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The map label for this gene is hflC [H]

Identifier: 86749161

GI number: 86749161

Start: 2318718

End: 2319674

Strand: Direct

Name: hflC [H]

Synonym: RPB_2039

Alternate gene names: 86749161

Gene position: 2318718-2319674 (Clockwise)

Preceding gene: 86749160

Following gene: 86749162

Centisome position: 43.49

GC content: 65.31

Gene sequence:

>957_bases
ATGAAGACCGGAATCGCAGGTATCGTCGCCCTGATCGTCCTCCTGGTCGCGATCATCGTCGGTTGGTCGTCGCTGTTCAC
CGTCCGCCAGACCGAGCAGGTGCTGCTCGTCCGGCTCGGCGAGCCGGTGCGCGTCGTCACTGAACCGGGCCTGCATTTCA
AGGCGCCGTTCATCGACACCGTGATCAGCATCGACAAGCGGATTCTCGATCTCGAAAATCCGTCTCAGGAAGTCATCGCG
TCCGATCAGAAGCGGCTCGTGGTCGATGCGTTCGCGCGCTATCGCATCAACAATGCGCTGCGCTTCTACCAGAGCATCGG
GTCGATCCCGGCCGCGAACATCCAGCTCACGACGCTGTTGAACTCGGCGCTGCGCCGCGTGCTCGGCGAGGTCACCTTCA
TTCAGGTGGTGCGCGACGAGCGTGAGGGCTTGATGCAGCGGATTCGTGCCCAGCTCGACCGCGAGGCGGAAGGCTACGGC
ATTCAGGTCATCGACGTGCGTATCCGCCGTGCCGATCTGCCGGAGCAGAACAGCCAGGCGGTGTATCAGCGGATGCAGAC
CGAACGTCAGCGCGAGGCCGCCGAGTTCCGCGCTCAGGGTGCCCAGAAGGCCCAGGAGATCCGTTCGAGGGCCGACCGCG
AGGCGACCGTGATCGTCGCCGAGGCGAATTCGCAGGCCGAAGAAATCCGCGGTTCGGGCGACGCCGAGCGTAACCGCCTG
TTCGCGGCCGCCTACGGCAAGGACCCGGAATTCTTCTCGTTCTATCGGTCGATGACGGCCTATGATCAGTCGCTGAAGAG
CTCGGACACCCGCTTCCTGCTGCGGCCCGATTCGGAGTTCTTCCGCTTCTTCGCCAATTCGTCCGGCAGGCCTGCGATAC
GGCCGGCGACTGCGGCGGCTCCCGCGCCGGGCGGGACGGGGCAGGCAATGCCTGAACCGGCCGCCGCGCCGCGCTAG

Upstream 100 bases:

>100_bases
TCGTGCCGTATCTGCCGCTGAGTGAGTTGAGCCCGCGCCGCACGGCGCCGGCTACACCGACGCAGCCGCAGAACCAGCAG
ACCCAGGGCGGAGGCAGCCG

Downstream 100 bases:

>100_bases
CGTTTCCGGTTCTGATCGAAACCAGAACCGGGCACCGGATCGCCGTCGTGACGGGTCGTCATGACCCGATCCGGTGCCCG
TTTCCCGCGAAACCATTTCG

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKTGIAGIVALIVLLVAIIVGWSSLFTVRQTEQVLLVRLGEPVRVVTEPGLHFKAPFIDTVISIDKRILDLENPSQEVIA
SDQKRLVVDAFARYRINNALRFYQSIGSIPAANIQLTTLLNSALRRVLGEVTFIQVVRDEREGLMQRIRAQLDREAEGYG
IQVIDVRIRRADLPEQNSQAVYQRMQTERQREAAEFRAQGAQKAQEIRSRADREATVIVAEANSQAEEIRGSGDAERNRL
FAAAYGKDPEFFSFYRSMTAYDQSLKSSDTRFLLRPDSEFFRFFANSSGRPAIRPATAAAPAPGGTGQAMPEPAAAPR

Sequences:

