Click here to switch to the map view.

The map label for this gene is livH [H]

Identifier: 86749172

GI number: 86749172

Start: 2328765

End: 2329646

Strand: Direct

Name: livH [H]

Synonym: RPB_2050

Alternate gene names: 86749172

Gene position: 2328765-2329646 (Clockwise)

Preceding gene: 86749171

Following gene: 86749173

Centisome position: 43.68

GC content: 64.85

Gene sequence:

>882_bases
ATGAATTGGGGTTTCATCGTCACCAACGCGATCACGCTGGCCTGCATCTACGGGACGCTGGCGATCGGGATTTCGGTCAC
CTGGTCGAGCCTCGGCCTGGTCAATATGGCCTACGGCTTCATCTTTGCGCTGTCCGGCTACGGGGCGTGGATGGCGAGCG
TGTATATCGGCCCGTATCCGGTCGTCGTGATGGCGGCAGGGATCCTGACCGGCGCGCTCGGCGGGCTGATCGTCTGTCTG
CTCGCCTTCATTCCGATCCACGACAAGCCGAACTTCCCGTTGCGCGCGCTGATCGCCACGCTGGCGATCAGCCTGGTCGG
CAATCAGATCCTGCTGTGGTGGTTCGGACCCCGGGCGAAATCGCTGCCGCGGCTGTTCGGCAACTGGAACGCCGACATCC
TCGGCGTCGTCGTGACCTCGGACAAGCTCGGCGCCTCGCTGTCGGCGATCCTGCTGCTGACCCTGATCCTGCTGTGGATG
CGCTCCAGCCGCCGCGGCCTCGAAATTCGGGCGATGATGATGAACCCGCACGCCGCCTCGATCGTCGGCATCGGCGTCCG
CCGCACCAGCATCTACGTGATGGCCTTGACCGGGTCGCTCGCCGGACTGGCGGCGGTGCTGCTGGCGCAGACCTATTACG
TCGCGCCGTTCAGCGGCATCACGCCGATGATCAAGGGACTGAGCATCGCGCTGGTCGGCGGCCTCGGCAGCATCCCCGGA
GCGATCATCGGCGCCATCATGCTGGGGGTGAACGAGTCGCTGACCTCGACCTTCCTCGGCGGCCAATACGTTCTGATCAC
GCAGTTCCTGCTCATCATCGTCGTGCTTCTGATCCGCCCGCGCGGGATCTCCGGAATTCTCGACAAGGCGCGCGAGGCAT
AG

Upstream 100 bases:

>100_bases
CGCTGCTCGAAGGCAGCGTCGATCGCATCATCGGAATGCACGCCGGCAAGCTGAAGGGCGAGGCCTCGGCCTCCAAGTCC
ATGTCGACGGAGCGCAGCTG

Downstream 100 bases:

>100_bases
CCGATGTCCGACACCACCGCTCCGATCTGGATCGACCCGACCGACTCGCAGCATCCGGAGACTCCGGCGCGCGAGGTGGC
GACCAACCCATTCCTGTCGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNWGFIVTNAITLACIYGTLAIGISVTWSSLGLVNMAYGFIFALSGYGAWMASVYIGPYPVVVMAAGILTGALGGLIVCL
LAFIPIHDKPNFPLRALIATLAISLVGNQILLWWFGPRAKSLPRLFGNWNADILGVVVTSDKLGASLSAILLLTLILLWM
RSSRRGLEIRAMMMNPHAASIVGIGVRRTSIYVMALTGSLAGLAAVLLAQTYYVAPFSGITPMIKGLSIALVGGLGSIPG
AIIGAIMLGVNESLTSTFLGGQYVLITQFLLIIVVLLIRPRGISGILDKAREA

Sequences:

>Translated_293_residues
MNWGFIVTNAITLACIYGTLAIGISVTWSSLGLVNMAYGFIFALSGYGAWMASVYIGPYPVVVMAAGILTGALGGLIVCL
LAFIPIHDKPNFPLRALIATLAISLVGNQILLWWFGPRAKSLPRLFGNWNADILGVVVTSDKLGASLSAILLLTLILLWM
RSSRRGLEIRAMMMNPHAASIVGIGVRRTSIYVMALTGSLAGLAAVLLAQTYYVAPFSGITPMIKGLSIALVGGLGSIPG
AIIGAIMLGVNESLTSTFLGGQYVLITQFLLIIVVLLIRPRGISGILDKAREA
>Mature_293_residues
MNWGFIVTNAITLACIYGTLAIGISVTWSSLGLVNMAYGFIFALSGYGAWMASVYIGPYPVVVMAAGILTGALGGLIVCL
LAFIPIHDKPNFPLRALIATLAISLVGNQILLWWFGPRAKSLPRLFGNWNADILGVVVTSDKLGASLSAILLLTLILLWM
RSSRRGLEIRAMMMNPHAASIVGIGVRRTSIYVMALTGSLAGLAAVLLAQTYYVAPFSGITPMIKGLSIALVGGLGSIPG
AIIGAIMLGVNESLTSTFLGGQYVLITQFLLIIVVLLIRPRGISGILDKAREA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=303, Percent_Identity=29.7029702970297, Blast_Score=101, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30934; Mature: 30934

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWGFIVTNAITLACIYGTLAIGISVTWSSLGLVNMAYGFIFALSGYGAWMASVYIGPYP
CCCCEEHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHH
VVVMAAGILTGALGGLIVCLLAFIPIHDKPNFPLRALIATLAISLVGNQILLWWFGPRAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCH
SLPRLFGNWNADILGVVVTSDKLGASLSAILLLTLILLWMRSSRRGLEIRAMMMNPHAAS
HHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHH
IVGIGVRRTSIYVMALTGSLAGLAAVLLAQTYYVAPFSGITPMIKGLSIALVGGLGSIPG
EEEEEEEEHEEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCCCCHH
AIIGAIMLGVNESLTSTFLGGQYVLITQFLLIIVVLLIRPRGISGILDKAREA
HHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure
MNWGFIVTNAITLACIYGTLAIGISVTWSSLGLVNMAYGFIFALSGYGAWMASVYIGPYP
CCCCEEHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHH
VVVMAAGILTGALGGLIVCLLAFIPIHDKPNFPLRALIATLAISLVGNQILLWWFGPRAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCH
SLPRLFGNWNADILGVVVTSDKLGASLSAILLLTLILLWMRSSRRGLEIRAMMMNPHAAS
HHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHH
IVGIGVRRTSIYVMALTGSLAGLAAVLLAQTYYVAPFSGITPMIKGLSIALVGGLGSIPG
EEEEEEEEHEEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCCCCHH
AIIGAIMLGVNESLTSTFLGGQYVLITQFLLIIVVLLIRPRGISGILDKAREA
HHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]