKRVSP
SVVHVFAQSSRRSPSLFEQQQEGGVQSGSGVIWDAAGHVITNNHVIQGATALGARLSTGEFVTARVVGTAPNYDLAVLQL
ERPRAELRPIAIGSSSDLQVGQSAFAIGSPYGLEQTLTTGIVSALQRRLPTAAAHEVSGVIQTDAAINPGNSGGPLLDSA
GRLIGLNTAIISGSGASAGIGFAIPVDSVNRIATALIKTGTVPVPGIGIIAADENEAARLGIDGVVVVRTLPGSPAARAG
LTGASETGMVEDVIVGANGQEIHSMSDLAATLERVGIGNEVKLQVIRDGRARTINVEVTDIARLRRS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=302, Percent_Identity=31.1258278145695, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI22129776, Length=296, Percent_Identity=33.445945945946, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI24308541, Length=300, Percent_Identity=32, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI7019477, Length=332, Percent_Identity=30.1204819277108, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1786356, Length=277, Percent_Identity=40.7942238267148, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1789629, Length=278, Percent_Identity=41.3669064748201, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1789630, Length=369, Percent_Identity=34.1463414634146, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646839, Length=277, Percent_Identity=32.4909747292419, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40250; Mature: 40119

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSVPPTRPPPDPQIRRAQRTDLLLRAAVIWLLLLATAWVAQPYLSSLWFSVSGPRTVT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEE
ARGDLAPAETATIELFKRVSPSVVHVFAQSSRRSPSLFEQQQEGGVQSGSGVIWDAAGHV
ECCCCCCCHHHHHHHHHHCCHHHEEHHHHCCCCCCHHHHHHHHCCCCCCCEEEEECCCCE
ITNNHVIQGATALGARLSTGEFVTARVVGTAPNYDLAVLQLERPRAELRPIAIGSSSDLQ
EECCEEEECHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCEEEECCCCCCC
VGQSAFAIGSPYGLEQTLTTGIVSALQRRLPTAAAHEVSGVIQTDAAINPGNSGGPLLDS
CCCHHEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCEEEECCCCCCCCCCCCCHHC
AGRLIGLNTAIISGSGASAGIGFAIPVDSVNRIATALIKTGTVPVPGIGIIAADENEAAR
CCCEEEEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEE
LGIDGVVVVRTLPGSPAARAGLTGASETGMVEDVIVGANGQEIHSMSDLAATLERVGIGN
ECCCCEEEEEECCCCCHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
EVKLQVIRDGRARTINVEVTDIARLRRS
CEEEEEEECCCEEEEEEEHHHHHHHHCC
>Mature Secondary Structure 
PPSVPPTRPPPDPQIRRAQRTDLLLRAAVIWLLLLATAWVAQPYLSSLWFSVSGPRTVT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEE
ARGDLAPAETATIELFKRVSPSVVHVFAQSSRRSPSLFEQQQEGGVQSGSGVIWDAAGHV
ECCCCCCCHHHHHHHHHHCCHHHEEHHHHCCCCCCHHHHHHHHCCCCCCCEEEEECCCCE
ITNNHVIQGATALGARLSTGEFVTARVVGTAPNYDLAVLQLERPRAELRPIAIGSSSDLQ
EECCEEEECHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCEEEECCCCCCC
VGQSAFAIGSPYGLEQTLTTGIVSALQRRLPTAAAHEVSGVIQTDAAINPGNSGGPLLDS
CCCHHEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCEEEECCCCCCCCCCCCCHHC
AGRLIGLNTAIISGSGASAGIGFAIPVDSVNRIATALIKTGTVPVPGIGIIAADENEAAR
CCCEEEEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEE
LGIDGVVVVRTLPGSPAARAGLTGASETGMVEDVIVGANGQEIHSMSDLAATLERVGIGN
ECCCCEEEEEECCCCCHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
EVKLQVIRDGRARTINVEVTDIARLRRS
CEEEEEEECCCEEEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]