>Translated_318_residues
MKTGIAGIVALIVLLVAIIVGWSSLFTVRQTEQVLLVRLGEPVRVVTEPGLHFKAPFIDTVISIDKRILDLENPSQEVIA
SDQKRLVVDAFARYRINNALRFYQSIGSIPAANIQLTTLLNSALRRVLGEVTFIQVVRDEREGLMQRIRAQLDREAEGYG
IQVIDVRIRRADLPEQNSQAVYQRMQTERQREAAEFRAQGAQKAQEIRSRADREATVIVAEANSQAEEIRGSGDAERNRL
FAAAYGKDPEFFSFYRSMTAYDQSLKSSDTRFLLRPDSEFFRFFANSSGRPAIRPATAAAPAPGGTGQAMPEPAAAPR
>Mature_318_residues
MKTGIAGIVALIVLLVAIIVGWSSLFTVRQTEQVLLVRLGEPVRVVTEPGLHFKAPFIDTVISIDKRILDLENPSQEVIA
SDQKRLVVDAFARYRINNALRFYQSIGSIPAANIQLTTLLNSALRRVLGEVTFIQVVRDEREGLMQRIRAQLDREAEGYG
IQVIDVRIRRADLPEQNSQAVYQRMQTERQREAAEFRAQGAQKAQEIRSRADREATVIVAEANSQAEEIRGSGDAERNRL
FAAAYGKDPEFFSFYRSMTAYDQSLKSSDTRFLLRPDSEFFRFFANSSGRPAIRPATAAAPAPGGTGQAMPEPAAAPR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI38016911, Length=202, Percent_Identity=28.7128712871287, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI7657615, Length=194, Percent_Identity=30.4123711340206, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI21686995, Length=230, Percent_Identity=27.8260869565217, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI221316744, Length=230, Percent_Identity=27.8260869565217, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790617, Length=310, Percent_Identity=32.9032258064516, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786697, Length=279, Percent_Identity=23.2974910394265, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790616, Length=202, Percent_Identity=27.2277227722772, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71987621, Length=248, Percent_Identity=29.0322580645161, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25153583, Length=248, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71987612, Length=230, Percent_Identity=29.5652173913043, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17569493, Length=173, Percent_Identity=29.4797687861272, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193209764, Length=196, Percent_Identity=29.0816326530612, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32566490, Length=220, Percent_Identity=29.0909090909091, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17569497, Length=202, Percent_Identity=26.7326732673267, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI32564147, Length=211, Percent_Identity=26.5402843601896, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17570161, Length=243, Percent_Identity=29.2181069958848, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193210507, Length=243, Percent_Identity=29.2181069958848, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71989955, Length=189, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989948, Length=189, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281365664, Length=219, Percent_Identity=30.5936073059361, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24657857, Length=219, Percent_Identity=30.5936073059361, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI62484448, Length=219, Percent_Identity=30.5936073059361, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI62484274, Length=219, Percent_Identity=30.5936073059361, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550506, Length=208, Percent_Identity=25.4807692307692, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45556022, Length=227, Percent_Identity=27.3127753303965, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI18860517, Length=177, Percent_Identity=27.683615819209, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 35426; Mature: 35426

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGIAGIVALIVLLVAIIVGWSSLFTVRQTEQVLLVRLGEPVRVVTEPGLHFKAPFIDT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCEEECHHHHH
VISIDKRILDLENPSQEVIASDQKRLVVDAFARYRINNALRFYQSIGSIPAANIQLTTLL
HHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
NSALRRVLGEVTFIQVVRDEREGLMQRIRAQLDREAEGYGIQVIDVRIRRADLPEQNSQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCHHH
VYQRMQTERQREAAEFRAQGAQKAQEIRSRADREATVIVAEANSQAEEIRGSGDAERNRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHCCCCCCHHHEE
FAAAYGKDPEFFSFYRSMTAYDQSLKSSDTRFLLRPDSEFFRFFANSSGRPAIRPATAAA
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCC
PAPGGTGQAMPEPAAAPR
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTGIAGIVALIVLLVAIIVGWSSLFTVRQTEQVLLVRLGEPVRVVTEPGLHFKAPFIDT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCEEECHHHHH
VISIDKRILDLENPSQEVIASDQKRLVVDAFARYRINNALRFYQSIGSIPAANIQLTTLL
HHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
NSALRRVLGEVTFIQVVRDEREGLMQRIRAQLDREAEGYGIQVIDVRIRRADLPEQNSQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCHHH
VYQRMQTERQREAAEFRAQGAQKAQEIRSRADREATVIVAEANSQAEEIRGSGDAERNRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHCCCCCCHHHEE
FAAAYGKDPEFFSFYRSMTAYDQSLKSSDTRFLLRPDSEFFRFFANSSGRPAIRPATAAA
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCC
PAPGGTGQAMPEPAAAPR
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]