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The map label for this gene is hflK [H]

Identifier: 86749160

GI number: 86749160

Start: 2317549

End: 2318721

Strand: Direct

Name: hflK [H]

Synonym: RPB_2038

Alternate gene names: 86749160

Gene position: 2317549-2318721 (Clockwise)

Preceding gene: 86749159

Following gene: 86749161

Centisome position: 43.47

GC content: 66.41

Gene sequence:

>1173_bases
ATGCCGTGGAAGAATCAAGGCGGAGGACCGTGGGGTTCTGGTCCGAAGGGGCCATGGGGCTCCGGGCCGCAATCATCGGG
ATCGGGGCCGCGGCCGCCTGACCTGGAAGATCTGCTCCGTCGCGGCCAGGACCGGCTTCAGCAGTTGCTTCCCGGCGGTT
ATTTCAGCGGTCTCGGCATCGCCATCGCGGTGCTCGGCGCGCTGACGATCTGGGGCCTGTCCGGGTTCTTCCGGGTACAG
TCCGAAGAACTCGGCGTCGTGCTGCGCTTCGGCAAGCATGTCCGCACCGTTCAGCCGGGCCTGAATTATCATCTGCCGTA
TCCGATCGAGACCGTACTGCTGCCGAAGGCGCTGCGCGTGTCGACGATCAGTATCGGCATGACGATGATCAACGACCCCG
CGCGGCGCGGCACGACGGTGCGTGACGTTCCCGAAGAGAGCCTGATGCTGACCGGCGACGAGAACATCGTCGACGTCGAC
TTCGCCGTGCTGTGGCGGATCAAGCCCGACGGCGTCGGCAATTTCCTGTTCAACATCCAGAACCCGGAAGGCACCGTGAA
GGCCGTCGCCGAAAGCGCGATGCGCGAAGTGATCGGCCGCTCCAACATCCAGCCGATCCTGACCGGCGCCCGAACCACGA
TCGAGGGCGGCGTCCAGGAACTGATGCAGAAGACGCTCGACGGCTACGGCGCCGGCGTTCTCATCCAGCAGGTGCAGATG
CAGAAGGTCGACCCGCCGCTGCAGGTCATCGACGCGTTCCGCGACGTGCAGGCGGCGCGCGCCGACCTCGAGCGGCTGCA
GAACGAGGCGCAGACCTACGCCAACCGGGTCATCCCGGACGCCAAGGGTCGCGGCGCCCAGATCATCCAGGCCGCCGAAG
GCTACAAAGGACAGGCGGTCGCCGAGGCCAAGGGCCAGAGCGCGCGCTTCCTCGACGTCTATGAAGAATACAGGAAGGCG
CCCGACGTGACCCGTCAGCGGATCTATCTCGAAACCATGGAGCGTGTGCTCGGCCCGGCCGAGAAGCTCGTTTACGATTC
GGGGTCTGGCCCCGGGGGAGGCCAGGGCATCGTGCCGTATCTGCCGCTGAGTGAGTTGAGCCCGCGCCGCACGGCGCCGG
CTACACCGACGCAGCCGCAGAACCAGCAGACCCAGGGCGGAGGCAGCCGATGA

Upstream 100 bases:

>100_bases
GACAAGTGACGACGCGCGTTGTGCCTGCCGGGCCCGTCCCCTATAAAGCCGTTCACGAATTGGGGTCCGCACGATCGCCG
GACCGCTGAGGAGACTTTTG

Downstream 100 bases:

>100_bases
AGACCGGAATCGCAGGTATCGTCGCCCTGATCGTCCTCCTGGTCGCGATCATCGTCGGTTGGTCGTCGCTGTTCACCGTC
CGCCAGACCGAGCAGGTGCT

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MPWKNQGGGPWGSGPKGPWGSGPQSSGSGPRPPDLEDLLRRGQDRLQQLLPGGYFSGLGIAIAVLGALTIWGLSGFFRVQ
SEELGVVLRFGKHVRTVQPGLNYHLPYPIETVLLPKALRVSTISIGMTMINDPARRGTTVRDVPEESLMLTGDENIVDVD
FAVLWRIKPDGVGNFLFNIQNPEGTVKAVAESAMREVIGRSNIQPILTGARTTIEGGVQELMQKTLDGYGAGVLIQQVQM
QKVDPPLQVIDAFRDVQAARADLERLQNEAQTYANRVIPDAKGRGAQIIQAAEGYKGQAVAEAKGQSARFLDVYEEYRKA
PDVTRQRIYLETMERVLGPAEKLVYDSGSGPGGGQGIVPYLPLSELSPRRTAPATPTQPQNQQTQGGGSR

Sequences:

>Translated_390_residues
MPWKNQGGGPWGSGPKGPWGSGPQSSGSGPRPPDLEDLLRRGQDRLQQLLPGGYFSGLGIAIAVLGALTIWGLSGFFRVQ
SEELGVVLRFGKHVRTVQPGLNYHLPYPIETVLLPKALRVSTISIGMTMINDPARRGTTVRDVPEESLMLTGDENIVDVD
FAVLWRIKPDGVGNFLFNIQNPEGTVKAVAESAMREVIGRSNIQPILTGARTTIEGGVQELMQKTLDGYGAGVLIQQVQM
QKVDPPLQVIDAFRDVQAARADLERLQNEAQTYANRVIPDAKGRGAQIIQAAEGYKGQAVAEAKGQSARFLDVYEEYRKA
PDVTRQRIYLETMERVLGPAEKLVYDSGSGPGGGQGIVPYLPLSELSPRRTAPATPTQPQNQQTQGGGSR
>Mature_389_residues
PWKNQGGGPWGSGPKGPWGSGPQSSGSGPRPPDLEDLLRRGQDRLQQLLPGGYFSGLGIAIAVLGALTIWGLSGFFRVQS
EELGVVLRFGKHVRTVQPGLNYHLPYPIETVLLPKALRVSTISIGMTMINDPARRGTTVRDVPEESLMLTGDENIVDVDF
AVLWRIKPDGVGNFLFNIQNPEGTVKAVAESAMREVIGRSNIQPILTGARTTIEGGVQELMQKTLDGYGAGVLIQQVQMQ
KVDPPLQVIDAFRDVQAARADLERLQNEAQTYANRVIPDAKGRGAQIIQAAEGYKGQAVAEAKGQSARFLDVYEEYRKAP
DVTRQRIYLETMERVLGPAEKLVYDSGSGPGGGQGIVPYLPLSELSPRRTAPATPTQPQNQQTQGGGSR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=400, Percent_Identity=33.25, Blast_Score=178, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 42202; Mature: 42070

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWKNQGGGPWGSGPKGPWGSGPQSSGSGPRPPDLEDLLRRGQDRLQQLLPGGYFSGLGI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
AIAVLGALTIWGLSGFFRVQSEELGVVLRFGKHVRTVQPGLNYHLPYPIETVLLPKALRV
HHHHHHHHHHHHCCHHEEECHHHHHHHHHHCCHHHEECCCCCCCCCCCHHHHHHCHHHHH
STISIGMTMINDPARRGTTVRDVPEESLMLTGDENIVDVDFAVLWRIKPDGVGNFLFNIQ
HHHEECHHHHCCHHHCCCCCCCCCCCCEEEECCCCEEEEEEEEEEEECCCCCCCEEEEEE
NPEGTVKAVAESAMREVIGRSNIQPILTGARTTIEGGVQELMQKTLDGYGAGVLIQQVQM
CCCHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QKVDPPLQVIDAFRDVQAARADLERLQNEAQTYANRVIPDAKGRGAQIIQAAEGYKGQAV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCH
AEAKGQSARFLDVYEEYRKAPDVTRQRIYLETMERVLGPAEKLVYDSGSGPGGGQGIVPY
HHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHEEECCCCCCCCCCCCCC
LPLSELSPRRTAPATPTQPQNQQTQGGGSR
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PWKNQGGGPWGSGPKGPWGSGPQSSGSGPRPPDLEDLLRRGQDRLQQLLPGGYFSGLGI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
AIAVLGALTIWGLSGFFRVQSEELGVVLRFGKHVRTVQPGLNYHLPYPIETVLLPKALRV
HHHHHHHHHHHHCCHHEEECHHHHHHHHHHCCHHHEECCCCCCCCCCCHHHHHHCHHHHH
STISIGMTMINDPARRGTTVRDVPEESLMLTGDENIVDVDFAVLWRIKPDGVGNFLFNIQ
HHHEECHHHHCCHHHCCCCCCCCCCCCEEEECCCCEEEEEEEEEEEECCCCCCCEEEEEE
NPEGTVKAVAESAMREVIGRSNIQPILTGARTTIEGGVQELMQKTLDGYGAGVLIQQVQM
CCCHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QKVDPPLQVIDAFRDVQAARADLERLQNEAQTYANRVIPDAKGRGAQIIQAAEGYKGQAV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCH
AEAKGQSARFLDVYEEYRKAPDVTRQRIYLETMERVLGPAEKLVYDSGSGPGGGQGIVPY
HHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHEEECCCCCCCCCCCCCC
LPLSELSPRRTAPATPTQPQNQQTQGGGSR
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]